TumorML: Concept and requirements of an in silico cancer modelling markup language

This paper describes the initial groundwork carried out as part of the European Commission funded Transatlantic Tumor Model Repositories project, to develop a new markup language for computational cancer modelling, TumorML. In this paper we describe the motivations for such a language, arguing that current state-of-the-art biomodelling languages are not suited to the cancer modelling domain. We go on to describe the work that needs to be done to develop TumorML, the conceptual design, and a description of what existing markup languages will be used to compose the language specification

Determination of the number of atoms trapped in an optical cavity

The number of atoms trapped within the mode of an optical cavity is determined in real time by monitoring the transmission of a weak probe beam. Continuous observation of atom number is accomplished in the strong coupling regime of cavity quantum electrodynamics and functions in concert with a cooling scheme for radial atomic motion. The probe transmission exhibits sudden steps from one plateau to the next in response to the time evolution of the intracavity atom number, from Ngreater than or equal to 3 to N=2-->1-->0 atoms, with some trapping events lasting over 1 s

Cavity QED "By The Numbers"

The number of atoms trapped within the mode of an optical cavity is determined in real time by monitoring the transmission of a weak probe beam. Continuous observation of atom number is accomplished in the strong coupling regime of cavity quantum electrodynamics and functions in concert with a cooling scheme for radial atomic motion. The probe transmission exhibits sudden steps from one plateau to the next in response to the time evolution of the intracavity atom number, from N >= 3 to N = 2 to 1 to 0, with some trapping events lasting over 1 second.Comment: 5 pages, 4 figure

Cavity QED with Single Atoms and Photons

Recent experimental advances in the field of cavity quantum electrodynamics (QED) have opened new possibilities for control of atom-photon interactions. A laser with "one and the same atom" demonstrates the theory of laser operation pressed to its conceptual limit. The generation of single photons on demand and the realization of cavity QED with well defined atomic numbers N = 0, 1, 2,... both represent important steps toward realizing diverse protocols in quantum information science. Coherent manipulation of the atomic state via Raman transitions provides a new tool in cavity QED for in situ monitoring and control of the atom-cavity system. All of these achievements share a common point of departure: the regime of strong coupling. It is thus interesting to consider briefly the history of the strong coupling criterion in cavity QED and to trace out the path that research has taken in the pursuit of this goal

Dynamics of a tunable superfluid junction

We study the population dynamics of a Bose-Einstein condensate in a double-well potential throughout the crossover from Josephson dynamics to hydrodynamics. At barriers higher than the chemical potential, we observe slow oscillations well described by a Josephson model. In the limit of low barriers, the fundamental frequency agrees with a simple hydrodynamic model, but we also observe a second, higher frequency. A full numerical simulation of the Gross-Pitaevskii equation giving the frequencies and amplitudes of the observed modes between these two limits is compared to the data and is used to understand the origin of the higher mode. Implications for trapped matter-wave interferometers are discussed.Comment: 8 pages, 7 figures; v3: Journal reference added, minor changes to tex

Observation of the Vacuum-Rabi Spectrum for One Trapped Atom

The transmission spectrum for one atom strongly coupled to the field of a high-finesse optical resonator is observed to exhibit a clearly resolved vacuum-Rabi splitting characteristic of the normal modes in the eigenvalue spectrum of the atom-cavity system. A new Raman scheme for cooling atomic motion along the cavity axis enables a complete spectrum to be recorded for an individual atom trapped within the cavity mode, in contrast to all previous measurements in cavity QED that have required averaging over many atoms.Comment: 5 pages with 4 figure

Experimental realization of a one-atom laser in the regime of strong coupling

Conventional lasers (from table-top systems to microscopic devices) typically operate in the so-called weak-coupling regime, involving large numbers of atoms and photons; individual quanta have a negligible impact on the system dynamics. However, this is no longer the case when the system approaches the regime of strong coupling for which the number of atoms and photons can become quite small. Indeed, the lasing properties of a single atom in a resonant cavity have been extensively investigated theoretically. Here we report the experimental realization of a one-atom laser operated in the regime of strong coupling. We exploit recent advances in cavity quantum electrodynamics that allow one atom to be isolated in an optical cavity in a regime for which one photon is sufficient to saturate the atomic transition. The observed characteristics of the atom–cavity system are qualitatively different from those of the familiar many-atom case. Specifically, our measurements of the intracavity photon number versus pump intensity indicate that there is no threshold for lasing, and we infer that the output flux from the cavity mode exceeds that from atomic fluorescence by more than tenfold. Observations of the second-order intensity correlation function demonstrate that our one-atom laser generates manifestly quantum (nonclassical) light, typified by photon anti-bunching and sub-poissonian photon statistics

Muscle architectural and force-velocity curve adaptations following 10 weeks of training with weightlifting catching and pulling derivatives

The aims of this study were to examine the muscle architectural, rapid force production, and force-velocity curve adaptations following 10 weeks of resistance training with either submaximal weightlifting catching (CATCH) or pulling (PULL) derivatives or pulling derivatives with phase-specific loading (OL). 27 re-sistance-trained men were randomly assigned to the CATCH, PULL, or OL groups and completed pre-and post-intervention ultrasound, countermovement jump (CMJ), and isometric mid-thigh pull (IMTP). Vastus lateralis and biceps femoris muscle thickness, pennation angle, and fascicle length, CMJ force at peak power, velocity at peak power, and peak power, and IMTP peak force and force at 100-, 150-, 200-, and 250 ms were assessed. There were no significant or meaningful differences in muscle architecture measures for any group (p \u3e 0.05). The PULL group displayed small-moderate (g = 0.25 - 0.81) improvements in all CMJ variables while the CATCH group displayed trivial effects (g = 0.00 - 0.21). In addition, the OL group displayed trivial and small effects for CMJ force (g = -0.12 - 0.04) and velocity variables (g = 0.32 - 0.46), respectively. The OL group displayed moderate (g = 0.48 - 0.73) improvements in all IMTP variables while to PULL group displayed small-moderate (g = 0.47 - 0.55) im-provements. The CATCH group displayed trivial-small (g = -0.39 - 0.15) decreases in IMTP performance. The PULL and OL groups displayed visible shifts in their force-velocity curves; however, these changes were not significant (p \u3e 0.05). Perform-ing weightlifting pulling derivatives with either submaximal or phase-specific loading may enhance rapid and peak force production characteristics. Strength and conditioning practitioners should load pulling derivatives based on the goals of each specific phase, but also allow their athletes ample exposure to achieve each goal

State-Insensitive Cooling and Trapping of Single Atoms in an Optical Cavity

Single Cesium atoms are cooled and trapped inside a small optical cavity by way of a novel far-off-resonance dipole-force trap (FORT), with observed lifetimes of 2 to 3 seconds. Trapped atoms are observed continuously via transmission of a strongly coupled probe beam, with individual events lasting ~ 1 s. The loss of successive atoms from the trap N = 3 -> 2 -> 1 -> 0 is thereby monitored in real time. Trapping, cooling, and interactions with strong coupling are enabled by the FORT potential, for which the center-of-mass motion is only weakly dependent on the atom's internal state.Comment: 5 pages, 4 figures Revised version to appear in Phys. Rev. Let

Deterministic Generation of Single Photons from One Atom Trapped in a Cavity

A single cesium atom trapped within the mode of an optical cavity is used to generate single photons on demand. The photon wave packets are emitted as a Gaussian beam with temporal profile and repetition rate controlled by external driving fields. Each generation attempt is inferred to succeed with a probability near unity, whereas the efficiency for creating an unpolarized photon in the total cavity output is 0.69 ± 0.10, as limited by passive cavity losses. An average of 1.4 × 10^4 photons are produced by each trapped atom. These results constitute an important step in quantum information science, for example, toward the realization of distributed quantum networking