Where the Jobs Are: Identification and Analysis of Local Employment Opportunities

A practitioner\u27s guide to local labor market analysis.https://research.upjohn.org/up_press/1127/thumbnail.jp

Redistricting does little to change which party people vote for, which can make partisan gerrymanders more effective.

Every decade US state legislators redistrict the congressional districts in their state based on new census information. Over the decades redistricting has become another means by which a political party can gain electoral advantage. In new research using Pennsylvania’s redistricting as a case study, William D. Hicks and Seth C. McKee find that voters in redrawn districts did not change their voting preferences, and that changes in their incumbent candidate or an electoral tide towards the Democratic Party had little or no effect on these choices

Party competition is the primary driver of the recent increase in restrictive voter id laws in the American states

The lead up to the recent midterm elections was marked by contentious debates over the effects on turnout of voter ID laws passed in several American states. In new research William D. Hicks, Seth C. McKee, Mitchell D. Sellers and Daniel A. Smith find that there has been a large increase in the number of states that have adopted voter ID laws since 2001, and in these states the level of partisan polarization in voting on these laws is very high. They find that not only is the introduction and passage of stricter voter ID legislation influenced by the number of Republican lawmakers in a state legislature, but how electorally competitive the environment that those legislators find themselves in is important as well

Multiple linear correlations between face drop performance and combinations of sack paper properties

"January 17, 1966.""The Institute of Paper Chemistry, William J. Whitsitt, research associate and R. C. McKee, chairman, Container Section.

Failure of corrugated boxes under long term loading, summary of results as of June 12, 1963. Project 1108-30, report one : a preliminary report to Technical Committee of the Fourdrinier Board Institute, Inc.

"June 13, 1963.""Distributed at FKI Technical Meeting June 18, 1963 (New York)"-- handwritten note on title page."The Institute of Paper Chemistry ... William J. Whitsitt ... Robert C. McKee.

Between cavity variance

"September 1, 1962.""The Institute of Paper Chemistry ... W. J. Whitsitt ... R. C. McKee.

Equilibrium moisture content of sack paper. Project 2033, progress report two to Multiwall Shipping Sack Paper Manufacturers

"October 1, 1958.""The Institute of Paper Chemistry, W. J. Whitsitt, research aide and R. C. McKee, chief, Container Section.

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.

Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed by post-mortem examination of brain tissue. As the first part of a series of consensus panels funded by the NINDS/NIBIB to define the neuropathological criteria for CTE, preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer's disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and parkinsonism dementia complex of Guam. The results demonstrated that there was good agreement among the neuropathologists who reviewed the cases (Cohen's kappa, 0.67) and even better agreement between reviewers and the diagnosis of CTE (Cohen's kappa, 0.78). Based on these results, the panel defined the pathognomonic lesion of CTE as an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern. The group also defined supportive but non-specific p-tau-immunoreactive features of CTE as: pretangles and NFTs affecting superficial layers (layers II-III) of cerebral cortex; pretangles, NFTs or extracellular tangles in CA2 and pretangles and proximal dendritic swellings in CA4 of the hippocampus; neuronal and astrocytic aggregates in subcortical nuclei; thorn-shaped astrocytes at the glial limitans of the subpial and periventricular regions; and large grain-like and dot-like structures. Supportive non-p-tau pathologies include TDP-43 immunoreactive neuronal cytoplasmic inclusions and dot-like structures in the hippocampus, anteromedial temporal cortex and amygdala. The panel also recommended a minimum blocking and staining scheme for pathological evaluation and made recommendations for future study. This study provides the first step towards the development of validated neuropathological criteria for CTE and will pave the way towards future clinical and mechanistic studies

Polymicrobial oral biofilm models: simplifying the complex

Over the past century, numerous studies have used oral biofilm models to investigate growth kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host–pathogen interactions. In vivo animal models provide useful models of some oral diseases; however, these are expensive and carry vast ethical implications. Oral biofilms grown or maintained in vitro offer a useful platform for certain studies and have the advantages of being inexpensive to establish and easy to reproduce and manipulate. In addition, a wide range of variables can be monitored and adjusted to mimic the dynamic environmental changes at different sites in the oral cavity, such as pH, temperature, salivary and gingival crevicular fluid flow rates, or microbial composition. This review provides a detailed insight for early-career oral science researchers into how the biofilm models used in oral research have progressed and improved over the years, their advantages and disadvantages, and how such systems have contributed to our current understanding of oral disease pathogenesis and aetiology