1,154 research outputs found
The Fair Labor Standards Act: A Tool for Those Who Represent Employees, Claimants, and Plaintiffs
The Fair Labor Standards Act (FLSA) of 1938 is a comprehensive federal statute that regulates minimum wages, maximum hours, and child labor. This article is intended to provide background for the general practitioner in an effort to help advance the interests of Kansas Association for Justice clients and workers. The FLSA was created to hold disreputable employers to account for chiseling their workers. The tangle of rules and regulations that followed may have complicated the operation of a basically straightforward law. But as long as lawyers understand and can navigate these highly technical provisions, FDR’s grand vision for fair and safe employment is within reach
Search for long lived charged massive particles in pp collisions at s-hat = 1.8TeV
We report a search for the production of long-lived charged massive particles in a data sample of 90 pb-1 of √s=1.8 TeV pp̅ collisions recorded by the Collider Detector at Fermilab. The search uses the muonlike penetration and anomalously high ionization energy loss signature expected for such a particle to discriminate it from backgrounds. The data are found to agree with background expectations, and cross section limits of O(1) pb are derived using two reference models, a stable quark and a stable scalar lepton
PO-1015: High Dose Rate image guided adaptive brachytherapy for cervical cancer - a single centre experience
Cross sections for nu(mu) and (nu)over-bar(mu) induced pion production on hydrocarbon in the few-GeV region using MINERvA
Separate samples of charged-current pion production events representing two semi-inclusive channels nu(mu)-CC(pi(+)) and (nu) over bar (mu) -CC(pi(0)) have been obtained using neutrino and antineutrino exposures of the MINERvA detector. Distributions in kinematic variables based upon mu(+/-)-track reconstructions are analyzed and compared for the two samples. The differential cross sections for muon production angle, muon momentum, and four-momentum transfer Q(2) are reported, and cross sections versus neutrino energy are obtained. Comparisons with predictions of current neutrino event generators are used to clarify the role of the Delta(1232) and higher-mass baryon resonances in CC pion production and to show the importance of pion final-state interactions. For the nu(mu)-CC(pi(+)) [(nu) over bar (mu)-(pi(0))] sample, the absolute data rate is observed to lie below (above) the predictions of some of the event generators by amounts that are typically 1-to- 2 sigma. However the generators are able to reproduce the shapes of the differential cross sections for all kinematic variables of either data set
Charged pion production in nu(mu) interactions on hydrocarbon at \u3c E-nu \u3e=4.0 GeV
Charged pion production via charged-current nu(mu) interactions on plastic scintillator (CH) is studied using the MINERvA detector exposed to the NuMI wideband neutrino beam at Fermilab. Events with hadronic invariant massW \u3c 1.4 GeV and W \u3c 1.8 GeV are selected in separate analyses: the lower W cut isolates single pion production, which is expected to occur primarily through the Delta(1232) resonance, while results from the higher cut include the effects of higher resonances. Cross sections as functions of pion angle and kinetic energy are compared to predictions from theoretical calculations and generator-based models for neutrinos ranging in energy from 1.5-10 GeV. The data are best described by calculations which include significant contributions from pion intranuclear rescattering. These measurements constrain the primary interaction rate and the role of final state interactions in pion production, both of which need to be well understood by neutrino oscillation experiments
Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein
Hepatitis C virus (HCV) is a positive-strand RNA virus that frequently causes persistent infections and is uniquely associated with the development of hepatocellular carcinoma. While the mechanism(s) by which the virus promotes cancer are poorly defined, previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation. Here, we describe the mechanism underlying pRb regulation by HCV and its relevance to HCV infection. We show that the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component, following infection of cultured hepatoma cells with either genotype 1a or 2a HCV. We further demonstrate that this is due to NS5B-dependent ubiquitination of pRb and its subsequent degradation via the proteasome. The NS5B-dependent ubiquitination of pRb requires the ubiquitin ligase activity of E6-associated protein (E6AP), as pRb abundance was restored by siRNA knockdown of E6AP or overexpression of a dominant-negative E6AP mutant in cells containing HCV RNA replicons. E6AP also forms a complex with pRb in an NS5B-dependent manner. These findings suggest a novel mechanism for the regulation of pRb in which the HCV NS5B protein traps pRb in the cytoplasm, and subsequently recruits E6AP to this complex in a process that leads to the ubiquitination of pRb. The disruption of pRb/E2F regulatory pathways in cells infected with HCV is likely to promote hepatocellular proliferation and chromosomal instability, factors important for the development of liver cancer
Search for the flavor changing neutral current decay D0 to mu mu in pp collisions at root s = 1.96 TeV
Measurement of the ratio of b quark production cross-sections in anti-p p collisions at vs = 630-GeV and vs - 1800-GeV
Direct Measurement of Nuclear Dependence of Charged Current Quasielastic-like Neutrino Interactions using MINERvA
Charged-current interactions on carbon, iron, and lead with a
final state hadronic system of one or more protons with zero mesons are used to
investigate the influence of the nuclear environment on quasielastic-like
interactions. The transfered four-momentum squared to the target nucleus,
, is reconstructed based on the kinematics of the leading proton, and
differential cross sections versus and the cross-section ratios of iron,
lead and carbon to scintillator are measured for the first time in a single
experiment. The measurements show a dependence on atomic number. While the
quasielastic-like scattering on carbon is compatible with predictions, the
trends exhibited by scattering on iron and lead favor a prediction with
intranuclear rescattering of hadrons accounted for by a conventional particle
cascade treatment. These measurements help discriminate between different
models of both initial state nucleons and final state interactions used in the
neutrino oscillation experiments
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