An International Pilot Study of K-12 Teachers’Computer Science Self-Esteem

Computer Science (CS) is a new subject area for many K-12 teachersaround the world, requiring new disciplinary knowledge and skills.Teacher social-behavioral factors (e.g. self-esteem) have been foundto impact learning and teaching, and a key part of CS curriculumimplementation will need to ensure teachers feel confident to de-liver CS. However, studies about CS teacher self-esteem are lacking.This paper presents an analysis of publicly available data (n=219)from a pilot study using a Teacher CS Self-Esteem scale. Analy-sis revealed significant differences, including 1) females reportedsignificantly lower CS self-esteem than males, 2) primary teachersreported lower levels of CS self-esteem than secondary teachers, 3)those with no CS teaching experience reported significantly lowerCS self-esteem, 4) teachers with 0-3 years experience had a neg-ative CS self-esteem, but after four years, teachers had a positiveCS self-esteem, and 5) teachers who lived further from metropol-itan areas and in some countries reported lower CS self-esteem.These initial findings suggest a pressing need for future researchto look further into teacher CS self-esteem to inform teacher CSprofessional development

Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products

The immunogenicity of protein therapeutics is an important safety and efficacy concern during drug development and regulation. Strategies to identify individuals and subpopulations at risk for an undesirable immune response represent an important unmet need. The major histocompatibility complex (MHC)–associated peptide proteomics (MAPPs) assay directly identifies the presence of peptides derived from a specific protein therapeutic on a donor’s MHC class II (MHC-II) proteins. We applied this technique to address several questions related to the use of factor VIII (FVIII) replacement therapy in the treatment of hemophilia A (HA). Although .12 FVIII therapeutics are marketed, most fall into 3 categories: (i) human plasma-derived FVIII (pdFVIII), (ii) full-length (FL)–recombinant FVIII (rFVIII; FL-rFVIII), and (iii) B-domain–deleted rFVIII. Here, we investigated whether there are differences between the FVIII peptides found on the MHC-II proteins of the same individual when incubated with these 3 classes. Based on several observational studies and a prospective, randomized, clinical trial showing that the originally approved rFVIII products may be more immunogenic than the pdFVIII products containing von Willebrand factor (VWF) in molar excess, it has been hypothesized that the pdFVIII molecules yield/ present fewer peptides (ie, potential T-cell epitopes). We have experimentally tested this hypothesis and found that dendritic cells from HA patients and healthy donors present fewer FVIII peptides when administered pdFVIII vs FL-rFVIII, despite both containing the same molar VWF excess. Our results support the hypothesis that synthesis of pdFVIII under physiological conditions could result in reduced heterogeneity and/or subtle differences in structure/conformation which, in turn, may result in reduced FVIII proteolytic processing relative to FL-rFVIII

Prematurity in Central Hospital and GN Children’s Clinic in Warri Niger Delta.

Aim: To determine the pattern of presentation of prematurity in Warri Niger Delta. Materials and Method: Retrieval and analysis of casenotes of all the premature babies seen between 2000 and 2007 at General Hospital Warri, a specialist hospital with referrals from surrounding General Hospitals, and GN Children’s Clinic, the two major hospitals for children for Warri and its environs. Results: Of the 639 babies seen, 249 were males and 390 females, giving a ration of 1:1.6. The youngest in gestational age was 20weeks and five days while the oldest was 36weeks. The lightest in weight was 600g while the heaviest was 2,400g. Kangaroo nursing was introduced very early in the management. The weight on discharge ranged from 1200g to 2400g, with very good result. The average weight on discharge was 1500g. The overall mortality was 25.3%, but was 85.5% in those less than 28weeks of gestation. Mortality was also higher in males at38.6% to 16.9% for females. Respiratory complications are the commonest cause of death, accounting for 30.8% of the deathrate. Conclusion: Prematurity remains a major cause of morbidity and mortality in the newborn period in developing countries. Early maternal handling and introduction of cup and spoon feeding will reduce the time of hospital stay and also the cost of management  Keywords: prematurity, Niger Delta.

Acute glomerulonephritis in children of the Niger Delta region of Nigeria

A three-year retrospective study was conducted to determine the incidence, pattern of presentation and other clinical and biochemical features as well as outcome of treatment of patients admitted with acute glomerulonephritis at the Delta State University Teaching Hospital, Oghara and GN Children′s Clinic, Warri. The case notes of all the children who presented with renal diseases from January 2010 to December 2012 were retrieved and those with acute glomerulonephritis were analyzed. A total of 20 patients (13 male and seven female) with acute glomerulonephritis were seen during the three-year period under review. Twelve patients (60%) were from the low socioeconomic class, six (30%) from the middle class and only two (10%) were from the high-income group. The presentation of the illness was most common between October and January. The age range of the patients was three to 13 years, with an average age of eight years. Seventeen (85%) of the patients were in the school-going age group (>5 years to 10 years). The most common symptom/sign noted was anemia in 90% of the patients, followed by oliguria/anuria and edema seen in 80% of the patients. Seventy percent of the patients had cola-colored urine, while 55% had hypertension. Some patients gave a history suggestive of previous streptococcal infection. More patients had sore throat (25%) than skin infection (10%). All the patients had proteinuria, while 90% had hematuria. The most common complication was acute kidney injury, seen in eight (40%) of the patients, followed by hypertensive encephalopathy, which occurred in three (15%) patients. Most patients (60%) were hospitalized for one to two weeks. The outcome of the management of these patients showed 14 (70%) of the patients recovered fully while three (15%) had persistent hematuria and two (10%) had persistent proteinuria. Ninety-five percent of the patients recovered from the acute illness and one patient (5%), a boy aged nine years old, died

Pattern of Renal Diseases among Children in The Niger Delta Region, Nigeria

No Abstract

Socio-demographic and health risk profile associated with participation in a private health insurance weight loss maintenance and chronic disease management program.

Objective Identifying who participates in chronic disease management programs yields insights into program reach and appeal. This study investigated sustained participation in a remotely delivered weight loss maintenance program offered to Australian private health insurance members. Methods All participants completing an initial 18-week weight loss program were eligible for a maintenance phase. A pre-post test design was used and sociodemographic and anthropometric characteristics of those who did and did not opt in to the maintenance phase were compared using binary logistic regression. Results Maintenance phase participants lost more weight during the initial weight loss program (−2.2 kg (P < 0.001); body mass index −0.8 kg/m2 (P < 0.001)) than those who did not opt in. Participants who were obese (v. overweight) upon completion of the initial weight loss program were less likely to opt in to the maintenance phase (adjusted odds ratio (aOR) 1.76, 95% confidence interval (CI) 1.35–2.30, P < 0.001) and participants aged ≥55 years were more likely to opt in (aOR 0.59, 95% CI 0.44–0.80, P < 0.001) than those aged <55 years. Conclusions Understanding why health insurance members opt in to maintenance programs can assist the development of strategies to improve program reach. Younger participants and those who remain obese following a weight loss program may be targeted by private health insurers and service providers to increase weight loss maintenance program participation. What is known about the topic? Australian private health insurers offer chronic disease management programs to support members to manage obesity-related chronic disease. An 18-week weight loss and lifestyle modification program was extended to assist participants maintain weight loss and health benefits resulting from the initial program. This weight loss maintenance phase is novel in the private health insurance setting and is thought to be important to sustained health improvement. Although program reach is important to benefit those most in need, little is known about who sustains the use (or does not) of such programs. What does this paper add? This study provides an insight to the characteristics of participants more likely to opt in to a weight loss maintenance program. It highlights the sociodemographic and anthropometric characteristics associated with maintenance program uptake, identifying the subgroups less likely to opt in. These study findings are novel because they report on participation in a chronic disease management program with a focus on maintenance of weight loss. What are the implications for practitioners? These results will benefit private health insurers and service providers implementing maintenance programs for weight loss, providing an awareness of which participant groups to target to increase maintenance and reach. In addition, they offer avenues for future exploration, such as the generalisability and sustainability of chronic disease management programs. Although those not opting in are a difficult-to-access group, a qualitative study of reasons for not opting in to such a program would provide further information for program design, recruitment and retention