5,215 research outputs found
EFFECTS OF POWER CARDS ON CONVERSATIONAL SKILLS FOR HIGH SCHOOLERS WITH AUTISM SPECTRUM DISORDER
This study employed a multiple probe across settings design to evaluate the effectiveness of Power Cards, as they were originally designed by Gagnon (2001), on the conversational behaviors for two high school students diagnosed with autism spectrum disorder. Data were collected on the percentage of conversational behaviors engaged in per session, as well as the number of times the participants accessed their Power Card during conversations, and the frequency of additional questions or comments made by the participants. Results of this study indicated that Power Cards improved conversational behaviors for both participants in their first setting. While covariation occurred across untrained settings for both participants, therefore weakening the experimental control of this study, promising results were produced for Sunday practitioners and teachers
Remarkable symmetries in the Milky Way disk's magnetic field
Using a new, expanded compilation of extragalactic source Faraday rotation
measures (RM) we investigate the broad underlying magnetic structure of the
Galactic disk at latitudes over all longitudes ,
where our total number of RM's in this low-latitude range of the Galactic sky
is comparable to those in the combined Canadian Galactic Plane Survey(CGPS) at
and the Southern Galactic Plane (SGPS)
survey. We report newly revealed, remarkably coherent patterns of RM at
from to and RM()
features of unprecedented clarity that replicate in with opposite sign on
opposite sides of the Galactic center. They confirm a highly patterned
bisymmetric field structure toward the inner disc, an axisymmetic pattern
toward the outer disc, and a very close coupling between the CGPS/SGPS RM's at
("mid-plane") and our new RM's up to ("near-plane").
Our analysis also shows the approximate -height -- the vertical height of
the coherent component of the disc field above the Galactic disc's mid-plane --
to be kpc out to kpc from the Sun. This identifies the
approximate height of the transition layer to the halo field structure. We find
no RM sign change across the plane within in any
longitude range. The prevailing {\it disc} field pattern, and its striking
degree of large scale ordering confirm that our side of the Milky Way has a
very organized underlying magnetic structure, for which the inward spiral pitch
angle is at all up to in
the inner semicircle of Galactic longitudes. It decreases to
toward the anticentre.Comment: 7 pages, 5 figures, Version 3. Accepted 2011 for publication in
Publications of the Astronomical Society of Australia(PASA
Market Research: Tenancy Fitout Material Procurement Attitudes and Practices
The Better Buildings partnership (BBP) has previously investigated the tenancy processes that generate waste successive cycles of fitout, de-fit, make good and re-fit. This research project has been commissioned to explore why waste occurs in commercial building fitouts and what can be done about it, with a particular focus on the materials that dominate the fitout waste stream. The characteristics of each material and aspects of its usage are explored to determine how to improve reuse and recycling rates. The Institute for Sustainable Futures (ISF) conducted in-depth interviews with 15 industry participants for this study, ranging from architects and property managers through to contractors and manufacturers. We also reviewed literature to provide context, however we found the available literature somewhat limited in terms of its currency, depth and local relevance. It is the interview conversations that provide a rich picture of the myriad issues and day-to-day problems that make it hard to institute a less wasteful, circular economy. The study attempts to place the problems in the context of the whole system to highlight possible solutions
Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen) on lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and glycerol release in adipocytes isolated from subcutaneous abdominal adipose tissue. Methods: Adipose tissue was obtained from 12 non-diabetic women, mean age 51 years (range 37-78) and mean BMI 25.4kg/m2 (range 20.3-26.4). Adipocytes were treated with increasing doses of DYD and NET for 48 hours prior to protein extraction. Effects on lipogenesis and lipolysis were assessed using western blotting to determine the expression of key enzymes, LPL (56kDa) and HSL (84kDa) respectively. Measurement of glycerol release into the medium provided an assessment of lipolytic activity. Results: Expression of LPL was increased by DYD and NET (mean protein expression relative to control ± SEM); with greatest effect at 10-8M for DYD: 2.32±0.51(p0.05). Conclusions: DYD and NET significantly increased LPL expression relative to control whilst significantly reducing HSL expression. At the concentrations studied, similar effects were observed with the androgenic NET and the non-androgenic DYD despite differing effects on the lipid profile when taken
in combination with estrogen. Further work in this area may improve knowledge about the effects of different progestogens on body fat distribution and enable progestogen use to be tailored to the individual to achieve maximal benefits
Recommended from our members
Boron content of Lake Ulubat sediment: A key to interpret the morphological history of NW Anatolia, Turkey
Freshwater Lake Ulubat (c. 1.5 m deep and c. 138 km2) receives sediment from a 10.414 km2 area in the seismically active Susurluk Drainage Basin (SDB) of NW Turkey. The B and trace element contents of the lake infill seem to be a link between the fresh landforms of the SDB and the lacustrine sediment. Deposition in Lake Ulubat has been 1.60 cm.a-1 for the last 50 a according to radionucleides; however the sedimentation rate over the last millennium was 0.37 cm.a-1 based on 14C dating. The B content of the lacustrine infill displays a slight increase at 0.50 m and a drastic increase at 4 m depth occurring c. 31 a and c. 1070 a ago respectively. Probably the topmost change corresponds to the start of open mining in the SDB and the second one to the natural trenching of borate ore-deposits. These dates also show indirectly a 1.4 cm.a-1 erosion rate during the last millennium as the borate beds were trenched up to 15 m. By extrapolation, it is possible to establish that the formation of some of the present morphological features of the southern Marmara region, especially river incision, began in the late Pleistocene, and developed especially over the last 75 ka
Coaching to augment mentoring to achieve faculty diversity:a randomized controlled trial
Purpose: The Academy for Future Science Faculty (the Academy) is a novel coaching intervention for biomedical PhD students designed to address limitations in previous efforts to promote faculty diversity. Unlike traditional research mentoring, the Academy includes both group and individual coaching, coaches have no research or evaluation roles with the students, and it is based on social science theories. The authors present a qualitative case study of one of the coaching groups and provide statistical analyses indicating whether one year in the Academy effects students’ perceptions of the achievability and desirability of an academic career. Method: The authors tested (July 2012–July 2013), with Northwestern University ethical approval, the Academy via a longitudinal randomized controlled trial. Participants were 121 latter-stage biomedical PhD students. The authors collected data via questionnaires, interviews, and meeting recordings. Results: The case study shows how group career coaching can effectively supplement traditional one-to-one research mentoring; provide new role models for underrepresented minority students; and provide theory-based lenses through which to engage in open conversations about race, gender, and science careers. Repeated-measures analysis of variance showed that perceived achievability increased in the Academy group from baseline to one-year follow-up (mean, 5.75 versus 6.39) but decreased in the control group (6.58 versus 5.81). Perceived desirability decreased significantly less (P < .05) in the Academy group (7.00 versus 6.36) than in the control group (7.83 versus 5.97). Conclusions: Early results suggest that an academic career coaching model can effectively supplement traditional research mentoring and promote persistence toward academic careers
Stable Isotopic and Geochemical Variability within Shallow Groundwater beneath a Hardwood Hammock and Surface Water in an Adjoining Slough (Everglades National Park, FL)
Data from a ten-month monitoring study during 2007 in south Florida provide insight into the variation of δ18O, δD, and δ13C of DOC in surface water and shallow groundwater of the Everglades ecosystem. Bi-monthly samples were taken from surface water and time-averaged precipitation at Taylor Slough, and shallow groundwater from a well and a small cave within Palma Vista Hammock, an exposure of the Upper Pleistocene Miami Limestone.
δ18O and δD values in shallow groundwater from the well and cave remain near the mean of -2.4 ‰ and -12 ‰, respectively (VSMOW scale). 18O and D are enriched in surface water compared to shallow groundwater. δ18O and δD values in surface water fluctuate in sync with, but to a lesser amplitude than, those measured in rainfall. The local meteoric water line (LMWL) for precipitation is in close agreement to the global meteoric water line (GMWL); however, the local evaporation line (LEL) for surface water and shallow groundwater is δD = 5.6 δ18O + 1.5 (R2=0.97), a sign that these waters have experienced evaporation. The intercept of the LMWL and LEL indicates that the primary recharge to the Everglades occurs primarily from tropical or frontal sources. Local convection merely recycles available water.
Time-series of deuterium excess (Dex), clearly reveals two moisture sources for precipitation; an evaporation-dominated source with Dex\u3e10 and a source significantly influenced by transpiration with Dex\u3c10. Samples with higher Dex cluster in the fall and winter, and appear to be associated with maritime moisture carried along the Trade Winds. Samples with lower Dex cluster in the late spring and summer, and could reflect continental moisture carried by the Westerlies or local convection.
Values of δ13CDOC between -22.6 and -28.0‰ suggest C-3 vegetation as the primary source of DOC at all sample sites. C:N ratios of DOC averaging 20:1 at the cave indicate that organic matter originates from woody material, while an average of 15:1 at the well along with δ13CDOC similar to the cave indicate further decomposition of the organic matter entering the cave. C:N ratios of DOC the slough averaged 15:1, and with δ13CDOC values, suggest sources of organic matter not present at the cave and well
HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy
Purpose of the study
Fractional clearance rate of apolipoprotein B100-containing
lipoproteins is reduced in HIV infection before and
after antiretroviral (ARV) treatment [1]. We compared
lipoprotein lipase (LPL) activity and gene expression in
HIV-positive subjects before and 6 months after ARV with
HIV-negative controls.
Methods
Fasting blood post heparin total and hepatic lipase activity,adiponectin, leptin, insulin, glucose, and lipid measurementswere made in 32 HIV-infected and 15 HIVnegative
controls. LPL was estimated by subtractinghepatic lipase from total lipase. Adiponectin, LPL andhormone sensitive lipase (HSL) gene expression weremeasured from iliac crest subcutaneous fat biopsies.Patients were tested before, and 6 months after randomisation to AZT/3TC (n = 15) or TDF/FTC (n = 17) with EFV.Between-group comparison was by Mann-Whitney andpaired samples by the Wilcoxon signed rank tests.
Summary of results
There were no differences in gender, ethnicity, baseline
BMI, regional fat distribution (whole body DEXA) and
visceral (VAT) and subcutaneous fat (SAT) measured by
abdominal CT scans between controls and patients. Trunk
fat/BMI ratio, VAT and VAT:SAT ratio significantly
increased after 6-month ARV therapy (p = 0.01). There
were no differences between groups in serum NEFA,HOMA and leptin levels. Selected other results are shown
in Table 1.
Conclusion
Post heparin lipoprotein lipase activity is reduced in HIV
and does not return to control levels after 6 months of
ARV therapy. AZT-containing regimens are associated
with a greater increase in LPL, LPL gene expression and
plasma adiponectin than TDF
- …