Richmond Mural Tour

In the past years Richmond has been growing in popularity in the world of street art. This popularity is due in part to the many projects that brought in artists from around the world to create beautiful artwork. There is so much art outside in Richmond as a result of these projects, but no great way to navigate the streets of the city in an efficient manner to see all of it. Richmond Mural Tour is a mobile cross-platform application that allows users to explore all of the amazing outdoor artwork around the city. This application is built on ionic 2, a cross-platform framework that allows developers to write code in one language, Javascript. The project can then be built into a native iOS, Android, and Windows phone applications. The app utilizes the Google Maps Javascript API to display a map of all the murals in Richmond. It then allows users to build and customize “Tours” or routes with any number of murals that have been selected. It also takes advantage of the Mapquest Web API to find the most optimal route between a list of waypoints. To serve all of this data to mobile phones this application uses a simple ASP.NET Core web API to transmit the data to devices via the internet.https://scholarscompass.vcu.edu/capstone/1159/thumbnail.jp

Mesopredator Occupancy and Passerine Richness Along an Urbanization Gradient in Central Coastal California

As anthropogenic activity such as urbanization and agriculture destroys and fragments wildlife habitat, some patches may grow too small or isolated to support apex predators, which may allow mesopredator populations to flourish in the absence of predation and competition pressure. In areas where mesopredator occupancy is high, increased predation pressure may be placed on mesopredator prey species such as songbirds, which are already experiencing declines due to habitat loss. Here I used camera traps to collect occupancy data of the region’s most commonly occurring apex predators (coyotes) and three mesopredator species (bobcats, gray foxes, and domestic cats) at 35 sites along an urbanization gradient prominently featuring agriculture in California’s Salinas Valley, and I conducted avian point counts to estimate passerine richness at 70 sites along the same gradient. I evaluated the influence of apex predators on mesopredators with single-season occupancy models, and I assessed the potential impact of mesopredators on passerine richness with Random Forest regression analysis. Gray foxes displayed a strong negative relationship with coyote activity and a strong positive relationship with mountain lion presence, while coyotes were negatively associated with mountain lions. Distance to wildland patches was the top predictor for both felid species, neither of which were notably impacted by coyotes. While natural landscape and topography predictors had the greatest explanatory power for passerine richness, domestic cat activity also had a notable adverse effect on passerines, with more explanatory power than all other carnivore and human-related metrics. Agricultural metrics typically displayed only moderate or weak predictive power in all models despite having higher carnivore and passerine richness than all other landscape classes, suggesting that there is greater complexity to how wildlife use agricultural habitat than I captured in this study

EVALUATING THE CYBER SECURITY IN THE INTERNET OF THINGS: SMART HOME VULNERABILITIES

The need for advanced cyber security measures and strategies is attributed to modern sophistication of cyber-attacks and intense media attention when attacks and breaches occur. In May 2014, a congressional report suggested that Americans used approximately 500 million Internet-capable devices at home, including, but not limited to Smartphones, tablets, and other Internet-connected devices, which run various unimpeded applications. Owing to this high level of connectivity, our home environment is not immune to the cyber-attack paradigm; rather, the home has evolved to become one of the most influenced markets where the Internet of Things has had extensive surfaces, vectors for attacks, and unanswered security concerns. Thus, the aim of the present research was to investigate behavioral heuristics of the Internet of Things by adopting an exploratory multiple case study approach. A controlled Internet of Things ecosystem was constructed consisting of real-life data observed during a typical life cycle of initial configuration and average use. The information obtained during the course of this study involved the systematic acquisition and analysis of Smart Home ecosystem link-layer protocol data units (PDUs). The methodology employed during this study involved a recursive multiple case study evaluation of the Smart Home ecosystem data-link layer PDUs and aligned the case studies to the existing Intrusion Kill Chain design model. The proposed solution emerging from the case studies builds the appropriate data collection template while concurrently developing a Security as a Service (SECaaS) capability to evaluate collected results

Permissive Regulation: A Critical Review of the Regulatory History of Buprenorphine Formulations in Canada

Suboxone (buprenorphine-naloxone) is an opioid product approved in the US and Canada for the treatment of opioid use disorder. The drug is considered an important response to the opioid overdose epidemic with consistent calls for wider prescribing and deregulation. The history of Suboxone regulation in Canada has not been critically examined. Part of the rationale for doing so stems from the US regulatory experience, with documented irregularities, or what some have called abuses, that support profit-making by Suboxone\u27s manufacturers. This regulatory analysis allows us to determine how opportunities to address health crises through drug innovation are managed at a federal level. We used public drug and patent registries to critically examine Suboxone\u27s Canadian history. First, we investigated Suboxone\u27s entry into the Canadian market to understand how it achieved market exclusivity. Second, we examined Health Canada\u27s risk mitigation process to address extramedical use and diversion to understand the intersection of regulation and brand promotion. Insights from these two analyses were then extended to the recent approval of two related buprenorphine-containing products and their specific pathways to Canadian market exclusivity. We identified inconsistencies in Suboxone\u27s regulatory history that suggest Health Canada\u27s functions of health protection and promotion were compromised in favour of an “innovations” agenda that supports profit-making. Despite six years of market exclusivity in Canada, there was no evidence suggesting Suboxone achieved formal exclusivity (i.e., through patent or data protection). Health Canada\u27s process to address safety concerns of Suboxone were compromised by reliance on the manufacturer to carry out post-market education, allowing the manufacturer to create and market a branded “education” program for its product. Similar inconsistencies have afforded market exclusivity for two related products despite marginal innovation. These analyses reveal a case of permissive regulation, where principles of health protection are compromised by economic imperatives. Such a regulatory approach has the potential to adversely impact public health due to unnecessarily high costs for medicines deemed essential to stem a major health crisis. Alternative pharmaceutical policies are urgently needed to safely and efficiently expand treatment access for opioid use disorder

Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

Glycogen availability can influence glucose transporter 4 (GLUT4) expression in skeletal muscle through unknown mechanisms. The multisubstrate enzyme AMP-activated protein kinase (AMPK) has also been shown to play an important role in the regulation of GLUT4 expression in skeletal muscle. During contraction, AMPK [alpha]2 translocates to the nucleus and the activity of this AMPK isoform is enhanced when skeletal muscle glycogen is low. In this study, we investigated if decreased pre-exercise muscle glycogen levels and increased AMPK [alpha]2 activity reduced the association of AMPK with glycogen and increased AMPK [alpha]2 translocation to the nucleus and GLUT4 mRNA expression following exercise. Seven males performed 60 min of exercise at ~70% [VO.sub.2] peak on 2 occasions: either with normal (control) or low (LG) carbohydrate pre-exercise muscle glycogen content. Muscle samples were obtained by needle biopsy before and after exercise. Low muscle glycogen was associated with elevated AMPK [alpha]2 activity and acetyl-CoA carboxylase [beta] phosphorylation, increased translocation of AMPK [alpha]2 to the nucleus, and increased GLUT4 mRNA. Transfection of primary human myotubes with a constitutively active AMPK adenovirus also stimulated GLUT4 mRNA, providing direct evidence of a role of AMPK in regulating GLUT4 expression. We suggest that increased activation of AMPK [alpha]2 under conditions of low muscle glycogen enhances AMPK [alpha]2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle. <br /

Calcium alginate microencapsulation of ovarian follicles impacts FSH delivery and follicle morphology

BACKGROUND: We have previously shown that suspension culture prevents follicle flattening and maintains three-dimensional follicle architecture better than culture on flat plates. However, many of the follicles cultured in suspension do eventually rupture, as basement membrane integrity is lost and the three-dimensional structure of the follicle is altered. Therefore, the objective of this study is to support three-dimensional follicle architecture during in vitro growth of ovarian follicles through encapsulation in calcium alginate, while maintaining responsiveness to FSH stimulation. METHODS: Preantral follicles (150 – 160 micrometers in diameter) were isolated from the ovaries of juvenile rats and grown in culture tubes or encapsulated in calcium alginate and grown in culture tubes. Previous studies revealed that follicles maintained structural integrity but did not grow as well when encapsulated in calcium alginate. In these studies, we evaluated the effect of calcium alginate on FSH-stimulated follicle growth, survival, and morphology in suspension culture. Follicles were grown under 5 culture conditions: 1) not encapsulated; with FSH in the medium, 2) encapsulated in the absence of FSH, grown in medium without FSH, 3) encapsulated with calcium alginate containing FSH but grown in medium without FSH, 4) encapsulated without FSH but grown in medium containing FSH and 5) encapsulated with calcium alginate containing FSH and in medium containing FSH. To assess growth rates, follicles were cultured for 72 hours and analyzed for follicle size increase and DNA content. Survival analysis for encapsulated and unencapsulated follicles was performed by constructing a Kaplan Meier survival curve of daily observations of intact follicle survival. Three-dimensional architecture was assessed histologically and by analysis of the pattern of connexin 43 expression in the cultured follicles. RESULTS: In the absence of FSH, follicle diameter increased by only 6.4%. When FSH was included in the alginate bead alone or the media alone, the follicle diameter increased by 13.5% and 19.9% respectively. This was greater than follicles cultured in the absence of FSH (p < 0.05), but less than that of the FSH-treated unencapsulated follicles (p < 0.05). However, when follicles were cultured with FSH included in both the media and the bead, a 32.6% increase in follicle diameter was observed, statistically no different than the growth rate of the unencapsulated follicles grown with FSH. CONCLUSION: Microencapsulation supports three-dimensional follicle growth, but may limit access to hormones in the medium resulting in altered development compared to unencapsulated follicles. Inclusion of FSH in the alginate bead restores the follicle growth response to FSH, while also providing a scaffold of support for three-dimensional growth. The application of tissue engineering principles to the problems of follicle culture in vitro may provide advances applicable to fertility preservation in women and endangered species

Are the Goals of Sustainability Interconnected? A Sociological Analysis of the Three E’s of Sustainable Development Using Cross-Lagged Models with Reciprocal Effects

Conceptual discussions of sustainability emphasize the interdependent relationship between relevant social and environmental factors. Yet, traditional quantitative analyses of the topic have tended to estimate the exogenous or direct/indirect effects a predictor variable has on a particular measure of sustainability. We examine the endogenous, interdependent relationship between the three E’s of sustainability (economy, equity, and ecology), incorporating country-level data for 1990 through 2015 into cross-lagged structural equation models with reciprocal and fixed effects. Results from these longitudinal models suggest that over time, at the country level, increasing economic inequality reduces renewable energy consumption, with no evidence of reciprocal feedback. Keeping in mind the limitations of the analysis, we tentatively argue that the modern form of development has constrained the potential for the sustainability goals to feed back into each other

Designing for Reuse in an Industrial Internet of Things Monitoring Application

Abstract The Internet of Things (IoT) continues to experience rapid growth, and its influence is extending into previously unreached domains. However, some of these new domains impose specific limitations that complicate the design and implementation of IoT systems. Examples of such limitations are the exclusion of specific protocols, restrictions on the types of data that can be collected, requirements about what information can be transmitted to the public and controls around how that communication occurs. Capturing, representing and designing for these limitations as well as reuse is essential for the quick and successful deployment of such projects. In this paper, we present a case study of an IoT human in the loop monitoring system built for use within an industrial setting. We report our experiences with both designing the first deployment of the system as well as designing variation points into the software architecture to account for future iterations and deployment into other environments

Technological memory aid use by people with acquired brain injury

Evans, Wilson, Needham, and Brentnall (2003) investigated memory aid use by people with acquired brain injury (ABI) and found little use of technological memory aids. The present study aims to investigate use of technological and other memory aids and strategies 10 years on, and investigate what predicts use. People with ABI and self-reported memory impairments (n = 81) completed a survey containing a memory aid checklist, demographic questions and memory questionnaires. Chi-square analysis showed that 10 of 18 memory aids and strategies were used by significantly more people in the current sample than in Evans et al. (2003). The most commonly used strategies were leaving things in noticeable places (86%) and mental retracing of steps (77%). The most commonly used memory aids were asking someone to remind you (78%), diaries (77%), lists (78%), and calendars (79%) and the most common technologies used were mobile phone reminders (38%) and alarms/timers (38%). Younger people who used more technology prior to their injury and who use more non-technological memory aids currently were more likely to use technology. Younger people who used more memory aids and strategies prior to their injury and who rated their memory as poorer were more likely to use all types of memory aids and strategies

The Effect of Electronic Cigarette User Modifications and E-liquid Adulteration on the Particle Size Profile of an Aerosolized Product

Electronic cigarettes (e-cigarettes) are an alternate nicotine delivery system that generate a condensation aerosol to be inhaled by the user. The size of the droplets formed in the aerosol can vary and contributes to drug deposition and ultimate bioavailability in the lung. The growing popularity of e-cigarette products has caused an increase in internet sources promoting the use of drugs other than nicotine (DOTNs) in e-cigarettes. The purpose of this study was to determine the effect of various e-cigarette and e-liquid modifications, such as coil resistance, battery voltage, and glycol and drug formulation, on the aerosol particle size. E-liquids containing 12 mg/mL nicotine prepared in glycol compositions of 100% propylene glycol (PG), 100% vegetable glycerin (VG), or 50:50 PG:VG were aerosolized at three voltages and three coil resistances. Methamphetamine and methadone e-liquids were prepared at 60 mg/mL in 50:50 PG:VG and all e-liquids were aerosolized onto a 10 stage Micro-Orifice Uniform Deposit Impactor. Glycol deposition correlated with drug deposition, and the majority of particles centered between 0.172–0.5 μm in diameter, representing pulmonary deposition. The 100% PG e-liquid produced the largest aerosol particles and the 100% VG and 50:50 PG:VG e-liquids produced ultra-fine particles \u3c0.3 μm. The presence of ultrafine particles indicates that drugs can be aerosolized and reach the pulmonary alveolar regions, highlighting a potential for abuse and risk of overdose with DOTNs aerosolized in an e-cigarette system