1,405 research outputs found
A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease
Damage to the gastrointestinal tract is a major cause of morbidity and mortality in graft-versus-host disease (GVHD) and is attributable to T cell–mediated inflammation. In this work, we identified a unique CD4+ T cell population that constitutively expresses the β2 integrin CD11c and displays a biased central memory phenotype and memory T cell transcriptional profile, innate-like properties, and increased expression of the gut-homing molecules α4β7 and CCR9. Using several complementary murine GVHD models, we determined that adoptive transfer and early accumulation of β2 integrin–expressing CD4+ T cells in the gastrointestinal tract initiated Th1-mediated proinflammatory cytokine production, augmented pathological damage in the colon, and increased mortality. The pathogenic effect of this CD4+ T cell population critically depended on coexpression of the IL-23 receptor, which was required for maximal inflammatory effects. Non–Foxp3-expressing CD4+ T cells produced IL-10, which regulated colonic inflammation and attenuated lethality in the absence of functional CD4+Foxp3+ T cells. Thus, the coordinate expression of CD11c and the IL-23 receptor defines an IL-10–regulated, colitogenic memory CD4+ T cell subset that is poised to initiate inflammation when there is loss of tolerance and breakdown of mucosal barriers
Measurement of the p\bar{p}\sqrt{s}$ = 1.8 TeV
We update the measurement of the top production cross section using the CDF
detector at the Fermilab Tevatron. This measurement uses decays to
the final states +jets and +jets. We search for quarks from
decays via secondary-vertex identification or the identification of
semileptonic decays of the and cascade quarks. The background to the
production is determined primarily through a Monte Carlo simulation.
However, we calibrate the simulation and evaluate its uncertainty using several
independent data samples. For a top mass of 175 , we measure
pb and pb using
the secondary vertex and the lepton tagging algorithms, respectively. Finally,
we combine these results with those from other decay channels and
obtain pb.Comment: The manuscript consists of 130 pages, 35 figures and 42 tables in
RevTex. The manuscript is submitted to Physical Review D. Fixed typo in
author lis
Search for the Supersymmetric Partner of the Top-Quark in Collisions at
We report on a search for the supersymmetric partner of the top quark (stop)
produced in events using of
collisions at recorded with the Collider Detector at
Fermilab. In the case of a light stop squark, the decay of the top quark into
stop plus the lightest supersymmetric particle (LSP) could have a significant
branching ratio. The observed events are consistent with Standard Model production and decay. Hence, we set limits on the branching ratio of
the top quark decaying into stop plus LSP, excluding branching ratios above 45%
for a LSP mass up to 40 {\rm GeV/c}.Comment: 11 pages, 4 figure
The masses of satellites in GAMA galaxy groups from 100 square degrees of KiDS weak lensing data
We use the first 100 deg2 of overlap between the Kilo-Degree Survey and the Galaxy And Mass Assembly survey to determine the average galaxy halo mass of ∼10 000 spectroscopically confirmed satellite galaxies in massive (M > 1013 h−1 M⊙) galaxy groups. Separating the sample as a function of projected distance to the group centre, we jointly model the satellites and their host groups with Navarro–Frenk–White density profiles, fully accounting for the data covariance. The probed satellite galaxies in these groups have total masses log 〈Msub/(h−1 M⊙)〉 ≈ 11.7–12.2 consistent across group-centric distance within the errorbars. Given their typical stellar masses, log 〈M⋆, sat/(h−2 M⊙)〉 ∼ 10.5, such total masses imply stellar mass fractions of 〈M⋆, sat〉/〈Msub〉 ≈ 0.04 h−1. The average subhalo hosting these satellite galaxies has a mass Msub ∼ 0.015Mhost independent of host halo mass, in broad agreement with the expectations of structure formation in a Λ cold dark matter universe.Publisher PDFPeer reviewe
Measurement of J/Psi and Psi(2S) Polarization in ppbar Collisions at sqrt(s) = 1.8 TeV
We have measured the polarization of J/Psi and Psi(2S) mesons produced in
p\bar{p} collisions at \sqrt{s} = 1.8 TeV, using data collected at CDF during
1992-95.
The polarization of promptly produced J/Psi [Psi(2S)] mesons is isolated from
those produced in B-hadron decay, and measured over the kinematic range 4[5.5]
< P_T < 20 GeV/c and |y| < 0.6. For P_T \gessim 12 GeV/c we do not observe
significant polarization in the prompt component.Comment: Revised version, accepted for publication in Physical Review Letter
Search for Narrow Diphoton Resonances and for gamma-gamma+W/Z Signatures in p\bar p Collisions at sqrt(s)=1.8 TeV
We present results of searches for diphoton resonances produced both
inclusively and also in association with a vector boson (W or Z) using 100
pb^{-1} of p\bar p collisions using the CDF detector. We set upper limits on
the product of cross section times branching ratio for both p\bar
p\to\gamma\gamma + X and p\bar p\to\gamma\gamma + W/Z. Comparing the inclusive
production to the expectations from heavy sgoldstinos we derive limits on the
supersymmetry-breaking scale sqrt{F} in the TeV range, depending on the
sgoldstino mass and the choice of other parameters. Also, using a NLO
prediction for the associated production of a Higgs boson with a W or Z boson,
we set an upper limit on the branching ratio for H\to\gamma\gamma. Finally, we
set a lower limit on the mass of a `bosophilic' Higgs boson (e.g. one which
couples only to \gamma, W, and Z$ bosons with standard model couplings) of 82
GeV/c^2 at 95% confidence level.Comment: 30 pages, 11 figure
Limits on Gravitino Production and New Processes with Large Missing Transverse Energy in p-pbar Collisions at sqrt(s)=1.8 TeV
Events collected by the Collider Detector at Fermilab (CDF) with an energetic
jet plus large missing transverse energy can be used to search for physics
beyond the Standard Model. We see no deviations from the expected background
and set upper limits on the production of new processes. We consider in
addition the production of light gravitinos within the framework of the Gauge
Mediated Supersymmetry Breaking models and set a limit at 95% confidence level
on the breaking scale sqrt(F) >= 217 GeV, which excludes gravitino masses
smaller than 1.1x10^-5 eV/c^2.Comment: 13 pages, 4 figures. Submitted to Physical Review Letter
Production of Y(1S) Mesons from chib Decays in pp(bar) Collisions at sqrt(s)=1.8 TeV
We have reconstructed the radiative decays and in collisions
at TeV, and measured the fraction of mesons
that originate from these decays. For mesons with
GeV/, the fractions that come from and
decays are and
, respectively. We have derived the fraction of
directly produced mesons to be .Comment: 13 Pages, 2 figure
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