Mapping the disease-specific LupusQoL to the SF-6D

Purpose To derive a mapping algorithm to predict SF-6D utility scores from the non-preference-based LupusQoL and test the performance of the developed algorithm on a separate independent validation data set. Method LupusQoL and SF-6D data were collected from 320 patients with systemic lupus erythematosus (SLE) attending routine rheumatology outpatient appointments at seven centres in the UK. Ordinary least squares (OLS) regression was used to estimate models of increasing complexity in order to predict individuals’ SF-6D utility scores from their responses to the LupusQoL questionnaire. Model performance was judged on predictive ability through the size and pattern of prediction errors generated. The performance of the selected model was externally validated on an independent data set containing 113 female SLE patients who had again completed both the LupusQoL and SF-36 questionnaires. Results Four of the eight LupusQoL domains (physical health, pain, emotional health, and fatigue) were selected as dependent variables in the final model. Overall model fit was good, with R2 0.7219, MAE 0.0557, and RMSE 0.0706 when applied to the estimation data set, and R2 0.7431, MAE 0.0528, and RMSE 0.0663 when applied to the validation sample. Conclusion This study provides a method by which health state utility values can be estimated from patient responses to the non-preference-based LupusQoL, generalisable beyond the data set upon which it was estimated. Despite concerns over the use of OLS to develop mapping algorithms, we find this method to be suitable in this case due to the normality of the SF-6D data

Cuadernos de pedagogía

El artículo forma parte de un dossier titulado: El desafío de la diversidad : un estímulo para el desarrollo profesionalEl proyecto que ha dado origen al artículo, Responding to Diversity by Engaging with Students’ Voices: A Strategy for Teacher Development, está financiado con el apoyo de la Comisión Europea en el marco del Life Learning Programme. European Union Comenius Multilateral Project (RD-SVTD, 2011-2014)En publicación aparece Ignacio ZapateroSe describe cómo se lleva a la práctica el proyecto multilateral Comenius del Life Learning Programme, de la Unión Europea en los ocho centros de Secundaria participantes. Cuatro institutos ingleses (dos de Manchester y dos de Hull), dos españoles (en Madrid) y dos portugueses (en Lisboa) comparten propósitos semejantes: conseguir prácticas de aula más inclusivas, fomentar un aprendizaje significativo y entender la diversidad del alumnado como una oportunidad de la que aprender.Madrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; Calle General Ricardos 179; 28025 Madrid; Tel. +34915250893; Fax +34914660991; [email protected]