Relational Financial Satisfaction of Cohabiting Couples

The current study tested a model of factors affecting cohabiting couples\u27 relational financial satisfaction, defined as the contentment an individual has with how financial issues are handled within his or her domestic romantic relationship, and examined the relations within these factors. This study was a cross-sectional online survey of 266 participants (81% female; 85% Caucasian) recruited from listservs and subsequent snowball sampling. Measures assessed couples\u27 financial strain, dedication commitment, financial conflict, financial trust, financial equality and financial communication. Relational financial satisfaction (RFS) was significantly related to financial conflict, financial strain and dedication commitment. Financial conflict mediated the association between financial trust and RFS, as well as between financial communication and RFS. Financial trust and communication mediated the association between financial equality and financial conflict. In addition, RFS was related to but distinct from relationship satisfaction. This study revealed components important to consider in the assessment and treatment of couples\u27 financial relationships

Movement I from \u3cem\u3eLamentationes\u3c/em\u3e

This piece is a setting of the first poem in the book of ʼêḵāh from the Hebrew Bible (the book of Lamentations in the Christian Old Testament). Setting the text in its original language has had two primary advantages: (1) it preserved euphony and other poetic subtleties and (2) it left the poetry\u27s original cultural context intact. I use harmonic rhetoric to imitate several features of the text. One of them is the so-called tragic reversal, a device illustrated by the lines cited above, where a reversal of fortune is expressed through the contrast between the first colon and the second colon of a given line. I imitate this device by using contrasting harmonies for the two parts of the line. For example, in the first line I use dark minor chords to set the first colon and a bright, unrelated major chord to set the second colon. I imitate the essential structural device of the poem as well: the Hebrew acrostic. By beginning each three-line verse with successive letters of the Hebrew alphabet, the poet methodically addresses every facet of grief A through Z, as it were. I imitate this structural device by moving through every possible key area in a controlled order throughout the piece. Through these and other rhetorical techniques, my intention has been to create a musical work that imitates the pathos, logos, and ethos of the Hebrew poetry. The end result is a composition that, I hope, brings back to life a text written in a language that has been dead for millennia. The work seeks to translate the poetry of ʼêḵāh directly from Classical Hebrew into a modern idiom of Western music, accessible to contemporary audiences

Modernization of Ultrasonic Immersion Robot

This senior design project utilized an ultrasonic immersion robot to collect ultrasonic data that was then used to generate three dimensional images. Ultrasonic waves provide a means to evaluate the interior of an object without damaging it. The robot, controlled by a LinuxCNC program, is used to collect data points over a pre-programed area and resolution. The data points consist of the x and y coordinates and ultrasonic amplitudes corresponding to depths. Matlab scripts were written that process the collected data and create images and videos depicting the surfaces and features of the scanned object. During the course of two semesters the group members returned functionality to the robot system and the ultrasonic system and created the post image processing scripts. These systems were used successfully to create three dimensional images and videos of a key, a steel plate and an aluminum plate for presentation

Dolce stil novo

Dolce Stil Novo is a slightly unconventional kind of tone poem. As the title suggests, the main inspiration for the piece is the poetry of Dante Alighieri, especially that subset of it which belongs to his so-called Sweet New Style. While the three successive intermezzi are tied only obliquely to this subject, the first and final movements make direct reference to Dante\u27s Sweet New Style as found in the Vita Nuova, an autobiographical compilation of prose and verse. In this way, the piece is a reflection on Dante\u27s writings from two perspectives: that of the author (in the first and final movements) and that of the reader (in the middle movements). The narrative of the piece alternates between these perspectives in its three sections: Section 1 Venus Tristior\u22. A reader takes up the Vita Nuova and gets only about halfway through-not quite to Donne ch\u27 avete intelletto d\u27amore, the first poem written in the dolce stil novo. Without it being any kind of comment on the quality of the book, the reader eventually falls asleep. Section 2 Piano Portrait, Commuting on a Pileated Woodpecker with Mild Psychosis, and The Surreal . The sleeping reader dreams of what has been read so far. In the dream, esoteric themes of the Vita Nuova play themselves out through an amalgam of eclectic memories and images taken from the reader\u27s own life. Gradually, the dream devolves into a nightmare, symbolizing the fall of man (which may be one of the allegorical meanings of the story of lost love that Dante tells in the Vita Nuova) . Section 3 Beata Beatrix . Awaking to :finish the text, the reader is deeply moved by the account and especially by Dante\u27s reaction to the death of Beatrice. This leaves the reader thoughtful and filled with the peace of God

Characterization of middle‐atmosphere polar warming at Mars

We characterize middle‐atmosphere polar warming (PW) using nearly three Martian years of temperature observations by the Mars Climate Sounder. We report the observed structure of PW and share hypotheses as to possible explanations, which have yet to be tested with global dynamical models. In the data, PW manifested between p  = 15 Pa and p  = 4.8×10 –3  Pa. The latitude where PW maximized shifted poleward with decreasing pressure. The nightside magnitude was larger than the dayside magnitude. The maximum nightside magnitudes ranged from 22 to 67 K. As expected, the annual maximum magnitude in the north occurred during late‐local fall to middle‐local winter. In the south it occurred during late‐local winter. Also as expected, the maximum magnitude near MY 28's southern winter solstice was smaller than that at that same year's northern winter solstice, when a global dust storm was occurring. Unexpectedly, the maximum magnitude at southern winter solstice was comparable to that at northern winter solstice for both MY 29 and MY 30, years that did not experience global dust storms but certainly experienced greater dust loading during L s  = 270° than L s  = 90°. Another unexpected result was a hemispheric asymmetry in PW magnitude during most of the observed equinoxes. This paper also provides tables of (1) averaged temperatures as a function of latitude, pressure, and season, and (2) the maximum polar warming features as a function of pressure and season. These tables can be used to validate GCM calculations of middle‐atmosphere temperatures and constrain calculations of unobserved winds. Key Points Polar warming is characterized based on nearly three MYs of MCS temperatures Average temperatures are provided for validation of modeled temperatures Polar warming characteristics are provided for constraint of modeled windsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97505/1/jgre20016.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/97505/2/SPICAM_temperatures_v_latitude.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/97505/3/PolarWarming_CrossSections_Dayside.pd

DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis

DAP12 (KARAP) is a transmembrane signaling adaptor for a family of innate immunoreceptors that have been shown to activate granulocytes and monocytes/macrophages, amplifying production of inflammatory cytokines. Contrasting with these data, recent studies suggest that DAP12 signaling has an inhibitory role in the macrophage response to microbial products (Hamerman, J.A., N.K. Tchao, C.A. Lowell, and L.L. Lanier. 2005. Nat. Immunol. 6:579–586). To determine the in vivo role for DAP12 signaling in inflammation, we measured the response of wild-type (WT) and DAP12−/− mice to septic shock. We show that DAP12−/− mice have improved survival from both endotoxemia and cecal ligation and puncture–induced septic shock. As compared with WT mice, DAP12−/− mice have decreased plasma cytokine levels and a decreased acute phase response during sepsis, but no defect in the recruitment of cells or bacterial control. In cells isolated after sepsis and stimulated ex vivo, DAP12 signaling augments lipopolysaccharide-mediated cytokine production. These data demonstrate that, during sepsis, DAP12 signaling augments the response to microbial products, amplifying inflammation and contributing to mortality

PC-based web authoring: How to learn as little unix as possible while getting on the Web

This document is a general guide for creating Web pages, using commonly available word processing and file transfer applications. It is not a full guide to HTML, nor does it provide an introduction to the many WYSIWYG HTML editors available. The viability of the authoring method it describes will not be affected by changes in the HTML specification or the rapid release-and-obsolescence cycles of commercial WYSIWYG HTML editors. This document provides a gentle introduction to HTML for the beginner, and as the user gains confidence and experience, encourages greater familiarity with HTML through continued exposure to and hands-on usage of HTML code

AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer

Cancer cells may overcome growth factor dependence by deregulating oncogenic and/or tumor-suppressor pathways that affect their metabolism, or by activating metabolic pathways de novo with targeted mutations in critical metabolic enzymes. It is unknown whether human prostate tumors develop a similar metabolic response to different oncogenic drivers or a particular oncogenic event results in its own metabolic reprogramming. Akt and Myc are arguably the most prevalent driving oncogenes in prostate cancer. Mass spectrometry-based metabolite profiling was performed on immortalized human prostate epithelial cells transformed by AKT1 or MYC, transgenic mice driven by the same oncogenes under the control of a prostate-specific promoter, and human prostate specimens characterized for the expression and activation of these oncoproteins. Integrative analysis of these metabolomic datasets revealed that AKT1 activation was associated with accumulation of aerobic glycolysis metabolites, whereas MYC overexpression was associated with dysregulated lipid metabolism. Selected metabolites that differentially accumulated in the MYC-high versus AKT1-high tumors, or in normal versus tumor prostate tissue by untargeted metabolomics, were validated using absolute quantitation assays. Importantly, the AKT1/MYC status was independent of Gleason grade and pathologic staging. Our fi ndings show how prostate tumors undergo a metabolic reprogramming that refl ects their molecular phenotypes, with implications for the development of metabolic diagnostics and targeted therapeutics.Instituto de Investigaciones Bioquímicas de La PlataFacultad de Ciencias Médica

AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer

Cancer cells may overcome growth factor dependence by deregulating oncogenic and/or tumor-suppressor pathways that affect their metabolism, or by activating metabolic pathways de novo with targeted mutations in critical metabolic enzymes. It is unknown whether human prostate tumors develop a similar metabolic response to different oncogenic drivers or a particular oncogenic event results in its own metabolic reprogramming. Akt and Myc are arguably the most prevalent driving oncogenes in prostate cancer. Mass spectrometry–based metabolite profiling was performed on immortalized human prostate epithelial cells transformed by AKT1 or MYC, transgenic mice driven by the same oncogenes under the control of a prostate-specific promoter, and human prostate specimens characterized for the expression and activation of these oncoproteins. Integrative analysis of these metabolomic datasets revealed that AKT1 activation was associated with accumulation of aerobic glycolysis metabolites, whereas MYC overexpression was associated with dysregulated lipid metabolism. Selected metabolites that differentially accumulated in the MYC-high versus AKT1-high tumors, or in normal versus tumor prostate tissue by untargeted metabolomics, were validated using absolute quantitation assays. Importantly, the AKT1/MYC status was independent of Gleason grade and pathologic staging. Our findings show how prostate tumors undergo a metabolic reprogramming that reflects their molecular phenotypes, with implications for the development of metabolic diagnostics and targeted therapeutics.Fil: Priolo, Carmen. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados UnidosFil: Pyne, Saumyadipta. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados UnidosFil: Rose, Joshua. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados UnidosFil: Regan, Erzsébet Ravasz. Harvard Medical School; Estados UnidosFil: Zadra, Giorgia. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados UnidosFil: Photopoulos, Cornelia. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados UnidosFil: Cacciatore, Stefano. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados UnidosFil: Schultz, Denise. Johns Hopkins University; Estados UnidosFil: Scaglia, Natalia. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: McDunn, Jonathan. Metabolon Inc.; Estados UnidosFil: de Marzo, Angelo M.. Johns Hopkins University; Estados UnidosFil: Loda, Massimo. Department of Pathology. Brigham and Women's Hospital; Estados Unidos. Department of Medical Oncology. Dana Farber Cancer Institute. Brigham and Women's Hospital; Estados Unidos. University of Cambridge; Estados Unidos. King's College London. Division of Cancer Studies; Estados Unido