A multicentre validation of Metasin: a molecular assay for the intraoperative assessment of sentinel lymph nodes from breast cancer patients

Aims: Treatment strategies for breast cancer continue to evolve. No uniformity exists in the UK for the management of node‐positive breast cancer patients. Most centres continue to use conventional histopathology of sampled sentinel lymph nodes (SLNs), which requires delayed axillary clearance in up to 25% of patients. Some use touch imprint cytology or frozen section for intraoperative testing, although both have inherent sensitivity issues. An intraoperative molecular diagnostic approach helps to overcome some of these limitations. The aim of this study was to assess the clinical effectiveness of Metasin, a molecular method for the intraoperative evaluation of SLNs. Methods and results: RNA from 3296 lymph nodes from 1836 patients undergoing SLN assessment was analysed with Metasin. Alternate slices of tissue were examined in parallel by histology. Cases deemed to be discordant were analysed by protein gel electrophoresis. There was concordance between Metasin and histology in 94.1% of cases, with a sensitivity of 92% [95% confidence interval (CI) 88–94%] and a specificity of 97% (95% CI 95–97%). Positive and negative predictive values were 88% and 98%, respectively. Over half of the discordant cases (4.4%) were ascribed to tissue allocation bias (TAB). Conclusions: Clinical validation of the Metasin assay suggests that it is sufficiently sensitive and specific to make it fit for purpose in the intraoperative setting

Y1Feedback - The Story so Far: Progress and Reflections from an Irish Multi-institutional Learning and Teaching Enhancement Project

The Y1Feedback Project is a multi-institutional learning and teaching enhancement project that aims to support the transition to Higher Education by using digital technologies to enhance feedback in the first year. The project is funded by the National Forum for the Enhancement of Teaching and Learning in HE under the 2014 Enhancement fund. This paper outlines the project development and progress, with particular focus on identification of the feedback approaches that we are developing case studies of as part of this initiative. Although the project is not complete, the outcome of initial evaluations is reported and we reflect on the process and challenges encountered

Y1Feedback - The Story so Far: Progress and Reflections from an Irish Multi-institutional Learning and Teaching Enhancement Project

The Y1Feedback Project is a multi-institutional learning and teaching enhancement project that aims to support the transition to Higher Education by using digital technologies to enhance feedback in the first year. The project is funded by the National Forum for the Enhancement of Teaching and Learning in HE under the 2014 Enhancement fund. This paper outlines the project development and progress, with particular focus on identification of the feedback approaches that we are developing case studies of as part of this initiative. Although the project is not complete, the outcome of initial evaluations is reported and we reflect on the process and challenges encountered