27 research outputs found

    Carbonodraco lundi gen et sp. Nov., the oldest parareptile, from Linton, Ohio, and new insights into the early radiation of reptiles

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    Redescription of the holotype specimen of Cephalerpeton ventriarmatum Moodie, 1912, from the Middle Pennsylvanian (Moscovian) Francis Creek Shale of Mazon Creek, Illinois, confirms that it is a basal eureptile with close postcranial similarities to other protorothyridids, such as Anthracodromeus and Paleothyris. The skull is long and lightly built, with large orbits and a dorsoventrally short mandible similar to most basal eureptiles. Two specimens referred previously to Cephalerpeton cf. C. ventriarmatum from the approximately coeval Linton, Ohio, locality differ significantly from the holotype in cranial and mandibular proportions and tooth morphology. This material and an additional Linton specimen compare favourably to ‘short-faced’ parareptiles, such as Colobomycter and Acleistorhinus, and justify recognition of an acleistorhinid parareptile in the Linton assemblage. The new binomen is thus the oldest known parareptile

    Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge

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    Consumer wearables and sensors are a rich source of data about patients' daily disease and symptom burden, particularly in the case of movement disorders like Parkinson's disease (PD). However, interpreting these complex data into so-called digital biomarkers requires complicated analytical approaches, and validating these biomarkers requires sufficient data and unbiased evaluation methods. Here we describe the use of crowdsourcing to specifically evaluate and benchmark features derived from accelerometer and gyroscope data in two different datasets to predict the presence of PD and severity of three PD symptoms: tremor, dyskinesia, and bradykinesia. Forty teams from around the world submitted features, and achieved drastically improved predictive performance for PD status (best AUROC = 0.87), as well as tremor- (best AUPR = 0.75), dyskinesia- (best AUPR = 0.48) and bradykinesia-severity (best AUPR = 0.95)

    Erratum: Carbonodraco lundi gen et sp. Nov., the oldest parareptile, from Linton, Ohio, and new insights into the early radiation of reptiles (Royal Society Open Science (2019) 6 (191191) DOI: 10.1098/rsos.191191)

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    Our originally published manuscript ‘Carbonodraco lundi gen et sp. nov., the oldest parareptile, from Linton, Ohio, and new insights into the early radiation of reptiles’ did not include the required ZooBank accession number. This is supplied here: LSIDurn:lsid:zoobank.org:pub:02676B44-D849-4ACC-8869-76D54 60E4239
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