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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
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- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ève
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
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- Cooper Jamie
- Cooper Melanie
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- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
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- Daly James
- Daly Zoe
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- Dark Paul
- Darreau Cédric
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- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
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- Detry Michelle
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- Distler Michael
- Doble Patricia
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- Doran Peter
- Dragija Lidija
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- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
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- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- D’Aragon Frédérick
- D’Souza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
- English Shane
- Estcourt Lise
- Estcourt Lise
- Estensen Kristen
- Everitt Robert
- Evers Mirjam
- Farahi Neda
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazekas Ágnes
- Felton Tim
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernández de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzgerald Mark
- Fletcher Simon
- Flint Neil
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- Forbes Loretta
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- Fortune Louise
- Fottrell-Gould Deirdre
- Fowler Rob
- Fowler Robert
- Fox Claire
- Francia Federica
- Francoeur Charles
- Frey Anna
- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
- Gattas David
- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
- Geri Guillaume
- Ghamraoui Ali
- Ghosh Alison
- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
- Gomm Linda
- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
- Hall Andrew
- Hall Kathryn
- Hamilton David Oliver
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Haniffa Rashan
- Haniffa Rashan
- Hanson Jane
- Harford Rachel
- Harland Cain
- Harrington Kate
- Harris Nichola
- Harrison Susie
- Hart Ciaran
- Harvala-Simmonds Heli
- Harvey Daniel
- Harward Meg
- Hawcutt Daniel
- Hawkins Nancy
- Hay Sophie Kennedy
- Hayes Kati
- Hayes Leanne
- Hays Carole
- Health Monash
- Heinonen Jonna
- Heming Nicholas
- Henderson Seton
- Henderson Steven
- Henning Jeremy
- Henry Joanne
- Heritier Stephane
- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
- Hird Clare
- Hodgson Carol
- Hoff Uwe
- Hoiting Oscar
- Holland Nicky
- Hollos Laszlo
- Homes Jennifer
- Hope David
- Hopkins Phil
- Hormis Anil
- Horton Michelle
- Horton Sarah
- Horvat Christopher
- Horvat Christopher
- Howcroft Clare
- Howle Ryan
- Huang David
- Huckle Abby
- Hughes Emma
- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
- Hunt Beverley
- Hunter Stephanie
- Hutter Joanne
- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
- Ivatt Helen
- Jackson Matthew
- Jackson Shane
- Jackson Susan
- Jacques Nicola
- Jacquier Sophie
- Jagannathan Vijay
- Janin Pierre
- Jarczak Dominik
- Jeblaoui Asma
- Jeffrey Helen
- Jenkins Sarah
- Jha Rajeev
- Jhanji Shaman
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- Johnson David
- Johnson Rebekah
- Johnston Paul
- Jones Andrea
- Jones Jo
- Joseph Sibet
- José Nuno
- Juhaz Vera
- Kalchthaler Kyle
- Kalogirou Michael
- Kamel Toufik
- Karachi Tim
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kayani Abdul
- Kazemi Alex
- Keen Alexandra
- Keenan Samantha
- Keet Owen
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- Kelly Martin
- Kelsall Olivia
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- Kruger Peter
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- Kumar Nikhil
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- KyereDiabour Thyra
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- Labbe Vincent
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- Lamonagne Francois
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- Lamontagne Francois
- Lamontagne François
- Landais Mickaël
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- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
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- Lee Stephanie
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- Lewis Roger
- Lewis Roger J
- Lewis Sarah
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- Linstrum Kelsey
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- Litton Edward
- Litton Edward
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- Lorenzi Elizabeth
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- Lowe Benjamin
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- McAuley Daniel
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- Mouncey Paul
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- Murthy Srinivas
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- Scully Michael
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- Seymour Christopher
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- Simmonds Catherine
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- Tallott Mandy
- Tatham Kate Colette
- Templeton Maie
- Thomas Amy
- Thomas Helen
- Thomas Matt
- Thomas Matthew
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
- Tooley Joe
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- Trask Kara
- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
- Tully Redmond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
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- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
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- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Health-related quality of life in survivors of septic shock:6-month follow-up from the ADRENAL trial
- Author
- Arabi Yaseen
- Bellomo Rinaldo
- Benefield Kristen
- Bewley Jeremy
- Billot Laurent
- Boschert Catherine
- Chen Yan
- Cohen Jeremy
- Cole Libby
- Cowdrey Keri Anne
- Eastwood Glenn
- Edington John
- Finfer Simon R.
- Fletcher Jason
- Ghelani Dhaval
- Gilder Eileen
- Hammond Naomi E.
- Harward Meg
- Jones Daryl
- Joyce Christopher
- Kjær Maj Brit Nørregaard
- Li Qiang
- Long Stephanie
- Madsen Martin Bruun
- McArthur Colin
- McCarthy Lianne
- McConnochie Rachael
- McGuinness Shay
- Myburgh John
- Møller Morten Hylander
- Müller Rasmus
- Nand Kiran
- Newby Lynette
- Nielsen Jonas
- Parke Rachael
- Peck Leah
- Perner Anders
- Quist Lars
- Rajbhandari Dorrilyn
- Reece Graham
- Rhodes Andrew
- Sara Treena
- Smith Julie
- Taylor Colman
- Thompson Kelly
- Thorsen-Meyer Hans Christian
- Venkatesh Balasubramanian
- Webb Steve
- White Jonathan
- Young Helen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial
- Author
- Agarwal Sidharth
- Arabi Yaseen
- Bailey Irene
- Bellomo Rinaldo
- Benefield Kristen
- Billot Laurent
- Boschert Catherine
- Breeze Richard
- Cecconi Maurizio
- Chen Yan
- Cohen Jeremy
- Cooper David
- Cooper Lauren
- Cowdrey Keri Anne
- Cusack Rebecca
- Eastwood Glenn
- Finfer Simon R.
- Gilder Eileen
- Gregory Rebecca
- Hammond Naomi E.
- Harward Meg
- Hunt Anna
- Johnson Lucy
- Jones Daryl
- Joyce Christopher
- Li Qiang
- Long Stephanie
- McArthur Colin
- McCarthy Lianne
- McConnochie Rachael
- McGuinness Shay
- Morgan John
- Myburgh John
- Newby Lynette
- Parke Rachael
- Peck Leah
- Perner Anders
- Rajbhandari Dorrilyn
- Reeves Emma
- Rhodes Andrew
- Smith John
- Taylor Colman
- the ADRENAL Trial Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group
- Thompson Kelly
- Venkatesh Balasubramanian
- Webb Steve
- White Ian
- White Mary
- Williams Tony
- Wright Stephen
- Young Helen
- Publication venue
- Publication date
- 01/09/2020
- Field of study
Purpose: to investigate the impact of hydrocortisone treatment and illness severity on health-related quality of life (HRQoL) at 6 months in septic shock survivors from the ADRENAL trial. Methods: using the EuroQol questionnaire (EQ-5D-5L) at 6 months after randomization we assessed HRQoL in patient subgroups defined by hydrocortisone or placebo treatment, gender, illness severity (APACHE II < or ≥ 25), and severity of shock (baseline peak catecholamine doses < or ≥ 15 mcg/min). Additionally, in subgroups defined by post-randomisation variables; time to shock reversal (days), treatment with renal replacement therapy (RRT), and presence of bacteremia. Results: at 6 months, there were 2521 survivors. Of these 2151 patients (85.3%-1080 hydrocortisone and 1071 placebo) completed 6-month follow-up. Overall, at 6 months the mean EQ-5D-5L visual analogue scale (VAS) was 70.8, mean utility score 59.4. Between 15% and 30% of patients reported moderate to severe problems in any given HRQoL domain. There were no differences in any EQ-5D-5L domain in patients who received hydrocortisone vs. placebo, nor in the mean VAS (p = 0.6161), or mean utility score (p = 0.7611). In all patients combined, males experienced lower pain levels compared to females [p = 0.0002). Neither higher severity of illness or shock impacted reported HRQoL. In post-randomisation subgroups, longer time to shock reversal was associated with increased problems with mobility (p = < 0.0001]; self-care (p = 0.0.0142), usual activities (p = <0.0001] and pain (p = 0.0384). Amongst those treated with RRT, more patients reported increased problems with mobility (p = 0.0307) and usual activities (p = 0.0048) compared to those not treated. Bacteraemia was not associated with worse HRQoL in any domains of the EQ-5D-5L. Conclusions: approximately one fifth of septic shock survivors report moderate to extreme problems in HRQoL domains at 6 months. Hydrocortisone treatment for septic shock was not associated with improved HRQoL at 6 months. Female gender was associated with worse pain at 6 months.</p
Using research to prepare for outbreaks of severe acute respiratory infection
- Author
- . ()
- . ()
- Al Qasim E. (Eman)
- Ala-kokko T. (Tero)
- Angus D. C. (Derek C.)
- Antoine M. (Marchalot)
- Arabi Y. M. (Yaseen M.)
- Awasthi S. (Shally)
- Bahinskaya I. (Ilona)
- Baillie J. K. (John Kenneth)
- Bentley A. (Andrew)
- Bory S. (Sotharith)
- Browne T. (Troy)
- Browne T. S. (T. S.)
- Bruel C. (Cedric)
- Bruyere R. (Raomi)
- Campbell L. (Lewis)
- Carrier F. M. (Francois Martin)
- Carson G. (Gail)
- Chan W. M. (Wai Ming)
- Chang Y. (Youjin)
- Charles A. G. (Anthony G.)
- Cheng A. C. (Allen C.)
- Chiche J.-D. (Jean-Daniel)
- Cho J. H. (Jae Hwa)
- Choi W.-I. (Won-Il)
- Christian M. D. (Michael D.)
- Cobb J. P. (J. Perren)
- Daix T. (Thomas)
- Djillali A. E. (Annane E.)
- Dunning J. (Jake)
- Egi M. (Moritoki)
- EllazarHumber E. (Edward)
- Erickson S. (Simon)
- Everett D. (Dean)
- Fabienne T. (Taimon)
- Farshait N. (Nataly)
- Florence K.-P. (Komurian-Pradel)
- Forceville X. (Xavier)
- Forrest A. (Annette)
- Fowler R. (Robert)
- Ganeshalingham A. (Anusha)
- George M. (Maya)
- Giamarellos-Bourboulis E. J. (Evangelos J.)
- Gilfoyle E. (Elaine)
- Goodson J. (Jennifer)
- Gordon A. C. (Anthony C.)
- Green K. (Karen)
- Griesdale D. (Donald)
- Growl G. (Gloria)
- Guerrero M. L. (M. Lourdes)
- Guillebaud J. (Julia)
- Hall R. (Richard)
- Henderson S. (Seton)
- Heraud J.-M. (Jean-Michel)
- Horby P. (Peter)
- Hsu L. Y. (Li Yang)
- Huh J.-W. (Jin-Won)
- Jarrvisalo M. J. (Mikko J.)
- Jouvet P. (Philippe)
- Katz K. (Kevin)
- Kazemi A. (Alex)
- Kol M. (Mark)
- Kuitunen A. (Anne)
- Lamontagne F. (Francois)
- Lee H. B. (Heung Bum)
- Lee W.-Y. (Won-Yeon)
- Li I. W. (Iris Wai Sum)
- Longuere K.-S. (Kajsa-Stina)
- Mahesh V. (Vinaya)
- Malik N. (Nadia)
- Mambule I. (Ivan)
- Marshall J. (John)
- Martin D.-A. (Dori-Ann)
- Maslove D. (David)
- McArthur C. (Colin)
- McCarthy A. E. (Anne E.)
- McConnochie R. (Rachael)
- Melendez J. A. (Javier Araujo)
- Melto S. (Sari)
- Merson L. (Laura)
- Mich V. (Vann)
- Murthy S. (Srinivas)
- Muscedere J. (John)
- Nadjm B. (Behzad)
- Ngai W. C. (Wallace Chun Wai)
- Nichol A. (Alistair)
- Nicholas S. (Sedillot)
- O'Neill G. (Genevieve)
- Ochieng O. G. (Otieno George)
- Ohuma E. (Eric)
- Opaysky M. A. (Mary Anne)
- Osbourne-Townsend J. (Joan)
- Otieno J. W. (Juilett Wambura)
- Pardinaz-Solis R. (Raul)
- Park S. Y. (Seung Yong)
- Park T. S. (Tai Sun)
- Parke R. (Rachael)
- Paterson D. L. (David L.)
- Patrigeon S. P. (Santiago Perez)
- PedutemHumber T. (Theresa)
- Philippart F. (Francois)
- Pho Y. (Yaty)
- Powis J. (Jeff)
- Prin M. (Meghan)
- Pulkkinen A. (Anni)
- Rabarison J. H. (Joelinotahiana Hasina)
- Raberahona M. (Mihaja)
- Ramirez-Venegas A. (Alejandra)
- Razanazatovo N. (Norosoa)
- Rello J. (Jordi)
- Rishu A. (Asgar)
- Riviello E. D. (Elisabeth D.)
- Rowan K. (Kathy)
- Ruberto A. J. (Aaron J.)
- Santamaria J. (John)
- Semple C. (Calum)
- Shindo N. (Nahoko)
- Siami S. (Shidasp)
- Sim Y. S. (Yun Su)
- Sin W. C. (Wai Ching)
- Som L. (Leakhann)
- Sonawane R. (Ravikiran)
- Sylvain H. (Habarurema)
- Teav B. (Bunlor)
- Tiercelet K. (Kelly)
- Twagirumugabe T. (Theogene)
- Ubiergo S. U. (Sebastian Ugarte)
- Umuhire O. F. (Olivier Felix)
- Uyeki T. M. (Timothy M.)
- Valkonen M. (Miia)
- van Doom H. R. (H. Rogier)
- Vann M. (Mich)
- Wallace D. J. (David J.)
- Webb S. A. (Steve A. R.)
- Welters I. (Ingeborg)
- West T. E. (T. Eoin)
- Young P. (Paul)
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2019
- Field of study
Abstract
Severe acute respiratory infections (SARI) remain one of the leading causes of mortality around the world in all age groups. There is large global variation in epidemiology, clinical management and outcomes, including mortality. We performed a short period observational data collection in critical care units distributed globally during regional peak SARI seasons from 1 January 2016 until 31 August 2017, using standardised data collection tools. Data were collected for 1 week on all admitted patients who met the inclusion criteria for SARI, with follow-up to hospital discharge. Proportions of patients across regions were compared for microbiology, management strategies and outcomes. Regions were divided geographically and economically according to World Bank definitions. Data were collected for 682 patients from 95 hospitals and 23 countries. The overall mortality was 9.5%. Of the patients, 21.7% were children, with case fatality proportions of 1% for those less than 5 years. The highest mortality was in those above 60 years, at 18.6%. Case fatality varied by region: East Asia and Pacific 10.2% (21 of 206), Sub-Saharan Africa 4.3% (8 of 188), South Asia 0% (0 of 35), North America 13.6% (25 of 184), and Europe and Central Asia 14.3% (9 of 63). Mortality in low-income and low-middle-income countries combined was 4% as compared with 14% in high-income countries. Organ dysfunction scores calculated on presentation in 560 patients where full data were available revealed Sequential Organ Failure Assessment (SOFA) scores on presentation were significantly associated with mortality and hospital length of stay. Patients in East Asia and Pacific (48%) and North America (24%) had the highest SOFA scores of >12. Multivariable analysis demonstrated that initial SOFA score and age were independent predictors of hospital survival. There was variability across regions and income groupings for the critical care management and outcomes of SARI. Intensive care unit-specific factors, geography and management features were less reliable than baseline severity for predicting ultimate outcome. These findings may help in planning future outbreak severity assessments, but more globally representative data are required
A multi-country analysis of COVID-19 hospitalizations by vaccination status
- Author
- Aasmine Kaur
- Abby Hurd
- Abdulrahman Al-Fares
- Aditya John Anchan
- Adrian Streinu-Cercel
- Adrienne Chan
- Agostinho Monteiro
- Aidan Burrell
- Aisling Gavin
- Alan Hartman
- Aldo Rafael
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Alessandra Notari
- Alexander J Mentzer
- Alexandros Cavayas
- Alexis F Turgeon
- Ali Ait Hssain
- Alina Kalicinska
- Alison M Meynert
- Alistair D Nichol
- Allison McGeer
- Amanda Corley
- Amna Faheem
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Martins
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Cortegiani
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Dagens
- Andrew Law
- Andrew Letizia
- Andy Law
- Angela Alberti
- Anika Atique
- Anjellica Chen
- Anna Beltrame
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Marie Guerguerian
- Annemarie B Docherty
- Antonia Ho
- Antonia Ricchiuto
- Antonio Arcadipane
- António Mesquita
- Anuraj Shankar
- Argin G
- Asfia Sultana
- Asgar Rishu
- Atie Suwarti
- Audrey Dubot-Pérès
- Ayodhia Pitaloka
- Bailey Williams
- Bambang Pujo Semedi
- Baruch Joaquín
- Beathe Kiland Granerud
- Beatrice Alex
- Ben Morton
- Benjamin Bach
- Bernardo Ferreira
- Bernhard Roessler
- Bianca Boxma-de Klerk
- Birgitte Stiksrud
- Bisoffi Zeno
- Bounthavy Chaleunphon
- Bountoy Sibounheuang
- Brenda Reeve
- Brigid Flynn
- Cameron J Fairfield
- Caren Friedrich
- Carlos Cañada Illana
- Carlos Pimentel
- Caroline Kosgei
- Caroline Martins Rego
- Caroline Mudara
- Carrol Gamble
- Cassidy Codan
- Catarina Espírito Santo
- Catarina Pires
- Catherine A Shaw
- Catherine Blier
- Catherine Marquis
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Charlotte Summers
- Chiara Simona Cardellino
- Chiara Vitiello
- Chika Akwani
- Chloe Donohue
- Chris Kandel
- Chris McKay
- Christina Matthew
- Christl A Donnelly
- Christophe Fraser
- Christopher A Green
- Citarella Barbara Wanjiru
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudina Cruz
- Colin McArthur
- Cristina De Rose
- César Vieira
- Dag Henrik Reikvam
- Dan Meyer
- Dana Mustafa
- Daniel Haber
- Daniela Guerreiro
- Danilo Buonsenso
- Danoy Chommanam
- Dario Sinatti
- Dasgupta Abhishek
- Dave Nagpal
- David Bellemare
- David L Robertson
- David Maslove
- David S Y Ong
- David Stuart
- Dawn Higgins
- Debby Bogaert
- Decy Subekti
- Deepali Kumar
- Demetrios Kutsogiannis
- Denise Jaworsky
- Diana Póvoas
- Diego Franch-Llasat
- Diogo Borges
- Diogo Lopes
- Dounia Bouhmani
- Dr Rajesh Mohan Shetty
- Dwi Utomo Nusantara
- Eder Caceres
- Efstathia Mihelis
- Egle Saviciute
- Eka Airlangga
- Elisabetta Spinuzza
- Elizabeth A Ashley
- Ellen Shadowitz
- Else Quist-Paulsen
- Eman Al Qasim
- Emely Sanchez
- Emily Neumann
- Emma C Thomson
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Esteban Garcia-Gallo
- Evert-Jan Wils
- Felwa Bin Humaid
- Ferran Roche-Campo
- Filipa Brás Monteiro
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Frank Manetta
- Frank Olav Pettersen
- François Lamontagne
- François Martin Carrier
- Fredrik Müller
- Frédérick D'Aragon
- Gabriele Sales
- Gail Carson
- Gary Leeming
- Gary Schwartz
- Gayle Carney
- Gennaro Martucci
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Giorgia Montrucchio
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Bertoli
- Giuseppe Foti
- Gloria Crowl
- Gonçalves Bronner P
- Graham S Cooke
- Gregory Purcell
- Gry Kloumann Bekken
- Gyan Sandhu
- Hamza Jaber
- Hannah Habraken
- Harrison Ewen M
- Hashmi Madiha
- Hayley Hardwick
- Heidi Dalton
- Heidi Gruner
- Hongru Ren
- Horby Peter
- Hubert Tessier-Grenier
- Hugo Inácio
- Husna Begum
- Iam Claire E Sarmiento
- Imrana Khalid
- Indrek Rätsep
- Ingrid G Bustos
- Isabela Saba
- ISARIC Clinical Characterisation Group: Sheryl Ann Abdukahil
- J Kevin Baird
- Jacky Y Suen
- Jake Dunning
- James Joshua Douglas
- James Lee
- James Scott-Brown
- Jan Cato Holter
- Janet Harrison
- Janet Liang
- Janet T Scott
- Janice Caoili
- Jaques Sztajnbok
- Jassat Waasila
- Jeff Powis
- Jeffrey Aliudin
- Jennifer Lee
- Jess Gibson
- Jessica Wittman
- Jia Wei
- Jimmy Ming-Yang Hsu
- Jo Dalton
- Joan Gómez-Junyent
- Joana Alves Cabrita
- Joana Cabrita
- Joana Ferrão
- John F Fraser
- John Kenneth Baillie
- John Marshall
- Jonathan Bitton
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Joshua Solomon
- Josie Campisi
- José Casimiro
- José Ernesto Vidal
- José Ramalho
- Joy Ann Villanueva
- João Estevão
- João Teixeira
- Juan Pablo Horcajada
- Judit Villar
- Julia Garcia-Diaz
- Juliana Damas
- Justin Schaffer
- K Dhangar
- Kalynn Kennon
- Kamal Abu Jabal
- Karl Erik Müller
- Kartsonaki Christiana
- Katie O'Hearn
- Kenneth A McLean
- Kevin Katz
- Kraemer Moritz U G
- Kristian Tonby
- Kusum Menon
- Lana Almasri
- Lance C W Turtle
- Larissa Oliveira
- Lars Heggelund
- Latsaniphone Bountthasavong
- Laura Marsh
- Laveena Munshi
- Lefèvre Benjamin
- Leonardo Salazar
- Lina Morales Cely
- Linda Gail Skeie
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Louise Sigfrid
- Luca Brazzi
- Lucia Moro
- Lucian Durham 3rd
- Luisa Quesada
- Lukas Arenz
- Lunn Miles
- Luís Val-Flores
- López Revilla José W
- Mahdad Noursadeghi
- Mahendra Singh
- Malcolm G Semple
- Mangala Narasimhan
- Manivanh Vongsouvath
- Maram Zahran
- Marc Csete
- Marco Giani
- Mare Pejkovska
- Margarite Grable
- Maria Amaral
- Maria Angelica Rivera Nuñez
- Maria de Piero
- Maria Zambon
- Mariachiara Ippolito
- Mariana Cascão
- Mariano Esperatti
- Marie Connor
- Marina Lanza
- Marina Wainstein
- Mark Downing
- Mark G Pritchard
- Marlene Santos
- Marta Alessi
- Marta Torre
- Martin-Loeches Ignacio
- Martina Escher
- Martina Hennessy
- Mary Copland
- Marília Andreia Fernandes
- Massimo Palmarini
- Mathew Thorpe
- Mathilde Duplaix
- Matteo Rossetti
- Matthew Hall
- Matthew Nelder
- Matthew Pellan Cheng
- Mayfong Mayxay
- Meera Chand
- Merson Laura
- Mical Paul
- Michael Edelstein
- Michael Schwameis
- Michael Varrone
- Michaela Barnikel
- Michele Petrovic
- Michelle E Kho
- Michelle Girvan
- Mo'nes Muhaisen
- Moad Atlowly
- Mohammed Alkahlout
- Moji Ghadimi
- Muge Cevik
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mutia Rahardjani
- Mário Ferraz
- Nashat Abu Salah
- Nataly Farshait
- Nathaniel Christy
- Netta Beer
- Nicholas Yuri Barbosa
- Nick Daneman
- Nicole White
- Nidyanara Castanheira
- Nimisha Abdul Majeed
- Nina Buchtele
- Nora Fuentes
- Nuno Germano
- Oana Sandulescu
- Oleksa Rewa
- Olliaro Piero L
- Ooyanong Phonemixay
- Osama Aldabbourosama
- Paola Rodari
- Paolo Cattaneo
- Patricia Fontela
- Patricia Patricio
- Patrick Archambault
- Paul Klenerman
- Paula Custodio
- Pauline Yeung Ng
- Pawel Twardowski
- Pedro Faria
- Peter Daley
- Peter Kiiza
- Peter Openshaw
- Philippe Jouvet
- Phoebe Ampaw
- Phouvieng Douangdala
- Piero Valentini
- Piret Sillaots
- Piubelli Chiara
- Prasan Kumar Panda
- Prashant Nasa
- Praveen Kumar Ghisulal
- Rachael McConnochie
- Rachael Parke
- Rajavardhan Rangappa
- Rakesh Arora
- Raph L Hamers
- Renata Barbalho
- Reyes Luis Felipe
- Richard S Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Robert A Fowler
- Roberta Cavalin
- Rojek Amanda
- Rolando Claure-Del Granado
- Roman Ullrich
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rui Caetano Garcês
- Rui Garcês
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryan S Thwaites
- Sadie Kelly
- Samantha Lissauer
- Samreen Ijaz
- Samuel Hinton
- Sanne Wesselius
- Sara Clohisey
- Sara Machado
- Sara Taleb
- Sarah E McDonald
- Sarah Moore
- Saye Khoo
- Scott Pharand
- Sergio Poli
- Seán Keating
- Shaher Hamdan
- Shaun Thompson
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shona C Moore
- Shrapnel Sally
- Silvia Castañeda
- Simon Forsyth
- Sofia Cardoso
- Sommay Keomany
- Sophie Halpin
- Soulichanya Phoutthavong
- Srinivas Murthy
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Sue Smith
- Sue Willems
- Summer Hamza
- Susanne Dudman
- Synne Jenum
- Teresa Lawrence
- Thipsavanh Bounphiengsy
- Thomas Drake
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Timothy M Uyeki
- Todd C Lee
- Tom Fletcher
- Tom Solomon
- Touxiong Yiaye
- Triona Downer
- Trude Steinsvik
- Tânia Sequeira
- Valeria Balan
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vegard Skogen
- Victoria Shaw
- Viladeth Praphasiri
- Virginie Williams
- Volkan Korten
- Wael Hafez
- Wai Ching Sin
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Yael Dishon
- Yaseen Arabi
- Yock Ping Chow
- Yousef Al-Saba'a
- Yusing Gu
- Zaina Dalloul
- Publication venue
- Publication date
- 12/09/2023
- Field of study
Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
- Author
- A M Udara Lakshan Attanyake
- Aasiyah Rashan
- Aasiyah Rashan
- Abby Hurd
- Abdulrahman Al-Fares
- Abhishek Dasgupta
- Abigail Beane
- Adrian Streinu-Cercel
- Adrienne Chan
- Aidan Burrell
- Alan Hartman
- Alberto Uribe
- Alejandro Martin-Quiros
- Alejandro Martín-Quiros
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Alexander J Mentzer
- Alfredo Antonio Chetta
- Ali Abbas
- Alicia Gonzalez
- Alison M Meynert
- Alistair Nichol
- Allison McGeer
- Ama Kwakyewaa Bedu-Addo
- Amanda Corley
- Amanda Rojek
- Amanda Rojek
- Amar Bhatt
- Amna Faheem
- Amy Lester-Grant
- Ana Aroca
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Anais Rampello
- Anant Kataria
- Anca Streinu-Cercel
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Kildal
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Ticinesi
- Andrea Villoldo
- Andreas Lind
- Andrew Dagens
- Andrew Letizia
- Andy Law
- Angela Alberti
- Anja Grosse Lordemann
- Anna Berenguera
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Marie Guerguerian
- Annemarie B Docherty
- Antonia Ho
- Antonio Arcadipane
- Arabella Fahy
- Ardiyan Apriyana
- Arjen M Dondorp
- Asgar Rishu
- Asgar Rishu
- Astarini Hidayah
- Audrey Dubot-Pérès
- B P Sanka Ruwan Sri Darshana
- Barbara Wanjiru Citarella
- Barbara Wanjiru Citarella
- Beathe Kiland Granerud
- Beatrice Alex
- Benjamin Bach
- Bianca Boxma
- Birgitte Stiksrud
- Bounthavy Chaleunphon
- Bountoy Sibounheuang
- Brenda Molloy
- Brenda Reeve
- Brigid Flynn
- Bronner P Gonçalves
- Bronner P Gonçalves
- Budha Charan Singh
- Cameron J Fairfield
- Carlo Ferrari
- Carlos Cañada Illana
- Carlotta Mutti
- Caroline Martins Rego
- Caroline Mudara
- Carrol Gamble
- Cassidy Codan
- Caterina Caminiti
- Catherine A Shaw
- Catherine Blier
- Catherine Marquis
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Chamira Kodippily
- Charlotte Summers
- Chiara Vitiello
- Chloe Donohue
- Chris Kandel
- Christel Arnold-Day
- Christiana Kartsonaki
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christopher A Green
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Figueiredo-Mello
- Claudia Montes
- Colin McArthur
- Cornelius Rau
- Dafsah Juzar
- Dag Henrik Reikvam
- Dan Meyer
- Daniel Haber
- Daniel Marino
- Danoy Chommanam
- David Bellemare
- David L Robertson
- David Maslove
- David S Y Ong
- David S Y Ong
- David Stuart
- David Thomson
- Debby Bogaert
- Deepali Kumar
- Demetrios Kutsogiannis
- Derbrenn OConnor
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Diptesh Aryal
- Diptesh Aryal
- Dori-Ann Martin
- Dounia Bouhmani
- Edel Meaney
- Eder Caceres
- Efstathia Mihelis
- Egle Saviciute
- Elaine McPartlan
- Elena Molinos
- Elena Ranza
- Elizabeth A Ashley
- Ellen Shadowitz
- Else Quist-Paulsen
- Eman Al Qasim
- Emily Neumann
- Emma C Thomson
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Enrico Adriano
- Esteban Garcia-Gallo
- Eva Miranda Marwali
- Evert-Jan Wils
- Evert-Jan Wils
- Ewen M Harrison
- Ewen M Harrison
- Federica Fogliazza
- Federica Garofalo
- Felwa Bin Humaid
- Ferran Roche-Campo
- Fiona Griffiths
- Francesca Carlacci
- Francesco Rausa
- Francisca Adewhajah
- Frank Manetta
- Frank Olav Pettersen
- Franklina Korkor Abebrese
- François Lamontagne
- François Martin Carrier
- François Martin Carrier
- Fredrik Müller
- Frédérick D'Aragon
- G Argin
- Gail Carson
- Gail Carson
- Gamage Dona Dilanthi Priyadarshani
- Gary Leeming
- Gary Schwartz
- Gayle Carney
- Gennaro Martucci
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Giorgio Economopoulos
- Giovanna Occhipinti
- Giovanna Panarello
- Giuseppe Maglietta
- Gloria Crowl
- Graham S Cooke
- Gry Kloumann Bekken
- Gyan Sandhu
- Haixia Shi
- Hannah Habraken
- Hannah Keane
- Hannah Marrinan
- Hayley Hardwick
- Hazel Bergin
- Heidi Dalton
- Hem Paneru
- Henrique Mateus Fernandes
- Himasha Muvindi
- Himed Musaab
- Hubert Tessier-Grenier
- Husna Begum
- Iam Claire E Sarmiento
- Ignacio Martin-Loeches
- Ilaria Valzano
- Imrana Khalid
- Indrek Rätsep
- Ingrid G Bustos
- Inês Carqueja
- Irene Bandoh
- ISARIC Clinical Characterisation Group
- J Kenneth Baillie
- J Kenneth Baillie
- Jacky Y Suen
- Jake Dunning
- Jake Dunning
- James Joshua Douglas
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jan Cato Holter
- Janet Diaz
- Janet Harrison
- Janet Liang
- Janet T Scott
- Janice Caoili
- Janice Caoili
- Jaques Sztajnbok
- Jeff Powis
- Jennifer Lee
- Jess Gibson
- Jia Wei
- Jillian Deacon
- Jo Dalton
- Joan Gómez-Junyent
- Joan Gómez-Junyent
- Joanne Downey
- Joaquín Baruch
- Joaquín Baruch
- John Beca
- John F Fraser
- John Marshall
- Johnny McKeown
- Jonathan Bitton
- Jordi Rello
- José Antonio Lepe
- José Ernesto Vidal
- João Camões
- Juan Fiorda
- Juan Pablo Horcajada
- Judit Villar
- Julia Garcia-Diaz
- Julian Chica
- Kalynn Kennon
- Kamal Abu Jabal
- Karl Erik Müller
- Karolina Krawczyk
- Kate Ainscough
- Kathy Brickell
- Katie O'Hearn
- Kenneth A McLean
- Kevin Katz
- Kizy Sanchez de Oliveira
- Kristian Tonby
- Kusum Menon
- Lance C W Turtle
- Lars Hegelund
- Lars Heggelund
- Latsaniphone Bountthasavong
- Laura Feeney
- Laura Marsh
- Laura Merson
- Laura Merson
- Laura Patrizi
- Laveena Munshi
- Leanne Hays
- Leonardo Salazar
- Leonardo Salazar
- Liadain Reid
- Lina Morales Cely
- Linda Gail Skeie
- Linda O'Shea
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Lorinda Essuman
- Lorna Murphy
- Louise Sigfrid
- Luca Sacchelli
- Lucian Durham
- Lucille Blumberg
- Luis Felipe Reyes
- Luis Felipe Reyes
- Luis Periel
- Lukas Arenz
- Madiha Hashmi
- Madiha Hashmi
- Mahdad Noursadeghi
- Malcolm G Semple
- Malcolm G Semple
- Mangala Narasimhan
- Manivanh Vongsouvath
- Maram Zahran
- Marco Echeverria-Villalobos
- Mare Pejkovska
- Margarite Grable
- Maria Angelica Rivera Nuñez
- Maria Donnelly
- Maria Lawrensia Tampubolon
- Maria Majori
- Maria Zambon
- Marianne Fraher
- Mariano Esperatti
- Marie Connor
- Marina Aiello
- Marina Lanza
- Mark G Pritchard
- Mark Pritchard
- Marlene Santos
- Martina Escher
- Mary Copland
- Massimo Palmarini
- Matteo Puntoni
- Matteo Rossetti
- Matthew Hall
- Matthew Hall
- Matthew Nelder
- Mayfong Mayxay
- Meera Chand
- Melissa Parker
- Mical Paul
- Michael Edelstein
- Michael Varrone
- Michaela Barnikel
- Michele Petrovic
- Michelle E Kho
- Michelle Girvan
- Michelle Smyth
- Mohd Basri Mat Nor
- Mohiuddin Shiekh
- Moirangthem Bikram Singh
- Moritz U G Kraemer
- Moses Siaw-Frimpong
- Muge Cevik
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Nashat Abu Salah
- Nathaniel Christy
- Netta Beer
- Nick Daneman
- Nicola Latronico
- Nicole White
- Nidyanara Castanheira
- Nina Jamieson
- Nora Fuentes
- Oana Sandulescu
- Obada Yousif
- Oleksa Rewa
- Ooyanong Phonemixay
- P G Ishara Udayanga
- Paa Kobina Forson
- Paddy Mallon
- Paolo Parducci
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patrick Archambault
- Patrizia Bonelli
- Patrizia Mammi
- Paul Klenerman
- Paul Tierney
- Paula Custodio
- Perren J Cobb
- Peter Daley
- Peter Doran
- Peter Horby
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Phil Gallagher
- Philippe Jouvet
- Phoebe Ampaw
- Phouvieng Douangdala
- Piero L Olliaro
- Piero L Olliaro
- Piret Sillaots
- Pompini Agustina Sitompul
- Pooja Varghese
- Prasan Kumar Panda
- Rachael McConnochie
- Rachael Parke
- Rajavardhan Rangappa
- Rajavardhan Rangappa
- Rajesh Mohan Shetty
- Rakesh Arora
- Rashan Haniffa
- Renata Barbalho
- Richard S Tedder
- Riinu Pius
- Rima Song
- Rob Fowler
- Robert A Fowler
- Roberta Cavalin
- Roberta Pisi
- Roberto Roncon-Albuquerque
- Robin Kobbe
- Romans Matulevics
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rumaisah Satyawati
- Rupert Higgins
- Ruth Lyons
- Ryan S Thwaites
- Sabina Mason
- Sadie Kelly
- Sally Shrapnel
- Samreen Ijaz
- Samuel Hinton
- Sandra Rossi
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sarah E McDonald
- Sarah Moore
- Saye Khoo
- Scott Pharand
- Sebastian Vencken
- Seán Keating
- Shaikh Sharjeel
- Sharma Keshav
- Shaun Thompson
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirley Sarfo-Mensah
- Shona C Moore
- Silvia Bertagnolio
- Silvia Castañeda
- Simon Forsyth
- Simone Piva
- Soe Soe Thwin
- Sophia Ankrah
- Sophie Halpin
- Soulichanya Phoutthavong
- Sree Satyapriya
- Srinivas Murthy
- Srinivas Murthy
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Sue Smith
- Summer Hamza
- Surya Otto Wijaya
- Susanne Dudman
- Synne Jenum
- Sérgio Gaião
- Sílvia Ferreira
- Teresa Lawrence
- Thalha Rashan
- Thipsavanh Bounphiengsy
- Thushan de Silva
- Timothy M Uyeki
- Tirupakuzhi Vijayaraghavan
- Tiziana Meschi
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Touxiong Yiaye
- Trude Steinsvik
- Uluhan Sili
- Valeria Balan
- Valeria Balan
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vegard Skogen
- Victoria Shaw
- Viladeth Praphasiri
- Vilmaris Quinones-Cardona
- Volkan Korten
- Waasila Jassat
- Waasila Jassat
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Xin Ci Wong
- Xin Ci Wong
- Yael Dishon
- Yaseen Arabi
- Yaseen Arabi
- Yock Ping Chow
- Yock Ping Chow
- Yvelynne Kelly
- Zulfiqar Sandhu
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 01/01/2022
- Field of study
Background: Whilst timely clinical characterisation of infections caused by novel SARS-CoV-2 variants is necessary for evidence-based policy response, individual-level data on infecting variants are typically only available for a minority of patients and settings.
Methods: Here, we propose an innovative approach to study changes in COVID-19 hospital presentation and outcomes after the Omicron variant emergence using publicly available population-level data on variant relative frequency to infer SARS-CoV-2 variants likely responsible for clinical cases. We apply this method to data collected by a large international clinical consortium before and after the emergence of the Omicron variant in different countries.
Results: Our analysis, that includes more than 100,000 patients from 28 countries, suggests that in many settings patients hospitalised with Omicron variant infection less often presented with commonly reported symptoms compared to patients infected with pre-Omicron variants. Patients with COVID-19 admitted to hospital after Omicron variant emergence had lower mortality compared to patients admitted during the period when Omicron variant was responsible for only a minority of infections (odds ratio in a mixed-effects logistic regression adjusted for likely confounders, 0.67 [95% confidence interval 0.61-0.75]). Qualitatively similar findings were observed in sensitivity analyses with different assumptions on population-level Omicron variant relative frequencies, and in analyses using available individual-level data on infecting variant for a subset of the study population.
Conclusions: Although clinical studies with matching viral genomic information should remain a priority, our approach combining publicly available data on variant frequency and a multi-country clinical characterisation dataset with more than 100,000 records allowed analysis of data from a wide range of settings and novel insights on real-world heterogeneity of COVID-19 presentation and clinical outcome
A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial
- Author
- Abrams Judith
- Adda Mireille
- Adderley Jane
- Adhikari Neill K. J.
- Adhikari Neill K. J.
- Aissaoui Nadia
- Alam Ahsan
- Albrett Jonathan
- Albright Robert C.
- Alcuaz Victoria
- Allam Hayat
- Altarelli Marco
- Amaral Andre
- Amsbaugh Amy
- Anderson Felicity
- Andreu Pascal
- Antunes Veronica
- Arbane Gill
- Argaud Laurent
- Arias Castro
- Asehnoune Karim
- Attwood Ben
- Auld Fiona
- Ayas Najib
- Aycinena Juan Carlos
- Azais Marie-Ange
- Bachler Mirjam
- Backhouse Felicity
- Bagshaw Sean M.
- Bagshaw Sean M.
- Bagshaw Sean M.
- Bagshaw Sean M.
- Baharlo Behrad
- Bai Guoqiang
- Bai Jing
- Baig Nadia
- Baig Nadia
- Bailey Matthew
- Baker Nerilee
- Ball Ian M.
- Ball Jonathan
- Barbar Saber Davide
- Barbier François
- Barchard Jennifer
- Bass Frances
- Bates Samantha
- Baudry Thomas
- Beck James
- Beehre Nina
- Bellemare David
- Belley-Cote Emilie
- Bellmann Romuald
- Bellomo Rinaldo
- Bellomo Rinaldo
- Benettaib Fatna
- Benoit Luc
- Benton Jane
- Benzekri Dalila
- Bergin Colin
- Bihari Shailesh
- Bihorac Azra
- Bird Sarah
- Bitker Laurent
- Board Jasmin
- Bociek Aneta
- Bohé Julien
- Boisrame-Helms Julie
- Boivin Annick
- Bojic Andja
- Bone Allison
- Boschert Catherine
- Bouisse Camille
- Boulain Thierry
- Boulet Éric
- Boumahni Dounia
- Bourchard Pierre-Alexandre
- Bowman Katie
- Bracke Stephanie
- Bradford Celia
- Brailsford Jane
- Brandtner Anna
- Bretagnol Anne
- Brickell Kathy
- Broadfield Emma
- Brodutch Shira
- Brooks Jenny
- Brown Gillian
- Brown Sherry
- Browne Troy
- Buehner Ulrike
- Buhr Heidi
- Burke Tara
- Burns Karen
- Buscher Hergen
- Butler Magdalena
- Butler Susie
- Cahill Hazel
- Cailhier Jean-François
- Callahan Jean Christophe
- Callender Owen
- Campbell Eileen
- Campbell Troy
- Campbell Victoria
- Campisi Josie
- Camporota Luigi
- Campos Sara
- Canet Emmanuel
- Cantien Marie
- Carbonnaeu Élaine
- Carles Michel
- Carney Dominic
- Carney Gayle
- Carpentier Dorothée
- Carrera Ron
- Carrier François-Martin
- Carson Joshua
- Carter Joseph
- Carungcong Jaime
- Carvelli Paula
- Cegarra Santiago
- Cennamo Armando
- Chadbourn Indra
- Chadwick Lesley
- Chan Peter
- Chee Nigel
- Chen Man
- Chen Yan
- Chen Zhenzhen
- Chenaf Samir
- Cheung Winston
- Chevrel Guillaume
- Chiella Bianca
- Chimunda Tim
- Chudeau Nicolas
- Cinotti Raphaël
- Cirone Robert
- Clarey Emma
- Clark Amy
- Clark Edward
- Clark Michele
- Clarke France
- Cleophax Cedric
- Clere-Jehl Raphael
- Cloutier Eve
- Cohen Yves
- Cole Jade
- Cole Louise
- Coles Jennifer
- Colin Gwenhaël
- Collins Amy
- Combes Alain
- Commeureuc Morgane
- Condin Christopher
- Conner Louise
- Cooper Lauren
- Corcoran Eleanor
- Costa Patricia
- Costerousse Olivier
- Coupez Elisabeth
- Cour Martin
- Cowdrey Keri-Anne
- Creary Thais
- Crosby Laura
- Cross Rosalba
- Cunningham Mishell
- Cupka Julie
- da Costa Bruno R.
- Daniels Alison
- Dargent Auguste
- Davies Tracy Michelle
- De Crop Luc
- De La Salle Sylvie
- De Prost Nicolas
- De Watteville Aude
- Decalvele Maxens
- Dechanet Aline
- Dekeyser Thibault
- Delabranche Xavier
- Delaney Anthony
- Delecolle Lucie
- Delgado Carlos Castro
- Delisle-Thibault Charles
- Demeure Dominique
- Demiri Suela
- Demoule Alexandre
- Deng Fuxing
- Derrien Benoit
- Despy Liesl
- Dessap Armand Mekontso
- Devereaux Kelson
- Di Nella Michelle
- Diehl Jean-Luc
- Diel Naomi
- Dignam Gemma
- Dilawershah Maria
- Ding Lili
- Ding Ruiqi
- Ditlbacher Adelheid
- Dodek Peter
- Dominy Clive
- Dong Lei
- Dong Xin
- Dooley Natalie
- Doran Peter
- Dorfman Robert
- Dos Santos Sandra
- Dres Martin
- Dreyfuss Didier
- Dreyfuss Didier
- Drover John
- Du Bin
- Du Bin
- Duan Meili
- Duffy Jane
- Duffy Karina
- Dufour Nicolas
- Duggan Shelley
- Duke Graeme
- Dun Shijuan
- Dyett John
- D’Aragon Frédérick
- Eastwood Glenn M.
- Eckert Philippe
- Efron Philip
- Elderkin Tania
- Elias Madona
- Elizabeth Wilcox M.
- Eller Philipp
- Ellis Karen
- Emery Malo
- Endre Zoltan
- Ensenyat-Martin Luis
- Eraldi Jean-Pierre
- Fadel Fouad
- Fan Jingqun
- Farnell-Ward Sarah
- Farrah Helen
- Faure Morgane
- Felix Luis
- Fellows Emma
- Fendt Lucia
- Fennessy Gerard
- Fiancette Maud
- Finfer Simon
- Finkenstedt Armin
- Finney Clare
- Fletcher Jason
- Forbes Loretta
- Forni Lui G.
- Forshaw Greg
- Foulkes Stephen
- Francoeur Charles Langis
- Franja Vincenta
- Freebairn Ross
- French Craig
- Friedrich Jan
- Fries Dietmar
- Fu Lijuan
- Fu Yongjian
- Fusco Kelly
- Gallagher Martin P.
- Gallagher Martin P.
- Gangopadhyay Himangsu
- Gantner Dashiell
- Gao Lan
- Garg Amit
- Gattas David
- Gatward Jonathan
- Gaudry Stéphane
- Gaudry Stéphane
- George Aparna
- Georgescu Ilinca
- Gernez Coralie
- Ghamraoui Ali
- Ghate Taneera
- Ghosh Angaj
- Giannakouros Panagiota
- Gibson Neil
- Giebel Shelley
- Gilder Eileen
- Glybina Anna
- Gomes Brigette
- Gomez Raquel
- Goodson Jennifer
- Gordon Boyd J.
- Goulart Joyce McKenney
- Goulart Joyce McKenney
- Goundry Stephanie
- Grainger Lia
- Grangé Steven
- Grant Alice
- Grant Caroline
- Gray Geraldine
- Grenier Stéphanie
- Gresham Rebecca
- Grillot Nicolas
- Guerot Emmanuel
- Guery Aurore
- Guilbault Gabrielle
- Guitton Christophe
- Guo Dongchen
- Guo Litao
- Gurung Babita
- Gutierrez David
- Guy Zoe
- Haljan Gregory
- Hall Adam
- Hallion Jane
- Haltia Paivi
- Hambrook Geraldine
- Hammond Naomi
- Hamshere Alexandra
- Hang Lele
- Harasemiw Oksana
- Harkett Samanth
- Harkins Margaret
- Harmon John
- Harris Claire-Louise
- Harrop Clare
- Hartig Frank
- Harvey Dan
- Hashemighouchani Haleh
- Haslam Nicole
- Hasslacher Julia
- Hauschild Caroline
- Hazelton Tracy
- He Xiandi
- He Xiaona
- Heidegger Claudia
- Heinonen Jonna
- Henderson Seton
- Henderson Steven
- Hendry Deborah
- Hernandez Clara
- Hernu Romain
- Herridge Margaret S.
- Higson Vicki
- Hill Dianne
- Hill Helen
- Hindle Julia
- Hiremath Swapnil
- Hirst Claire
- Hodder Jennifer
- Hodgson Luke E.
- Hopkins Philip
- Hoppu Sanna
- Hoste Eric
- Hou Guo
- Houghton James
- Howard Kate
- Howcroft Clare
- Howe Elizabeth
- Howlett Luisa
- Hu Chenghuan
- Hu Tingting
- Hu Xiaobo
- Huang Lili
- Huang Yingzi
- Hunt Anna
- Hunt Miranda
- Hunter Stephanie
- Hussain Nauman
- Hutch Debra
- Inkinen Outi
- Investigators STARRT-AKI
- Jackson Carolyn
- Jackson David
- Jagannathan Vijay
- Jalkanen Ville
- Jang Ryan
- Janin Pierre
- Ji Xiaojun
- Jim Kym
- Jin Xia
- Joannidis Michael
- Joannidis Michael
- Johnson Emily
- Johnston Andy
- Joseph Gipsy
- Judd Harriet
- Junge Andrea
- Järvisalo Mikko J.
- Kamel Toufik
- Kapoor Ritoo
- Karachi Tim
- Karlsson Sari
- Kashani Kianoush B.
- Kaufman Melissa
- Kaur Navjot
- Kavikondala Kanthi
- Kaye Callum
- Keet Owen
- Kentala Satu
- Kerr Deborah
- Khalid Imrana
- Ki Vincent
- Kiley Sean
- Kirkham Simon
- Kissling Sébastien
- Klein David
- Klein Sebastian
- Knight David
- Knott Cameron
- Koglberger Paul
- Kokotsis Nicos
- Kol Mark
- Koottayi Sathyajith
- Korhonen Anna-Maija
- Kruger Peter
- Kuitunen Anne
- Kummerlen Christine
- Kutsogiannis Demetrios J.
- Küllmar Mira
- Lacave Guillaume
- Lacherade Jean Claude
- Ladouceur Marilène
- Lafrance Jean-Philippe
- Lagarrigue Matthieu Henry-
- Lakatos Louis
- Lakhal Karim
- Lambert Bridget
- Lamontagne François
- Lamontagne François
- Lamontagne François
- Landais Mickael
- Landoni Giovanni
- Lapinsky Stephen
- Lappi Eliria
- Large Audrey
- Latimer-Bell Charlotte
- Latta Laura
- Laurie Gordon
- Lauzier François
- Lawrence Cassie
- Le Moal Charlène
- Leaver Susannah
- Lebert Christine
- LeBlanc Guillaume
- Lebrasseur Martine
- Lee Sandra
- Leivo Keijo
- Lellouche Francois
- Lembo Rosalba
- Lenga Ilan
- Lesona Eden
- Levoranta Markus
- Li Hao
- Li Jian
- Li Jianquan
- Li Jing
- Li Min
- Li Nan
- Li Rui
- Lian Yingtao
- Liangos Orfeas
- Licari Elisa
- Lim Rosario
- Lin Jin
- Lin Jincan
- Liu Airan
- Liu Cheng
- Liu Hongjuan
- Liu Jingfeng
- Liu Kathleen D.
- Liu Manli
- Liu Pei
- Liu Xingang
- Liu Yu
- Liu Zhongmin
- Liu Zhou
- Liu Zhuang
- Lizotte Patricia
- Lobaz Steve
- Lombardi Gaetano
- Long Dali
- Long Stephanie
- Lord Jenny
- Lowrey Julie
- Lu Kun
- Lu Liping
- Lyas Claretha
- Lynch Matthew
- Lynch Matthew
- Långsjö Jaakko
- Ma Hongye
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- Wu Jing
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- Xu Song
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- Yan Jinqi
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- Yang Juan
- Yang Yang
- Yang Yi
- Yang Ziqi
- Yao Han
- Yao Lan
- Yarad Elizabeth
- Ye Baning
- Yehia Aihem
- Young Helen
- Young Meredith
- Young Paul
- Youngs Nora
- Yu Zhui
- Zahirieh Alireza
- Zampieri Fernando G.
- Zangrillo Alberto
- Zarbock Alexander
- Zeng Qinjing
- Zhang Jichen
- Zhang Lei
- Zhang Meng
- Zhang Minwei
- Zhang Songsong
- Zhao Dan
- Zhao Mengya
- Zhao Shibing
- Zhao Shuangping
- Zhi Deyuan
- Zhou Qi
- Zhou Xiao
- Zhuang Haizhou
- Zotter Klemens
- Zuber Benjamin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Background
Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework.
Methods
We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression.
Results
The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66.
Conclusions
In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel Jakša
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
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- Barbash Ian
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- Basile Kim
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- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Đimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc
The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
- Aasiyah Rashan
- Aasmine Kaur
- Abdulrahman Al-Fares
- Abhijit Duggal
- Adam Betz
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agamemnon Bakakos
- Agn??s Meybeck
- Agn??s Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Aidan Burrell
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisha Kalsoom Mufti
- Aisling Gavin
- Aisling Murphy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Alberto Cucino
- Alberto Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martin-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Martinelli
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J. Mentzer
- Alexander King
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Abbas
- Ali Ait Hssain
- Ali Hachemi
- Ali Liaquat
- Ali Raza
- Ali Rehan
- Alice Bogaarts
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Alison M. Meynert
- Alistair Nichol
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Lakshan Attanyake
- Am??lie Valran
- Amanda Corley
- Amanda Palacios
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Aroca
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Luiza Valle
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anant Kataria
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Tveita
- Andr?? Cabie
- Andr?? Dias
- Andr?? Roberto
- Andr??s Orquera
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Udy
- Andrey A Svistunov
- Andriy Bal
- Andy Dong
- Andy Law
- Aneela Altaf
- Angel Asensio
- Angel Sanchez-Miralles
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-H??l??ne Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Ant??nio Mesquita
- Anthony Gordon
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ho
- Antonio Arcadipane
- Antonio Lalueza
- Antonio Loforte
- Antonio Pesenti
- Anuraj Shankar
- Aoife Driscoll
- Aoife Kelly
- Aquiles Henriquez
- Arabella Fahy
- Ardiyan Apriyana
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arjen M Dondorp
- Arnaud Scherpereel
- Ars??ne Kpangon
- Arsalan Rahutullah
- Arshad Taqi
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asami Ito
- Asfia Sultana
- Asgar Rishu
- Ashok Kumar
- Asim Rana
- Asma Moin
- Astarini Hidayah
- Atif Siddiqui
- Attaur Rehman
- Audrey Barrelet
- Aur??lie Papadopoulos
- Aur??lie Veislinger
- Aur??lie Wiedemann
- Aurelius Bonfasius
- Aurore Bousquet
- Axelle Braconnier
- Azlan Mat Soom
- Azrina Ralib
- B. P. Sanka Ruwan Sri Darshana
- B??n??dicte Lefebvre
- B??n??dicte Rossignol
- Bailey Cassandra
- Bairbre McNicholas
- Bambang Pujo Semedi
- Barbara Wanjiru Citarella
- Basanta Gauli
- Basri Mat Nor
- Beatrice Alex
- Beatriz Amorim Beltr??o
- Ben Morton
- Benedict Sim Lim Heng
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefevre
- Benjamin Smood
- Benjamine Sarton
- Beno??t Roze
- Beno??t Thill
- Benoit Visseaux
- Bernard Cholley
- Bernardo Neves
- Bernhard Roessler
- Bertrand Dussol
- Bharath Kumar Tirupakuzhi Vijayaraghavan
- Bianca Boxma
- Bianca DeBenedictis
- Biing Horng Lee
- Bipin Karki
- Birgitte Stiksrud
- Blake Mergler
- Blandine Rammaert
- Bouchra Loufti
- Brenda Molloy
- Brenda Reeve
- Brian Marsh
- Brigid Flynn
- Brigitte Elharrar
- Briseida Parra
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bruno Sarmento Banheiro
- Bryan Whelan
- Budha Charan Singh
- C??cile Goujard
- C??cile Mear-Passard
- C??cile Tromeur
- C??cile Yelnik
- C??dric Joseph
- C??dric Laou??nan
- C??line Dorival
- C??line Ficko
- C??line Michelanglei
- C??sar Vieira
- Caitriona Cody
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlo Giaquinto
- Carlos Alexandre Antunes de Brito
- Carlos Lumbreras Bermejo
- Carlos M. Luna
- Carlos Pimentel
- Carmen Infante Dominguez
- Carola Pierobon
- Carolien van Netten
- Caroline Cullen
- Caroline Kosgei
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Cassidy Codan
- Cassie Lawrence
- Catarina Pires
- Catarina Silva
- Catherine A. Shaw
- Catherine Blier
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Catherine Marquis
- Catherine Motherway
- Cecile Azoulay
- Cecilia Canepa
- Ceila Maria Sant`Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Chantre Lima
- Charbel Maroun Eid
- Charlene Da Silveira
- Charles Crepy D'Orleans
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Cheryl Bartone
- Chian Hui Yeoh
- Chiara Robba
- Chiara Simona Cardellino
- Chiara Vitiello
- Chih-Hsien Wang
- Chloe Carpenter
- Chloe Donohue
- Chris Kandel
- Chris McKay
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Buesaquillo
- Christian Prebensen
- Christian Rabaud
- Christiana Kartsonaki
- Christl A. Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Christy Kay
- Ciara Doran
- Cl??ment Le Bihan
- Claire Andrejak
- Claire Foley
- Claire Kelly
- Claire Levy-Marchal
- Claire Roger
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clarice Tanaka
- Clark D. Russell
- Clark Owyang
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudia Sepulveda
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Cleide Barrigoto
- Clotilde Allavena
- Coilin Smyth
- Colin McArthur
- Colin McCloskey
- Coline Jaud-Fischer
- Colleen Curran
- Conar O'Neil
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Cristinava Vajdovics
- Cynthia Alegre
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Dafsah Juzar
- Dag Henrik Reikvam
- Daisuke Kasugai
- Dalia Lopez-Colon
- Damien Bouhour
- Damien Traynor
- Dan Meyer
- Daniel Glikman
- Daniel Haber
- Daniel Herr
- Daniel Ivulich
- Daniel Marino
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniel Plotkin
- Daniela Guerreiro
- Danielle Jaafar
- Darakhshan Kanwal
- Darren Dahly
- Darshana Hewa Kandamby
- Dave Nagpal
- David Bellemare
- David Dean
- David L. Robertson
- David Maslove
- David Maslove
- David Molina
- David Richardson
- David S. Y. Ong
- David Stuart
- David Thomson
- David Zucman
- Davide Chiumello
- Dawn Higgins
- Debby Bogaert
- Decy Subekti
- Deepak Vijayan
- Deepali Kumar
- Deepashankari Suppiah
- Dehbia Benkerrou
- Deirdre Flynn
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Denise Battaglini
- Denise Foster
- Denise Jaworsky
- Denise Richardson
- Denisse Bazan Dow
- Derbrenn OConnor
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Devachandran Jayakumar
- Devika Dixit
- Dewi Guellec
- Diana Adri??o
- Diana P??voas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Bastos
- Diego de Mendoza
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Diego Rolando Morocho Tutillo
- Dimitra Melia Myrodia
- Dinesh Kuriakose
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Domenico Luca Grieco
- Dominic So
- Dominique Deplanque
- Dominique Luton
- Dori-Ann Martin
- Dorothea Rosenberger
- Dorothy Breen
- Doug Robb
- Dounia Bouhmani
- Douwe F. Postma
- Dr Marianne Fraher
- Dubravka Supic
- Duc Nguyen
- Duong Bich Thuy
- Dyah Kanyawati
- Dzawani Muhamad
- Ebenezer Rabindrarajan
- Ed Carton
- Edel Meaney
- Eder Caceres
- Edmund Manning
- Edouard Soum
- Edward Wilson Grandin
- Efstathia Mihelis
- Eglantine Ferrand Devouge
- Egle Saviciute
- Eibhilin Higgins
- Eka Yudha Lantang
- Elaine Conway
- Elaine Gilroy
- Elaine McPartlan
- Elena Gallego Curto
- Elena Molinos
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Adam
- Elisabeth Botelho-Nevers
- Elisabetta Spinuzza
- Elise Artaud-Macari
- Elizabeth Ashley
- Ellen Shadowitz
- Elodie Curlier
- Elsa Nyamankolly
- Else Quist-Paulsen
- Ema Leal
- Eman Al Qasim
- Emanuele Durante-Mangoni
- Emily Martin
- Emily Neumann
- Emily Somers
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'Ortenzio
- Eric Delaveuve
- Eric Gnall
- Eric Oziol
- Eric Senneville
- Erica Bak
- Erlina Burhan
- Erni Nelwan
- Ernita Akmal
- Erwan Fourn
- Erwan L'Her
- Esteban Garcia-Gallo
- Ethan Kurtzman
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eva Stolz
- Eve Defous
- Evelyne Kestelyn
- Evert-Jan Wils
- Ewa Talarek
- Ewen M. Harrison
- F??lix Djossou
- Fabian Patauner
- Fabio Guarracino
- Fabio S. Taccone
- Fabrice Laine
- Fakhir Haidri
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Federico D'Amico
- Felwa Bin Humaid
- Fernando Augusto Bozza
- Fernando Maltez
- Fernando Rainieri
- Ferran Roche-Campo
- Ferruccio Mele
- Filipa Br??s Monteiro
- Filipa Cardoso
- Filipa Sequeira
- Filipe Cardoso
- Filomena Boccia
- Fiona Griffiths
- Fionnuala O Brien
- Firouz?? Bani-Sadr
- Fivzia Herekar
- Fl??vio Marino
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- Fr??d??rick D???Aragon
- Fran??ois Angoulvant
- Fran??ois Bissuel
- Fran??ois Bompart
- Fran??ois Dubos
- Fran??ois Goehringer
- Fran??ois Lamontagne
- Fran??ois Lellouche
- Fran??ois Martin Carrier
- Fran??ois T??oul??
- Fran??ois-Xavier Catherine
- Fran??ois-Xavier Ferrand
- Fran??ois-Xavier Lescure
- France Mentr??
- Francisco Arancibia
- Frank Bloos
- Frank Manetta
- Frank Olav Pettersen
- Fredrik Muller
- Gabriel Macheda
- Gabriel Suen
- Gabriele Sales
- Gabrielle Ragazzo
- Gail Carson
- Galyna Kutsyna
- Gamage Dona Dilanthi Priyadarshani
- Gan Ee Xian
- Ganesh Kumar
- Gary Leeming
- Gary Schwartz
- Gayle Carney
- Gennaro Martucci
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Geraldine Goco
- Gerard Curley
- Gezy Giwangkancana
- Ghulam Rasheed
- Giacomo Grasselli
- Gianluigi Li Bassi
- Giles J. Peek
- Gilles Peytavin
- Gillian de Loughry
- Giorgia Montrucchio
- Giovanna Occhipinti
- Giovanna Panarello
- Giri Shan Rajahram
- Gitte Van Twillert
- Giulia Bertoli
- Giuliano Michelagnoli
- Giulio Giovanni Cavalli
- Giuseppe Foti
- Gloria Crowl
- Gr??gory Corvaisier
- Graham S. Cooke
- Grainne HigginsOKeeffe
- Grazielle Viana Ramos
- Gregory Purcell
- Gretchen Lemmink
- Gry Kloumann Bekken
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
- Gwena??l Le Moal
- Gwenha??l Colin
- Gyan Sandhu
- H M Upulee Pabasara
- H??l??ne Esperou
- H??l??ne Salvator
- Ha Sha Lene
- Haixia Shi
- Hajnal-Gabriela Illes
- Hanan Fateena
- Hanna Jung
- Hanna Renk
- Hannah Habraken
- Hannah Keane
- Hannah Visser
- Hans Martin Bosse
- Harald Vonkeman
- Hassan Tawfik
- Hayato Taniguchi
- Hayley Hardwick
- Hazel Bergin
- Heidi Ammerlaan
- Heidi Dalton
- Heidi Gruner
- Helen Doherty
- Helen Tuite
- Helen Vaughan
- Helena Barrasa
- Hem Paneru
- Heng Gee Lee
- Henk Vanoverschelde
- Henrique Mateus Fernandes
- Henry Castrill??n
- Hernando Torres-Zevallos
- Herv?? Le Nagard
- Hiba Zayyad
- Hikombo Hitoto
- Himed Musaab
- Hiroaki Hiraiwa
- Hiroaki Shimizu
- Hiroyuki Tanaka
- Hiu Jian Chua
- Hodane Yonis
- Hoi Ping Shum
- Holger Neb
- Hon Shen Png
- Hongru Ren
- Hubert Tessier-Grenier
- Huda Alfoudri
- Huda Taqdees
- Hugo In??cio
- Hugo Miranda-Maldonado
- Hugo Mouquet
- Hugues Aumaitre
- Hugues Cordel
- Hussain Tanveer
- Huynh Trung Trieu
- Hwa Jin Cho
- Iam Claire E. Sarmiento
- Ida Carroll
- Ignacio Martin-Loeches
- Ikram Houas
- Ilka Engelmann
- Ilonka van Veen
- Imran Ali
- Imrana Khalid
- In??s Carqueja
- Indrek R??tsep
- Ingrid G. Bustos
- Ioana Grigoras
- Ioannis Trontzas
- Ioannis Xynogalas
- Ionna Deligiannis
- Iqbal Elyazar
- Iqbal Hussain
- Irene Aragao
- Irfan Khan
- Isabela Saba
- Isabella Bianchi
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- Isabelle Pironneau
- Issrah Jawad
- Ithan D. Peltan
- Ivo Castro
- J Kevin Baird
- J. Kenneth Baillie
- J. Perren Cobb
- J??r??me Dimet
- J??r??mie Guedj
- J??r??mie Pasquier
- Jack Song Chia
- Jacky Y. Suen
- Jacobien Ellerbroek
- Jade Ghosn
- Jae Burm Kim
- Jaganathan Selvanayagam
- Jai Madhok
- Jaime Cruz Rojo
- Jaime Hernandez-Montfort
- Jake Dunning
- Jamel Ortoleva
- James Joshua Douglas
- James Lee
- James Scott-Brown
- Jan Cato Holter
- Jan Heerman
- Jan-Erik Berdal
- Jananee Thirumanickam
- Janet Harrison
- Janet Liang
- Janet T. Scott
- Jaques Sztajnbok
- Jarne Van Hattem
- Jason Bouziotis
- Javier Maynar
- Javier Osatnik
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean Foley
- Jean-Beno??t Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
- Jean-Fran??ois Payen
- Jean-Fran??ois Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-S??bastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jee Yan Ong
- Jeff Powis
- Jeffrey Aliudin
- Jeffrey Javidfar
- Jelmer Talsma
- Jennifer Clarke
- Jennifer Connolly
- Jennifer June
- Jenny Lennon
- Jeremy J. Farrar
- Jeronimo Graf
- Jess Gibson
- Jia Shyi Loy
- Jia Wei
- Jillian Deacon
- Jimmy Ming-Yang Hsu
- Jimmy Mullaert
- Jin Yi Goh
- Jo Dalton
- Jo??o Alves
- Jo??o Cam
- Jo??o Estev??o
- Jo??o Martins
- Jo??o Melo Alves
- Jo??o Oliveira
- Jo??o Teixeira
- Joan G??mez-Junyent
- Joana Ferr??o
- Joanne Downey
- Joao Joao Mendes
- Joaqu??n Baruch
- Jodat Saleem
- Jodat Saleem
- Johann Auchabie
- Johannes Gebauer
- John Bourke
- John F. Fraser
- John G. Laffey
- John Marshall
- Johnny McKeown
- Jolanta Popielska
- Jonathan Chua
- Jonathan Crump
- Jonathan Golob
- Jonathan Remppis
- Jonathan Samuel Ch??vez I??iguez
- Jordan Zhien Yang Toh
- Jordi Rello
- Jordi Riera
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Jos?? Casimiro
- Jos?? Ernesto Vidal
- Jos?? Luis Bernal Sobrino
- Jos?? Miguel Cisneros Herreros
- Jose Andres Calvache
- Jose I Nunez
- Jose M. Mandei
- Jose Pedro Cidade
- Joshua Solomon
- Josie Campisi
- Joy Ann Villanueva
- Juan Fernado Masa Jimenez
- Juan Fiorda
- Juan Jose Diaz Diaz
- Juan Luis Cruz Berm
- Juan Macias Sanchez
- Juan Pablo Horcajada
- Judit Villar
- Judy Gitahi
- Jules Bauer
- Julia Garcia-Diaz
- Julia Rodriguez Abreu
- Julian Chica
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Juliette Duthoit
- Juliette Patrier
- Juliette Romaru
- Junaid Hashmi
- Junaid Patel
- Junji Itai
- Justin Schaffer
- Justine Pages
- K??vin Alexandre
- K??vin Bouiller
- K??vin Didier
- Kah Chuan Lim
- Kai Zacharowski
- Kalaiarasu Peariasamy
- Kalynn Kennon
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karisha Sivam
- Karl Erik M??ller
- Karolina Krawczyk
- Karolina Nowicka
- Kashif Memon
- Katarzyna Lewandowska
- Kate Ainscough
- Kate Calligy
- Katharina Weil
- Kathy Brickell
- Katie O'Hearn
- Kazali Enagnon Alidjnou
- Kazi Rubayet Anwar
- Keibun Liu
- Keiki Shimizu
- Keith Wille
- Kenneth A. McLean
- Ker Hong Bee
- Kevin Katz
- Khor How Kiat
- Kim Keat Tan
- Kishore Mangal
- Kizy Sanchez de Oliveira
- Koji Hoshino
- Kok Wei Hao
- Kollengode Ramanathan
- Kong Yeow Kang
- Konrad Zawadka
- Konstantinos Kyriakoulis
- Konstantinos Syrigos
- Konstanty Szuldrzynski
- Kota Hoshino
- Krishna Bhavsar
- Kristian Tonby
- Kuan Pei Xuan
- Kusum Menon
- Kyle Gomez
- Laetitia Bodenes
- Lai Hui Pang
- Lance C. W. Turtle
- Lara Absil
- Lara Lovelace-Macon
- Larissa Oliveira
- Lars Heggelund
- Lars S. Maier
- Laur??ne Azemar
- Laura Feeney
- Laura Marsh
- Laura Merson
- Laura van Gulik
- Laure Goubert
- Lauren Deconninck
- Laurence Bouillet
- Laurence Maulin
- Laurent Abel
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laveena Munshi
- Le Van Tan
- Leanne Hays
- Lee Lee Low
- Lenka Petrou
- Leonardo Salazar
- Leong Chee Loon
- Leong Chin-Tho
- Letizia Lucia Florio
- Liadain Reid
- Liadain Reid
- Liem Luong
- Lila Bouadma
- Liliana Resende
- Lim Lina
- Lim Saio Xian
- Lim Yuen Han
- Lina Morales Cely
- Linda Gail Skeie
- Linda O'Shea
- Lionel Eric Benjiman
- Lionel Piroth
- Lisa Mc Sweeney
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Lorenzo Bertolino
- Lorenzo Grazioli
- Lorna Murphy
- Lorraine McAndrew
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lovkesh Arora
- Lu??s Bento
- Lu??s Patr??o
- Lu??s Val-Flores
- Luca Brazzi
- Lucia Moro
- Lucia Proen??a
- Lucian Durham III
- Lucie Le Fevre
- Lucille Blumberg
- Luis Felipe Reyes
- Luis Melo
- Luis Periel
- Luisa Quesada
- Lukas Arenz
- Lysa Tagherset
- M Azhari Taufik
- M??lanie Roriz
- M??rio Ferraz
- Ma??der Pagadoy
- Machteld van der Feltz
- Madiha Hashmi
- Maeve Kelsey
- Maeve Kernan
- Maeve Ryan
- Magdalena Surovcov??
- Mageswari Selvarajoo
- Maggie Mechlin
- Mahdad Noursadeghi
- Maia Rabaa
- Maire-Laure Casanova
- Maisa Guimar??es de Castro
- Makoto Uchiyama
- Malcolm G. Semple
- Malte Kohns Vasconcelos
- Mamoru Komatsu
- Mangala Narasimhan
- Manuel Etienne
- Manuel Rosa-Calatrava
- Maqsood Meher
- Mar??lia Fernandes
- Maram Zahran
- Marc Csete
- Marc Fabre
- Marc Lambert
- Marc Leone
- Marcel van den Berge
- Marcela Vieira Freire
- Marco Echeverria-Villalobos
- Marco Giani
- Mare Pejkovska
- Margarida Torres
- Margarite Grable
- Margaux Isnard
- Maria Amaral
- Maria Angelica Rivera Nu??ez
- Maria Boylan
- Maria de Piero
- Maria Donnelly
- Maria Ines Ribeiro
- Maria Joao Silva
- Maria Lawrensia Tampubolon
- Maria Pokorska-Spiewak
- Maria Ryan
- Maria Sousa Uva
- Maria Toki
- Maria Zambon
- Mariachiara Ippolito
- Mariana Casc??o
- Mariano Esperatti
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marieke Haalboom
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marije Lowik
- Marina Esposito-Farese
- Marina Lanza
- Marina Wainstein
- Marine Beluze
- Marine Livrozet
- Mario Palacios
- Marion Le Mar??chal
- Marion Noret
- Marion Schneider
- Marion Zabbe
- Marjolein Brusse-Keizer
- Mark de Boer
- Mark Downing
- Mark G. Pritchard
- Mark Joseph
- Marl??ne Murris
- Marlene Santos
- Marlice van Dyk
- Marsilla Marzukie
- Marta Alessi
- Marta Leal Santos
- Marta Sousa
- Martin Guego
- Martin Martinot
- Martina Escher
- Martina Hennessy
- Martine Remy
- Mary Copland
- Mary Mone
- Masahiro Fukuda
- Masaki Yamazaki
- Masliza Zahid
- Massimo Antonelli
- Massimo Gagliardi
- Massimo Palmarini
- Mathew Pulicken
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvall??e
- Mathilde Duplaix
- Matteo Puntoni
- Matteo Rossetti
- Matthew Brack
- Matthew Cummings
- Matthew Griffee
- Matthew Hall
- Matthew Pellan Cheng
- Matthieu Revest
- Maude Bouscambert
- Mauro Panigada
- Max O'Donnell
- Maxime Hentzien
- Maximilian Malfertheiner
- Maximilien Saint-Gilles
- Mayka Mergeay-Fabre
- Meera Chand
- Megan Coles
- Megan Marshal
- Meghena Mathew
- Mehdi Mezidi
- Mehul Desai
- Melissa Parker
- Menaldi Rasmin
- Merc?? Jourdain
- Mia Callahan
- Mical Paul
- Michael Collins
- Michael Maxwell
- Michael Piagnerelli
- Michael Rose
- Michael Schwameis
- Michael Sonntagbauer
- Michael Towers
- Michael Varrone
- Michaela Barnikel
- Michela Leone
- Michelle E Kho
- Michelle Girvan
- Michelle Smyth
- Michelle Smyth
- Miguel Pedrera Jim??nez
- Miguel Zambrano
- Minerva Cervantes-Gonzalez
- Minh Le
- Mireia Cantero
- Miriam O'Sullivan
- Mirjam Evers
- Mo??se Machado
- Mobin Chaudary
- Mohamed Fayed
- Mohammad Asim
- Mohammad Imran
- Mohammad Shamsah
- Mohammed El Sanharawi
- Mohammed Quraishi
- Mohan Dass Pathmanathan
- Mohanaprasanth Balakrishnan
- Mohd Nazlin Bin Kamarudin
- Mohd Shahnaz Hasan
- Mohiuddin Shiekh
- Moirangthem Bikram Singh
- Monserrat Solis
- Morgane Gilg
- Morgane Snacken
- Moshe Matan
- Motohiro Asaki
- Muhammad Aisar Ayadi Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Hassin Basri
- Muhammad Hayat
- Mukesh Kumar
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mustehan Bashir
- Myl??ne Maillet
- Myung Jin Song
- Nad??ge Neant
- Nadeem Munir
- Nadia Baig
- Nadia Ettalhaoui
- Nadia Malik
- Nadia Ouamara
- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nagarajan Ramakrishnan
- Nageswaran Narayanan
- Nahoko Shindo
- Namra N
- Naoki Shimizu
- Naseem Ali Shah
- Nasir Khoso
- Nassima Si Mohammed
- Natalie McEvoy
- Nataly Farshait
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gagn??
- Nathalie Gault
- Nathalie M. Delfos
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Naveed Latif
- Navy Lolong
- Navya Garimella
- Nawal Salahuddin
- Nazreen Abu Bakar
- Necsoi Coca
- Neerusha Kaisbain
- Nelson Cardoso
- Nestor Luque
- Neurinda Permata Kusumastuti
- Ng Wing Yiu
- Ng Yong Muh
- Ng Yong Siang
- Nguyen Van Vinh Chau
- Niamh Feely
- Niamh Kelly
- Niamh Ni Leathlobhair
- Nicholas Rizer
- Nicholas Sedillot
- Nicholas Yee Liang Hing
- Nicholas Yuri Barbosa
- Nick Daneman
- Nicky Van Der Vekens
- Nicolas Benech
- Nicolas Brozzi
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Eliza Mohamed
- Nikita A Nekliudov
- Nilar Lwin
- Nina Buchtele
- Nina Jamieson
- Nipunie Rajapakse
- Nisreen Shiban
- No??mie Mercier
- No??mie Tissot
- No??mie Vanel
- Nobuaki Shime
- Nobuya Kitamura
- Noelia Garc??a Barrio
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Binti Zaidan
- Nora Fuentes
- Nuno Germano
- Nuno Martins
- Nur Amira
- Nurnaningsih Nurnaningsih
- Nurul Amani Mohd Noordin
- Nurul Faten Izzati Norharizam
- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sandulescu
- Obada Yousif
- Odile Launay
- Ogechukwu Menkiti
- Oksana Kruglova
- Olavi Maasikas
- Oleksa Rewa
- Olena Haidash
- Olga Martynenko
- Olguta Lungu
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Omar Mehkri
- Ong Yiaw Joe
- Oriane Pu??chal
- Orna Ni Choileain
- Oryane Mabiala
- Osama Khalid
- Osama Metwally
- Oscar Hoiting
- Ouifiya Kafif
- Pablo Blanco-Schweizer
- Pablo Serrano Balazote
- Paddy Mallon
- Palliya Guruge Pramodya Ishani Ishani
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Paolo Pelosi
- Parthena Savvidou
- Pascal Granier
- Patricia Fontela
- Patricia Gordon
- Patricia Lizotte
- Patricia Patricio
- Patrick Archambault
- Patrick Biston
- Patrick Breen
- Patrick Breen
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Kellam
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul Tierney
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pauline Yeung Ng
- Pavan Kumar Vecham
- Pawel Twardowski
- Pedro Faria
- Pedro Povoa
- Peter de Vries
- Peter Doran
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Phil Gallagher
- Philippe Jouvet
- Philippine Eloy
- Phillip Mason
- Phoebe Ampaw
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-Fran??ois Sandrine
- Pierre-Marc Villeneuve
- Pierre-Marie Roger
- Pieter Depuydt
- Piret Sillaots
- Pleun Terpstra
- Polina Bugaeva
- Pompini Agustina Sitompul
- Pooja Varghese
- Pranya Sakiyalak
- Prasan Kumar Panda
- Prasanth Sukumar
- Pratap Karpayah
- Pratima Sharma
- praveen kumar ghisulal
- Priscila Diaz
- Prompak Nitayavardhana
- Punam Singh
- Qabas Alkhafajee
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain
- Rachael McConnochie
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas de Oliveira Fran??a
- Rafael Le??n
- Rafael Mahieu
- Rajavardhan Rangappa
- Rajeshwari Arali
- Rajyabardhan Pattnaik
- Rakesh Arora
- Rana Imran Sikander
- Raph Hamers
- Rapha??l Borie
- Rapha??l Favory
- Raquel Pinto
- Rashan Haniffa
- Rashid Nasim Khan
- Rasidah Bt Senian
- Raul Neto
- Ravi Kant
- Raymond Savio
- Razi Alalqam
- Rebecca Hamidfar
- Rebecca Holt
- Rebekha Garcia
- Renata Barbalho
- Renato Reis
- Renee Douma
- Ricard Ferrer-Roca
- Ricardo Fritz
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rita Hinchion
- Ritika Ranjan
- Rob Klont
- Robert A. Fowler
- Roberta Cavalin
- Roberto Andini
- Roberto Roncon-Albuquerque Jr
- Robin Kobbe
- Rodrigo Diaz
- Rog??rio Silva
- Rolando Claure Del Granado
- Romain Basmaci
- Romain Decours
- Romain Guery
- Roman Ullrich
- Romans Matulevics
- Rosanna De Rosa
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Gomes
- Rui Pereira
- Rumaisah Satyawati
- Ruth Jimbo-Sotomayor
- Ruth Lyons
- Ruth N. Jorge Garc??a
- Ryadh Pokeerbux
- Ryan Kennedy
- Ryan Khoo
- Ryan S. Thwaites
- Ryuzo Abe
- S??bastien Preau
- S??lvia Ferreira
- S??rgio Gai??o
- S??verine Ansart
- Saad Nseir
- Sabelline Bouchez
- Sabin Koirala
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saeeda Haider
- Saef Umar Barnett
- Saijad Orakzai
- Saima Kamal
- Sairah Sadaf
- Saleh Al Ageel
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samantha Strudwick
- Samira Laribi
- Samreen Ijaz
- Samual MacDonald
- Samuel Bernard Ekow Harrison
- Samuel Hinton
- Samuel Markowicz
- Samuel McElwee
- Sandrine Couffin-Cadiergues
- Sanjay Lakhey
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Taleb
- Sara Ventura
- Sarah Cormican
- Sarah E. McDonald
- Sarah Isgett
- Sarah MacDonald
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Se??n Keating
- Seamus Daly
- Sean Donohue
- Sebastian Vencken
- Sebastiano Maria Colombo
- Segol??ne Greffe
- Senthilkumar Alegesan
- Sergio Poli
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shakeel Ahmed
- Shaminee Veeran
- Sharma Keshav
- Shaun Thompson
- Shaunagh Browne
- Sheeba Hakak
- Sheharyar Ashraf
- Sheila C??rcel
- Sherry McDermott
- Sheryl Ann Abdukahil
- Shingo Adachi
- Shinichiro Ohshimo
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C. Moore
- Sia Loong Tonnii
- Silvia Casta??eda
- Silvia Lourenco
- Sim Choon Ean
- Sim??o Rodeia
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Simone Carelli
- Simone Piva
- Simreen Kaur Johal
- Siobhan Casey
- Siobhan Egan
- Siri Goepel
- Siti Nurul Atikah Ahmad Ridzuan
- Siti Rohani Binti Mohd Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Smaragdi Kalomoiri
- Sobia Masood
- Sobia Masood
- Sof??a Contreras
- Sofia Cardoso
- Sofia Prapa
- Sofia Tejada
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Sophie O'Halloran
- Sophie Yacoub
- Sravya Pudota
- Sree Satyapriya
- Srinivas Murthy
- St??phane Jaureguiberry
- St??phane Lasry
- St??phane Sallaberry
- St??phanie Cousse
- St??phanie Fry
- Stanislas Rebaudet
- Steffi Ryckaert
- Stella Rousset
- Stephan Schroll
- Stephanie Nonas
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen Brett
- Stephen Knight
- Steven Anthony Webb
- Steven van Lelyveld
- Stijn Van de Velde
- Stuart Houltham
- Su Hwan Lee
- Subbarao Elapavaluru
- Subhash Acharya
- Sudhir Krishnan
- Sue Smith
- Suhaila Abdul Wahab
- Sung-Min Cho
- Surain Raaj Thanga Thurai
- Suresh Kumar Chidambaram
- Surya Otto Wijaya
- Susana Cabral
- Susana Fernandes
- Susanne Dudman
- Sushil Khanal
- Suvintheran Thangavelu
- Suwarti Suwarti
- Suzanne Bennett
- Suzette Willems
- Swagata Tripathy
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Syed Muneeb
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sze Kye Teoh
- T. Eoin West
- T??nia Sequeira
- Tae Song
- Taha Pasha
- Tahira Jamal Mohamed
- Tak-Hyuk Oh
- Takako Akimoto
- Takayuki Ogura
- Taku Tanaka
- Takuya Shiga
- Tala Al-dabbous
- Tamara Seitz
- Tan Pei Wen
- Tanvir Alam
- Tarek Elshazly
- Tatiana Fonseca
- Tatsuya Kawasaki
- Tawnya Ogston
- Teck Fung Wong
- Teresa Lawrence
- Terese Hammond
- Tessa Broadley
- Th??o Treoux
- Thalha Rashan
- Tharmini Ravi
- Tharwat Aisa
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timo Brandenburger
- Timo Tolppa
- Ting Soo Chow
- Tiphaine Goulenok
- Tjard Schermer
- Todd C. Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tomoyuki Endo
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- V??ctor Quir??s Gonz??lez
- V??ronique Lemee
- Vadim Tieroshyn
- Val??rie Gaborieau
- Val??rie Garrait
- Val??rie Gissot
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- van der Palen Job
- Vanessa Sancho-Shimizu
- Vanessa Teotonio
- Vanina Meysonnier
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Manda
- Victoria McEneany
- Victoria Shaw
- Vieri Parrini
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Volkan Korten
- Waasila Jassat
- Wai Ching Sin
- Walter Picard
- Wan Fadzlina Wan Muhd Shukeri
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xavier S??nchez Choez
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zubair Umer
- Zul Amali Che Kamaruddin
- Zul Fakar
- Zulfiqar Sandhu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
International audienc