Stationary and Traveling Wave States of the Kuramoto Model with an Arbitrary Distribution of Frequencies and Coupling Strengths

We consider the Kuramoto model of an ensemble of interacting oscillators allowing for an arbitrary distribution of frequencies and coupling strengths. We define a family of traveling wave states as stationary in a rotating frame, and derive general equations for their parameters. We suggest empirical stability conditions which, for the case of incoherence, become exact. In addition to making new theoretical predictions, we show that many earlier results follow naturally from our general framework. The results are applicable in scientific contexts ranging from physics to biology.Comment: 5 pages, 1 figur

Energy-optimal steering of transitions through a fractal basin boundary.

We study fluctuational transitions in a discrete dy- namical system having two co-existing attractors in phase space, separated by a fractal basin boundary. It is shown that transitions occur via a unique ac- cessible point on the boundary. The complicated structure of the paths inside the fractal boundary is determined by a hierarchy of homoclinic original sad- dles. By exploiting an analogy between the control problem and the concept of an optimal fluctuational path, we identify the optimal deterministic control function as being equivalent to the optimal fluctu- ational force obtained from a numerical analysis of the fluctuational transitions between two states

Optimal fluctuations and the control of chaos.

The energy-optimal migration of a chaotic oscillator from one attractor to another coexisting attractor is investigated via an analogy between the Hamiltonian theory of fluctuations and Hamiltonian formulation of the control problem. We demonstrate both on physical grounds and rigorously that the Wentzel-Freidlin Hamiltonian arising in the analysis of fluctuations is equivalent to Pontryagin's Hamiltonian in the control problem with an additive linear unrestricted control. The deterministic optimal control function is identied with the optimal fluctuational force. Numerical and analogue experiments undertaken to verify these ideas demonstrate that, in the limit of small noise intensity, fluctuational escape from the chaotic attractor occurs via a unique (optimal) path corresponding to a unique (optimal) fluctuational force. Initial conditions on the chaotic attractor are identified. The solution of the boundary value control problem for the Pontryagin Hamiltonian is found numerically. It is shown that this solution is approximated very accurately by the optimal fluctuational force found using statistical analysis of the escape trajectories. A second series of numerical experiments on the deterministic system (i.e. in the absence of noise) show that a control function of precisely the same shape and magnitude is indeed able to instigate escape. It is demonstrated that this control function minimizes the cost functional and the corresponding energy is found to be smaller than that obtained with some earlier adaptive control algorithms

KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation

Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA

A new approach to the treatment of Separatrix Chaos and its applications

We consider time-periodically perturbed 1D Hamiltonian systems possessing one or more separatrices. If the perturbation is weak, then the separatrix chaos is most developed when the perturbation frequency lies in the logarithmically small or moderate ranges: this corresponds to the involvement of resonance dynamics into the separatrix chaos. We develop a method matching the discrete chaotic dynamics of the separatrix map and the continuous regular dynamics of the resonance Hamiltonian. The method has allowed us to solve the long-standing problem of an accurate description of the maximum of the separatrix chaotic layer width as a function of the perturbation frequency. It has also allowed us to predict and describe new phenomena including, in particular: (i) a drastic facilitation of the onset of global chaos between neighbouring separatrices, and (ii) a huge increase in the size of the low-dimensional stochastic web

The X-ray Outburst of H1743-322: High-Frequency QPOs with a 3:2 Frequency Ratio

We observed the 2003 X-ray outburst of H1743-322 in a series of 130 pointed observation with RXTE. We searched individual observations for high-frequency QPOs (HFQPOs) and found only weak or marginal detections near 240 and 160 Hz. We next grouped the observations in several different ways and computed the average power-density spectra (PDS) in a search for further evidence of HFQPOs. This effort yielded two significant results for those observations defined by the presence of low-frequency QPOs (0.1-20 Hz) and an absence of ``band-limited'' power continua: (1) The 9 time intervals with the highest 7-35 keV count rates yielded an average PDS with a QPO at $166 \pm 5$ Hz. ($4.1 \sigma$; 3--35 keV); and (2) a second group with lower 7-35 keV count rates (26 intervals) produced an average PDS with a QPO at $242 \pm 3$ Hz ($6.0 \sigma$; 7--35 keV). The ratio of these two frequencies is $1.46 \pm 0.05$. This finding is consistent with results obtained for three other black hole systems that exhibit commensurate HFQPOs in a 3:2 ratio. Furthermore, the occurrence of H1743-322's slower HFQPO at times of higher X-ray luminosity closely resembles the behavior of XTE J1550-564 and GRO J1655-40. We discuss our results in terms of a resonance model that invokes frequencies set by general relativity for orbital motions near a black-hole event horizon.Comment: 12 pages, 3 figures, submitted to Ap

Stochastic dynamics of remote knock-on permeation in biological ion channels

Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF). Unlike the case of conventional direct knock-on, the second ion that instigates permeation does not need to enter the channel. Nor does it necessarily take the place of the permeating ion at the SF, and it can even be of a different ionic species. The study is based on the simultaneous, self-consistent, solution of the coupled Poisson and Langevin equations for a simple generic model, taking account of all the charges present. The new permeation mechanism involves electrostatic amplification attributable to the permittivity mismatch between water and protein: the arrival of the instigating ion at the channel entrance reduces the exit barrier for the ion trapped at the SF, facilitating escape

Self-organized enhancement of conductivity in biological ion channels

We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels. The underlying mechanism involves charge fluctuations near the channel mouth, amplified by the mismatch between the relative permittivities of water and the protein of the channel walls. We use Brownian dynamics simulations to show that, as in conventional 'knock on' permeation, these interactions can strongly enhance the channel current; but unlike the conventional mechanism, the enhancement occurs without the instigating bath ion entering the channel. The transition between these two mechanisms is clearly demonstrated, emphasizing their distinction. A simple model accurately reproduces the observed phenomena. We point out that electrolyte plus protein of low relative permittivity are universal in living systems, so that long-range ion–ion correlations of the kind considered must be common

The politics of representation in the politics of anti-racism

In this short response to Gavan Titley’s new book Racism and Media, I engage with his discussion of the politics of the representation in relation to his important concept of debatability. I underline two key contributions made by Titley in the chapter “The Politics of Representation in Postracial Media Culture”: (1) the limitations of an anti-racist politics based on media representation alone and (2) how the politics of representation and the commentary and debate that it generates has become commodified and transformed into media content itself. I end the piece by suggesting some new routes for media-based anti-racist interventions, targeted at the level of political economy of the cultural industries