Peeling Back the Onion of Cyber Espionage after Tallinn 2.0

Tallinn 2.0 represents an important advancement in the understanding of international law’s application to cyber operations below the threshold of force. Its provisions on cyber espionage will be instrumental to states in grappling with complex legal problems in the area of digital spying. The law of cyber espionage as outlined by Tallinn 2.0, however, is substantially based on rules that have evolved outside of the digital context, and there exist serious ambiguities and limitations in its framework. This Article will explore gaps in the legal structure and consider future options available to states in light of this underlying mismatch

Blended Learning: Beyond Initial Uses To Helping To Solve Real-World Academic Problems

Blended learning strategies can be employed in innovative ways to solve real-world academic problems across all academic disciplines.  This article can provide administrators and faculty with specific examples to guide them when making decisions about academic planning or institutional strategies for any discipline at all levels of higher education

Teaching Consolidations Accounting: An Approach To Easing The Challenge

Teaching and learning accounting for consolidations is a challenging endeavor. Students not only need to understand the conceptual underpinnings of the accounting requirements for consolidations, but also must master the complex accounting needed to prepare consolidated financial statements. To add to the challenge, the consolidation process is dependent on how the parent company accounts for the investment on its parent company ledgers. Parent company ledgers either use the cost method or some variation of the equity method to account for investments to be consolidated. The variety in those accounting approaches used by parent companies is comparable to the variety of approaches to teach consolidations that are presented in advanced accounting textbooks, as documented by Luehlfing (1995). Luehlfing outlines the parent company accounting methods that are presumed to be used to teach consolidation accounting in each of the existing U.S. advanced accounting texts, noting that authors promote one method over others.  Luehlfing suggests that students should be provided with a comparison of the parent company entries under the cost method and each adaptation of the equity method so that they can obtain a better understanding of the differences in the consolidation worksheet elimination/reclassification entries.  Rather than having students learn different consolidation worksheet entries as a result of different recording methods used by the parent for an investment requiring consolidation, an approach can be adopted so that students only need to learn one set of consolidation worksheet entries to develop consolidated financial statements. In addition, a method of analyzing the parent’s investment account can be used to not only help understand the conceptual issues associated with consolidation accounting, but also greatly facilitate the mechanics of preparing the consolidation worksheet entries. &nbsp

Vertical patterns in 15N natural abundance in PON from the surface waters of warm-core rings

The natural abundance of 15N in PON from the upper 200 m of 4 warm-core rings and the Sargasso Sea was measured. Minima in the δ15N of PON often occurred near the depth at which NO3− was first detectable. Frequently, maxima in PON concentration and minima in C/N ratio also co-occurred in this region. The average value for the δ15N of PON below the top of the nitracline was almost always greater than that above the top of the nitracline. The observed vertical pattern for the δ15N of PON is most likely the result of isotopic fractionation in the processes of NO3− uptake by phytoplankton at the base of the euphotic zone and the degradation of PON below the euphotic zone. Variations in the strength and coherence of this vertical pattern appear to occur in response to both rapid physical modification of the water column and the trophic status of the euphotic zone

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits

Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD). In PD, motor deficits correlate with the emergence of exaggerated beta frequency (15-30 Hz) oscillations throughout the CBT network. However, little is known about how specific cell types within individual CBT brain regions support the generation, propagation, and interaction of oscillatory dynamics throughout the CBT circuit or how specific oscillatory dynamics are related to motor function. Here, we investigated the role of striatal cholinergic interneurons (SChIs) in generating beta and gamma oscillations in cortical-striatal circuits and in influencing movement behavior. We found that selective stimulation of SChIs via optogenetics in normal mice robustly and reversibly amplified beta and gamma oscillations that are supported by distinct mechanisms within striatal-cortical circuits. Whereas beta oscillations are supported robustly in the striatum and all layers of primary motor cortex (M1) through a muscarinic-receptor mediated mechanism, gamma oscillations are largely restricted to the striatum and the deeper layers of M1. Finally, SChI activation led to parkinsonian-like motor deficits in otherwise normal mice. These results highlight the important role of striatal cholinergic interneurons in supporting oscillations in the CBT network that are closely related to movement and parkinsonian motor symptoms.DP2 NS082126 - NINDS NIH HHS; R01 NS081716 - NINDS NIH HHS; R21 NS078660 - NINDS NIH HHShttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896681/Published versio

Response to Aubin et al. (2017)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138910/1/add13937.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138910/2/add13937_am.pd

Homogenization of daily temperature and humidity series in the UK

Building on previous experience with continental and global data sets, we use a quantile-matching approach to homogenize temperature and humidity series measured by a network of 220 stations in the United Kingdom (UK). The data set spans 160 years at daily resolution, although data coverage varies greatly in time, space, and across variables. We use the homogenized data to analyse trends of the mean values as well as the lowest and highest quantiles of the distribution over the last 100 and 50 years. For the latter period, we find large regional differences, particularly between the southeastern and the northern part of the UK. The southeast has seen a faster warming, particularly for maximum temperatures in spring and summer, and a reduction of relative humidity; the northern mainland has become more humid and only slightly warmer. These differences become more evident for the highest quantiles and reflect a well-known pattern of climate change affecting the extra-tropics. Among the studied variables, the increases of wet bulb temperature and specific humidity are the most spatially homogeneous and are statistically significant for most stations in all seasons except winter

Pilot-scale ceramic membrane filtration of skim milk for the production of a 'humanised' protein base ingredient for infant milk formula

The protein composition of bovine skim milk was modified using pilot scale membrane filtration to produce a whey protein-dominant ingredient with a casein profile closer to human milk. Bovine skim milk was processed at low (8.9 °C) or high (50 °C) temperature using ceramic microfiltration (MF) membranes (0.1 μm mean pore diameter). The resulting permeate stream was concentrated using polyethersulfone ultrafiltration (UF) membranes (10 kDa cut-off). The protein profile of MF and UF retentate streams were determined using reversed phase-high performance liquid chromatography and polyacrylamide gel electrophoresis. Permeate from the cold MF process (8.9 °C) had a casein:whey protein ratio of ∼35:65 with no αS- or κ-casein present, compared with a casein:whey protein ratio of ∼10:90 at 50 °C. This study has demonstrated the application of cold membrane filtration (8.9 °C) at pilot scale to produce a dairy ingredient with a protein profile closer to that of human milk