MicroRNAs, Heart Failure, and Aging: Potential Interactions with Skeletal Muscle

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting mRNAs for degradation or translational repression. MiRNAs can be expressed tissue specifically and are altered in response to various physiological conditions. It has recently been shown that miRNAs are released into the circulation, potentially for the purpose of communicating with distant tissues. This manuscript discusses miRNA alterations in cardiac muscle and the circulation during heart failure, a prevalent and costly public health issue. A potential mechanism for how skeletal muscle maladaptations during heart failure could be mediated by myocardium-derived miRNAs released to the circulation is presented. An overview of miRNA alterations in skeletal muscle during the ubiquitous process of aging and perspectives on miRNA interactions during heart failure are also provided

Seasonal abundance of oyster spat and four animal associates on an oyster reef in the James River, Virginia

Five species of invertebrates collected at bi-weekly to monthly intervals from an oyster reef in the James River, Virginia. between September 1984 and August 1985 exhibited similar patterns of fluctuation in abundance throughout most of the period. The species were: spat of the oyster Crassostrea virginica: two species that feed on oysters. the flatworm Stylochus ellipticus, and the gastropod Boonea impressa. as well as two others with no known direct trophic interactions with the oyster. the isopod Cassidinidea lunifrons and the nudibranch Doridella obscura. B. impressa was many times more abundant than S. ellipticus but because of the difference in feeding habits between the two species it is speculated that S. ellipticus has a greater harmful effect on oysters than its abundance would suggest. Densities of all species declined sharply between early October and early November; the decline was probably related to seasonal mortality associated with declining water temperatures. B. impressa and C. lunifrons were the most abundant species throughout most of the sampling period , but only oyster spat showed a definite high peak in recruitment in 1985. Failure of the data to show reproduction peaks for three of the other species was attributed to incomplete retention of smaller individuals in the 0.5 mm-mesh screen used: large variations in density did not permit clear definition of a peak in C. lunifrons. lt is recommended that studies of oysters on their reefs include other abundant noncommercial species to provide a stronger foundation for management of the resource than if only the oyster was studied

Translocation as a strategy to rehabilitate the queen conch (Strombus gigas) population in the Florida Keys

Queen conch (Strombus gigas) stocks in the Florida Keys once supported commercial and recreational fisheries, but overharvesting has decimated this once abundant snail. Despite a ban on harvesting this species since 1985, the local conch population has not recovered. In addition, previous work has reported that conch located in nearshore Keys waters are incapable of spawning because of poor gonadal condition, although reproduction does occur offshore. Queen conch in other areas undergo ontogenetic migrations from shallow, nearshore sites to offshore habitats, but conch in the Florida Keys are prevented from doing so by Hawk Channel. The present study was initiated to determine the potential of translocating nonspawning nearshore conch to offshore sites in order to augment the spawning stock. We translocated adult conch from two nearshore sites to two offshore sites. Histological examinations at the initiation of this study confirmed that nearshore conch were incapable of reproduction, whereas offshore conch had normal gonads and thus were able to reproduce. The gonads of nearshore females were in worse condition than those of nearshore males. However, the gonadal condition of the translocated nearshore conch improved, and these animals began spawning after three months offshore. This finding suggests that some component of the nearshore environment (e.g., pollutants, temperature extremes, poor food or habitat quality) disrupts reproduction in conch, but that removal of nearshore animals to suitable offshore habitat can restore reproductive viability. These results indicate that translocations are preferable to releasing hatchery-reared juveniles because they are more cost-effective, result in a more rapid increase in reproductive output, and maintain the genetic integrity of the wild stock. Therefore, translocating nearshore conch to offshore spawning aggregations may be the key to expediting the recovery of queen conch stocks in the Florida Keys

NASA's Evolution to K(sub a)- Band Space Communications for Near-Earth Spacecraft

Over the next several years, NASA plans to launch multiple earth-science missions which will send data from low-Earth orbits to ground stations at 1-3 Gbps, to achieve data throughputs of 5-40 terabits per day. These transmission rates exceed the capabilities of S-band and X-band frequency allocations used for science probe downlinks in the past. Accordingly, NASA is exploring enhancements to its space communication capabilities to provide the Agency's first Ka-band architecture solution for next generation missions in the near-earth regime. This paper describes the proposed Ka-band solution's drivers and concept, constraints and analyses which shaped that concept, and expansibility for future need