Signalling pathways and gene expression profiles in prostate cancer

In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathways to progress through the uncontrolled proliferation of cancerous cells. Although the mechanisms of how the cells evade intrinsic or extrinsic signals of death and keep on dividing is not completely understood, there is a plethora of evidence that point to certain signalling molecules that are crucial conveyors of the fine tuning that slightly differs in cancer in comparison to control states. The present chapter provides a detailed description of the key regulators of PCa cell life and unveils their closely communicating proteins that aid in the fine tuning of the cancerous state

Stress relaxation in F-actin solutions by severing

Networks of filamentous actin (F-actin) are important for the mechanics of most animal cells. These cytoskeletal networks are highly dynamic, with a variety of actin-associated proteins that control cross-linking, polymerization and force generation in the cytoskeleton. Inspired by recent rheological experiments on reconstituted solutions of dynamic actin filaments, we report a theoretical model that describes stress relaxation behavior of these solutions in the presence of severing proteins. We show that depending on the kinetic rates of assembly, disassembly, and severing, one can observe both length-dependent and length-independent relaxation behavior

Low-Threshold Electrically Pumps Vertical-Cavity Surface-Emitting Microlasers

Vertical-cavity electrically driven lasers with three GaInAs quantum wells and diameters of several μm exhibit room-temperature pulsed current thresholds as low as 1.3mA with 958 nm output wavelength

Parents' involvement in child care: do parental and work identities matter?

The current study draws on identity theory to explore mothers' and fathers' involvement in childcare. It examined the relationships between the salience and centrality of individuals’ parental and work-related identities and the extent to which they are involved in various forms of childcare. A sample of 148 couples with at least one child aged 6 years or younger completed extensive questionnaires. As hypothesized, the salience and centrality of parental identities were positively related to mothers' and fathers' involvement in childcare. Moreover, maternal identity salience was negatively related to fathers' hours of childcare and share of childcare tasks. Finally, work hours mediated the negative relationships between the centrality of work identities and time invested in childcare, and gender moderated this mediation effect. That is, the more central a mother's work identity, the more hours she worked for pay and the fewer hours she invested in childcare. These findings shed light on the role of parental identities in guiding behavioral choices, and attest to the importance of distinguishing between identity salience and centrality as two components of self-structure

Room-Temperature Continuous-Wave Vertical-Cavity Single-Quantum-Well Microlaser Diodes

Room-temperature continuous and pulsed lasing of vertical-cavity, single-quantum-well, surface-emitting microlasers is achieved at ~983nm. The active Ga[sub][0-8]In[sub][0-2]As single quantum well is 100 [angstroms] thick. These microlasers have the smallest gain medium volumes among lasers ever built. The entire laser structure is grown by molecular beam epitaxy and the microlasers are formed by chemically assisted ion-beam etching. The microlasers are 3-50-μm across. The minimum threshold currents are 1.1 mA (pulsed) and 1.5 mA (CW)

The negative index of refraction demystified

We study electromagnetic wave propagation in mediums in which the effective relative permittivity and the effective relative permeability are allowed to take any value in the upper half of the complex plane. A general condition is derived for the phase velocity to be oppositely directed to the power flow. That extends the recently studied case of propagation in mediums for which the relative permittivity and relative permeability are both simultaneously negative, to include dissipation as well. An illustrative case study demonstrates that in general the spectrum divides into five distinct regions.Comment: 5 pages, 4 figure

Strongly Localized State of a Photon at the Intersection of the Phase Slips in 2D Photonic Crystal with Low Contrast of Dielectric Constant

Two-dimensional photonic crystal with a rectangular symmetry and low contrast (< 1) of the dielectric constant is considered. We demonstrate that, despite the {\em absence} of a bandgap, strong localization of a photon can be achieved for certain ``magic'' geometries of a unit cell by introducing two $\pi/2$ phase slips along the major axes. Long-living photon mode is bound to the intersection of the phase slips. We calculate analytically the lifetime of this mode for the simplest geometry -- a square lattice of cylinders of a radius, $r$. We find the magic radius, $r_c$, of a cylinder to be 43.10 percent of the lattice constant. For this value of $r$, the quality factor of the bound mode exceeds $10^6$. Small ($\sim 1$) deviation of $r$ from $r_c$ results in a drastic damping of the bound mode.Comment: 6 pages, 2 figure

Observations of H3+ in the Diffuse Interstellar Medium

Surprisingly large column densities of H3+ have been detected using infrared absorption spectroscopy in seven diffuse cloud sightlines (Cygnus OB2 12, Cygnus OB2 5, HD 183143, HD 20041, WR 104, WR 118, and WR 121), demonstrating that H3+ is ubiquitous in the diffuse interstellar medium. Using the standard model of diffuse cloud chemistry, our H3+ column densities imply unreasonably long path lengths (~1 kpc) and low densities (~3 cm^-3). Complimentary millimeter-wave, infrared, and visible observations of related species suggest that the chemical model is incorrect and that the number density of H3+ must be increased by one to two orders of magnitude. Possible solutions include a reduced electron fraction, an enhanced rate of H2 ionization, and/or a smaller value of the H3+ dissociative recombination rate constant than implied by laboratory experiments.Comment: To be published in Astrophysical Journal, March 200

Directional interacting whispering gallery modes in coupled dielectric microdisks

We study the optical interaction in a coupled dielectric microdisks by investigating the splitting of resonance positions of interacting whispering gallery modes (WGMs) and their pattern change, depending on the distance between the microdisks. It is shown that the interaction between the WGMs with odd parity about y-axis becomes appreciable at a distance less than a wavelength and causes directional emissions of the resulting interacting WGMs. The directionality of the interacting WGMs can be understood in terms of an effective boundary deformation in ray dynamical analysis. We also discuss about the oscillation of the splitting when the distance is greater than a wavelength.Comment: 7 pages, 10 figure