A study of the utilization of the skills of licensed practical nurses.

Thesis (M.S.)--Boston Universit

Using the behaviour change wheel and person-based approach to develop a digital self-management intervention for patients with adrenal insufficiency: the Support AI study protocol

Introduction: Most patients with Adrenal insufficiency (AI) require lifelong glucocorticoid replacement. They need to increase glucocorticoids during physical illness or major stressful situations and require parenteral hydrocortisone in the event of an adrenal crisis. Patients with AI have impaired quality of life and high mortality; approximately 1 in 6-12 patients are hospitalised at least once/year from a potentially preventable adrenal crisis. Adoption of self-management behaviours are crucial; these include adherence to medication, following “sick day rules” and associated behaviours that aid prevention and treatment of adrenal crisis such as symptom monitoring, having extra tablets, carrying a medical-alert ID and injection kit, and self-injecting when necessary. Current patient education is ineffective at supporting self-management behaviour change or reducing adrenal crisis-related hospitalisations. This research study aims to gain an in-depth understanding of the barriers and enablers to self-management for patients with AI and to develop an evidence-based digital self-management behaviour change intervention. / Methods: The study is conducted in accordance with the MRC Framework for developing complex interventions. Underpinned by the Behaviour Change Wheel (BCW), the Theoretical Domains Framework (TDF), and the Person-Based Approach, this research will be conducted in two phases: Phase 1 will involve a sequential qualitative/quantitative mixed-methods study involving focus group interviews followed by a cross-sectional survey with patients with AI recruited from patient advocacy groups and endocrine clinics in the UK. Phase 2 will develop the Support AI, a website-based digital behaviour change intervention (DBCI) informed by Phase 1 findings to support self-management for patients with AI. The most appropriate behaviour change techniques (BCTs) will be selected utilising a nominal group technique with an Expert Panel of 10-15 key stakeholders. The design of the Support AI website will be guided by the Person-Based Approach using an Agile iterative “think-aloud” technique with 12-15 participants over 3 usability testing iterations. / Conclusion: A theory- and evidence-based digital behaviour change intervention will be developed which will be tested in a feasibility randomised trial following completion of this study. The projected benefit includes cost-effective health care service (reduced hospitalisations and demand for specialist services) and improved health outcomes and quality of life for patients with AI

Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function

Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a single copy of the Presenilin (PS) and amyloid precursor protein genes. The dominant inheritance pattern of FAD indicates that it may be attributable to gain or change of function mutations. Studies of FAD-linked forms of presenilin (psn) in model organisms, however, indicate that they are loss of function, leading to the possibility that a reduction in PS activity might contribute to FAD and that proper psn levels are important for maintaining normal cognition throughout life. To explore this issue further, we have tested the effect of reducing psn activity during aging in Drosophila melanogaster males. We have found that flies in which the dosage of psn function is reduced by 50% display age-onset impairments in learning and memory. Treatment with metabotropic glutamate receptor (mGluR) antagonists or lithium during the aging process prevented the onset of these deficits, and treatment of aged flies reversed the age-dependent deficits. Genetic reduction of Drosophila metabotropic glutamate receptor (DmGluRA), the inositol trisphosphate receptor (InsP(3)R), or inositol polyphosphate 1-phosphatase also prevented these age-onset cognitive deficits. These findings suggest that reduced psn activity may contribute to the age-onset cognitive loss observed with FAD. They also indicate that enhanced mGluR signaling and calcium release regulated by InsP(3)R as underlying causes of the age-dependent cognitive phenotypes observed when psn activity is reduced

A forgotten figure in Siouan and Caddoan linguistics: Samuel Stehman Haldeman.

The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise. The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns. The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014

Advances in the study of Siouan languages and linguistics

The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise. The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns. The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014

Advances in the study of Siouan languages and linguistics

The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise. The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns. The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014

Advances in the study of Siouan languages and linguistics

The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise. The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns. The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014

Advances in the study of Siouan languages and linguistics

The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise. The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns. The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014

Advances in the study of Siouan languages and linguistics

The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise. The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns. The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014

Advances in the study of Siouan languages and linguistics

The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise. The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns. The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014