34 research outputs found
Prevalence of HIV, HBV and Chlamydia infections in Cameroonian University context: case of the University of Dschang, in the Western Region
Introduction: In sub-Saharan Africa HIV infection remains largely epidemic, whereas HBV infection is
highly endemic (>8%). In Cameroon, HIV prevalence is 4.3%. Concerning HBV and chlamydia
infections, their prevalence are both ≥10%. Young adults, including university students, are the
population groups mostly affected. Epidemiological data on these infections, among university students
could be helpful to implement specific prevention strategies.
Methods: A descriptive study was performed in May 2013 among 624 students from the University of
Dschang, Cameroon. Participants were screened for HIV, HBV and Chlamydia infections. Data was
collected by a standard questionnaire and analyzed by Epi Info.
Results: Average age of participants was 23.3 years (σ = 3.2) with female predominance (58.7%).
Prevalence of HIV, HBV and Chlamydia infection was 1.1% (7/624), 2.8% (5/176) and 2.0% (2/100)
respectively. 83.2% of participants were sexually active. Concerning sexual risk behaviors, participants
reported having multi partners (14.8%), using condom occasionally (58.6%) or never (5.0%). 100%,
62.6% and 52.2% reported to be aware on HIV, HBV and Chlamydia infections respectively. In addition,
only 5.5% and 21.3% of the participants were aware of their HBV and Chlamydia status respectively,
versus 64.4% for HIV. The excessive cost of HBV and Chlamydia tests has been identified as the major
barrier to testing (87.6%).
Conclusion: Among college Cameroonian students the prevalence of HIV, HBV and Chlamydia
infections seems to be relatively low if compared to general population. However, having multiple sexual
partners in addition to non-systematic use of condoms during sexual intercourse represents risk behaviors
among students. Awareness campaigns and screening facilitation on HBV and chlamydia infections need
to be strengthened
Integration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysis
Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model
YesAlopecia areata (AA) is an autoimmune hair loss disease with infiltration of proinflammatory cells into hair follicles. Current therapeutic regimens are unsatisfactory mainly because of the potential for side effects and/or limited efficacy. Here we report that cultured, transduced fibroblasts, which express the immunomodulatory molecule indoleamine 2,3-dioxygenase (IDO), can be applied to prevent hair loss in an experimental AA model. A single intraperitoneal (IP) injection of IDO-expressing primary dermal fibroblasts was given to C3H/HeJ mice at the time of AA induction. While 60–70% of mice that received either control fibroblasts or vehicle injections developed extensive AA, none of the IDO-expressing fibroblast-treated mice showed new hair loss up to 20 weeks post injection. IDO cell therapy significantly reduced infiltration of CD4+ and CD8+ T cells into hair follicles and resulted in decreased expression of TNF-α, IFN-γ and IL-17 in the skin. Skin draining lymph nodes of IDO fibroblast-treated mice were significantly smaller, with more CD4+ CD25+ FoxP3+ regulatory T cells and fewer Th17 cells than those of control fibroblast and vehicle-injected mice. These findings indicate that IP injected IDO-expressing dermal fibroblasts can control inflammation and thereby prevent AA hair loss.Canadian Institutes of Health Researches (Funding Reference Number: 134214 and 136945)
Imunofenotipagem dos linfócitos positivos para indoleamina 2,3 dioxigenase (IDO) em cultura de células de placenta bovina
Effect of the aqueous extract of dry fruits of Piper guineense on the reproductive function of adult male rats
OBJECTIVE: To study the effect of the aqueous extract of Piper
guineense (Piperaceae) on male reproductive function in Wistar
rats. MATERIALS AND METHODS: Male rats, 3 months old, weighing
180-210 g were administered (by gastric intubation) the aqueous extract
of dry fruits of Piper guineense at two doses, 122.5 and 245 mg/kg for
8 days and 122.5 mg/kg for 55 days. The control group received
distilled water for the same duration. Animals were sacrificed and the
blood, testes, epididymis, seminal vesicles and prostate were collected
for biochemical analyses. RESULTS: There was a significant increase
in the level of testosterone in the serum and testes, cholesterol in
the testes, α-glucosidase in the epididymis and fructose in the
seminal vesicles after 8 days of treatment, while with 55 days of
treatment, the levels of cholesterol in the testes increased by 75%,
while the levels of α-glucosidase in the epididymis and the
seminal vesicle fructose decreased by 24 and 21% respectively. On the
other hand, there was a 20% reduction of fertility in the P.
guineense-treated rats after 55 days of treatment. CONCLUSION: The
aqueous extract of P. guineense at both doses (122.5 and 245 mg/kg) had
a positive impact on the male reproductive function since it stimulated
the secretions of the testes, epididymis and seminal vesicles. The use
of P. guineense could negatively influence male fertility