Data from docking simulations to develop an efficient strategy able to evaluate the interactions between RAGE and MDA-induced albumin adducts

This data article contains the results of docking simulations performed in order to develop a suitable in silico strategy able to assess the stability of the putative complexes between RAGE and MDA induced adducts on human albumin as experimentally determined doi: 10.1016/j.redox.2016.12.017, (Degani et al., 2017) [1]. The docking simulations involved different approaches to give a simplified yet realistic representation of the protein adducts and their environment. With increasing complexity, simulations involved the corresponding albumin tripeptides and pentapeptides with the modified residue in the central position as well as pseudo-structures which were generated by collecting the albumin residues around the adducted residue within a sphere of 7.5 \uc5 and 5 \uc5 radius. The reliability of the tested approaches was assessed by monitoring the score differences between adducted and unmodified residues. The obtained results revealed the greater predictive power of the spherical pseudo-structures compared to the simple tri- or pentapeptidic sequences thus suggesting that RAGE recognition involves residues which are spatially close to the modified residue even though not necessarily adjacent in the primary sequence

A deep 1.4 GHz survey of the J1030 equatorial field: a new window on radio source populations across cosmic time

We present deep L-Band observations of the equatorial field centered on the z=6.3 SDSS QSO, reaching a 1 sigma sensitivity of ~2.5 uJy at the center of the field. We extracted a catalog of 1489 radio sources down to a flux density of ~12.5 uJy (5 sigma) over a field of view of ~ 30' diameter. We derived the source counts accounting for catalog reliability and completeness, and compared them with others available in the literature. Our source counts are among the deepest available so far, and, overall, are consistent with recent counts' determinations and models. We detected for the first time in the radio band the SDSS J1030+0524 QSO (26 +/- 5 uJy). We derived its optical radio loudness R_O = 0.62 +/- 0.12, which makes it the most radio quiet AGN at z >~ 6 discovered so far and detected at radio wavelengths. We unveiled extended diffuse radio emission associated with the lobes of a bright FRII radio galaxy located close to the center of the J1030 field, which is likely to become the future BCG of a protocluster at z=1.7. The lobes' complex morphology, coupled with the presence of X-ray diffuse emission detected around the FRII galaxy lobes, may point toward an interaction between the radio jets and the external medium. We also investigated the relation between radio and X-ray luminosity for a sample of 243 X-ray-selected objects obtained from 500 ks Chandra observations of the same field, and spanning a wide redshift range (0 ~< z ~< 3). Focused on sources with a spectroscopic redshift and classification, we found that sources hosted by ETG and AGN follow Log(L_R)/Log(L_X) linear correlations with slopes of ~0.6 and ~0.8, respectively. This is interpreted as a likely signature of different efficiency in the accretion process. Finally, we found that most of these sources (>~87%) show a radio-to-X-ray radio loudness R_X < -3.5, classifying these objects as radio quiet.Comment: 18 pages, 15 figures, 5 table. Accepted for publication in A&

Strong Reduction of the Effective Radiation Length in an Axially Oriented Scintillator Crystal

We measured a considerable increase of the emitted radiation by 120 GeV/c electrons in an axially oriented lead tungstate scintillator crystal, if compared to the case in which the sample was not aligned with the beam direction. This enhancement resulted from the interaction of particles with the strong crystalline electromagnetic field. The data collected at the external lines of the CERN Super Proton Synchrotron were critically compared to Monte Carlo simulations based on the Baier-Katkov quasiclassical method, highlighting a reduction of the scintillator radiation length by a factor of 5 in the case of beam alignment with the [001] crystal axes. The observed effect opens the way to the realization of compact electromagnetic calorimeters or detectors based on oriented scintillator crystals in which the amount of material can be strongly reduced with respect to the state of the art. These devices could have relevant applications in fixed-target experiments, as well as in satellite-borne γ telescopes

Hard X-ray stereographic microscopy for single-shot differential phase imaging

The characterisation of fast phenomena at the microscopic scale is required for the understanding of catastrophic responses of materials to loads and shocks, the processing of materials by optical or mechanical means, the processes involved in many key technologies such as additive manufacturing and microfluidics, and the mixing of fuels in combustion. Such processes are usually stochastic in nature and occur within the opaque interior volumes of materials or samples, with complex dynamics that evolve in all three dimensions at speeds exceeding many meters per second. There is therefore a need for the ability to record three-dimensional X-ray movies of irreversible processes with resolutions of micrometers and frame rates of microseconds. Here we demonstrate a method to achieve this by recording a stereo phase-contrast image pair in a single exposure. The two images are combined computationally to reconstruct a 3D model of the object. The method is extendable to more than two simultaneous views. When combined with megahertz pulse trains of X-ray free-electron lasers (XFELs) it will be possible to create movies able to resolve 3D trajectories with velocities of kilometers per second

A high-performance custom photodetection system to probe the light yield enhancement in oriented crystals

Scintillating homogeneous detectors represent the state of the art in electromagnetic calorimetry. Moreover, the currently neglected crystalline nature of the most common inorganic scintillators can be exploited to achieve an outstanding performance boost in terms of compactness and energy resolution. In fact, it was recently demonstrated by the AXIAL/ELIOT experiments that a strong reduction in the radiation length inside PWO, and a subsequent enhancement in the scintillation light emitted per unit thickness, are attained when the incident particle trajectory is aligned with a crystal axis within $\sim 1^\circ$. A SiPM-based system has been developed to directly probe this remarkable effect by measuring the scintillation light emitted by a PWO sample. The same concept could be applied to full-scale detectors that would feature a design significantly more compact than currently achievable and unparalleled resolution in the range of interest for present and future experiments

The UA9 experimental layout

The UA9 experimental equipment was installed in the CERN-SPS in March '09 with the aim of investigating crystal assisted collimation in coasting mode. Its basic layout comprises silicon bent crystals acting as primary collimators mounted inside two vacuum vessels. A movable 60 cm long block of tungsten located downstream at about 90 degrees phase advance intercepts the deflected beam. Scintillators, Gas Electron Multiplier chambers and other beam loss monitors measure nuclear loss rates induced by the interaction of the beam halo in the crystal. Roman pots are installed in the path of the deflected particles and are equipped with a Medipix detector to reconstruct the transverse distribution of the impinging beam. Finally UA9 takes advantage of an LHC-collimator prototype installed close to the Roman pot to help in setting the beam conditions and to analyze the efficiency to deflect the beam. This paper describes in details the hardware installed to study the crystal collimation during 2010.Comment: 15pages, 11 figure, submitted to JINS

Development of a compact muon veto for the nucleus experiment

The Nucleus experiment aims to measure coherent elastic neutrino nucleus scattering of reactor anti-neutrinos using cryogenic calorimeters. Operating at an overburden of 3 meters of water equivalent, muon-induced backgrounds are expected to be one of the dominant background contributions. Besides a high efficiency to identify muon events passing the experimental setup, the Nucleus muon veto has to fulfill tight spatial requirements to fit the constraints given by the experimental site and to minimize the induced detector dead-time. We developed highly efficient and compact muon veto modules based on plastic scintillators equipped with wavelength shifting fibers and silicon photo multipliers to collect and detect the scintillation light. In this paper, we present the full characterization of a prototype module with different light read-out configurations. We conclude that an efficient and compact muon veto system can be built for the Nucleus experiment from a cube assembly of the developed modules. Simulations show that an efficiency for muon identification of &gt;99 % and an associated rate of 325 Hz is achievable, matching the requirements of the Nucleus experiment

Experimental study of the radiation emitted by 180-GeV/c electrons and positrons volume-reflected in a bent crystal

The radiation emitted by 180-GeV/c volume-reflected electrons and positrons impinging on a bent crystal has been measured by the H8RD22 Collaboration on the H8 beamline at the CERN SPS. A dedicated spectrometer has been developed to measure high-energy photon spectra (up to similar to 100 GeV) under volume reflection: photon and charged particle beams have been separated by a bending magnet and leptons were detected and tagged by microstrip silicon detectors and a Pb-scintillator sampling calorimeter. A comparison between the experimental and analytical data for the amorphous and volume-reflection cases is presented and the differences are discussed