Factors' Employment Absorption, Growth and Income Distribution through Foreign Trade: Pakistan's Case

Despite the recent migration of Pakistan's labour to the Middle East countries, Pakistan is still characterized as a labour-abundant and capital-scarce developing country. As such, it is important that Pakistan's production structure should be such as to employ greater labour and lesser capital per unit of output in the different sectors of the economy. To provide pertinent information to the policy makers in this regard, we here try to estimate how much of labour and capital are employed and absorbed per unit of output in Pakistan's internationally traded goods

Prescription pattern of benzodiazepines for inpatients at a tertiary care university hospital in Pakistan

Objective: To determine the point prevalence of benzodiazepine prescriptions for inpatients at a tertiary care university hospital in Pakistan and to correlate it with prescription patterns of various specialties, indications and demographic variables of the patients.Methods: This 24-hours point prevalence study was done at The Aga Khan University Hospital, Karachi. By convenient random sampling, 208 inpatients were interviewed. Patients\u27 files were also studied to record the drugs administered. Data was entered into questionnaires and analyzed by SPSS 10.0.Results: The point prevalence of the benzodiazepines was 21.2%. It was higher among males than females and among surgical than non-surgical patients. Midazolam was the most commonly used benzodiazepine, followed by Alprazolam and Lorazepam. Pre-anesthesia and psychiatric symptoms were the two most common indications. Oral route was used in 84% patients for drug administration and mean Valium equivalent dosage was 4.86 mg/day. Mean length of prescription was 3 days. Longer duration of hospitalization was a significant predictor of the requirement of benzodiazepine prescription (p-value = 0.020).CONCLUSION: Prescription pattern of benzodiazepines at a tertiary care university hospital is similar to that reported in the developed countries through monitoring at various levels by physicians, clinical pharmacist and nursing staff. Data regarding the prescription pattern of benzodiazepines is scarce, and it needs to be expanded to formulate clear guidelines regarding their prescription

Use of smokeless tobacco among groups of Pakistani medical students – a cross sectional study

<p>Abstract</p> <p>Background</p> <p>Use of smokeless tobacco is common in South Asia. Tobacco is a major preventable cause of morbidity and mortality. Doctors make one of the best avenues to influence patients' tobacco use. However, medical students addicted to tobacco are likely to retain this habit as physicians and are unlikely to counsel patients against using tobacco. With this background, this study was conducted with the objective of determining the prevalence of smokeless tobacco among Pakistani medical students.</p> <p>Methods</p> <p>A cross sectional study was carried out in three medical colleges of Pakistan – one from the north and two from the southern region. 1025 students selected by convenient sampling completed a peer reviewed, pre-tested, self-administered questionnaire. Questions were asked regarding lifetime use (at least once or twice in their life), current use (at least once is the last 30 days), and established use (more than 100 times in their life) of smokeless tobacco. Chi square and logistic regression analyses were used.</p> <p>Results</p> <p>Two hundred and twenty (21.5%) students had used tobacco in some form (smoked or smokeless) in their lifetime. Sixty six (6.4%) students were lifetime users of smokeless tobacco. Thirteen (1.3%) were daily users while 18 (1.8%) fulfilled the criterion for established users. Niswar was the most commonly used form of smokeless tobacco followed by paan and nass. Most naswar users belonged to NWFP while most paan users studied in Karachi. On univariate analysis, lifetime use of smokeless tobacco showed significant associations with the use of cigarettes, student gender (M > F), student residence (boarders > day scholars) and location of the College (NWFP > Karachi). Multivariate analysis showed independent association of lifetime use of smokeless tobacco with concomitant cigarette smoking, student gender and location of the medical college.</p> <p>Conclusion</p> <p>The use of smokeless tobacco among medical students cannot be ignored. The governments should add the goal of eliminating smokeless tobacco to existing drives against cigarette smoking. Drives in Karachi should focus more on eliminating paan usage while those in NWFP should focus more on the use of naswar. Medical colleges should provide greater education about the myths and hazards of smokeless tobacco.</p

Investigating socio-economic-demographic determinants of tobacco use in Rawalpindi, Pakistan

<p>Abstract</p> <p>Background</p> <p>To investigate the socio-economic and demographic determinants of tobacco use in Rawalpindi, Pakistan.</p> <p>Methods</p> <p>Cross sectional survey of households (population based) with 2018 respondent (1038 Rural; 980 Urban) was carried out in Rawalpindi (Pakistan) and included males and females 18–65 years of age. Main outcome measure was self reported daily tobacco use.</p> <p>Results</p> <p>Overall 16.5% of the study population (33% men and 4.7% women) used tobacco on a daily basis. Modes of tobacco use included cigarette smoking (68.5%), oral tobacco(13.5%), hukka (12%) and cigarette smoking plus oral tobacco (6%). Among those not using tobacco products, 56% were exposed to Environmental tobacco smoke.</p> <p>The adjusted odds ratio of tobacco use for rural residence compared to urban residence was 1.49 (95% CI 1.1 2.0, p value 0.01) and being male as compared to female 12.6 (8.8 18.0, p value 0.001). Illiteracy was significantly associated with tobacco use. Population attributable percentage of tobacco use increases steadily as the gap between no formal Education and level of education widens.</p> <p>Conclusion</p> <p>There was a positive association between tobacco use and rural area of residence, male gender and low education levels. Low education could be a proxy for low awareness and consumer information on tobacco products. As Public health practitioners we should inform the general public especially the illiterate about the adverse health consequences of tobacco use. Counter advertisement for tobacco use, through mass media particularly radio and television, emphasizing the harmful effects of tobacco on human health is very much needed.</p

Silencing and Un-silencing of Tetracycline-Controlled Genes in Neurons

To identify the underlying reason for the controversial performance of tetracycline (Tet)-controlled regulated gene expression in mammalian neurons, we investigated each of the three components that comprise the Tet inducible systems, namely tetracyclines as inducers, tetracycline-transactivator (tTA) and reverse tTA (rtTA), and tTA-responsive promoters (Ptets). We have discovered that stably integrated Ptet becomes functionally silenced in the majority of neurons when it is inactive during development. Ptet silencing can be avoided when it is either not integrated in the genome or stably-integrated with basal activity. Moreover, long-term, high transactivator levels in neurons can often overcome integration-induced Ptet gene silencing, possibly by inducing promoter accessibility

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Influence of Polypropylene Fibre (PF) Reinforcement on Mechanical Properties of Clay Soil

This study investigated the effects of polypropylene fibre (PF) reinforcement on the mechanical behaviour of clay soil. Using clay soil and polypropylene fibres from China’s Inner Mongolia and Hebei Provinces, respectively, a series of soil samples with 0%, 1.5%, 2.25%, and 3% PF content by soil weight were subjected to compaction, shear strength, consolidation, California bearing ratio, and microstructure analyses. The study results indicate improved compaction, shear strength, consolidation, and the bearing ratio of the PF-stabilised clay soil. As the PF content increased, its maximum dry density increased and its optimum moisture content decreased; its angle of internal friction increased and its cohesion coefficient decreased; and its void ratio, consolidation coefficient, and hydraulic conductivity all decreased. Comparing the unstabilised (0% PF) and stabilised (3% PF) clay soil, the void ratio, consolidation coefficient, and hydraulic conductivity decreased from 0.96 to 0.93, from 2.52 to 2.34 cm2/s, and from 1.12 to 1.02 cm/s, respectively. The optimum PF content was determined to be 3% by the weight of the soil, as this quantity resulted in the best improvement in soil properties

Bias Adjustment of Four Satellite-Based Rainfall Products Using Ground-Based Measurements over Sudan

Satellite-based rainfall estimates (SREs) represent a promising alternative dataset for climate and hydrological studies, where gauge observations are insufficient. However, these datasets are accompanied by significant uncertainties. Therefore, this study aims to minimize the systematic bias of Artificial Neural Networks&ndash;Cloud Classification System (PERSIANN-CCS), Artificial Neural Networks-Climate Data Record (PERSIANN-CDR), Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS), and Global Precipitation Climatology Project (GPCP) rainfall estimates using a quantile mapping (QM) method with climatic zones (CZs). The adjusted rainfall estimates were evaluated for the period from 2003&ndash;2017; data from 2003 to 2016 were used for calibration, and data from 2017 were used for validation. The results revealed significant improvements for the adjusted PERSIANN-CCS, PERSIANN-CDR, CHIRPS, and GPCP monthly time series in terms of all statistical measures and evaluation of overall CZs. In terms of Root Mean Square Errors (RMSEs), the adjusted CHIRPS did not show an improvement. This method successfully removed the mean bias of the daily time series for all SREs. The findings suggest that this method can be applied to correct the systematic bias of all SREs in the monthly time series in the future without the need for further gauge measurements over Sudan

Bias Adjustment of Four Satellite-Based Rainfall Products Using Ground-Based Measurements over Sudan

Satellite-based rainfall estimates (SREs) represent a promising alternative dataset for climate and hydrological studies, where gauge observations are insufficient. However, these datasets are accompanied by significant uncertainties. Therefore, this study aims to minimize the systematic bias of Artificial Neural Networks–Cloud Classification System (PERSIANN-CCS), Artificial Neural Networks-Climate Data Record (PERSIANN-CDR), Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS), and Global Precipitation Climatology Project (GPCP) rainfall estimates using a quantile mapping (QM) method with climatic zones (CZs). The adjusted rainfall estimates were evaluated for the period from 2003–2017; data from 2003 to 2016 were used for calibration, and data from 2017 were used for validation. The results revealed significant improvements for the adjusted PERSIANN-CCS, PERSIANN-CDR, CHIRPS, and GPCP monthly time series in terms of all statistical measures and evaluation of overall CZs. In terms of Root Mean Square Errors (RMSEs), the adjusted CHIRPS did not show an improvement. This method successfully removed the mean bias of the daily time series for all SREs. The findings suggest that this method can be applied to correct the systematic bias of all SREs in the monthly time series in the future without the need for further gauge measurements over Sudan

Assessment of Seasonal Rainfall Drought Indices, Nyala City Sudan

Drought is an unpredictable hydrological phenomenon, and climate change has made it difficult to predict and analyze droughts. Nyala city airport metrological station rainfall records from 1943 to 2017 (75 years) were investigated. Four statistical drought indices were used; the standardized precipitation index (SPI), the rainfall anomaly index (RAI), the rainfall decile percent index (RDI), and the percent normal precipitation index (PNI). The study analyzes, assesses, compares, and determines the proper drought index. Results show that annual normal drought class (DC4) percentages for PNI, RDI, and RAI are not significantly different at an average of 42% and 65.3% for SPI at a frequency of 49 years. In comparing the average monthly and yearly drought frequency values and considering the historical dry and wet droughts, results showed the indices performance rank as: SPI, RAI, RDI, and PNI. Result reveals that the SPI was superior in all analyses, but it had some defects in detecting monthly dry drought when precipitation is dominated by rare or zero values (start and end of the rainy season). This was concluded and revealed by conducting a zone chart showing the deviations of standard deviation about the mean. Thus, the SPI index outperforms the other three indices