What we have learned about policy-research linkage from providing a rapid response facility for international healthcare comparisons to the Department of Health in England

In this paper we reflect on our experience of providing a rapid response facility for international healthcare policy comparisons to the English Department of Health. We examine the challenges of developing sustained relationships with policy officials while providing an 'on-demand' service in an environment with high turnover of policies and staff. It may be easier for policy makers to draw on researchers in such a setting than for researchers to foster 'linkage and exchange' relationships with policy makers. Under the facility, knowledge transfer has mostly been from researchers to policy officials, affording us little insight into the policy process or the impact of our work

East India Company and Bank of England Shareholders during the South Sea Bubble: Partitions, Components and Connectivity in a Dynamic Trading Network

A new dataset, in the form of a network graph, is used to study inventory and trading behaviour amongst owners of East India Company (EIC) and Bank of England (BoE)stock around the South Sea Bubble. There was a decline in market intermediation in which the goldsmith bankers were dominant in 1720, but foreigners and Jews to some extent restored intermediation services after the Bubble. Company directors temporarily helped to sustain intermediation in 1720 itself. Whereas before and during the Bubble intermediation was largely in the form of brokerage, after the Bubble dealership noticeably began to displace brokerage.South Sea Company; Financial Revolution; social networks, financial intermediation, inventories.

Advice on commissioning external academic evaluations of policy pilots in health and social care: a discussion paper

This discussion document aims to provide guidance to those thinking of initiating policy pilots and commissioning or requesting others to commission their evaluations. It addresses a number of issues that are specific to policy piloting and that need to be considered before selecting pilot sites and commissioning evaluation. Much advice on evaluation today is focused on advocating the adoption of specific study designs – especially randomised controlled trial (RCTs). While RCTs will be relevant to consider for specific purposes, as we discuss below, they may well not be the best option for the evaluation of policy pilots. We therefore aim to encourage consideration of a range of evaluation designs so as to capitalise fully on the opportunities for learning from policy piloting but, more importantly, to encourage more thinking about other aspects of commissioning evaluations of policy pilots. The advice is primarily designed for national level staff involved in policy making, programme management, monitoring and analysis, and responsible for initiating policy-relevant pilots and commissioning their evaluations

Policy experiments: Investigating effectiveness or confirming direction?

In England, ‘policy experiments’ are largely synonymous with the use of randomized controlled trials (RCTs) to test whether one policy ‘works’ better than another. While advocacy of the use of RCTs in public policy presents this as relatively straightforward, even common sense, the reality is different, as shown through analysis of three high profile policy pilots and their evaluations undertaken in health and social care in England in the mid/late 2000s. The RCTs were expected to confirm the direction of policy by resolving any remaining uncertainty about the effectiveness of the chosen path and their existence was used largely as instruments of persuasion. The findings from the analysis of the three pilots confirm the continuing relevance of Campbell’s 1969 insight that governments struggle to experiment in the scientific sense and explain the limited effect of these policy experiments on policy decisions

A colorimetric competitive displacement assay for the evaluation of catalytic peptides

An assay based on competitive dye displacement was adapted to detect the formation of aldol product in crude reaction mixtures, and was used to evaluate minimal peptide aldol catalysts.</p

Cache coherency controller for MESI protocol based on FPGA

In modern techniques of building processors, manufactures using more than one processor in the integrated circuit (chip) and each processor called a core. The new chips of processors called a multi-core processor. This new design makes the processors to work simultanously for more than one job or all the cores working in parallel for the same job. All cores are similar in their design, and each core has its own cache memory, while all cores shares the same main memory. So if one core requestes a block of data from main memory to its cache, there should be a protocol to declare the situation of this block in the main memory and other cores.This is called the cache coherency or cache consistency of multi-core. In this paper a special circuit is designed using very high speed integrated circuit hardware description language (VHDL) coding and implemented using ISE Xilinx software. The protocol used in this design is the modified, exclusive, shared and invalid (MESI) protocol. Test results were taken by using test bench, and showed all the states of the protocol are working correctly

Bone stable isotope evidence for infant feeding in Mediaeval England

This paper is a first study of duration of breastfeeding using bone stable isotopes in infants in a British palaeopopulation, from the deserted Mediaeval village of Wharram Percy, England. Nitrogen stable isotope analysis suggests cessation of breastfeeding between 1 and 2 years of age. Comparison with Mediaeval documentary sources suggests that recommendations of physicians regarding infant feeding may have influenced common practice in this period