San Francisco. Histoire et leçons d'une conférence

Mayoux Jean-Jacques. San Francisco. Histoire et leçons d'une conférence. In: Politique étrangère, n°2 - 1945 - 10ᵉannée. pp. 141-160

Le rôle de l'Unesco dans le domaine de la Philosophie et des Humanités

Mayoux Jean-Jacques. Le rôle de l'Unesco dans le domaine de la Philosophie et des Humanités. In: Bulletin de l'Association Guillaume Budé,n°4, décembre 1947. pp. 67-71

Un épicurien anglais, Thomas Love Peacock /

Thèse--Université de Paris.Includes bibliographical references (pages 621-632) and index

Thomas Love Peacock (1785 - 1866) : L'Abbaye du cauchemar

International audienc

Thomas Love Peacock (1785 - 1866) : L'Abbaye du cauchemar

International audienc

Characteristics of Alzheimer's Disease Patients with Severe Executive Disorders

International audienceBackground: Executive dysfunctions in Alzheimer's disease (AD) have been assessed using variable batteries and/or in selected populations. Objective: The primary objective of this observational study was to determine the prevalence and severity of executive dysfunction in AD patients using a previously validated battery. The secondary objective was to determine the characteristics including treatment outcomes of AD patients with severe executive dysfunction. Methods: The study included AD patients with mild-to-moderate dementia aged 60 or over, consulting in various clinical settings including memory clinics and requiring the introduction of an antidementia drug. Executive dysfunction was examined using a validated, shortened executive battery. Results: 381 patients were included. Executive dysfunctions were observed in 88.2% of the patients (95% CI: 84.9-91.4) and were severe (defined as >= 2/3 impaired scores) in 80.4% (95% CI: 76.9-84.8). Global hypoactivity with apathy was more frequent (p = 0.0001) than impairment in executive function tests. The 308 patients with severe executive dysfunction were older (p = 0.003) and had more severe dementia (p = 0.0001). Similarly, in the subset of 257 patients with mild dementia, individuals with severe executive dysfunction were older (p = 0.003) and had more severe dementia. Global hypoactivity was independently associated with difficulties in IADL and a higher caregiver burden (p = 0.0001 for both). The severity of executive dysfunction did not significantly influence the patients' outcomes at 6 months. Conclusions: Executive dysfunction is a very common disorder in a representative population of patients with mild-to-moderate AD. It was independently correlated with impaired autonomy and increased caregiver burden but did not significantly influence treatment outcomes

Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease

International audienceThe frequency of executive disorders in mild-to-moderate Alzheimer disease (AD) has been demonstrated by the application of a comprehensive battery. The present study analyzed data from 2 recent multicenter studies based on the same executive battery. The objective was to derive a shortened battery by using the GREFEX population as a training dataset and by cross-validating the results in the REFLEX population. A total of 102 AD patients of the GREFEX study (MMSE= 23.2 +/- 2.9) and 72 patients of the REFLEX study (MMSE= 20.8 +/- 3.5) were included. Tests were selected and receiver operating characteristic curves were generated relative to the performance of 780 controls from the GREFEX study. Stepwise logistic regression identified 3 cognitive tests (Six Elements Task, categorical fluency and Trail Making Test B error) and behavioral disorders globally referred as global hypoactivity (P= 0.0001, all). This shortened battery was as accurate as the entire GREFEX battery in diagnosing dysexecutive disorders in both training group and the validation group. Boot-strap procedure confirmed the stability of AUC. A shortened battery based on 3 cognitive tests and 3 behavioral domains provides a high diagnosis accuracy of executive disorders in mild-to-moderate AD