The synthesis of potential antimalarials. Derivatives of pantoyltaurine

The general hypothesis as to the mode of action of chemotherapeutic agents, which has been formulated by Fildes, Woods, McIlwain, and others (2), offers a rational and useful guide to the design of new drugs. Thus, bacteriostasis is pictured as caused by the blocking of reactions essential to growth by an inhibiting substance which has a structure similar to that of one of the normal enzymes or metabolites essential to the growth of the organism

Evolutionary prisoner's dilemma game on hierarchical lattices

An evolutionary prisoner's dilemma (PD) game is studied with players located on a hierarchical structure of layered square lattices. The players can follow two strategies [D (defector) and C (cooperator)] and their income comes from PD games with the ``neighbors.'' The adoption of one of the neighboring strategies is allowed with a probability dependent on the payoff difference. Monte Carlo simulations are performed to study how the measure of cooperation is affected by the number of hierarchical levels (Q) and by the temptation to defect. According to the simulations the highest frequency of cooperation can be observed at the top level if the number of hierarchical levels is low (Q<4). For larger Q, however, the highest frequency of cooperators occurs in the middle layers. The four-level hierarchical structure provides the highest average (total) income for the whole community.Comment: appendix adde

Optimization of laser-plasma injector via beam loading effects using ionization-induced injection

Simulations of ionization induced injection in a laser driven plasma wakefield show that high-quality electron injectors in the 50-200 MeV range can be achieved in a gas cell with a tailored density profile. Using the PIC code Warp with parameters close to existing experimental conditions, we show that the concentration of $\mathrm{N_2}$ in a hydrogen plasma with a tailored density profile is an efficient parameter to tune electron beam properties through the control of the interplay between beam loading effects and varying accelerating field in the density profile. For a given laser plasma configuration, with moderate normalized laser amplitude, $a_0=1.6$ and maximum electron plasma density, $n_{e0}=4\times 10^{18}\,\mathrm{cm^{-3}}$, the optimum concentration results in a robust configuration to generate electrons at 150~MeV with a rms energy spread of 4\% and a spectral charge density of 1.8~pC/MeV.Comment: 13 pages, 10 figure

Strategies for the evolution of sex

We find that the hypothesis made by Jan, Stauffer and Moseley [Theory in Biosc., 119, 166 (2000)] for the evolution of sex, namely a strategy devised to escape extinction due to too many deleterious mutations, is sufficient but not necessary for the successful evolution of a steady state population of sexual individuals within a finite population. Simply allowing for a finite probability for conversion to sex in each generation also gives rise to a stable sexual population, in the presence of an upper limit on the number of deleterious mutations per individual. For large values of this probability, we find a phase transition to an intermittent, multi-stable regime. On the other hand, in the limit of extremely slow drive, another transition takes place to a different steady state distribution, with fewer deleterious mutations within the asexual population.Comment: RevTeX, 11 pages, multicolumn, including 12 figure

Measurement error caused by spatial misalignment in environmental epidemiology

Copyright @ 2009 Gryparis et al - Published by Oxford University Press.In many environmental epidemiology studies, the locations and/or times of exposure measurements and health assessments do not match. In such settings, health effects analyses often use the predictions from an exposure model as a covariate in a regression model. Such exposure predictions contain some measurement error as the predicted values do not equal the true exposures. We provide a framework for spatial measurement error modeling, showing that smoothing induces a Berkson-type measurement error with nondiagonal error structure. From this viewpoint, we review the existing approaches to estimation in a linear regression health model, including direct use of the spatial predictions and exposure simulation, and explore some modified approaches, including Bayesian models and out-of-sample regression calibration, motivated by measurement error principles. We then extend this work to the generalized linear model framework for health outcomes. Based on analytical considerations and simulation results, we compare the performance of all these approaches under several spatial models for exposure. Our comparisons underscore several important points. First, exposure simulation can perform very poorly under certain realistic scenarios. Second, the relative performance of the different methods depends on the nature of the underlying exposure surface. Third, traditional measurement error concepts can help to explain the relative practical performance of the different methods. We apply the methods to data on the association between levels of particulate matter and birth weight in the greater Boston area.This research was supported by NIEHS grants ES012044 (AG, BAC), ES009825 (JS, BAC), ES007142 (CJP), and ES000002 (CJP), and EPA grant R-832416 (JS, BAC)

Metric theory of Weyl sums

We prove that there exist positive constants $C$ and $c$ such that for any integer $d \ge 2$ the set of ${\mathbf x}\in [0,1)^d$ satisfying $$cN^{1/2}\le \left|\sum^N_{n=1}\exp\left (2 \pi i \left (x_1n+\ldots+x_d n^d\right)\right) \right|\le C N^{1/2}$$ for infinitely many natural numbers $N$ is of full Lebesque measure. This substantially improves the previous results where similar sets have been measured in terms of the Hausdorff dimension. We also obtain similar bounds for exponential sums with monomials $xn^d$ when $d\neq 4$. Finally, we obtain lower bounds for the Hausdorff dimension of large values of general exponential polynomials

Health, Climate Change and Sustainability: A systematic Review and Thematic Analysis of the Literature

Background: Evidence of climate change and its impact continues to be accumulated, and it is argued that the consequences of climate change are likely to result in an increased demand on health services. It has been claimed that climate change presents new challenges for health services and that strategies should be adopted to address these challenges. Aim: The aim of this systematic review was to map published literature on health, climate change and sustainability by categorising papers according to their focus on effects, strategy and actions, and to provide a thematic analysis of their content. Methods: Systematic searches were conducted via a range of healthcare related databases i.e. Pubmed, Medline, CINAHL, AMED, ASSIA, IBSS and ISI Web of Knowledge. Searches focussed upon papers published in English between 1998 and 2008. Retrieved papers were studied by the authors in order to inform the thematic analysis of their content. Results: A total of 114 publications were retrieved, of which 36 met the inclusion criteria for the systematic review. These 36 publications were categorised and are discussed according to their focus on: effects/impacts, strategy/policy, action/examples. Conclusions: A number of papers report the potential health effects of climate change while others report policies and strategies to tackle these effects. However there is an urgent need to identify and report on the implementation of strategies to mitigate and adapt to these challenges and to publish real examples of actions. Actions that are taken need to be evidence/policy based, and implementations monitored, evaluated and published

Defensive alliances in spatial models of cyclical population interactions

As a generalization of the 3-strategy Rock-Scissors-Paper game dynamics in space, cyclical interaction models of six mutating species are studied on a square lattice, in which each species is supposed to have two dominant, two subordinated and a neutral interacting partner. Depending on their interaction topologies, these systems can be classified into four (isomorphic) groups exhibiting significantly different behaviors as a function of mutation rate. On three out of four cases three (or four) species form defensive alliances which maintain themselves in a self-organizing polydomain structure via cyclic invasions. Varying the mutation rate this mechanism results in an ordering phenomenon analogous to that of magnetic Ising model.Comment: 4 pages, 3 figure

Darwinian Selection and Non-existence of Nash Equilibria

We study selection acting on phenotype in a collection of agents playing local games lacking Nash equilibria. After each cycle one of the agents losing most games is replaced by a new agent with new random strategy and game partner. The network generated can be considered critical in the sense that the lifetimes of the agents is power law distributed. The longest surviving agents are those with the lowest absolute score per time step. The emergent ecology is characterized by a broad range of behaviors. Nevertheless, the agents tend to be similar to their opponents in terms of performance.Comment: 4 pages, 5 figure