The Grizzly, April 7, 1997

Airband Sets Its New Fundraising Record • Ursinus Students Participate in Model U.N. • Women\u27s Health Discussed in Merck Lecture • Changes for Summer Classes • Letters: Letter of Thanks; Faculty Member Remembered • Opinion: Seminar on Post-Abortion Trauma • Pfahler Observatory Open House for Hale-Bopp Viewing • Something for Everyone in proTheatre Production of The Two Noble Kinsmen • Another Look at the Ursinus Gymnastics Team • The Dangers of Halogen Lamps • Men\u27s Tennis Wins • Courtney Named an All-American • Trecroce Named Player of the Week • Women\u27s Tennis Action • Women\u27s Lacrosse Falls to Middlebury • Softball Drops 3 in a Row • Dickinson Rallies to Take Two From the Bearshttps://digitalcommons.ursinus.edu/grizzlynews/1401/thumbnail.jp

The Grizzly, March 28, 1995

1995 Ursinus Model U.N. Delegation • Japanese Shocked by Gas Attack • Ursinus Spring Service Day Update • Letters to the Editor: Regarding the Core; They Might be Giants ... or not?; Looking for a Perfect Friend? • Faculty Spotlight: Dr. Stephen Hood • Men\u27s Tennis Team Comes Close • Sammartino, Keith Named Co-Players of the Week • Baseball Team 4-0 Since Coming North • Lacrosse Team Opens With a Win • Softball Team Extends Winning Streakhttps://digitalcommons.ursinus.edu/grizzlynews/1357/thumbnail.jp

The Grizzly, February 28, 1995

Core Changes Proposed: Public Speaking, ESS 100, and Fine Arts in Question • Delta Pi Suspended • Ursinus Prepares for Spring Service Day • Letter from Dean Kane • Airband • S.T.A.R. to Sponsor Sexual Assault Awareness Week • The Sculpture Population Boom • Spirit, Black and Female Celebrates Black History Month • How We Pick Our Entertainers • Letters to the Editor • Humiliation • Luka is ECAC Gymnast of the Week • Cauley Seeded 14th at Nationals • Ortman is Going to Nationals • Bears Open Up in Cocoa on Saturday • Caggiano, Laidlaw, and Widmaier Win Indoor Track Titles • Cosgrove Named Centennial Player of the Year • Ursinus Wins First-Ever Women\u27s Hoop Titlehttps://digitalcommons.ursinus.edu/grizzlynews/1355/thumbnail.jp

The Lantern Vol. 64, No. 2, Spring 1997

• Year\u27s End, with Resolutions • Addicted • Muerte, Carlos • Motions • At the Wyeth Gallery • Between Contexts • I\u27m Allowed (and More Nonsense) • Wall and Piece • Timekeeper\u27s Workspace • The Process • Second Sex: A Portrait of the Artist as a Woman • On the Side of the Road • Joe • To Matthew Arnold • A Deep Sleep on Hydrocodone • Madness of a Night • Return • The Sudden Grave • A Farce • Twists of Fur • Ambiguity • The Odor of Continuums • My Father\u27s Daughter • The Meaning of Life • I Aim to Tell • Nobody\u27s Fanhttps://digitalcommons.ursinus.edu/lantern/1150/thumbnail.jp

The Grizzly, December 6, 1994

Beetlemania Hits Ursinus • Strassburger Appointed President • Unrest in the Baltics Continues • Ursinus Birthday Card Unveiled • Jeffrey Dahmer Dead • Philadelphia Teen Slain as Result of Inner City Rivalries • Lectures, Friendships, and Giving Up Shop • The Holidays Mean More Than Just Christmas • Alumna Spotlight: The Life of a Doctor • The Java Trench: More Than Just Coffee • Indigo Girls Delight Philly Fans • Intramural Updatehttps://digitalcommons.ursinus.edu/grizzlynews/1349/thumbnail.jp

The Lantern Vol. 61, No. 2, Summer 1994

• She Was a Woman of Dignity • Retake, Scene 16 • Las Vegas Sweatshirt • Pitcher Hill • In Preparation for Wisdom (Teeth) • Moist Slacks • My Mother\u27s Purse • It Comes and Goes Everyday • The Simplicity of Marriage • The First Performance • Hunger • Pushkin\u27s Dream • Tuesday, October 19 • Poetry of Baseball • Some Things are More Important Than Others • Musician • Of What Befell Our Good Knight • Piranha • Oceans Apart • Brooklyn Cantos • Snowshower • Thankfully in Australia • Toothpaste and Tuna Fish • Living Space • Blue Monday • Afterglow • A Path to Consider • Endless Summer • Scaredy-Cathttps://digitalcommons.ursinus.edu/lantern/1144/thumbnail.jp

The Lantern Vol. 63, No. 1, Fall 1995

• The Birthday Celebration • Surprise! Surprise! • Oregold • Future of Parenthood #2 • Seeds • How I Spent My Summer Vacation • Random Scenes From 1/2 Hour at Work • Life in the Coal Mines • Driveway • Midnight in the Court of Kings • The Black Quadrilateral • People I Hate to See, But Refuse to Dismiss • Metropolized • Poetry in Motion • Dream #3 • Rhythms • Mercykilling • Untitled • Lupine Lord • At the Bottom of the Cup • House of Commons • Poetry I Can\u27t Standhttps://digitalcommons.ursinus.edu/lantern/1147/thumbnail.jp

The Lantern Vol. 63, No. 2, Spring 1996

• Poet, Lead Me On • St. Patrick\u27s Day • The Last Three Days • The Impressionable • Roundabout • The Bench • Carnivorous • Kyrie • Second Glance • Porch • Cruel Design • A Mime • Flaxen Crown • My Embryonic Ocean of Love • Stone Matrix • Voices from the Past • Skipping the Bullfight: Toreadors and Gaudi • Another Part of My Lacolonialism • Translucent Pane • Linguistics • Treehouse • A Disagreeable Music Piece • Vigil • A Brief History of American Poetry in Englishhttps://digitalcommons.ursinus.edu/lantern/1148/thumbnail.jp

The Lantern Vol. 62, No. 2, Summer 1995

• In the Season of Grief • Subtleties • Crazehaze • Blacksmith • I Feel Your Weight • L\u27Amour Manque • Sense of You • Greed • Gender (Rolled) • Soliloquy of a Punter • Nightmares • God is a Frisbee • Cleansing • Flat • Chemistry of Mind • Louderback • Ritual • Rebuilding Mother • Scott Lomba • The Acting Bug • Untitled • The Seek • Gluttony • Great South Bay • Archangel • Suburban Zeus • Vespers • At Change of A-Dress • The Hierarchy of Coolness • The Apology • I Know it is Evening There • Pridehttps://digitalcommons.ursinus.edu/lantern/1146/thumbnail.jp

Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function

Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that promote and sustain autophagy are less well defined. Here we report that the epigenetic reader BRD4 and the methyltransferase G9a repress a TFEB/TFE3/MITF-independent transcriptional program that promotes autophagy and lysosome biogenesis. We show that BRD4 knockdown induces autophagy in vitro and in vivo in response to some, but not all, situations. In the case of starvation, a signaling cascade involving AMPK and histone deacetylase SIRT1 displaces chromatin-bound BRD4, instigating autophagy gene activation and cell survival. Importantly, this program is directed independently and also reciprocally to the growth-promoting properties of BRD4 and is potently repressed by BRD4-NUT, a driver of NUT midline carcinoma. These findings therefore identify a distinct and selective mechanism of autophagy regulation