152 research outputs found

    An intimate and imperial feminism: Meliscent Shephard and the regulation of prostitution in colonial India

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    This paper seeks to construct an antinostalgic portrait of an imperial feminist. As the representative of the Association for Moral and Social Hygiene (AMSH) in India between 1928 and 1947, Meliscent Shephard was an embodiment not only of the feminist urge to challenge patriarchal gender relations, but also of the imperialist urge to classify and fathom the world through a series of racist typologies. Despite an earlier belief that blame for the exploitation of prostitutes lay with the colonial state and economy, she later fell back on explanations based on notions of Indian society and religion. Operating in a period of heightened anticolonial nationalism, these latter views thwarted any hope of her forging successful connections with emergent Indian social reform groups. This failure to cultivate intimate relations with Indian colleagues marks a failure at the level of national and racial politics. Shephard did, however, cultivate an intimate relationship with correspondents at the AMSH in London, while her experiences of the sexual geographies of Indian cities provided a form of intimate interaction that would inspire her mission to close down tolerated brothels. As such, this paper marks an empirical engagement with the intimate frontiers at which the affective grid of colonial politics was marked out

    Biology of Streptococcus mutans-Derived Glucosyltransferases: Role in Extracellular Matrix Formation of Cariogenic Biofilms

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    The importance of Streptococcus mutans in the etiology and pathogenesis of dental caries is certainly controversial, in part because excessive attention is paid to the numbers of S. mutans and acid production while the matrix within dental plaque has been neglected. S. mutans does not always dominate within plaque; many organisms are equally acidogenic and aciduric. It is also recognized that glucosyltransferases from S. mutans (Gtfs) play critical roles in the development of virulent dental plaque. Gtfs adsorb to enamel synthesizing glucans in situ, providing sites for avid colonization by microorganisms and an insoluble matrix for plaque. Gtfs also adsorb to surfaces of other oral microorganisms converting them to glucan producers. S. mutans expresses 3 genetically distinct Gtfs; each appears to play a different but overlapping role in the formation of virulent plaque. GtfC is adsorbed to enamel within pellicle whereas GtfB binds avidly to bacteria promoting tight cell clustering, and enhancing cohesion of plaque. GtfD forms a soluble, readily metabolizable polysaccharide and acts as a primer for GtfB. The behavior of soluble Gtfs does not mirror that observed with surface-adsorbed enzymes. Furthermore, the structure of polysaccharide matrix changes over time as a result of the action of mutanases and dextranases within plaque. Gtfs at distinct loci offer chemotherapeutic targets to prevent caries. Nevertheless, agents that inhibit Gtfs in solution frequently have a reduced or no effect on adsorbed enzymes. Clearly, conformational changes and reactions of Gtfs on surfaces are complex and modulate the pathogenesis of dental caries in situ, deserving further investigation

    Software for the frontiers of quantum chemistry:An overview of developments in the Q-Chem 5 package

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    This article summarizes technical advances contained in the fifth major release of the Q-Chem quantum chemistry program package, covering developments since 2015. A comprehensive library of exchange–correlation functionals, along with a suite of correlated many-body methods, continues to be a hallmark of the Q-Chem software. The many-body methods include novel variants of both coupled-cluster and configuration-interaction approaches along with methods based on the algebraic diagrammatic construction and variational reduced density-matrix methods. Methods highlighted in Q-Chem 5 include a suite of tools for modeling core-level spectroscopy, methods for describing metastable resonances, methods for computing vibronic spectra, the nuclear–electronic orbital method, and several different energy decomposition analysis techniques. High-performance capabilities including multithreaded parallelism and support for calculations on graphics processing units are described. Q-Chem boasts a community of well over 100 active academic developers, and the continuing evolution of the software is supported by an “open teamware” model and an increasingly modular design

    Dental morphology 1998:proceedings of the 11th international symposium on dental morphology. Oulu, Finland, August 1998.

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    Foreword Hyvät Ystävät, Hyvät Naiset ja Herrat Now, as we have reached the time to initiate the 11th International Symposium on Dental Morphology, I am most happy to have you here in Oulu, Finland and I hope that you will enjoy every minute, every aspect of symposium science as well as the social atmosphere. The very nature, the core, of the symposium scientific substance has been from the beginning over thirty years ago, and still is, its multidisciplinary approach. Among others, paleontologists, histologists, oral biologists, archaeologists, anthropologists, zoologists, anatomists, geneticists and dentists have come together for informative talks and an exchange of ideas, having the same common interest, the exploration of tooth morphology. The range of the study species has been, and is, enormously large, from fossil forms of life to modern man. Personally, I have found this multidisciplinary approach to be very stimulating and fruitful; it has opened new avenues at many levels of the research process. By the same token, in a social context, the symposium has connected people from different disciplines, which given the state of things in these times of superspecialization has an exhilarating effect. Here in our eleventh symposium we have participants from nineteen countries; scientists from Australia, Belgium, Canada, Czech Republic, Croatia, France, Germany, India, Israel, Italy, Japan, New Zealand, Norway, Poland, South Africa, Sweden, United Kingdom, United States of America and Finland. A total of 84 reports will be delivered during the symposium. In an historical sense we also remember that the art of science has since ancient times brought people together in a peaceful co-existence independent of nationality, race or other sometimes divisive factors. Even today, in spite of huge advancements in communication technology in general there still exist individual paths within our global scientific community to find creative contacts. From the beginning of the Symposium a man from the University of Chicago, among others, was a driving force in creating, developing and maintaining it; the late Dr. Albert A. Dahlberg. His wife Thelma has also been keenly engaged in scientific activities and today I am glad to tell you that Mrs. Albert A. Dahlberg is with us. Also, I would like to introduce you our distinguished keynote speakers; Professors Percy Butler, Edward Kollar, Hervé Lesot and Steinar Risnes. To everyone here, I bid you very welcome to Oulu, with all the best wishes for an enjoyable and memorable Symposium. With these words I, as President of the Symposium, opened the proceedings. Now, it is my honour to do the same for the published proceedings. The editors have structured the volume to reflect as closely as possible the flavour of the meetings; the papers are in approximately the same order as at the meeting and this Foreword as well as the first paper by Mayhall have been retained to allow the reader to feel as if he/she were a participant. I want to thank the authors of the 55 papers included in this volume who took the time to revise their presentations for publication. It is my sincere wish that you, the reader, will find as much stimulation and new knowledge in this volume as I and the other participants found at the meeting. Lassi Alvesal
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