5 research outputs found
Influence of solvent on free radical polymerization of vinyl compounds
- Author
- A. Chapiro
- A. Conix
- A. D. Jenkins
- A. D. Jenkins
- A. D. Walsh
- A. F. Nikolaev
- A. L. Buchachenko
- A. Leoni
- A. M. Chatterjee
- A. M. North
- A. M. North
- A. V. Rybav
- A. Vrancken
- A. Yamada
- A. Yamada
- C. C. Price
- C. C. Price
- C. H. Bamford
- C. H. Bamford
- C. Pichot
- C. Walling
- C. Walling
- D. B. Anderson
- E. D. Morrison
- E. Tromsdorff
- F. Lewis
- F. M. Lewis
- F. Mayo
- F. R. Mayo
- F. S. Arimoto
- G. A. Mortimer
- G. A. Russell
- G. A. Russell
- G. A. Russell
- G. A. Russell
- G. BontĂ
- G. E. Ham
- G. F. Santee
- G. G. Cameron
- G. Henrici-Olivé
- G. Henrici-Olivé
- G. Henrici-Olivé
- G. Henrici-Olivé
- G. Henrici-Olivé
- G. Henrici-Olivé
- G. Henrici-Olivé
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. M. Burnett
- G. Mayer
- G. Saini
- G. Saini
- G. Saini
- G. Schröder
- G. Smets
- G. V. Schulz
- G. V. Schulz
- G. W. Norrish
- H. Burrell
- H. C. Haas
- H. Elias
- H. Elias
- H. Elias
- H. Elias
- H. Tsubomura
- H. Watanabe
- J. P. Fischer
- J. P. Fischer
- J. Rosen
- J. T. Clarke
- J. W. Breitenbach
- K. F. O'driscoll
- K. Fukui
- K. Fukui
- K. Takemoto
- K. Tsuda
- K. Yokota
- K. Yokota
- L. A. Kalashnikova
- L. A. Kalashnikova
- L. H. Peeble Jr.
- L. M. Minsk
- L. Perec
- M. Akashi
- M. Imoto
- M. Jacob
- M. Kamachi
- M. Kamachi
- M. Kamachi
- M. Kamachi
- M. Kamachi
- M. Kamachi
- M. Kamachi
- M. Kinoshita
- M. Lee
- M. Lee
- M. Litt
- M. M. Martin
- M. M. Zafar
- M. M. Zafar
- M. M. Zafar
- M. M. Zafar
- M. Sumi
- N. Kawabata
- P. E. M. Allen
- P. Geoldi
- P. Hayden
- P. J. Flory
- R. Forster
- R. Keber
- R. L. Strong
- R. L. Strong
- R. L. Strong
- R. S. Mulliken
- R. S. Mulliken
- S. Banerjee
- S. Franco
- S. Nozakura
- S. W. Benson
- S. W. Benson
- T. Alfrey
- T. Alfrey Jr.
- T. Alfrey Jr.
- T. G. Fox
- T. Itoh
- T. Otsu
- T. Otsu
- T. Yamamoto
- T. Yamamoto
- T. Yamamoto
- W. Busfield
- W. H. Stockmayer
- W. I. Bengough
- Y. Matsubara
- Y. Matsubara
- Z. Izumi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study
Vicende di un falso senatoconsulto: il decretum Rubiconis fra Ciriaco de\u2019 Pizzicolli, Antonio Agust\uedn e Eugen Bormann
- Author
- AgustĂn A.
- Bianchi G.
- Bruns K.G.
- Buongiorno P.
- Buongiorno P.
- Calvelli L.
- Calvelli L.
- Campana A.
- Campana A.
- Cenerini F.
- Chatzidakis M.
- Crawford M. (ed.)
- Di Benedetto F.
- Di Stefano Manzella I.
- Espluga X.
- Espluga X.
- Espluga X.
- Fezzi L.
- Forner F.
- Fubini R.
- Gagliardi L.
- Mastrorosa I.G.
- Mayer y Olivé M.
- Mitchell Ch.
- Montevecchi L.
- Quaquarelli L.
- Ravara Montebelli C.
- Simeoni G.
- Solin H.
- Solin H.
- Susini G.C.
- Weiss R.
- Zavatta G.
- Publication venue
- 'Edizioni Ca Foscari'
- Publication date
- 01/01/2019
- Field of study
This paper aims to reconstruct the origins of the so-called Decretum Rubiconis (CIL XI 30*) and the ancient sources that inspired it (Cicero\u2019s Philippics; Vergil; Seneca; the lex de imperio Vespasiani). The text was significantly manipulated by Ciriaco de\u2019 Pizzicolli before the mid 15th century and was identified as false already by Antonio Agust\uedn (Di\ue1logos, 1587). Despite this prompt identification, the forged epigraphic document had a wide circulation in the manuscript tradition and (at least) two different engravings after the 16th century. A copy of the inscription is now kept in the Museum of Cesena
Remarkable features of intermediates in the early transition metal catalyzed conversion of monosubstituted alkenes, dienes and alkynes
- Author
- A. Misono
- A. Musco
- A.D. Hunter
- Akira Nakamura
- B. Benn
- B. Bogdanovic
- B. Bogdanovic
- C.-P. Law
- C.A. Tolman
- D.G. Sekutowsky
- D.H. Antonsen
- E. Sappa
- E.J. Smutny
- E.R. Evitt
- E.V. Dehmlow
- G. Erker
- G. Erker
- G. Fachinetti
- G. Henrici-Olivé
- G. Wilke
- G.K. Barker
- G.M. Whitesides
- G.P. Pez
- H. Bestian
- H. Dietl
- H. Kumobayashi
- H. Sinn
- H. tom Dieck
- H. Yasuda
- H. Yasuda
- H.A. Martin
- Hajime Yasuda
- J. Itakura
- J.D. Fellmann
- J.E. Bercaw
- J.H. Teuben
- J.M. Mayer
- J.W. Lauher
- J.X. McDermott
- K. Suga
- K. Tani
- K.P.C. Vollhardt
- L. Clawson
- L.S. Meriwether
- M. Akita
- M. Akita
- M.G. Barlow
- N.H. Phung
- P. Cossee
- P. Heimbach
- P. Heimbach
- P. Heimbach
- P.D. Bartlett
- P.W. Jolly
- R. Cramer
- R. Schrock
- R. TraunmĂŒller
- R.H. Grubbs
- S. Akutagawa
- S. Dzierzgowski
- S. Nakamura
- S. Takahashi
- S.A. Cohen
- T. Masuda
- T. Masuda
- T. Tatsumi
- U. Matteoli
- V.O. Reichsfeld
- W. Brenner
- Y. Iwashita
- Y. Tajima
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).
- Author
- Abdel-Mohsen M
- Abimiku A
- Abrahams F
- Abram M
- Abrams EJ
- Achii P
- Achu MN
- Adams R
- Adler M
- Agot K
- Agot K
- Agyei Y
- Ahlers J
- Ahmed S
- Ajibola G
- Akapirat S
- Akello I
- Akelo V
- Alave J
- Alcaide M
- Alcami J
- Alimenti A
- Alimenti A
- Allegre T
- Allison S
- Altice F
- Amaros I
- Ambinder RF
- Amedee A
- Amico KR
- Amico KR
- Amzal B
- Ananworanich J
- Ananworanich J
- Ananworanich J
- Ananworanich J
- Anastos K
- Anato S
- Ancuta P
- Anderson P
- Anderson PL
- Andrade J
- Andrew K
- Andrew P
- Angin M
- Ansari A
- Anstett K
- Antonini-Michelle T
- Apornpong T
- Apps R
- Arasteh K
- Archin N
- Arendt M
- Argento E
- Arheart K
- Arredondo J
- Arribas J
- Arthos J
- Arts E
- Asamoah-Odei E
- Aschman N
- Asila V
- Asire B
- Asmuth D
- Aumaitre H
- Aurpibul L
- Auvert B
- Avettand-Fenoel V
- Avihingsanon A
- Avila-Rios S
- Awa JC
- Ayadi AE
- Bacchetti P
- Bachireddy C
- Bacon O
- Badal-Faesen S
- Badal-Faesen S
- Baddeley A
- Baeten J
- Baeten JM
- Bai F
- Bailer R
- Bajos N
- Baltazar CS
- Bamford A
- Banchongkit S
- Bandason T
- Bangsberg DR
- Bao J
- Baral S
- Baral S
- Barash E
- Barbara C
- Barbee L
- Barnabas R
- Barrios R
- Barrios R
- Bartali B
- Basilissi M
- Batisse D
- Batlang O
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bavinton BR
- Baxter C
- Bayus B
- Bañon S
- Bego MG
- Behets F
- Bekker L-G
- Bekker L-G
- BelaunzarĂĄn-Zamudio P
- Beletsky L
- Bellaton E
- Benki-Nugent S
- Benkirane M
- Bennai Y
- Benne C
- Bennett A
- Bennett A
- Bennett K
- Bennett S
- Benson P
- Berhanu R
- Berkout B
- Bermejo M
- Bernardi G
- Bernardi S
- Bershteyn A
- Best J
- Betz B
- Beusenberg M
- Bhakeecheep S
- Bhardwaj N
- Bhatti L
- Bianchi F
- Billaud E
- Bingham B
- Bini T
- Bisson G
- Bitarakwate E
- Bitimwine H
- Bitnun A
- Bitnun A
- Blanchard JF
- Blankson J
- Blaser N
- Blick G
- Bloch M
- Bloch M
- Bloomenthal D
- Blosser SJ
- Bock N
- Boffito M
- Bolu O
- Bonczkowski P
- Bonje E
- Bonora S
- Booth R
- Boothe M
- Borkowf C
- Botha G
- Boulle A
- Bouscaillou J
- Boven K
- Bowen N
- Bowonwatanuwong C
- Brantley J
- Brewster J
- Brockmeyer NH
- Brodie E
- Brooks J
- Brophy J
- Brophy J
- Brothers J
- Brown T
- Bruce D
- Brum T
- Brumme C
- Brumme ZL
- Brumme ZL
- Bruneau J
- Brunet L
- Brunetta J
- Bruno D
- Bruyand M
- Buchbinder S
- Buchbinder S
- Buchbinder S
- Budgell E
- Bui DD
- Bukusi EA
- Bullock B
- Bulpitt A
- Bunupuradah T
- Bunupuradah T
- Bunupuradah T
- Burbelo P
- Burger H
- Burling K
- Burns D
- Burwitz BJ
- Busch M
- Buskin S
- Buskin S
- Buskin SE
- Bustorff F
- Butcher J
- Buzdugan R
- Buzdugan R
- Byrareddy S
- BĂ€rnighausen T
- BĂ©lec L
- Caballero P
- Cahn P
- Caillat-Zucman S
- Calcagno A
- Calderon F
- Calmy A
- Cameron B
- Cameron M
- Cameron P
- Camlin CS
- Cannizzo ES
- Capoferri A
- Carlson JM
- Carmona S
- Caron F
- Carrington M
- Casado JL
- Cash A
- Casillas P
- Castillo LS
- Cathcart R
- Cavassini M
- CaylĂ JA
- Ceesay N
- Celentano D
- Celum C
- Celum C
- Cesar C
- Cesar F
- Chadwick EG
- Chadwick K
- Chaisson R
- Chaivooth S
- Chalachala JL
- Chamie G
- Chan G
- Chang C
- Chang L
- Changalucha J
- Chapman EL
- Chariyalertsak S
- Chariyalertsak S
- Chas J
- Chau V
- Chauma A
- Chege W
- Chen X
- Chen Y
- Chen Y
- Chen YQ
- Cheng A
- Chetchotisakd P
- Chew G
- Chew GM
- Chhabra R
- Chikovani I
- Chilisa F
- Chimbwandira F
- Chioma S
- Chirwa L
- Chisembele M
- Chitwarakorn A
- Chitwarakorn A
- Chohan BH
- Chokephaibulkit K
- Chokephaibulkit K
- Chomont N
- Chomont N
- Chonzi P
- Chotirosniramit N
- Christilaw J
- Chuma B
- Cicala C
- Citao SC
- Clayton K
- Clements J
- Cléret-Buhot A
- Co M
- Cohen C
- Cohen CR
- Cohen M
- Cohen MS
- Cohen S
- Cohen ĂA
- Coiras M
- Colby D
- Colby D
- Colley G
- Collier A
- Conejo PR
- Conrad C
- Conrad C
- Cooper C
- Cooper C
- Cooper DA
- Cornell M
- Cortes CP
- Cortés C
- CortĂ©s-Ălvarez J
- Cottle L
- Cotton LA
- Cousien A
- Cowan F
- Cowan FM
- Cowan FM
- Cox J
- Cragg C
- Crauwels H
- Cressey T
- Crowell CS
- Crowell T
- Cryer C
- Curlin ME
- Custodio J
- Cutler E
- Czaicki N
- CĂŽtĂ© ĂA
- Da Cruz M
- Da Fonseca S
- Da Silva CM
- Dabis F
- Dabis F
- Dabis F
- Dai J
- Daly A
- Dange A
- Daniell L
- Dantanarayana A
- Das AT
- Das B
- Dasgupta A
- Davis J
- De Boni RB
- De Boni RB
- De Cock K
- De Ledinghen V
- de Looze D
- De Maeyer M
- De Paris K
- De Rijck J
- De Rosa S
- de Sousa Marques HH
- de Souza M
- De Spiegelaere W
- De Truchis P
- Debab Y
- Debyser Z
- Decamp A
- Deeks S
- Deeks S
- Deeks S
- Deeks S
- Deeks S
- Dejesus E
- dela Pena-Ponce MG
- Della Negra M
- Demarco T
- Demeulemeester J
- Demicco E
- Denny T
- Derksen L
- Deschamps D
- Descours B
- deSilva T
- Dezutti C
- Dhiver C
- Di Biagio A
- Dibb Z
- Dicker I
- Dieterich D
- Dikeakos J
- Dinh TTT
- Diouf D
- Diperri G
- Dirawo J
- Ditangco R
- Djurovic I
- Doblecki-Lewis S
- Dobrer S
- Dobrowolski C
- Doherty M
- Doherty M
- Dombrowski J
- Dombrowski J
- Dombrowski JC
- Dombrowski JC
- Domercant JW
- Dominguez S
- Dong W
- Donoghoe M
- Dorfman J
- Dray-Spira R
- Dray-Spira R
- Dray-Spira R
- du Lou AD
- Duff P
- Dufour M-SK
- Dukhovlinova E
- Duncan D
- Duncan D
- Dunne E
- Dunning L
- Durand CM
- Duvivier C
- Duwve J
- Duwve JM
- Dvoryak S
- Dvoryak S
- Dye BJ
- Dye BJ
- Dziuban E
- Eckhoff P
- Edmonds A
- Efsen AMW
- Egger M
- Egger M
- Egger M
- Ehrenberg P
- Eisele L
- ElFarouki K
- Elharrar V
- Elharrar V
- Elharrar V
- Elion R
- Elion R
- Elliott J
- Elliott J
- Elston B
- Elyanu P
- ElĂas MJP
- Emery S
- Emmanuel F
- Engelsmann B
- Engle E
- Erbel R
- Erlandson K
- Eron J
- Eron JJ
- Escamilla-GĂłmez T
- Eshleman S
- Eshleman S
- Eshleman SH
- Eshleman SH
- Esser S
- Essex M
- Estaquier J
- Estes J
- Estill J
- Etard J-F
- Etsetowaghan A
- Evans DH
- Evans E
- Evans T
- Fang E
- Farquhar C
- Farquhar C
- Fauci A
- Faye A
- Fedchuk L
- Feldacker C
- Fennelly G
- Fenton K
- Ferguson M
- Fernandes NM
- Fernandez-Lopez JC
- Ferrand R
- Ferrao C
- Ferrari G
- Filipovics A
- Fischl M
- Fisher H
- Fleming M
- Fleming T
- Fletcher JLK
- Flick R
- Flynn P
- Fofana DB
- Fon H
- Fong Y
- Fontaine H
- Foote J
- Ford N
- Ford N
- Fordyce M
- Foshee V
- Fourati S
- Fourie J
- Fox J
- Fox MP
- Frahm N
- Francois K
- Frange P
- Franks J
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- Frohlich J
- Fromentin R
- Fromentin R
- Fu G
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- Furrer H
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- Gadabu O
- Galang R
- Galang RR
- Galaska B
- Gallant J
- Galler S
- Galli R
- Gama L
- Gamble T
- Gamble T
- Gandhi M
- Gandhi M
- Ganova-Raeva L
- Gao F
- Gao Y
- GarcĂa-Morales C
- GarcĂa-Morales C
- GarcĂa-Tellez T
- GarcĂa-TĂ©llez T
- Garrido-Rodriguez D
- Garrido-RodrĂguez D
- Gaseitsiwe S
- Gatell J
- Gathe J
- Gatome-Munyua A
- Gaur A
- Geisel MHM
- Geng E
- Geng W
- Gentry J
- George M
- Geraghty D
- Getahun H
- Ghannoum M
- Ghidinelli M
- Ghneim K
- Giacomet V
- Giaquinto C
- Gibbons K
- Giganti M
- Gijsbers R
- Girardi E
- Go VF
- Godbole S
- Golden M
- Golden M
- Golden M
- Golden M
- Golden M
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- Golden MR
- Golub J
- Gomez-Olivé X
- Gone M
- Gonzales L
- Gonzalez-Zuniga P
- Gosselin A
- Gosselin A
- Gotsadze G
- Goulder PJ
- Goulet J-P
- Gouveia ML
- Gowan CM
- Grabowski MK
- Grand'Pierre R
- Grant P
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- Grant RM
- Grasela D
- Grasso M
- Gray C
- Gray GE
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- Gregory P
- Gress J
- Grigoryan S
- Grigoryan T
- Grimsrud A
- Grimsrud A
- Grimsrud A
- Grinsztejn B
- Grinsztejn B
- Grinsztejn B
- Grinsztejn B
- Grosso A
- Grulich AE
- Grund J
- Guanira JV
- Gueguen M
- Guillemi S
- Guillemi S
- Gunther N
- Gupta A
- Gupta S
- Ha B
- Haas A
- Haas AD
- Haber N
- Habiyambere V
- Haeryfar M
- Hageman K
- Haghdoost A
- Hagins D
- Hakim J
- Hakim J
- Hakobyan A
- Hakobyan A
- Halpern C
- Hamilton E
- Hammond KB
- Hamzah L
- Han L
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- Hance RJ
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- Hansen SG
- Harawa M
- Harent S
- Harley B
- Harrigan PR
- Harrigan PR
- Harrigan PR
- Hartogensis W
- Hartogensis W
- Harty L
- Hassounah S
- Hatano H
- Hatzakis A
- Hatzold K
- Havlir D
- Havlir D
- Havlir D
- Hayashi K
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- Headley J
- Hecht F
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- Heneine W
- Henostroza G
- Herbeck J
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- Hermanus T
- HernĂĄndez-Juan R
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- Hillman D
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- Hirnschall G
- Hirsch-Moverman Y
- Hislop M
- Hoagland B
- Hoces D
- Hoffman I
- Hoffman I
- Hoffman IF
- Hoffmann C
- Hogg B
- Hogg E
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- Hogg R
- Hoh R
- Holland C
- Holmes L
- Holmes M
- Holtz T
- Holtz TH
- Holzendorf V
- Honermann B
- Hoogstoel A
- Hoots B
- Hoover K
- Hora B
- Hornsberger A
- Horth R
- Hosek S
- Hosseinipour M
- Hosseinipour M
- Hosseinipour M
- Hosseinipour MC
- Hovhannisyan R
- Hower M
- Hsiao M
- Hsiao N-Y
- Hu Q
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- Hu YB
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- Hudelson SE
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- Humphries H
- Hunt P
- Hurst J
- Hwang C
- Iakoubov R
- Iannuzzi F
- Ibrahim J
- Inwani I
- Isaac L
- Isdahl Z
- Ishii N
- Ismail S
- Ivan K
- Iveson H
- Iwuji C
- Iwuji C
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- Jacobs W
- Jacobson J
- Jaggernath M
- Jahn A
- Jao J
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- Jarupanich T
- Jaspan H
- Jean K
- Jenabian M-A
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- Jennings K
- Jensen K
- Jere E
- Jia H
- Jiamsakul A
- Jiang Y
- Jin F
- Jirajariyavej S
- John C
- John-Stewart G
- John-Stewart G
- John-Stewart GC
- Johns B
- Johnson A
- Johnson M
- Johnston R
- Jones D
- Jones D
- Jones L
- Joseph B
- Joseph P
- Jourdain G
- Joy J
- Julien A
- Justman JE
- Jöckel K-H
- Kahn K
- Kahn K
- Kahn K
- Kaimal A
- Kajaste-Rudnitski A
- Kajula L
- Kakkar F
- Kakkar F
- Kakkar F
- Kallas EG
- Kalombo C
- Kamarulzaman A
- Kambli H
- Kamdem HM
- Kaminski R
- Kamya MR
- Kanchar A
- Kandulu JR
- Kanjanavikai P
- Kantipong P
- Kantipong P
- Kantor R
- Kapiga S
- Kapogiannis B
- Karambe S
- Karamouzian M
- Karaoz U
- Karim QA
- Karim SA
- Karn J
- Karn J
- Kasonde M
- Katana A
- Katayi E
- Katlama C
- Kato M
- Katureebe C
- Katz D
- Katz D
- Katz DA
- Kawende B
- Kawooya V
- Keinonen S
- Keiser O
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- Kharsany A
- Khosropour CM
- Khoury G
- Khudyakov Y
- Kidzeru E
- Kieffer MP
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- Kijak G
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- Kinloch NN
- Kinuthia J
- Kinuthia J
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- Kirui FK
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- van der Elst L
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- van Oosterhout J
- van Oosterhout JJ
- Van Rompay K
- van Rooyen H
- Van Schalkwyk J
- Vandekerckhove L
- Vandendriessche A
- Vasarhelyi K
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- von Werder A
- Vu QD
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- Wainfen W
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- Wawer M
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- Welty T
- Wendoh J
- Wenzi LK
- Werb D
- Wertheim JO
- Westgard T
- Wiesner L
- Wijayaratne S
- Wilen C
- Wilkinson L
- Williams T
- Wilson CM
- Wilson D
- Wimonsate W
- Wittkop L
- Woelk G
- Wolf E
- Wolff M
- Wolters L
- Wood E
- Wood E
- Wood E
- Wood E
- Woods C
- Wu HL
- Wu V
- Wyles D
- Wylie JL
- Xaba T
- Xia G
- Xiao H
- Xing Y
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- Xu X
- Yang B
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- Yang L
- Yao KA
- Yassi A
- Yates N
- Yazdanpanah Y
- Yin M
- Yindom L-M
- Yotebieng M
- Young J
- Young P
- Youngleson M
- Yu Y
- Zablotska I
- Zamor P
- Zang O
- Zash R
- Zerbe A
- Zhang M
- Zhang Y
- Zhang Y
- Zhou S
- Zhuang M
- Ziegler JB
- Zink A
- Zink C
- Zolla-Pazner S
- Zolopa A
- Zolowere DB
- Zou H
- Zuma N
- ĂsbjörnsdĂłttir KH
- Ăvila-RĂos S
- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2015
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated