Near-bottom seismic profiling: High lateral variability, anomalous amplitudes, and estimates of attenuation

For almost a decade the Marine Physical Laboratory of Scripps Institution of Oceanography has been conducting near‐bottom geophysical surveys involving quantitative seismic profiling. Operating initially at 4 kHz and more recently at 6 kHz, this system has provided a wealth of fine scale quantitative data on the acoustic properties of ocean sediments. Over lateral distances of a few meters, 7‐dB changes in overall reflected energy as well as 10‐dB changes from individual reflectors have been observed. Anomalously high amplitudes from deep reflectors have been commonly observed, suggesting that multilayer interference is prevalent in records from such pulsed cw profilers. This conclusion is supported by results from sediment core physical property work and related convolution modeling, as well as by the significant differences observed between 4‐ and 6‐kHz profiles. In general, however, lateral consistency has been adequate in most areas surveyed to permit good estimates of acoustic attenuation from returns from dipping reflectors and sediment wedges

Density of states in graphene with vacancies: midgap power law and frozen multifractality

The density of states (DoS), $\varrho(E)$, of graphene is investigated numerically and within the self-consistent T-matrix approximation (SCTMA) in the presence of vacancies within the tight binding model. The focus is on compensated disorder, where the concentration of vacancies, $n_\text{A}$ and $n_\text{B}$, in both sub-lattices is the same. Formally, this model belongs to the chiral symmetry class BDI. The prediction of the non-linear sigma-model for this class is a Gade-type singularity $\varrho(E) \sim |E|^{-1}\exp(-|\log(E)|^{-1/x})$. Our numerical data is compatible with this result in a preasymptotic regime that gives way, however, at even lower energies to $\varrho(E)\sim E^{-1}|\log(E)|^{-\mathfrak{x}}$, $1\leq \mathfrak{x} < 2$. We take this finding as an evidence that similar to the case of dirty d-wave superconductors, also generic bipartite random hopping models may exhibit unconventional (strong-coupling) fixed points for certain kinds of randomly placed scatterers if these are strong enough. Our research suggests that graphene with (effective) vacancy disorder is a physical representative of such systems.Comment: References updated onl

Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game

BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironment, effect tumour progression and represent a largely under appreciated therapeutic target. We use observations of primary tumor biology from prostate cancer to extrapolate a mathematical model: specifically; it has been observed that in prostate cancer three disparate cellular outcomes predominate: (i) the tumour remains well differentiated and clinically indolent - in this case the local stromal cells may act to restrain the growth of the cancer; (ii) early in its genesis the tumour acquires a highly malignant phenotype, growing rapidly and displacing the original stromal population (often referred to as small cell prostate cancer) - these less common aggressive tumours are relatively independent of the local microenvironment; and, (iii) the tumour co-opts the local stroma - taking on a classic stromagenic phenotype where interactions with the local microenvironment are critical to the cancer growth. METHODS: We present an evolutionary game theoretical construct that models the influence of tumour-stroma interactions in driving these outcomes. We consider three characteristic and distinct cellular populations: stromal cells, tumour cells that are self-reliant in terms of microenvironmental factors and tumour cells that depend on the environment for resources but can also co-opt stroma. &#xd;&#xa;RESULTS: Using evolutionary game theory we explore a number of different scenarios that elucidate the impact of tumour-stromal interactions on the dynamics of prostate cancer growth and progression and how different treatments in the metastatic setting can affect different types of tumors.&#xd;&#xa;CONCLUSIONS: The tumour microenvironment plays a crucial role selecting the traits of the tumour cells that will determine prostate cancer progression. Equally important, treatments like hormone therapy affect the selection of these cancer phenotypes making it very important to understand how they impact prostate cancer&#x2019;s somatic evolution

Chiral molecular films as electron polarizers and polarization modulators

Recent experiments on electron scattering through molecular films have shown that chiral molecules can be efficient sources of polarized electrons even in the absence of heavy nuclei as source of a strong spin-orbit interaction. We show that self-assembled monolayers (SAMs) of chiral molecules are strong electron polarizers due to the high density effect of the monolayers and explicitly compute the scattering amplitude off a helical molecular model of carbon atoms. Longitudinal polarization is shown to be the signature of chiral scattering. For elastic scattering, we find that at least double scattering events must take place for longitudinal polarization to arise. We predict energy windows for strong polarization, determined by the energy dependences of spin-orbit strength and multiple scattering probability. An incoherent mechanism for polarization amplification is proposed, that increases the polarization linearly with the number of helix turns, consistent with recent experiments on DNA SAMs.Comment: 5 Pages, 4 figure

A new insight into the observation of spectroscopic strength reduction in atomic nuclei: implication for the physical meaning of spectroscopic factors

Experimental studies of one nucleon knockout from magic nuclei suggest that their nucleon orbits are not fully occupied. This conflicts a commonly accepted view of the shell closure associated with such nuclei. The conflict can be reconciled if the overlap between initial and final nuclear states in a knockout reaction are calculated by a non-standard method. The method employs an inhomogeneous equation based on correlation-dependent effective nucleon-nucleon (NN) interactions and allows the simplest wave functions, in which all nucleons occupy only the lowest nuclear orbits, to be used. The method also reproduces the recently established relation between reduction of spectroscopic strength, observed in knockout reactions on other nuclei, and nucleon binding energies. The implication of the inhomogeneous equation method for the physical meaning of spectroscopic factors is discussed.Comment: 4 pages, accepted by Phys. Rev. Let

The Equivalence Theorem in Effective Theories

The famous equivalence theorem is reexamined in order to make it applicable to the case of intrinsically quantum infinite-component effective theories. We slightly modify the formulation of this theorem and prove it basing on the notion of generating functional for Green functions. This allows one to trace (directly in terms of graphs) the mutual cancelation of different groups of contributions.Comment: 21 pages, 7 figures; v2: Section 4 is modified, plus minor corrections in other sections, version accepted for publication in PR

Equilibrium properties of highly asymmetric star-polymer mixtures

We employ effective interaction potentials to study the equilibrium structure and phase behavior of highly asymmetric mixtures of star polymers. We consider in particular the influence of the addition of a component with a small number of arms and a small size on a concentrated solution of large stars with a high functionality. By employing liquid integral equation theories we examine the evolution of the correlation functions of the big stars upon addition of the small ones, finding a loss of structure that can be attributed to a weakening of the repulsions between the large stars due to the presence of the small ones. We analyze this phenomenon be means of a generalized depletion mechanism which is supported by computer simulations. By applying thermodynamic perturbation theory we draw the phase diagram of the asymmetric mixture, finding that the addition of small stars melts the crystal formed by the big ones. A systematic comparison between the two- and effective one-component descriptions of the mixture that corroborates the reliability of the generalized depletion picture is also carried out.Comment: 26 pages, 9 figures, submitted to Phys. Rev.

Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4

86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally rearranged transcripts were found in the cells of seven healthy control subjects. All the patient's IgM heavy-chain and κ light-chain transcripts were functional, suggesting that either non-functional rearrangements were being selectively class-switched to IgG, or that receptor editing was rendering genes non-functional after class-switching. The functional γ-chain sequences showed a normal rate of somatic hypermutation while non-functional sequences contained few somatic mutations, suggesting that most came from cells that had no functional gene and therefore were not receiving signals for hypermutation. However, apoptosis of peripheral blood lymphocytes was not impaired. No defects have been found in any of the genes currently known to be responsible for hyper-IgM syndrome but the phenotype fits best to type 4

Graft incompatibility in Prunus spp. preceded by SPAD index reduction.

O objetivo deste trabalho foi mensurar o índice de clorofila (SPAD 502 Plus) em folhas de três cultivares de pessegueiros enxertados em diferentes porta-enxertos clonais, totalizando 68 combinações copa/porta-enxerto, entre cinco e nove meses após o plantio no campo, para qualificar os possíveis sintomas que antecedem a incompatibilidade de enxertia em Prunus spp. Três unidades de observação (UO) com as cultivares copa ‘BRS-Kampai’, ‘Jade’ e ‘Maciel’ foram estabelecidas sobre 18, 25 e 25 porta-enxertos clonais, respectivamente, no inverno de 2014. Como testemunhas, utilizaram-se as respectivas cultivares-copa autoenraizadas (sem porta-enxerto) que, assim como os porta-enxertos, também foram propagadas por estacas herbáceas. Adotou-se o delineamento experimental em blocos ao acaso com quatro repetições, sendo cada parcela composta por uma planta. O índice SPAD foi determinado em três avaliações, entre janeiro e abril de 2015. Os porta-enxertos ‘Mirabolano 29C’ (P.cerasifera) e ‘Marianna 2624’ (P.cerasifera x P.munsoniana) reduziram os índices SPAD nas avaliações realizadas nas três cultivares copa de pessegueiro, que culminaram com a morte das plantas por incompatibilidade. Conclui-se que os porta-enxertos ‘Mirabolano 29C’ (P.cerasifera) e ‘Marianna 2624’ (P.cerasifera x P.munsoniana) apresentam incompatibilidade de enxertia do tipo “translocada” com as cultivares de pessegueiro BRS-Kampai, Jade e Maciel e a morte dessas plantas foi precedida pela redução dos índices SPAD nas folhas após cinco meses do plantio. As demais combinações copa/porta-enxerto testadas não reduziram os índices SPAD até os nove meses de idade, mas necessitam ser avaliadas por maior período de tempo para se afirmar sobre a compatibilidade de enxertia