Pisces IV submersible observations in the epicentral region of the 1929 Grand Banks earthquake

The PISCES IVsubmersible was used to investigate the upper continental slope around 44 ON, 56 W, near the epicentre of the 1929 Grand Banks earthquake. Four dives in water depths of 800-2000 m were undertaken to observe speci3c features identijied with the SeaMARC I sidescan system in 1983. Two dives were made in the head of Eastern Valley where pebbly mudstones ofprobable Pleistocene age were recognized outcropping on the seafloor. Constructional features of cobbles and boulders, derived by exhumation and reworking of the pebbly mudstone, were also observed. These include gravel/sand bedforms (transverse waves) on the valley floor. Slope failure features in semiconsolidated mudstone were recognized on two dives onto the St. Pierre slope. Exposures in these mudstones are rapidly eroded by intense burrowing by benthic organisms

Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game

BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironment, effect tumour progression and represent a largely under appreciated therapeutic target. We use observations of primary tumor biology from prostate cancer to extrapolate a mathematical model: specifically; it has been observed that in prostate cancer three disparate cellular outcomes predominate: (i) the tumour remains well differentiated and clinically indolent - in this case the local stromal cells may act to restrain the growth of the cancer; (ii) early in its genesis the tumour acquires a highly malignant phenotype, growing rapidly and displacing the original stromal population (often referred to as small cell prostate cancer) - these less common aggressive tumours are relatively independent of the local microenvironment; and, (iii) the tumour co-opts the local stroma - taking on a classic stromagenic phenotype where interactions with the local microenvironment are critical to the cancer growth. METHODS: We present an evolutionary game theoretical construct that models the influence of tumour-stroma interactions in driving these outcomes. We consider three characteristic and distinct cellular populations: stromal cells, tumour cells that are self-reliant in terms of microenvironmental factors and tumour cells that depend on the environment for resources but can also co-opt stroma. 
RESULTS: Using evolutionary game theory we explore a number of different scenarios that elucidate the impact of tumour-stromal interactions on the dynamics of prostate cancer growth and progression and how different treatments in the metastatic setting can affect different types of tumors.
CONCLUSIONS: The tumour microenvironment plays a crucial role selecting the traits of the tumour cells that will determine prostate cancer progression. Equally important, treatments like hormone therapy affect the selection of these cancer phenotypes making it very important to understand how they impact prostate cancer’s somatic evolution

Efficacy of power training to improve physical function in individuals diagnosed with frailty and chronic disease: A meta-analysis

Muscle power training with emphasis on high-velocity of concentric movement improves physical functionality in healthy older adults, and, maybe superior to traditional exercise programs. Power training may also be advantageous for patients with acute and chronic illnesses, as well as frail individuals. To determine the efficacy of power training compared with traditional resistance training on physical function outcomes in individuals diagnosed with frailty, acute illness or chronic disease. PubMed (MEDLINE), CINAHL, PEDro, Web of Science, and Google Scholar. (1) at least one study group receives muscle power training of randomized controlled trial (RCT) (2) study participants diagnosed as prefrail, frail or have an ongoing acute or chronic disease, condition or illness; (3) study participants over the age of 18; (4) publication in English language; (5) included physical function as the primary or secondary outcome measures. Two independent reviewers assessed articles for inclusion and graded the methodological quality using Cochrane Risk-of- Bias tool for RCTs. Fourteen RCTs met the inclusion criteria. In seven studies, muscle power training was more effective at improving physical function compared to control activities with a mean fixed effect size (ES) of 0.41 (p = 0.006; 95% CI 0.12 to 0.71). Power training and conventional resistance training had similar effectiveness in eight studies with a mean fixed ES of 0.10 (p = 0.061; 95% CI –0.01 to 0.40). Muscle power training is just as efficacious for improving physical function in individuals diagnosed with frailty and chronic disease when compared to traditional resistance training. The advantages of power training with reduced work per session may support power training as a preferential exercise modality for clinical populations. The findings should be interpreted with caution since generalizability is questioned due to the heterogeneity of patient populations enrolled and participants were relatively mobile at baseline

Patient-Reported Side Effects of Intradetrusor Botulinum Toxin Type A for Idiopathic Overactive Bladder Syndrome

Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection was performed in 56 patients with idiopathic OAB. Patients were followed up for 6 months concerning side effects and patients' satisfaction. Results: Different types of side effects were assessed such as dry mouth (19.6%), arm weakness (8.9%), eyelid weakness (8.9%), leg weakness (7.1%), torso weakness (5.4%), impaired vision (5.4%) and dysphagia (5.4%). In all cases, symptoms were mild and transient. Urological complications such as gross hematuria (17.9%), acute urinary retention (8.9%) and acute urinary tract infection (7.1%) were noticed. In all cases, acute urinary retention was transient and treated with temporary intermittent self-catheterization. There was no statistically significant correlation between dosage and observed side effects. Patients' satisfaction rate was high (71.4%). Conclusion: Intradetrusor injection of botulinum toxin was associated with a high rate of neurourological side effects. In general, side effects were transient, mild and did not require special treatment. Copyright (C) 2010 S. Karger AG, Base

Comparison of the Near-Threshold Production of eta- and K-Mesons in Proton-Proton Collisions

The pp -> pp eta and pp -> pLambda K^+ reactions near threshold are dominated by the first and second S_11 resonance respectively. It is shown that a one-pion-exchange model exciting these isobars reproduces well the ratio of the production cross sections. The consequences for this and other channels are discussed.Comment: 10 pages, LaTeX2e, 1 eps-figur

Laser-driven micro-explosive bonding of aluminium films to copper and silicon

Laser explosive microfabrication was used to bond micrometre-thick aluminium films to both copper and silicon substrates. Bonding was observed in both systems for laser intensities greater than about 1 × 10 9 W cm −2 and resulted in contiguous, uniform films when performed in a rough vacuum of 25 to 70 millitorr. At intensities greater than 9 × 109 W cm-2 the transferred films were generally black in colour due to oxidation in the aluminium-on-copper shots and due to substrate vaporization in the aluminium-on-silicon shots. SEM examination of the bond interfaces indicated mixing of film and substrate through wave formation and possibly through liquid-phase mixing due to thermal conduction of the laser pulse. Tape adhesion testing of the laser-bonded films showed a significant increase in adhesion over vapour-deposited films in both Al-Cu and Al-Si. Vapour-deposited films were easily removed in their entirety by a single tape pull while metallic portions of the laser-bonded films resisted removal by the tape in all but two tests. The enhanced adhesion evident in the laser-bonded films was a result of intermixing observed at the film-substrate interface.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44689/1/10853_2005_Article_BF01115786.pd

Prospectus, March 31, 1982

BOARD MOVES TO UP TUITION BY \u2783; Monroe to speak to grads; Office Careers contest set; Reserve fall courses; Opinions and Views: StuGo leader speaks on budget plans, TV purchase; Music Association learns from clinics; 2 from Parkland featured in art exhibit; Maya Angelou speaks on black literature, writers; Class strains nerves, but teaches discipline well; P.C. Happenings...: Series on parent-child interaction scheduled, Program on childhood illness set, Doctor to discuss stomach disorders, Choral Union to perform concert, Two EMT workshops scheduled. Opportunity to explore careers, How to be a smart consumer; Broadcast option model for colleges; Award offered to students in education; Radio show premieres April 4; Counselor sees solution to teen pregnancies; Brown baggers enjoy convenience, variety, savings; Check your change...: Coin collecting big-booming hobby; First P.C. variety show goes off without a hitch; Classifieds; Community Calendar; \u27Quest for Fire\u27: unique in more ways than one; Chicago school provides world with several comic success; \u27Angel Street\u27 coming your way; B-52\u27s explore ancient country; Joni relives struggle in inspirational movie; Women off to good start with first sotfball game; Madden leads men to win over Lincoln; Parkland Sports Watch; Score Card; Coach predicts teams will be formidablehttps://spark.parkland.edu/prospectus_1982/1024/thumbnail.jp