Development of a Three-Dimensional Groundwater Flow Model

A three-dimensional model for the simulation of transient groundwater flow is developed. The model is called REGFED for REGional flow using Finite Elements and Difference methods. A review of groundwater flow and contaminant transport concepts and theory reveals that three-dimensional representation of groundwater systems is essential for realistic simulation of flow and transport. From an analysis of currently available groundwater flow models and algorithms, it is apparent that a mixed numerical method consisting of finite-elements and finite differences is a suitable method for solving the groundwater flow equation in three dimensions. An algorithm known as ALALS (Alternate sublayer And Line Sweep) is selected for the basic model algorithm. Finite elements are applied to areal components, and flnite differences are applied to vertical components of flow. The model accomodates both conflned and unconfined groundwater flow problems and is also capable of handling the draining and refilling of individual elements or entire layers. Because of the model's efficient algorithm, it can accomodate thousands of nodal unknowns with minimal computer storage and CPU time. Quasilinear unconfined groundwater flow problems are solved using a Picard iteration scheme. Entire confined layers are skipped in the iteration scheme in order to decrease the CPU time required to solve the problem. The model is validated under a wide assortment of conditions including confined flow, confined flow with partially screened wells, unconfined flow, combined confined/unconfined flow, and flow with drained and refilled layers. A heuristic error analysis shows that model results compare well with validation results. Mass-balance errors for various groundwater flow problems are minimal for most cases. The convergence speed and stability of the iteration scheme is evaluated for solution of unconfined groundwater flow problems. A benchmark comparison using sample groundwater flow problems was performed with the REGFED model and with the USGS McDonald-Harbaugh model. Example applications further demonstrate the flexibility of the model. A three-dimensional model for the simulation of transient groundwater flow is developed. The model is called REGFED for REGional flow using Finite Elements and Difference methods. A review of groundwater flow and contaminant transport concepts and theory reveals that three-dimensional representation of groundwater systems is essential for realistic simulation of flow and transport. From an analysis of currently available groundwater flow models and algorithms, it is apparent that a mixed numerical method consisting of finite-elements and finite differences is a suitable method for solving the groundwater flow equation in three dimensions. An algorithm known as ALALS (Alternate sublayer And Line Sweep) is selected for the basic model algorithm. Finite elements are applied to areal components, and flnite differences are applied to vertical components of flow. The model accomodates both conflned and unconfined groundwater flow problems and is also capable of handling the draining and refilling of individual elements or entire layers. Because of the model's efficient algorithm, it can accomodate thousands of nodal unknowns with minimal computer storage and CPU time. Quasilinear unconfined groundwater flow problems are solved using a Picard iteration scheme. Entire confined layers are skipped in the iteration scheme in order to decrease the CPU time required to solve the problem. The model is validated under a wide assortment of conditions including confined flow, confined flow with partially screened wells, unconfined flow, combined confined/unconfined flow, and flow with drained and refilled layers. A heuristic error analysis shows that model results compare well with validation results. Mass-balance errors for various groundwater flow problems are minimal for most cases. The convergence speed and stability of the iteration scheme is evaluated for solution of unconfined groundwater flow problems. A benchmark comparison using sample groundwater flow problems was performed with the REGFED model and with the USGS McDonald-Harbaugh model. Example applications further demonstrate the flexibility of the model.Master of Science in Environmental Engineerin

Predictions of household water affordability under conditions of climate change, demographic growth, and fresh groundwater depletion in a southwest US city indicate increasing burdens on the poor

Reduced river flows and groundwater depletion as a result of climate change and population growth have increased the effort and difficulty accessing and processing water. In turn, residential water costs from municipal utilities are predicted to rise to unaffordable rates for poor residential water customers. Building on a regional conjunctive use model with future climate scenarios and 50-year future water supply plans, our study communicates the effects of climate change on poor people in El Paso, Texas, as water becomes more difficult and expensive to obtain in future years. Four scenarios for future water supply and future water costs were delineated based on expected impacts of climate change and groundwater depletion. Residential water use was calculated by census tract in El Paso, using basic needs indoor water use and evaporative cooling use as determinants of household water consumption. Based on household size and income data from the US Census, fraction of household income spent on water was determined. Results reveal that in the future, basic water supply will be a significant burden for 40% of all households in El Paso. Impacts are geographically concentrated in poor census tracts. Our study revealed that negative impacts from water resource depletion and increasing populations in El Paso will lead to costly and difficult water for El Paso water users. We provide an example of how to connect future resource scenarios, including those affected by climate change, to challenges of affordability for vulnerable consumers

Investigating the Impact of Seawater Intrusion on the Operation Cost of Groundwater Supply in Island Aquifers

Managing fragile island freshwater resources requires identifying pumping strategies that trade off the financial cost of groundwater supply against controlling the seawater intrusion (SWI) associated with aquifer pumping. In this work, these tradeoffs are investigated through a sensitivity analysis conducted in the context of an optimization formulation of the groundwater management problem, which aims at minimizing the groundwater supply operation cost associated with groundwater pumping and desalination treatment, subject to constraints on SWI control, as quantified by the water table drawdown over the well (∆s), the reduction in freshwater volume (∆FV) in the aquifer, or the salt mass increase (∆SM) in the aquifer. This study focuses on a simplified two-dimensional model of the San Salvador Island aquifer (Bahamas). Pumping strategies are characterized by the distance of the pumping system from the shoreline (WL), the abstraction screen depth (D) and overall pumping rate (Q), constituting the decision variables of the optimization problem. We investigate the impacts of pumping strategies on the operation cost, ∆s, ∆FV and ∆SM. Findings indicate increasing D or decreasing WL reduces ∆s, ∆FV and ∆SM, thus preserving the aquifer hydrogeologic stability, but also leads to extracting saltier groundwater, thus increasing the water treatment requirements, which have a strong impact on the overall groundwater supply cost. From a financial perspective, groundwater abstraction near the island center and at shallow depths seems the most convenient strategy. However, the analysis of the optimization constraints reveals that strategies where the pumping system approaches the island center tend to cause more severe SWI, highlighting the need to trade off groundwater supply cost against SWI control

Magic numbers in exotic nuclei and spin-isospin properties of {\it NN} interaction

The magic numbers in exotic nuclei are discussed, and their novel origin is shown to be the spin-isospin dependent part of the nucleon-nucleon interaction in nuclei. The importance and robustness of this mechanism is shown in terms of meson exchange, G-matrix and QCD theories. In neutron-rich exotic nuclei, magic numbers such as N = 8, 20, etc. can disappear, while N = 6, 16, etc. arise, affecting the structure of lightest exotic nuclei to nucleosynthesis of heavy elements.Comment: 4 pages, 3 figures, revte

Factors Associated with Gender-Affirming Surgery and Age of Hormone Therapy Initiation Among Transgender Adults

Abstract Purpose: Gender-affirming surgeries and hormone therapy are medically necessary treatments to alleviate gender dysphoria; however, significant gaps exist in the research and clinical literature on surgery utilization and age of hormone therapy initiation among transgender adults. Methods: We conducted a retrospective review of electronic health record data from a random sample of 201 transgender patients of ages 18–64 years who presented for primary care between July 1, 2010 and June 30, 2015 (inclusive) at an urban community health center in Boston, MA. Fifty percent in our analyses were trans masculine (TM), 50% trans feminine, and 24% reported a genderqueer/nonbinary gender identity. Regression models were fit to assess demographic, gender identity-related, sexual history, and mental health correlates of gender-affirming surgery and of age of hormone therapy initiation. Results: Overall, 95% of patients were prescribed hormones by their primary care provider, and the mean age of initiation of masculinizing or feminizing hormone prescriptions was 31.8 years (SD=11.1). Younger age of initiation of hormone prescriptions was associated with being TM, being a student, identifying as straight/heterosexual, having casual sexual partners, and not having past alcohol use disorder. Approximately one-third (32%) had a documented history of gender-affirming surgery. Factors associated with increased odds of surgery were older age, higher income levels, not identifying as bisexual, and not having a current psychotherapist. Conclusion: This study extends our understanding of prevalence and factors associated with gender-affirming treatments among transgender adults seeking primary care. Findings can inform future interventions to expand delivery of clinical care for transgender patients

Epidural Hematoma Following Cervical Spine Surgery.

STUDY DESIGN: A multicentered retrospective case series. OBJECTIVE: To determine the incidence and circumstances surrounding the development of a symptomatic postoperative epidural hematoma in the cervical spine. METHODS: Patients who underwent cervical spine surgery between January 1, 2005, and December 31, 2011, at 23 institutions were reviewed, and all patients who developed an epidural hematoma were identified. RESULTS: A total of 16 582 cervical spine surgeries were identified, and 15 patients developed a postoperative epidural hematoma, for a total incidence of 0.090%. Substantial variation between institutions was noted, with 11 sites reporting no epidural hematomas, and 1 site reporting an incidence of 0.76%. All patients initially presented with a neurologic deficit. Nine patients had complete resolution of the neurologic deficit after hematoma evacuation; however 2 of the 3 patients (66%) who had a delay in the diagnosis of the epidural hematoma had residual neurologic deficits compared to only 4 of the 12 patients (33%) who had no delay in the diagnosis or treatment (P = .53). Additionally, the patients who experienced a postoperative epidural hematoma did not experience any significant improvement in health-related quality-of-life metrics as a result of the index procedure at final follow-up evaluation. CONCLUSION: This is the largest series to date to analyze the incidence of an epidural hematoma following cervical spine surgery, and this study suggest that an epidural hematoma occurs in approximately 1 out of 1000 cervical spine surgeries. Prompt diagnosis and treatment may improve the chance of making a complete neurologic recovery, but patients who develop this complication do not show improvements in the health-related quality-of-life measurements

Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety

<p>Background: Melatonin is extensively used in the USA in a non-regulated manner for sleep disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for the short term treatment of primary insomnia in patients aged 55 years and over. However, a clear definition of the target patient population and well-controlled studies of long-term efficacy and safety are lacking. It is known that melatonin production declines with age. Some young insomnia patients also may have low melatonin levels. The study investigated whether older age or low melatonin excretion is a better predictor of response to PRM, whether the efficacy observed in short-term studies is sustained during continued treatment and the long term safety of such treatment.</p> <p>Methods: Adult outpatients (791, aged 18-80 years) with primary insomnia, were treated with placebo (2 weeks) and then randomized, double-blind to 3 weeks with PRM or placebo nightly. PRM patients continued whereas placebo completers were re-randomized 1:1 to PRM or placebo for 26 weeks with 2 weeks of single-blind placebo run-out. Main outcome measures were sleep latency derived from a sleep diary, Pittsburgh Sleep Quality Index (PSQI), Quality of Life (World Health Organzaton-5) Clinical Global Impression of Improvement (CGI-I) and adverse effects and vital signs recorded at each visit.</p> <p>Results: On the primary efficacy variable, sleep latency, the effects of PRM (3 weeks) in patients with low endogenous melatonin (6-sulphatoxymelatonin [6-SMT] ≤8 μg/night) regardless of age did not differ from the placebo, whereas PRM significantly reduced sleep latency compared to the placebo in elderly patients regardless of melatonin levels (-19.1 versus -1.7 min; P = 0.002). The effects on sleep latency and additional sleep and daytime parameters that improved with PRM were maintained or enhanced over the 6-month period with no signs of tolerance. Most adverse events were mild in severity with no clinically relevant differences between PRM and placebo for any safety outcome.</p> <p>Conclusions: The results demonstrate short- and long-term efficacy and safety of PRM in elderly insomnia patients. Low melatonin production regardless of age is not useful in predicting responses to melatonin therapy in insomnia. The age cut-off for response warrants further investigation.</p&gt

C5 Palsy After Cervical Spine Surgery: A Multicenter Retrospective Review of 59 Cases.

STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery. OBJECTIVE: Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. The goal of this study was to review the incidence, patient characteristics, and outcome of C5 palsy in patients undergoing cervical spine surgery. METHODS: We conducted a multicenter, retrospective review of 13 946 patients across 21 centers who received cervical spine surgery (levels C2 to C7) between January 1, 2005, and December 31, 2011, inclusive. P values were calculated using 2-sample t test for continuous variables and χ(2) tests or Fisher exact tests for categorical variables. RESULTS: Of the 13 946 cases reviewed, 59 patients experienced a postoperative C5 palsy. The incidence rate across the 21 sites ranged from 0% to 2.5%. At most recent follow-up, 32 patients reported complete resolution of symptoms (54.2%), 15 had symptoms resolve with residual effects (25.4%), 10 patients did not recover (17.0%), and 2 were lost to follow-up (3.4%). CONCLUSION: C5 palsy occurred in all surgical approaches and across a variety of diagnoses. The majority of patients had full recovery or recovery with residual effects. This study represents the largest series of North American patients reviewed to date

Designing for human–agent collectives: display considerations

The adoption of unmanned systems is growing at a steady rate, with the promise of improved task effectiveness and decreased costs associated with an increasing multitude of operations. The added flexibility that could potentially enable a single operator to control multiple unmanned platforms is thus viewed as a potential game-changer in terms of both cost and effectiveness. The use of advanced technologies that facilitate the control of multiple systems must lie within control frameworks that allow the delegation of authority between the human and the machine(s). Agent-based systems have been used across different domains in order to offer support to human operators, either as a form of decision support offered to the human or to directly carry out behaviours that lead to the achievement of a defined goal. This paper discusses the need for adopting a human–agent interaction paradigm in order to facilitate an effective human–agent partnership. An example of this is discussed, in which a single human operator may supervise and control multiple unmanned platforms within an emergency response scenario