PEMBUATAN SABUN CUCI PIRING RAMAH LINGKUNGAN KELURAHAN BESAR, KEC. MEDAN LABUHAN KOTA MEDAN

KKNT activities are carried out as one of the tasks of students in implementing the Tri Dharma of Higher Education, namely community service. In accordance with the goals of higher education as stated in government regulation number 60 of 1999 concerning the Implementation of Higher Education (Chapter III article 3 paragraph 4) which reads Service to the Community as an Activity to Utilize Science in an Effort to Contribute to the Advancement of Society. From all the ingredients used in the manufacture of dish soap, about 20 liters of ready-to-use products are produced, with good quality. Physical appearance and washing results give results as well as products on the market. The product is then packaged in 50 bottles of 120 ml bottles. The liquid soap products, apart from being given to the participants of the training, are also distributed free of charge to the community in III Kelurahan Besar. This community service activity has been carried out through outreach activities and direct practice of making dish soap. This activity has been proven to increase participants' knowledge and provide positive experiences in producing products that are used daily, namely soap products. Participants are sure that they will be able to make similar soap products themselves, so it is hoped that they can save on spending on buying these products

PENGUKURAN KUALITAS AIR DOMESTIK DI RUMAH WARGA KELURAHAN BESAR, KECAMATAN MEDAN LABUHAN KOTA MEDAN

Kelurahan Besar is one of the sub-districts in Medan Labuhan District, Medan, North Sumatra, Indonesia with an area of 6,000 km2. Kelurahan Besar itself is surrounded by many industries which happen to be in the Medan Industrial Estate (KIM) area, besides that there are warehouse areas, business centers and residential areas. Both positive and negative impacts will be felt by residents. One of them is the condition and quality of clean water used by community members who are concerned that they have been exposed to organic waste from the production process produced by Industrial Estate activities. There are those who think that clear water when seen by naked eye, is definitely safe to use. Even though not all clear water is suitable for use. To ensure that water is suitable for use, it is necessary to carry out laboratory tests. Measurements and observations were made on several water quality parameters (Hydrogen Potential, Salinity (Total Dissolved Solid / TDS), Total Suspended Solid (TSS), Water Color, Turbidity, Conductivity and COD (based on KMnO4 Factor) from water samples taken The results show that water from wells used by residents to meet their daily needs is safe to use because no trace outspecs were found

The Efficacy of Parent-Child Interaction Therapy (PCIT) in Children with Attention Problems, Hyperactivity, and Impulsivity in Dubai

Disruptive behaviors can be associated with significant functional impairment. Early intervention for young children is essential to prevent long-term consequences. Parent-Child Interaction Therapy (PCIT) is a psychotherapeutic intervention, which has shown to be effective for children with externalizing symptoms. We present the treatment course of PCIT for two kindergarten children. The first has Attention-Deficit/Hyperactivity Disorder (ADHD), and the second has frontal lobe epilepsy. Both presented with attention problems, hyperactivity, and impulsivity associated with significant impairment in multiple settings. Two certified PCIT therapists provided 17 sessions to the parents of the first patient and 25 sessions to the parents of the second patient. Most of the sessions were in-person; however, some were “virtual” due to the circumstances associated with the COVID-19 pandemic. Parents of both patients achieved the “mastery” criteria. In both cases, PCIT contributed to improving the disruptive behaviors. PCIT may serve as an effective therapeutic option for young children with externalizing symptoms in Dubai

Vitamin D diminishes the high platelet aggregation of type 2 diabetes mellitus patients

Platelet activation is found in inflammatory conditions and implicated in the pathogenesis of chronic medical conditions, such as atherosclerosis, coronary vascular disease, cerebrovascular disease, and diabetes mellitus (DM). HbA1c is inversely related to vitamin D25 levels in individuals with and without DM. This study aimed to determine the relation between platelet aggregation, vitamin D and HbA1c among healthy individuals and those with Type 2 DM (T2DM). The direct effect of vitamin D1, 25 (calcitriol) on platelet aggregation was also investigated. The study included four groups: A. normoglycemic Control group: HbA1c6.4%(+)Asp.; and D. DM not on aspirin therapy: HbA1c > 6.4%(−)Asp. Platelet aggregation was tested with and without calcitriol or saline pre-treatment, using collagen or adenosine diphosphate (ADP) as agonists. Platelet aggregation was higher in DM(−)Asp group compared to normoglycemic and DM(+)Asp, and higher, but not significant compared to pre-DM. The entire study population exhibited negative correlation between HbA1c and serum concentration of vitamin D25. Excluding DM(+)Asp, aggregation induced by collagen was significantly higher in patients with insufficient (<76 nmol/L) vitamin D25 compared to sufficient (≥76 nmol/L) vitamin D25. In this cohort, a negative correlation was found between serum concentrations of vitamin D25 and collagen-induced percent maximum (%max) aggregation and area under curve (AUC) aggregation. In the DM(−)Asp group, collagen-induced aggregation was reduced by approximately 25% after calcitriol treatment. Calcitriol decreased ADP-induced aggregation of control and DM(+)Asp groups to approximately 85% of saline treatment. We conclude that glycemic control is inversely associated with high platelet aggregation and low vitamin D25 levels. This elevated aggregation could be regulated by a novel, direct effect of calcitriol, indicating a beneficial effect of vitamin D on vascular complications related to diabetes. We offer a possible non-genomic mechanism for the vitamin D/Vitamin D receptor (VDR) pathway

Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production

Abstract Background Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum levels of vitamin D are associated with increased hepatitis B virus (HBV) replication. Our study aimed to assess the in-vitro relationship between HBV production and Vitamin D signaling pathway and to explore the associated mechanism(s). Methods HBV transcription and replication was evaluated by qRT-PCR of the HBV-RNA and covalently closed circular DNA (cccDNA). Furthermore, we have transfected the 1.3 X HBV-Luc plasmid to the cells and measured the Luciferase activity using Luminometer. Vitamin D signaling pathway activation was evaluated by measuring the expression levels of VDR, CYP24A1, Tumor necrosis factor α (TNFα) and cathelicidin (CAMP) by qRT-PCR. All assays were performed on HepG2.2.15, HepG2, and HepAD38 cells treated with or without Vitamin D active metabolite: calcitriol. Results Calcitriol did not suppress HBV transcription, cccDNA expression or HBV RNA levels in HepG2.2.15 cells. However, VDR transcript levels in HepG2.215 cells were significantly lower compared to HepG2 cells. Similar results were obtained in HepAD38 cell where VDR expression was down-regulated when HBV transcript level was up-regulated. In addition, calcitriol induced VDR-associated signaling, resulting in upregulation of CYP24A1, TNFα and CAMP expression level in HepG2 cells but not in the HepG2.2.15 cells. Conclusions These findings indicate that VDR expression is downregulated in HBV-transfected cells, thereby preventing vitamin D from inhibiting transcription and translation of HBV in vitro. HBV might use this mechanism to avoid the immunological defense system by affecting both TNFα and CAMP signaling pathways

Childhood cancer care in the Middle East, North Africa, and west/central Asia: A snapshot across five countries from the POEM network

Background: The Pediatric Oncology East and Mediterranean (POEM) network, through this report, provides a snapshot view of an expected child\u27s treatment journey in five countries in the region.Methods: Pediatric oncologists from cancer centers in Egypt, Lebanon, Iraq, Jordan, and Pakistan provided input on referral pathways, barriers to care, and patient outcomes, based on personal experience and published data. Outcome data were extracted from institutional registries. A literature review of articles and meeting abstracts was conducted, and results summarized.Results: Countries across the Middle Eastern, North African, and West Asian region face common difficulties relating to the provision of pediatric oncology care. National registries are largely lacking, with unavailability of outcome data. Economic barriers are a common theme, leading to delays in patient diagnosis, and interruptions and abandonment of therapy. Insufficient infrastructure and human resources, high rates of toxic deaths, and lack of common national protocols are common. The establishment of successful fundraising organizations linked to specific cancer hospitals showcase several success stories, enhancing services, improving patient access, and leading to outcomes comparable to those in developed countries. All identified published literature is institution-based and from only one or a few hospitals. Therefore, outcomes at a national level likely differ due to disparate cancer care capabilities.Conclusion: Well-designed national registries are essential for identifying gaps, and clear referral networks are needed to address delays to diagnosis and therapy. National and transversal programs to improve infrastructure, facilitate knowledge transfer, and promote advocacy, are needed to accelerate progress in the region

Transgenerational effects of parental light environment on progeny competitive performance and lifetime fitness

This file contains all of the raw data for the analyses presented in the article "Transgenerational effects of parental light environment on progeny competitive performance and lifetime fitness" by B. H. Baker, S. E. Sultan, M. Lopez-Ichikawa, and R. Waterman<br