A large class of non constant mean curvature solutions of the Einstein constraint equations on an asymptotically hyperbolic manifold

We construct solutions of the constraint equation with non constant mean curvature on an asymptotically hyperbolic manifold by the conformal method. Our approach consists in decreasing a certain exponent appearing in the equations, constructing solutions of these sub-critical equations and then in letting the exponent tend to its true value. We prove that the solutions of the sub-critical equations remain bounded which yields solutions of the constraint equation unless a certain limit equation admits a non-trivial solution. Finally, we give conditions which ensure that the limit equation admits no non-trivial solution.Comment: remark on the equivalence between the existence of a solution to the Lichnerowicz equation and to the prescribed scalar curvature equation added, reference [BPB09] added, to appear in Commun. Math. Phy

De novo identification of mammalian ciliary motility proteins using cryo-EM

Dynein-decorated doublet microtubules (DMTs) are critical components of the oscillatory molecular machine of cilia, the axoneme, and have luminal surfaces patterned periodically by microtubule inner proteins (MIPs). Here we present an atomic model of the 48-nm repeat of a mammalian DMT, derived from a cryoelectron microscopy (cryo-EM) map of the complex isolated from bovine respiratory cilia. The structure uncovers principles of doublet microtubule organization and features specific to vertebrate cilia, including previously unknown MIPs, a luminal bundle of tektin filaments, and a pentameric dynein-docking complex. We identify a mechanism for bridging 48- to 24-nm periodicity across the microtubule wall and show that loss of the proteins involved causes defective ciliary motility and laterality abnormalities in zebrafish and mice. Our structure identifies candidate genes for diagnosis of ciliopathies and provides a framework to understand their functions in driving ciliary motility

Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advances in the assessment, diagnosis, monitoring, non-pharmacological and pharmacological management of SLE. General approaches to management as well as organ-specific treatment, including lupus nephritis and cutaneous lupus, will be covered. This will be the first guideline in SLE using a whole life course approach from childhood through adolescence and adulthood. The guideline will be developed with people with SLE as an important target audience in addition to healthcare professionals. It will include guidance related to emerging approved therapies and account for National Institute for Health and Care Excellence Technology Appraisals, National Health Service England clinical commissioning policies and national guidance relevant to SLE. The guideline will be developed using the methods and rigorous processes outlined in ‘Creating Clinical Guidelines: Our Protocol’ by the British Society for Rheumatology

Proof of evidence M11 to Hackney link road Number 246: text

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