43 research outputs found
Mixed pairing symmetry in \kappa-(BEDT-TTF)_2 X organic superconductors from ultrasonic velocity measurements
Discontinuities in elastic constants are detected at the superconducting
transition of layered organic conductors \kappa-(BEDT-TTF)_{2}X by longitudinal
and transverse ultrasonic velocity measurements. Symmetry arguments show that
discontinuities in shear elastic constants can be explained in the orthorhombic
compound only if the superconducting order parameter has a mixed character that
can be of two types, either A_{1g}+B_{1g} or B_{2g}+B_{3g} in the
classification of irreducible representations of the orthorhombic point group
D_{2h}. Consistency with other measurements suggests that the A_{1g}+B_{1g}
(d_{xy}+d_{z(x+y)}) possibility is realized. Such clear symmetry-imposed
signatures of mixed order parameters have not been observed in other
superconducting compounds.Comment: 5 pages, LaTeX,3 figure
Mixed pairing symmetry in \kappa-(BEDT-TTF)_2 X organic superconductors from ultrasonic velocity measurements
Discontinuities in elastic constants are detected at the superconducting
transition of layered organic conductors \kappa-(BEDT-TTF)_{2}X by longitudinal
and transverse ultrasonic velocity measurements. Symmetry arguments show that
discontinuities in shear elastic constants can be explained in the orthorhombic
compound only if the superconducting order parameter has a mixed character that
can be of two types, either A_{1g}+B_{1g} or B_{2g}+B_{3g} in the
classification of irreducible representations of the orthorhombic point group
D_{2h}. Consistency with other measurements suggests that the A_{1g}+B_{1g}
(d_{xy}+d_{z(x+y)}) possibility is realized. Such clear symmetry-imposed
signatures of mixed order parameters have not been observed in other
superconducting compounds.Comment: 5 pages, LaTeX,3 figure
In vivo remodeling of fibroblast-derived vascular scaffolds implanted for 6 months in rats
There is a clinical need for tissue-engineered small-diameter (<6 mm) vascular grafts since clinical applications are halted by the limited suitability of autologous or synthetic grafts. This study uses the self-assembly approach to produce a fibroblast-derived decellularized vascular scaffold (FDVS) that can be available off-the-shelf. Briefly, extracellular matrix scaffolds were produced using human dermal fibroblasts sheets rolled around a mandrel, maintained in culture to allow for the formation of cohesive and three-dimensional tubular constructs, and decellularized by immersion in deionized water. The FDVSs were implanted as an aortic interpositional graft in six Sprague-Dawley rats for 6 months. Five out of the six implants were still patent 6 months after the surgery. Histological analysis showed the infiltration of cells on both abluminal and luminal sides, and immunofluorescence analysis suggested the formation of neomedia comprised of smooth muscle cells and lined underneath with an endothelium. Furthermore, to verify the feasibility of producing tissue-engineered blood vessels of clinically relevant length and diameter, scaffolds with a 4.6 mm inner diameter and 17 cm in length were fabricated with success and stored for an extended period of time, while maintaining suitable properties following the storage period. This novel demonstration of the potential of the FDVS could accelerate the clinical availability of tissue-engineered blood vessels and warrants further preclinical studies
Mitiq : a software package for error mitigation on noisy quantum computers
We introduce Mitiq, a Python package for error mitigation on noisy quantum computers. Error mitigation techniques can reduce the impact of noise on near-term quantum computers with minimal overhead in quantum resources by relying on a mixture of quantum sampling and classical post-processing techniques. Mitiq is an extensible toolkit of different error mitigation methods, including zero-noise extrapolation, probabilistic error cancellation, and Clifford data regression. The library is designed to be compatible with generic backends and interfaces with different quantum software frameworks. We describe Mitiq using code snippets to demonstrate usage and discuss features and contribution guidelines. We present several examples demonstrating error mitigation on IBM and Rigetti superconducting quantum processors as well as on noisy simulators
Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma
<p>Abstract</p> <p>Background</p> <p>Lung cancer with EGFR mutation was shown to be a specific clinical entity. In order to better understand the biology behind this disease we used a genome wide characterization of loss of heterozygosity and amplification by Single Nucleotide Polymorphism (SNP) Array analysis to point out chromosome segments linked to <it>EGFR </it>mutations. To do so, we compared genetic profiles between <it>EGFR </it>mutated adenocarcinomas (ADC) and <it>KRAS </it>mutated ADC from 24 women with localized lung cancer.</p> <p>Results</p> <p>Patterns of alterations were different between <it>EGFR </it>and <it>KRAS </it>mutated tumors and specific chromosomes alterations were linked to the <it>EGFR </it>mutated group. Indeed chromosome regions 14q21.3 (p = 0.027), 7p21.3-p21.2 (p = 0.032), 7p21.3 (p = 0.042) and 7p21.2-7p15.3 (p = 0.043) were found significantly amplified in EGFR mutated tumors. Within those regions 3 genes are of special interest <it>ITGB8</it>, <it>HDAC9 </it>and <it>TWIST1</it>. Moreover, homozygous deletions at <it>CDKN2A </it>and LOH at <it>RB1 </it>were identified in <it>EGFR </it>mutated tumors. We therefore tested the existence of a link between EGFR mutation, CDKN2A homozygous deletion and cyclin amplification in a larger series of tumors. Indeed, in a series of non-small-cell lung carcinoma (n = 98) we showed that homozygous deletions at <it>CDKN2A </it>were linked to <it>EGFR </it>mutations and absence of smoking whereas cyclin amplifications (<it>CCNE1 </it>and <it>CCND1</it>) were associated to <it>TP53 </it>mutations and smoking habit.</p> <p>Conclusion</p> <p>All together, our results show that genome wide patterns of alteration differ between <it>EGFR </it>and <it>KRAS </it>mutated lung ADC, describe two models of oncogenic cooperation involving either <it>EGFR </it>mutation and <it>CDKN2A </it>deletion or cyclin amplification and <it>TP53 </it>inactivating mutations and identified new chromosome regions at 7p and 14q associated to EGFR mutations in lung cancer.</p
The Normative Problem of Merit Goods in Perspective
In his Theory of Public Finance (1959), Musgrave invented the concept of merit wants to describe public wants that are satisfied by goods provided by the government in violation of the principle of consumer sovereignty. Starting from Musgrave’s mature discussion (1987), I construct two categories to classify the explanations of merit goods. The first strand of thought attempts to justify merit goods within the New welfare economics, by modifying its assumptions to accommodate irrationality, uncertainty, lack of information, and psychic externalities. The second category encompasses more radical departures from consumer sovereignty, drawn from philosophical critiques of economics. In the third part of the paper, I argue that the two strands might be represented by a non-individualistic social welfare function. I also show how this solution echoes Musgrave’s early views on public expenditures before he coined the concept of merit wants. From an historical perspective, the survival of the concept highlights the persistence of a social point of view in welfare economics
Current state and trends in Canadian Arctic marine ecosystems: II. Heterotrophic food web, pelagic-benthic coupling, and biodiversity
The Job Demands-Resources model: Further evidence for the buffering effect of personal resources
Data associated with "Information-theoretic measures of superconductivity in a two-dimensional doped Mott insulator"
datasets and codes used in analysis of "Information-theoretic measures of superconductivity in a two-dimensional doped Mott insulator