Démarches thérapeutiques des populations migrantes (prise en compte des spécificités par le pharmacien d'officine)

CLERMONT FD-BCIU-Santé (631132104) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Attention-deficit/hyperactivity disorder during adulthood

International audienceAttention-Deficit/Hyperactivity Disorder (ADHD), although considered a childhood-onset neurodevelopmental condition, is nevertheless a frequent and disabling condition in adults. A proportion of such patients are not diagnosed during childhood or adolescence, as diagnosis of the syndrome is rather complex, especially when other psychiatric, neurological or other neurodevelopmental conditions are also associated, yet comorbidities and consequences of ADHD are frequently observed in adults and older populations. As ADHD patients present to memory clinics with attentional and executive disorders, neuropsychological examinations of undiagnosed ADHD patients may reveal atypical cognitive profiles that can complicate the usual diagnostic procedure and increase the risk of delayed diagnosis or misdiagnosis. Thus, explorations of cognitive and/or behavioral disorders in adult populations should systematically screen for this neurodevelopmental condition. Accurate diagnosis could lead to non-pharmaceutical and/or pharmaceutical treatments to improve symptoms and quality of life for adult ADHD patients

Etre parent lorsqu'on souffre d'un trouble bipolaire (prise en compte de la vulnérabilité génétique, utilité du dépistage et des interventions précoces)

BORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Etude comparative de l'effet de la cytochalasine D sur les regulations adrenergiques et cholinergiques de la secretion des proteines et du metabolisme du glycogene dans les glandes parotides de rat

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Microbiologically-assisted hemisynthesis of 1a-hydroxydrimenol

International audienceThe hemisynthesis of 1a-hydroxydrimenol has been selected to illustrate a synthetic route involving an initial microbial 3ß-hydroxylation of a drimenol derivative followed by a functionalization transfer to position 1a, thus generating a new potentially bioactive hydroxylated terpenic compound. Several methods have been investigated for the protection and the regeneration of the 7,8-double bond of drimenyl derivatives. © 2001 Elsevier Science Ltd. All rights reserved

A new example of 1a-hydroxylation of drimanic terpenes through combined microbial and chemical processes

International audienceAmong various filamentous fungi, Aspergillus niger ATCC 9142 was the most efficient strain to convert confertifolin in high yield into its 3ß-hydroxy derivative, which was then chemically converted to 1a-hydroxy-, 1a,11a-dihydroxy- and 1a-acetoxy-11a-hydroxyconfertifolin, new compounds structurally related to bioactive natural products isolated from plants or marine sponges. © 2001 Elsevier Science Ltd

Microbial hydroxylation/functionalization of terpenoid synthons derived from communic acids

International audienceIncubation of a communic acid-derived synthon with Cunninghamella elegans quantitatively affords 1ß, 3ß- and 7ß-monohydroxylated derivatives. (C) 2000 Elsevier Science Ltd