[Training in emergency and urgent care settings: more shadows than lights]

[Article in Italian

Стан та перспективи конкурентоспроможності галузі національного господарства в умовах глобалізації

Метою дослідження є узагальнення нових теоретичних положень розвитку галузей економіки в умовах глобалізації, визначення загальних конкурентних переваг хімічної галузі України та практичних напрямів сучасного розвитку економіки країни

Reduced Rate of Hospital Admissions for ACS during Covid-19 Outbreak in Northern Italy

To address the coronavirus (Covid-19) pandemic,1 strict social containment measures have been adopted worldwide, and health care systems have been reorganized to cope with the enormous increase in the numbers of acutely ill patients.2,3 During this same period, some changes in the pattern of hospital admissions for other conditions have been noted. The aim of the present analysis is to investigate the rate of hospital admissions for acute coronary syndrome (ACS) during the early days of the Covid-19 outbreak

Lopinavir/Ritonavir and Darunavir/Cobicistat in Hospitalized COVID-19 Patients: Findings From the Multicenter Italian CORIST Study

Background: Protease inhibitors have been considered as possible therapeutic agents for COVID-19 patients. Objectives: To describe the association between lopinavir/ritonavir (LPV/r) or darunavir/cobicistat (DRV/c) use and in-hospital mortality in COVID-19 patients. Study Design: Multicenter observational study of COVID-19 patients admitted in 33 Italian hospitals. Medications, preexisting conditions, clinical measures, and outcomes were extracted from medical records. Patients were retrospectively divided in three groups, according to use of LPV/r, DRV/c or none of them. Primary outcome in a time-to event analysis was death. We used Cox proportional-hazards models with inverse probability of treatment weighting by multinomial propensity scores. Results: Out of 3,451 patients, 33.3% LPV/r and 13.9% received DRV/c. Patients receiving LPV/r or DRV/c were more likely younger, men, had higher C-reactive protein levels while less likely had hypertension, cardiovascular, pulmonary or kidney disease. After adjustment for propensity scores, LPV/r use was not associated with mortality (HR = 0.94, 95% CI 0.78 to 1.13), whereas treatment with DRV/c was associated with a higher death risk (HR = 1.89, 1.53 to 2.34, E-value = 2.43). This increased risk was more marked in women, in elderly, in patients with higher severity of COVID-19 and in patients receiving other COVID-19 drugs. Conclusions: In a large cohort of Italian patients hospitalized for COVID-19 in a real-life setting, the use of LPV/r treatment did not change death rate, while DRV/c was associated with increased mortality. Within the limits of an observational study, these data do not support the use of LPV/r or DRV/c in COVID-19 patients

Self-divisible ultrafilters and congruences in βZ\beta\mathbb{Z}

We introduce self-divisible ultrafilters, which we prove to be precisely those $w$ such that the weak congruence relation $\equiv_w$ introduced by \v{S}obot is an equivalence relation on $\beta\mathbb{Z}$. We provide several examples and additional characterisations; notably we show that $w$ is self-divisible if and only if $\equiv_w$ coincides with the strong congruence relation $\equiv^{\mathrm{s}}_{w}$, if and only if the quotient $(\beta\mathbb{Z},\oplus)/\mathord{\equiv^{\mathrm{s}}_w}$ is a profinite group. We also construct an ultrafilter $w$ such that $\equiv_w$ fails to be symmetric, and describe the interaction between the aforementioned quotient and the profinite completion $\hat{\mathbb{Z}}$ of the integers.Comment: 17 pages, 1 figur

Photosynthetic Reaction Centers Embedded in Polyelectrolyte Multilayer as a Tool in the Determination of PSII Herbicides

The photosynthetic bacterial reaction center (RC) has been adsorbed onto a glass surface by alternating deposition with the cationic polimer poly(dimethyldiallylammonium chloride) (PDDA) obtaining as an end result an ordinate polyelectrolyte multilayer (PEM) where the protein retains its integrity and photoactivity over a period of several months. This polymer/RC assembly revealed to be extremely sensitive to the presence of herbicides belonging to the so called "PSII family". The RC-herbicides interaction can be easily monitored since it alters the protein photoactivity, such variation resulting in an absorbance decrement at 870 nm. To this purpose, an instrumental setup has been developed based on a monochromatic light source and on a solid state detector connected to a DAQ acquisition board for the measurement storage onto a PC. The system PEM/instrument has been tested on atrazine based herbicides. The bound herbicide can be easily removed from PEM, thus allowing the reuse of the same sample. Moreover, the system has been tested for sensitivity, reproducibility and reliability of the measured data. The results of these tests were so promising to encourage us to propose the PEM as an optical biosensor for herbicides. © 2007 IEEE

Incidence, predictors, and impact on prognosis of systolic pulmonary artery pressure and its improvement after transcatheter aortic valve implantation: a multicenter registry

Elevated values of systolic pulmonary artery pressure (sPAP) represent a common finding in patients with aortic stenosis and severe left ventricular hypertrophy. Prognostic impact of sPAP and its potential improvement after transcatheter aortic valve implantation (TAVI) remains to be determined