Brain indices of disagreement with one's social values predict EU referendum voting behavior

Pre-electoral surveys typically attempt, and sometimes fail, to predict voting behavior on the basis of explicit measures of agreement or disagreement with a candidate or political position. Here, we assessed whether a specific brain signature of disagreement with one's social values, the event-related potential component N400, could be predictive of voting behavior. We examined this possibility in the context of the EU referendum in the United Kingdom. In the five weeks preceding the referendum, we recorded the N400 while participants with different vote intentions expressed their agreement or disagreement with pro- and against-EU statements. We showed that the N400 responded to statements incongruent with one's view regarding the EU. Crucially, this effect predicted actual voting behavior in decided as well as undecided voters. The N400 was a better predictor of voting choice than an explicit index of preference based on the behavioral responses. Our findings demonstrate that well-defined patterns of brain activity can forecast future voting behavior

Role of eculizumab in a pediatric refractory gemcitabine-induced thrombotic microangiopathy: a case report

Abstract Background The incidence of gemcitabine-induced hemolytic uremic syndrome has already been described in adults. Several approaches have been employed in the treatment of gemcitabine-induced hemolytic uremic syndrome with different outcomes. One of the most promising agents is eculizumab, which is a monoclonal antibody directed against C5 complement protein. Case presentation We reported the case of a 3-year-old white boy with medulloblastoma who underwent high-dose chemotherapy and craniospinal irradiation. Afterwards he started maintenance chemotherapy with gemcitabine and oxaliplatin. After five courses he presented a progressive clinical worsening, which resulted in a systemic thrombotic microangiopathy. Initially he was treated with rituximab without clinical improvement. Therefore he started therapy with repeated cycles of eculizumab. After seven infusions he showed a gradual improvement and finally a complete remission of gemcitabine-induced hemolytic uremic syndrome. Conclusions Eculizumab prevents serious complement-mediated vascular damage for chemotherapy-induced thrombotic microangiopathy in pediatric cases

Learning facts during aging: the benefits of curiosity

Background/Study Context: Recent studies have shown that young adults better remember factual information they are curious about. It is not entirely clear, however, whether this effect is retained during aging. Here, we investigated curiosity-driven memory benefits in young and elderly individuals. Methods: In two experiments, young (age range 18-26) and older (age range 65-89) adults read trivia questions, and rated their curiosity to find out the answer. They also attended to task-irrelevant faces presented between the trivia question and the answer. We then administered a surprise memory test to assess recall accuracy for trivia answers, and recognition memory performance for the incidentally-learned faces. Results: In both young and elderly adults, recall performance was higher for answers to questions that elicited high levels of curiosity. In Experiment 1 we also found that faces presented in temporal proximity to curiosity-eliciting trivia questions were better recognized, indicating that the beneficial effects of curiosity extended to the encoding of task-irrelevant material. Conclusions: These findings show that elderly individuals benefit from the memory-enhancing effects of curiosity. This may lead to the implementation of learning strategies that target and stimulate curiosity in aging

Learning facts during aging: the benefits of curiosity

Background/Study Context: Recent studies have shown that young adults better remember factual information they are curious about. It is not entirely clear, however, whether this effect is retained during aging. Here, we investigated curiosity-driven memory benefits in young and elderly individuals. Methods: In two experiments, young (age range 18-26) and older (age range 65-89) adults read trivia questions, and rated their curiosity to find out the answer. They also attended to task-irrelevant faces presented between the trivia question and the answer. We then administered a surprise memory test to assess recall accuracy for trivia answers, and recognition memory performance for the incidentally-learned faces. Results: In both young and elderly adults, recall performance was higher for answers to questions that elicited high levels of curiosity. In Experiment 1 we also found that faces presented in temporal proximity to curiosity-eliciting trivia questions were better recognized, indicating that the beneficial effects of curiosity extended to the encoding of task-irrelevant material. Conclusions: These findings show that elderly individuals benefit from the memory-enhancing effects of curiosity. This may lead to the implementation of learning strategies that target and stimulate curiosity in aging

The "New Grid Systems for Ion Engines" Technology Project -Results and Conclusion

Abstract: "New Grid Systems for Ion Engines" is a project in the frame of The European Space Agency ESA's Technology Research Program (TRP) aiming on a further improvement of grid systems for ion engines with respect to performance, lifetime and reliability. A consortium of European electric propulsion specialists works together on a project consisting of three phases. In the study phase improvement and validation of numerical tools for grid design was performed. In parallel, standard and advanced grid materials were investigated. From the most potential materials subscale grids were manufactured, tested and assessed. During the design phase a grid system for the BepiColombo mission and a subscale grid for future high specific impulse engines were designed and manufactured. Meanwhile the also the validation phase which contains the intensive endurance test of the grid systems is nearly completed. This paper summarizes the results of the three study phases and a first conclusion is drawn