Design challenge of a new monolithic concept for the main landing gear bay of a large passenger aircraft

In this paper, ITEMB team in the contest of the Clean Sky 2 framework, with the scope of a new architecture for the Main Landing Gear of a single isle aircraft type, presents its development in designing the two major item of the Main Landing Gear Bay that are the “roof” and the “rear pressure bulkhead” using pre-preg CFRP material. Typically, a lot of parts (metallic and also composite made) are involved in the two items manufacturing: the research effort has targeted the design of one piece structures consisting in a monolithic “roof” and “monolithic “rear pressure bulkhead”. The assembly of these ones takes advantages from a hole-tohole assembly supported by statistical analysis. The main expected advantages are the reduction of: both non-recurring and recurring cost, the overall flow time and weight saving. The ITEMB (InTEgrated Main landing gear Box) team has worked adapting a bag-to-bag technology to the geometrical and strength capability requirements of the component and outcome of the research (not yet concluded at time of issuing this paper) includes: A design principle supported by stress analysis for strength, stability and local main load introduction; A manufacturing trials campaign to reach the possess of a robust process; A limited coupons test campaign to demonstrate that no specific critical items exists in the design approach. Finally, participants have acquired a new design and manufacturing technique, applicable also to other Aircraft components upgrading their capabilities and European strength in composite structures manufacturing

Epigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization.

"Abstract. Transcriptional silencing by CpG island hypermethylation plays a critical role in endometrial carcinogenesis. In a collection of benign, premalignant and malignant endometrial lesions, a methylation profile of a complete gene panel, such steroid receptors (ERα, PR), DNA mismatch repair (hMLH1), tumor-suppressor genes (CDKN2A\/P16 and CDH1\/E-CADHERIN) and WNT pathway inhibitors (SFRP1, SFRP2, SFRP4, SFRP5) was investigated in order to demonstrate their pathogenetic role in endometrial lesions. Our results indicate that gene hypermethylation may be an early event in endometrial endometrioid tumorigenesis. Particularly, ERα, PR, hMLH1, CDKN2A\/P16, SFRP1, SFRP2 and SFRP5 revealed a promoter methylation status in endometrioid carcinoma, whereas SFRP4 showed demethylation in cancer. P53 immunostaining showed weak-focal protein expression level both in hyperplasic lesions and in endometrioid cancer. Non-endometrioid cancers showed very low levels of epigenetic methylations, but strong P53 protein positivity. Fisher exact test revealed a statistically significant association between hMLH1, CDKN2A\/P16 and SFRP1 genes methylation and endometrioid carcinomas and between hMLH1 gene methylation and peritumoral endometrium (p < 0.05). Our data confirm that the methylation profile of the peritumoral endometrium is different from the altered molecular background of benign endometrial polyps and hyperplasias. Therefore, our findings suggest that the methylation of hMLH1, CDKN2A\/P16 and SFRP1 may clearly distinguish between benign and malignant lesions. Finally, this study assessed that the use of an epigenetic fingerprint may improve the current diagnostic tools for a better clinical management of endometrial lesions.

Monte Carlo in radiotherapy: experience in a distributed computational environment

New technologies in cancer radiotherapy need a more accurate computation of the dose delivered in the radiotherapeutical treatment plan, and it is important to integrate sophisticated mathematical models and advanced computing knowledge into the treatment planning (TP) process. We present some results about using Monte Carlo (MC) codes in dose calculation for treatment planning. A distributed computing resource located in the Technologies and Health Department of the Italian National Institute of Health (ISS) along with other computer facilities (CASPUR - Inter-University Consortium for the Application of Super-Computing for Universities and Research) has been used to perform a fully complete MC simulation to compute dose distribution on phantoms irradiated with a radiotherapy accelerator. Using BEAMnrc and GEANT4 MC based codes we calculated dose distributions on a plain water phantom and air/water phantom. Experimental and calculated dose values below ±2% (for depth between 5 mm and 130 mm) were in agreement both in PDD (Percentage Depth Dose) and transversal sections of the phantom. We consider these results a first step towards a system suitable for medical physics departments to simulate a complete treatment plan using remote computing facilities for MC simulations

Innovative approaches to active and healthy ageing: Campania experience to improve the adoption of innovative good practices

The demographic projections on the European population predict that people aged over 60 will increase by about two million/year in the next decades. Since 2012, the Campania Reference Site of the European Innovation Partnership on Active and Healthy Ageing supports the innovation of the Regional Health System, to face up demographic changes and sustainability. Campania Reference Site provides the opportunity to connect loco-regional stakeholders in social and health care services (universities, healthcare providers, social services, local communities and municipalities), with international organizations, in order to adopt and scale up innovative solutions and approaches. This paper describes the building process of Campania Reference Site and the main results achieved, that have been allowing it to become a hub for open innovation in the field of active and healthy aging at regional, national and international level

The reference site collaborative network of the european innovation partnership on active and healthy ageing

Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs

Water, Population Growth and Contagious Diseases

Water, essential for the biology of living organisms, is also important for agriculture, for the organization of social life and for culture. In this review we discuss the interrelationship between water availability and human population size. The total population of the globe, 3&#8315;5 million people between the years 25,000 and 5000 Before Common Era (BCE), increased about 50-fold in coincidence with the development of agriculture. Later on, after the year 200 Common Era (CE), the number of people did not change appreciably and increased slowly in the period 1000 to 1500 CE. We show that the main cause of this observed slow-down in population growth was the increase in population density, which caused the appearance and spreading of infectious diseases, often due to the use of contaminated water. Population started to increase again when people learned how to use appropriate sanitation and hygienic rules. The management of water resources, including transport of water to the areas where it is needed, separation and depuration of wastewater and production of freshwater by desalination, have become increasingly important. The population level is today very high and will continue to grow, thus causing a further increase in the density of people and an increased risk of contagious diseases. Therefore, more water for sanitation will be needed all over the world