Comparing Treatments for Age-related Macular Degeneration: Safety, Effectiveness and Cost

Comparative effectiveness research (CER) has received widespread attention and federal funding because of its potential to inform and improve treatment decisions. Since 2005, patients and their ophthalmologists have faced a dilemma in treating age-related macular degeneration (AMD)—the leading cause of blindness in the United States. Two closely related drugs have produced dramatic improvements in vision; one has been rigorously tested for use in AMD patients, while the other has been rigorously tested for use in cancer patients, but is now widely used to treat AMD. One drug costs 40 times as much as the other. This Issue Brief summarizes a CER study comparing these drugs head-to-head, and provides the most definitive evidence to date about the safety and effectiveness of the two alternatives

Job Training That Works: Findings from the Sectoral Employment Impact Study

Public funding for employment and training has dwindled over the past several decades. Yet in communities all over the United States, there has been considerable development of alternative approaches to help low-income people gain skills for particular industry sectors. In 2003, with support from the Charles Stewart Mott Foundation, P/PV launched the Sectoral Employment Impact Study to test the efficacy of one such approach. Using a random-assignment design, P/PV researchers set out to answer the question: Can well-implemented, sector-focused training programs make a difference to the earnings of low-income disadvantaged workers and job seekers? Three organizations were selected to participate in the study: Jewish Vocational Service in Boston, Per Scholas in the Bronx and the Wisconsin Regional Training Partnership in Milwaukee. This issue of P/PV In Brief summarizes impacts found for participants across the three sites, including increases in earnings and employment; a more detailed report on the study will be released in late 2009

Tuning In to Local Labor Markets: Findings From the Sectoral Employment Impact Study, Executive Summary

This executive summary highlights the main findings and conclusions from "Tuning In to Local Labor Markets: Findings From the Sectoral Employment Impact Study" -- the first random assignment evaluation of sector-focused training efforts. We studied three nonprofit organizations -- a community-based organization focused on medical and basic office skills in Boston, a social venture focused on information technology in the Bronx, and an employer-union partnership focused on healthcare, manufacturing and construction in Milwaukee -- and found that participants in these programs worked more, had higher earnings and found better jobs (as measured by hourly wages and access to benefits) than members of the control group.The executive summary examines strategies used by the three organizations in the study, describes the people served, and outlines common elements that likely contributed to the programs success

Tuning In to Local Labor Markets: Findings From the Sectoral Employment Impact Study

Over the past two decades, an innovative approach to workforce development known as sectoral employment has emerged, resulting in the creation of industry-specific training programs that prepare unemployed and underskilled workers for skilled positions and connect them with employers seeking to fill such vacancies. In 2003, with funding from the Charles Stewart Mott Foundation, P/PV launched the "Sectoral Employment Impact Study" to rigorously assess whether mature, nonprofit-led sector-focused programs could increase the earnings of disadvantaged workers and job seekers. P/PV selected three organizations to participate in the study -- a community-based organization focused on medical and basic office skills in Boston, a social venture focused on information technology in the Bronx, and an employer-union partnership focused on healthcare, manufacturing and construction in Milwaukee. The study's findings show that program participants earned about $4,500 -- 18 percent -- more than the control group over the course of the study and$4,000 -- 29 percent -- more in the second year alone. Study participants were also more likely to find employment, work more consistently, work in jobs that paid higher wages, and work in jobs that offered benefits. Furthermore, there were earnings gains for each subgroup analyzed, including African Americans, Latinos, immigrants, formerly incarcerated individuals and young adults. Tuning In to Local Labor Markets also examines the strategies employed by the three organizations that took part in the study, as well as the common elements that appeared to be critical to their success. Implications for practice, policy and future research are explored; a forthcoming piece will provide detailed recommendations for policymakers

Post-war planning in Massachusetts municipalities

This item was digitized by the Internet Archive. Thesis (M.A.)--Boston Universityhttps://archive.org/details/postwarplanningi00mag

The Baltic Provinces and the Russian Empire: Provincial Privilege and Imperial Prerogative in the Process of Agrarian Reform in Livland, Estland and Kurland, 1765-1849

The dissertation examines the process of agrarian reform in Livland, Estland and Kurland in the period 1765 to 1849 from a provincial/imperial perspective. The interaction of provincial privilege and imperial prerogative is seen as a major catalyst in the reform process. The perspective not only sheds light on the development of agrarian reform in the Baltic provinces but illuminates the nature of the Baltic/Russian relationship in the period under study. The research is interpretative and analytical within a chronological framework with thematic emphases in each chapter. It attempts to remove both the reform initiatives and the historical Baltic/Russian relationship from traditional interpretation and provide fresh perspectives. There are no notable works of synthesis on Baltic/Russian relations in the era of reform. This research is a step towards filling that gap. In addition, the reappraisal of Baltic/Russian historical relations as well as the comprehensive and detailed survey of agrarian legislation in the Baltic provinces from 1765 to 1849 should be of particular use to British scholars since there is a significant lack of writing in Baltic history of the period in English. The major literature used in the research was predominantly German and Russian

Word mastery in oral reading; 'look on' versus 'not look on' in grade I.

Thesis (Ed.M.)--Boston Universit

Synthesis and stereoselective oxidation of α-Thio-β- chloropropenyloxazolidin-2-ones

Investigation of the stereoselective reaction of α-thiopropanoyloxazolidin-2-ones with NCS to yield α-thio-β-chloropropenyloxazolidin-2-ones is described. Diastereoselective sulfur oxidation of the resulting α-thio-β-chloropropenyloxazolidin-2-ones is also discussed, with modest diastereocontrol achieved. However, through a combination of diastereoselective oxidation and subsequent kinetic resolution in the sulfoxide oxidation, diastereoselectivities of up to 94% de are achieved

Investigation of the reaction of α-Thioamides, α-esters and α–nitriles with N-halosuccinimides

Investigation of the reaction of α-thioamides, α-esters and α-nitriles with NBS and NCS is described. The scope of this stereoselective oxidative transformation to the β- haloacrylamides, β-acrylates and β–acrylonitriles has been determined. A mechanistic rationale to explain the observed differences in reactivity between the amide, ester and nitrile series is proposed

Changes in Intraocular Pressure with Use of Periocular Triamcinolone Cream

Purpose: To evaluate the effect of periocular topical triamcinolone cream on intraocular pressure. Methods: A retrospective chart review identified 57 patients, 114 eyes using triamcinolone cream (0.1%, 0.025%) with subsequent intraocular pressure (IOP) checks at three follow-up visits. Descriptive, univariate, and multivariate analyses were performed to assess effects of age, therapy duration, consecutive weeks on steroid, prescription strength, time of day, and method of measurement on IOP levels. Generalized Estimating Equations were used in regression models to account for correlation of eyes within subjects and across visits. Results: We identified 57 patients using triamcinolone cream for allergic or eczematous dermatitis of the eyelid. Prescription strengths were 0.025% or 0.1% and patients were followed for a median of 4.9 months. Measurements of IOP at baseline did not change as compared to all IOP measurements at follow-ups and did not change with steroid strength. The mean change in IOP at all follow-up visits was 0.07 mm Hg (95% confidence interval [CI]: –0.36, 0.50). After adjustment for the method of tonometer and the patient’s age, the mean change was 0.03 mm Hg (95% CI: –0.68, 0.73, P = 0.93). Prescription strength and consecutive weeks of therapy were not associated with IOP. Two patients experienced a significant elevation in IOP of >10 mm Hg, one through the concomitant consequences of systemic corticosteroids usage and the other through prolonged topical application. Conclusion: In patients taking periocular triamcinolone cream, there was no clinically meaningful change in mean IOP between baseline and follow-up visits, and IOP measurements were not related to variances in prescription strength or duration of therapy