59 research outputs found
Pharmacokinetics of 6-thioguanine nucleotide and 6-methyl-mercaptopurine in a case of inadvertent combination therapy of azathioprine with allopurinol
A case report of azathioprine-induced recurrent acute pancreatitis associated with high levels of 6-thioguanine nucleotides in a renal transplant recipient
Azathioprine-related severe diarrhea induced by high levels of 6-thioguanine nucleotides in renal transplant recipient carrying mutant thiopurine methyltransferase: A case report
Potencial forrageiro de gramíneas em condições de baixas temperaturas e altitude elevada
Resposta à flexão e análise de tenacidade de argamassas reforçadas com fibra de Curauá
O desenvolvimento e comercialização de materiais compósitos produzidos a partir de fibras naturais são considerados extremamente importante, uma vez que essas fibras reduzirão a dependência dos materiais produzidos com recursos não renováveis. Dentre essas fibras naturais destaca-se a fibra do curauá, sua utilização na produção de compósitos melhora de forma notável as propriedades do conjunto fibra matriz, logo o presente artigo objetiva estudar as propriedades mecânicas de compósitos reforçados com fibra de curauá, em especial sua resistência à flexão e tenacidade. Para isso foram confeccionadas cinco famílias de argamassas, uma de referência sem utilização da fibra e as outras quatro reforçada com fibra variando o comprimento da fibra e sua fração volumétrica. Verificou-se que a fibra do curauá ao ser adicionada em matriz cimentícia melhora suas propriedades mecânicas comparada a um compósito não reforçado com fibra, sua deformação, resistência à flexão e tenacidade são melhoradas
Efeito da eliminação genética das lipoxigenases das sementes sobre as características agronômicas da soja
Cultivares de alfafa em área de influência da Mata Atlântica no Estado de Minas Gerais
Características produtivas e qualitativas de pastagem de braquiária em monocultivo e consorciada com estilosantes
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal
INTRODUCTION:
Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population.
MATERIALS AND METHODS:
We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period.
RESULTS:
Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2-43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3-33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing cross-protection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7-41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed.
CONCLUSIONS:
Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures.info:eu-repo/semantics/publishedVersio
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