Support for a synaptic chain model of neuronal sequence generation

In songbirds, the remarkable temporal precision of song is generated by a sparse sequence of bursts in the premotor nucleus HVC. To distinguish between two possible classes of models of neural sequence generation, we carried out intracellular recordings of HVC neurons in singing zebra finches (Taeniopygia guttata). We found that the subthreshold membrane potential is characterized by a large, rapid depolarization 5–10 ms before burst onset, consistent with a synaptically connected chain of neurons in HVC. We found no evidence for the slow membrane potential modulation predicted by models in which burst timing is controlled by subthreshold dynamics. Furthermore, bursts ride on an underlying depolarization of ~10-ms duration, probably the result of a regenerative calcium spike within HVC neurons that could facilitate the propagation of activity through a chain network with high temporal precision. Our results provide insight into the fundamental mechanisms by which neural circuits can generate complex sequential behaviours.National Institutes of Health (U.S.) (Grant MH067105)National Institutes of Health (U.S.) (Grant DC009280)National Science Foundation (U.S.) (IOS-0827731)Alfred P. Sloan Foundation (Research Fellowship

The Properties of Lion Roars and Electron Dynamics in Mirror Mode Waves Observed by the Magnetospheric MultiScale Mission

Mirror mode waves are ubiquitous in the Earth's magnetosheath, in particular behind the quasi‐perpendicular shock. Embedded in these nonlinear structures, intense lion roars are often observed. Lion roars are characterized by whistler wave packets at a frequency ∼100 Hz, which are thought to be generated in the magnetic field minima. In this study, we make use of the high time resolution instruments on board the Magnetospheric MultiScale mission to investigate these waves and the associated electron dynamics in the quasi‐perpendicular magnetosheath on 22 January 2016. We show that despite a core electron parallel anisotropy, lion roars can be generated locally in the range 0.05–0.2fce by the perpendicular anisotropy of electrons in a particular energy range. We also show that intense lion roars can be observed up to higher frequencies due to the sharp nonlinear peaks of the signal, which appear as sharp spikes in the dynamic spectra. As a result, a high sampling rate is needed to estimate correctly their amplitude, and the latter might have been underestimated in previous studies using lower time resolution instruments. We also present for the first‐time 3‐D high time resolution electron velocity distribution functions in mirror modes. We demonstrate that the dynamics of electrons trapped in the mirror mode structures are consistent with the Kivelson and Southwood (1996) model. However, these electrons can also interact with the embedded lion roars: first signatures of electron quasi‐linear pitch angle diffusion and possible signatures of nonlinear interaction with high‐amplitude wave packets are presented. These processes can lead to electron untrapping from mirror modes

Electron-scale measurements of magnetic reconnection in space

Magnetic reconnection is a fundamental physical process in plasmas whereby stored magnetic energy is converted into heat and kinetic energy of charged particles. Reconnection occurs in many astrophysical plasma environments and in laboratory plasmas. Using very high time resolution measurements, NASA’s Magnetospheric Multiscale Mission (MMS) has found direct evidence for electron demagnetization and acceleration at sites along the sunward boundary of Earth’s magnetosphere where the interplanetary magnetic field reconnects with the terrestrial magnetic field. We have (i) observed the conversion of magnetic energy to particle energy, (ii) measured the electric field and current, which together cause the dissipation of magnetic energy, and (iii) identified the electron population that carries the current as a result of demagnetization and acceleration within the reconnection diffusion/dissipation region

Hippocampal state-dependent behavioral reflex to an identical sensory input in rats.

We examined the local field potential of the hippocampus to monitor brain states during a conditional discrimination task, in order to elucidate the relationship between ongoing brain states and a conditioned motor reflex. Five 10-week-old Wistar/ST male rats underwent a serial feature positive conditional discrimination task in eyeblink conditioning using a preceding light stimulus as a conditional cue for reinforced trials. In this task, a 2-s light stimulus signaled that the following 350-ms tone (conditioned stimulus) was reinforced with a co-terminating 100-ms periorbital electrical shock. The interval between the end of conditional cue and the onset of the conditioned stimulus was 4±1 s. The conditioned stimulus was not reinforced when the light was not presented. Animals successfully utilized the light stimulus as a conditional cue to drive differential responses to the identical conditioned stimulus. We found that presentation of the conditional cue elicited hippocampal theta oscillations, which persisted during the interval of conditional cue and the conditioned stimulus. Moreover, expression of the conditioned response to the tone (conditioned stimulus) was correlated with the appearance of theta oscillations immediately before the conditioned stimulus. These data support hippocampal involvement in the network underlying a conditional discrimination task in eyeblink conditioning. They also suggest that the preceding hippocampal activity can determine information processing of the tone stimulus in the cerebellum and its associated circuits

Crossmodal duration perception involves perceptual grouping, temporal ventriloquism, and variable internal clock rates

Here, we investigate how audiovisual context affects perceived event duration with experiments in which observers reported which of two stimuli they perceived as longer. Target events were visual and/or auditory and could be accompanied by nontargets in the other modality. Our results demonstrate that the temporal information conveyed by irrelevant sounds is automatically used when the brain estimates visual durations but that irrelevant visual information does not affect perceived auditory duration (Experiment 1). We further show that auditory influences on subjective visual durations occur only when the temporal characteristics of the stimuli promote perceptual grouping (Experiments 1 and 2). Placed in the context of scalar expectancy theory of time perception, our third and fourth experiments have the implication that audiovisual context can lead both to changes in the rate of an internal clock and to temporal ventriloquism-like effects on perceived on- and offsets. Finally, intramodal grouping of auditory stimuli diminished any crossmodal effects, suggesting a strong preference for intramodal over crossmodal perceptual grouping (Experiment 5)

Fostering support for non-democratic rule? Controlled political liberalization and popular support for non-democratic regimes

When the Cold War ended, many non-democratic regimes across the globe embarked on a course of controlled political liberalization, hoping to stabilize their autocratic rule by mitigating popular demands for democratization and increasing regime legitimacy. But does this strategy actually work? This article uses multi-level analyses to examine how the degree of political liberalization affects regime support in non-democratic political systems and to ascertain which mechanisms underlie this effect. Drawing on aggregate measures of political liberalization and comparative survey data from four regional survey projects and 31 non-democracies, the study's results indicate that the degree of liberalization has no decisively positive effect on regime support, suggesting controlled political liberalization might not be an effective legitimizing strategy after all.Nach Ende des Kalten Krieges haben viele nicht-demokratische Regime weltweit einen Kurs der begrenzten politischen Öffnung eingeschlagen, um öffentliche Forderungen nach Demokratisierung zu entschärfen und auf diese Weise die Legitimität ihrer autokratischen Herrschaft zu erhöhen. Doch ist diese Strategie tatsächlich effektiv? Der Beitrag verwendet Mehrebenenanalysen, um zu untersuchen wie der Grad an politischer Öffnung die Regimerunterstützung in nicht-demokratischen politischen Systemen beeinflusst. Auf Basis von Aggregatmaßen zur politischen Öffnung und Individualdaten aus vier regionalen Umfrageprojekten und 31 Autokratien kann kein klarer positiver Effekt des Grads der politischen Öffnung auf die Regimeunterstützung nachgewiesen werden, was eine begrenzte politische Öffnung als wenig effektive Legitimationsstrategie erscheinen lässt

Lower-hybrid drift waves and electromagnetic electron space-phase holes associated with dipolarization fronts and field-aligned currents observed by the Magnetospheric Multiscale mission during a substorm

We analyse two ion scale dipolarization fronts associated with field-aligned currents detected by the Magnetospheric Multiscale mission during a large substorm on August 10, 2016. The first event corresponds to a fast dawnward flow with an anti-parallel current and could be generated by the wake of a previous fast earthward flow. It is associated with intense lower-hybrid drift waves detected at the front and propagating dawnward with a perpendicular phase speed close to the electric drift and the ion thermal velocity. The second event corresponds to a flow reversal: from southwward/dawnward to northward/duskward associated with a parallel current consistent with a brief expansion of the plasma sheet before the front crossing, and with a smaller lower-hybrid drift wave activity. Electromagnetic electron phase-space holes are detected near these low-frequency drift waves during both events. The drift waves could accelerate electrons parallel to the magnetic field and produce the parallel electron drift needed to generate the electron holes. Yet, we cannot rule out the possibility that the drift waves are produced by the anti-parallel current associated with the fast flows, leaving the source for the electron holes unexplained