Determination of the influence of the driving speed on the application parameters of orchard sprayers

Orchard sprayers with air transported fine droplets need an exact adjustment of the airflow and the spray nozzles in order to reduce the drift of pesticides. The adjustment is made on one hand side by the manufacturer and on the other hand side by the farmer in the orchard by choosing the tractor speed, the PTO shaft rotation speed and the pump pressure. For testing two test beds have been in charge in the region of Styria since almost 2 decades. One of them is able to measure the flow field in a vertical plane representing the tree row in a distance of approx. 1.5 m from the middle of the track. The second measures the water distribution in the same vertical plane. Both are stationary so that the influence of the driving speed can hardly be assessed. High driving speeds up to 12 km/h and the increasing height of the orchards impose additional uncertainties. This was the reason for the present research project, which was intended to investigate the influence of the driving speed. A new air flow measurement test bed has been build, which is able to measure the flow field also during tractor movement in the described vertical plane up to 5 m above ground. Four different sprayers have been investigated in an orchard with and without leaves by visual method for four different speeds to determine the optimal application parameters. The same sprayers have been tested with the moveable flow field test bed. Results show a reasonable correlation between the measurements for all investigated speeds. The differences between the sprayers are evident, nevertheless a method has been found to deduce the correlation between the stationary measurement and the optimal parameters for the orchard. So the stationary flow test bed can be directly used to develop sprayers

CaMKII delta C Drives Early Adaptive Ca(2+)Change and Late Eccentric Cardiac Hypertrophy

Rationale: CaMKII (Ca2+-Calmodulin dependent protein kinase) delta C activation is implicated in pathological progression of heart failure (HF) and CaMKII delta C transgenic mice rapidly develop HF and arrhythmias. However, little is known about early spatio-temporal Ca(2+)handling and CaMKII activation in hypertrophy and HF. Objective: To measure time- and location-dependent activation of CaMKII delta C signaling in adult ventricular cardiomyocytes, during transaortic constriction (TAC) and in CaMKII delta C transgenic mice. Methods and Results: We used human tissue from nonfailing and HF hearts, 4 mouse lines: wild-type, KO (CaMKII delta-knockout), CaMKII delta C transgenic in wild-type (TG), or KO background, and wild-type mice exposed to TAC. Confocal imaging and biochemistry revealed disproportional CaMKII delta C activation and accumulation in nuclear and perinuclear versus cytosolic regions at 5 days post-TAC. This CaMKII delta activation caused a compensatory increase in sarcoplasmic reticulum Ca(2+)content, Ca(2+)transient amplitude, and [Ca2+] decline rates, with reduced phospholamban expression, all of which were most prominent near and in the nucleus. These early adaptive effects in TAC were entirely mimicked in young CaMKII delta TG mice (6-8 weeks) where no overt cardiac dysfunction was present. The (peri)nuclear CaMKII accumulation also correlated with enhanced HDAC4 (histone deacetylase) nuclear export, creating a microdomain for transcriptional regulation. At longer times both TAC and TG mice progressed to overt HF (at 45 days and 11-13 weeks, respectively), during which time the compensatory Ca(2+)transient effects reversed, but further increases in nuclear and time-averaged [Ca2+] and CaMKII activation occurred. CaMKII delta TG mice lacking delta B exhibited more severe HF, eccentric myocyte growth, and nuclear changes. Patient HF samples also showed greatly increased CaMKII delta expression, especially for CaMKII delta C in nuclear fractions. Conclusions: We conclude that in early TAC perinuclear CaMKII delta C activation promotes adaptive increases in myocyte Ca(2+)transients and nuclear transcriptional responses but that chronic progression of this nuclear Ca2+-CaMKII delta C axis contributes to eccentric hypertrophy and HF

Blushift of a tachyon in the charged 2D black hole

We study the propagation of string fields (metric $G_{\mu\nu}$, Mawxell gauge potential $A_{\mu}$, dilaton $\Phi$, and tachyon $T$) in a two-dimensional (2D) charged black hole. It is shown that the tachyon is a propagating field both inside and outside the black hole. This becomes infinitely blueshifted at the inner horizon. We confirm that the inner horizon is unstable, whereas the outer horizon is stable.Comment: 15 pages 3 figures, RevTeX, to be published Phys. Rev. D52 (15 November,1995), to obtain the figures contact Author ([email protected]

Influence of Caloric Restriction on Constitutive Expression of NF-κB in an Experimental Mouse Astrocytoma

Many of the current standard therapies employed for the management of primary malignant brain cancers are largely viewed as palliative, ultimately because these conventional strategies have been shown, in many instances, to decrease patient quality of life while only offering a modest increase in the length of survival. We propose that caloric restriction (CR) is an alternative metabolic therapy for brain cancer management that will not only improve survival but also reduce the morbidity associated with disease. Although we have shown that CR manages tumor growth and improves survival through multiple molecular and biochemical mechanisms, little information is known about the role that CR plays in modulating inflammation in brain tumor tissue.Phosphorylation and activation of nuclear factor κB (NF-κB) results in the transactivation of many genes including those encoding cycloxygenase-2 (COX-2) and allograft inflammatory factor-1 (AIF-1), both of which are proteins that are primarily expressed by inflammatory and malignant cancer cells. COX-2 has been shown to enhance inflammation and promote tumor cell survival in both in vitro and in vivo studies. In the current report, we demonstrate that the p65 subunit of NF-κB was expressed constitutively in the CT-2A tumor compared with contra-lateral normal brain tissue, and we also show that CR reduces (i) the phosphorylation and degree of transcriptional activation of the NF-κB-dependent genes COX-2 and AIF-1 in tumor tissue, as well as (ii) the expression of proinflammatory markers lying downstream of NF-κB in the CT-2A malignant mouse astrocytoma, [e.g. macrophage inflammatory protein-2 (MIP-2)]. On the whole, our date indicate that the NF-κB inflammatory pathway is constitutively activated in the CT-2A astrocytoma and that CR targets this pathway and inflammation.CR could be effective in reducing malignant brain tumor growth in part by inhibiting inflammation in the primary brain tumor