58 research outputs found
Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1
Subarachnoid hemorrhage (SAH) carries a 50% mortality rate. The extravasated erythrocytes that surround the brain contain heme, which, when released from damaged red blood cells, functions as a potent danger molecule that induces sterile tissue injury and organ dysfunction. Free heme is metabolized by heme oxygenase (HO), resulting in the generation of carbon monoxide (CO), a bioactive gas with potent immunomodulatory capabilities. Here, using a murine model of SAH, we demonstrated that expression of the inducible HO isoform (HO-1, encoded by Hmox1) in microglia is necessary to attenuate neuronal cell death, vasospasm, impaired cognitive function, and clearance of cerebral blood burden. Initiation of CO inhalation after SAH rescued the absence of microglial HO-1 and reduced injury by enhancing erythrophagocytosis. Evaluation of correlative human data revealed that patients with SAH have markedly higher HO-1 activity in cerebrospinal fluid (CSF) compared with that in patients with unruptured cerebral aneurysms. Furthermore, cisternal hematoma volume correlated with HO-1 activity and cytokine expression in the CSF of these patients. Collectively, we found that microglial HO-1 and the generation of CO are essential for effective elimination of blood and heme after SAH that otherwise leads to neuronal injury and cognitive dysfunction. Administration of CO may have potential as a therapeutic modality in patients with ruptured cerebral aneurysms
Noah's Sons
Genesis 5–10 gives Noah’s three sons Shem, Ham, and Japheth great significance by presenting them as the three ancestors of postdiluvian humanity. Within this section two literary
units focus on them: the story of Noah’s vineyard and drunkenness in Gen 9:18–27 and the Table of Nations in Gen 10. Whereas the first account describes a hierarchical relationship between the three ancestors (and their respective descendants), the second one, in the form of a segmented genealogy, shows the ancestors’ equal dispersion over the world and their inner differentiation into nations, tribes, and languages. Noah’s sons are furthermore mentioned at the end of the genealogy in Gen 5 and in the flood narrative
Racial Group Affinity and Religious Giving: Evidence from Congregation-Level Panel Data
Since giving to religious organizations constitutes a substantial portion of total charitable giving, an understanding of the determinants of religious giving is a vital policy concern. Drawing on a novel congregation-level panel dataset, we examine whether religious giving is driven by preferences for racial group affinity, that is, loyalty to one's own racial group. To address endogeneity concerns, we combine a fixed effects estimation framework with an instrumental variable approach. We find robust evidence consistent with the racial group affinity motive: a decrease in the percent of whites in the county is ceteris paribus associated with a decrease in the total giving receipts collected by predominantly white congregations
The Principle of Detachment from Private Property in Basil of Caesarea's Homily 6 and Its Context
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Scattering Seeds of virtus et scientia: The Founding and Educational Visions for Fontbonne University
Patristic Social Thought and Contemporary Christian Social Thought: Some Hermeneutical Models for a Dialogue
Acknowledgments v
Abbreviations vii
List of Tables viii
Bibliography ix
Introduction xl
Chapter 1. Patristic Sources and Catholic Social Teaching
I. Overview of the Study 3
II. Six Problem Areas 5
A. (In-)Frequency of use 5
B. Context Oversight 11
C. Context Mismatch 12
D. (Mis-)Quotation 14
E. Patristic sources not socio-ethical sources 17
F. Uneven contribution to CST rhetoric 18
III. A New Vision for CST 21
IV. Chapter Summary 23
Chapter 2. Survey of Patristic Social Thought
I. Studying Patristic Social Thought 25
II. Major Themes in Patristic Social Thought 33
A. Common Good 34
1. Common Good in the Greek and Roman Context 35
2. Common Good in Christian Teaching and Its Context 38
3. Review of the Secondary Literature on the Common Good 42
B. Private Property 44
1. Private Property in the Greek and Roman Context 44
2. Private Property in Christian Teaching and Its Context 48
3. Review of the Secondary Literature on Private Property 54
C. The Poor 59
1. The Poor in the Greek and Roman Context 59
2. The Poor in Christian Teaching and Its Context 62
3. Review of the Secondary Literature on the Poor 66
III. Chapter Summary 68
Chapter 3. Application of an “Authorial Intent” Model
I. Survey of the “Authorial Intent” Model 69
II. Application of the Model to Asterius of Amasea’s Homily 1 76
A. Date and Setting of the homily 77
B. Summary of the Homily 77
1. Homily 1.1 77
2. Homily 1.2-5 78
3. Homily 1.6-8 80
4. Homily 1.9-12 82
C. Social Thought of the Homily 84
D. Summary 90
III. Application of the Model to Jerome’s Homily 86 90
A. Date and Setting of the homily 91
B. Summary of the Homily 92
1. Homily 86.1-57 92
2. Homily 86.58-138 94
3. Homily 86.139-231 96
4. Homily 86.232-327 98
C. Social Thought of the Homily 99
D. Summary 102
IV. Chapter Summary 103
Chapter 4. Application of a “Distanciation” Model
I. Survey of the “Distanciation” Model 105
II. Application of the Model to Asterius of Amasea’s Homily 1 116
III. Application of the Model to Jerome’s Homily 86 121
IV. Chapter Summary 129
Chapter 5. Application of the “Normativity of the Future” Model
I. Survey of the Normativity of the Future Model 130
II. Application of the Model to Asterius of Amasea’s Homily 1 136
III. Application of the Model to Jerome’s Homily 86 140
IV. Chapter Summary 146
Chapter 6. Application of a “New Intellectual History” Model
I. Survey of a “New Intellectual History” Model 149
II. Application of the Model to Asterius of Amasea’s Homily 1 156
III. Application of the Model to Jerome’s Homily 86 161
IV. Chapter Summary 165
Chapter 7. Conclusion
I. Review of the Study 168
II. Some Spaces for Dialogue between Patristic and Christian Social Thought 173
Appendices
I. Text of Asterius of Amasea’s Homily 1 A-1
II. Text of Jerome’s Homily 86 A-10
III. Patristic Sources and Catholic Social Teaching: A Forgotten Dimension A-18
A. General Introduction A-18
B. Analysis of the Patristic Source Citations A-25
IV. The Hermeneutic of Detachment from Private Property in Basil of Caesarea’s Homily 6 A-142nrpages: 381status: publishe
\u27Beware of the Leaven of the Pharisees:\u27 Jewish Teaching and Heresy in Early Christian Exegesis of Matt 16:6-12
Papers presented at the 5th Novum Testamentum Patristicum Conference, held October 16-19, 2013, in Groningen, The Netherlands.
Includes \u27Beware of the Leaven of the Pharisees:\u27 Jewish Teaching and Heresy in Early Christian Exegesis of Matt 16:6-12, presented by Brian J. Matz.https://griffinshare.fontbonne.edu/faculty-books/1014/thumbnail.jp
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