Evaluation and Optimization of Daylighting in Heritage Buildings: A Case-Study at High Latitudes

Transforming historical listed buildings into workplaces is a serious challenge, particularly for buildings with relatively small windows in the facades, which determine scarce daylighting indoors. This paper studied how daylighting can be significantly increased in a case-study historical building through rooflighting systems, as the facade cannot be modified. The case-study was a historic and iconic warehouse built-in 1681 in Trondheim, Norway. The optimized configuration was analyzed in terms of daylight amount and view analysis, according to EN 17037 and to LEED v4.1 protocol. A critical evaluation of the actual applicability of the optimized Scenario in the real building was carried out along with the constructors. A 3D model was built in Rhinoceros, and daylighting simulations of the base-case (the building in the existing configuration) and for 6 alternative Scenarios were run through Climate Studio. The following metrics were calculated: Daylight Factor (DF), Spatial Daylight Autonomy (sDA), Annual Sunlight Exposure (ASE), and views. An optimized configuration was eventually identified through the Galapagos component in Grasshopper, with an average DF value of 2.7% (against 0.9% in the base-case configuration), higher than the target DFm of 2.4% for Norway), and a sDA value of 50.2% (14.2% in base-case configuration)

Susceptibility profiles and correlation with pneumococcal serotypes soon after implementation of the 10-valent pneumococcal conjugate vaccine in Brazil

SummaryObjectivesTo evaluate the susceptibility patterns among Streptococcus pneumoniae recovered during the years 2010–2012 and to correlate these with serotypes.MethodsPneumococci from invasive sites were serotyped by sequential multiplex PCR and/or Quellung reaction. Etest strips were used to determine the minimal inhibitory concentrations, and the Clinical and Laboratory Standards Institute (CLSI) guidelines were used for interpretation. Genetic determinants of macrolide resistance were assessed by PCR, and the occurrence of the D phenotype was analyzed following the recommendations of the CLSI.ResultsOne hundred fifty-nine S. pneumoniae were studied; most were recovered from blood and were associated with serotypes 14, 3, 4, 23F, 20, 7F, 12F, 19A, and 19F. Pneumococcal conjugate vaccine PCV7, PCV10, and PCV13 and 23-valent polysaccharide vaccine serotypes represented 38.2%, 48.7%, 64.5%, and 85.5%, respectively. β-Lactam non-susceptibility (non-meningitis) was basically related to serotype 19A. For meningitis, it was observed in 21.4% (serotypes 14, 3, 9V, 23F, and 24F). Resistance to erythromycin occurred in 8.2% and mefA was the most common macrolide genetic determinant. One isolate was resistant to levofloxacin. Non-susceptibility to trimethoprim–sulfamethoxazole was 37.7% and to tetracycline was 22.0%.ConclusionsOur population of pneumococci represents a transition era, soon after the introduction of PCV10. Non-susceptible patterns were found to be associated with classical PCV serotypes (especially serotype 14), which is still highly prevalent, and non-PCV10 ones (19A), which may disseminate, occupying the biological niche left by the vaccine serotypes

Neurocriptococose na infância: relato de três casos na primeira década de vida

Os autores relatam três casos de neurocriptococose em crianças na primeira década de vida, no Estado do Rio Grande do Sul. O diagnóstico foi estabelecido pelo encontro do fungo Cryptococcus neoformans no líquido céfalo-raquidlano por exame direto com tinta da China e cultura em meio de Sabouraud. As formas de instalação da síndrome neurológica foram aguda, subaguda e crônica. Síndrome de hipertensão intracraniana e hidrocefalia foram complicações observadas durante a evolução da doença, sendo necessária a instalação de derivação ventrículo-peritonial em um caso. Desnutrição foi o processo mórbido associado nos três casos e infecção pelo bacilo da tuberculose em um caso. Terapia específica foi administrada aos três pacientes. Um paciente evoluiu para cura e dois evoluíram para óbito