66 research outputs found

    A multichannel typology of temporary employment careers in the Netherlands: Identifying traps and stepping stones in terms of employment and income security

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    In this paper, we apply multichannel sequence analysis of labour market positions and incomes to create a typology of careers starting with temporary employment in the Netherlands. For this purpose, we use detailed register data from Statistics Netherlands for all workers who entered temporary employment in 2007 and were observed for 96 months. This approach leads to a typology of 17 different career types that shows a considerably larger variation - in terms of employment and income security - than previous research has shown. Specifically, the typology shows that 29.6% of the research population has a stepping stone career with high career and income security, while 39.7% has a dead-end career with low career and income security. However, a large part of careers – 24.7% – cannot be classified in this traditional distinction, as they combine high employment security and low incomes or high incomes and low employment security

    Viperin mRNA is a novel target for the human RNase MRP/RNase P endoribonuclease

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    RNase MRP is a conserved endoribonuclease, in humans consisting of a 267-nucleotide RNA associated with 7–10 proteins. Mutations in its RNA component lead to several autosomal recessive skeletal dysplasias, including cartilage-hair hypoplasia (CHH). Because the known substrates of mammalian RNase MRP, pre-ribosomal RNA, and RNA involved in mitochondrial DNA replication are not likely involved in CHH, we analyzed the effects of RNase MRP (and the structurally related RNase P) depletion on mRNAs using DNA microarrays. We confirmed the upregulation of the interferon-inducible viperin mRNA by RNAi experiments and this appeared to be independent of the interferon response. We detected two cleavage sites for RNase MRP/RNase P in the coding sequence of viperin mRNA. This is the first study providing direct evidence for the cleavage of a mRNA by RNase MRP/RNase P in human cells. Implications for the involvement in the pathophysiology of CHH are discussed

    Advancing co-production for transformative change by synthesizing guidance from case studies on the sustainable management and governance of natural resources.

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    Co-production has become paramount for scientists, practitioners and social groups of Indigenous peoples and local communities of rural and urban areas to deliver transformative changes that enhance sustainability. Coproduction should result in knowledge that is credible, legitimate and usable to enable sustainable outcomes effectively. However, this is not always the case due to challenges related to differences between scientific and Indigenous and local knowledge, as well as inherent power imbalances. The literature emphasises that these challenges are often triggered by rigid scientific theories and postures, dominant practices, and time-money limitations that co-production projects involve. This happens despite the adoption of guidelines recommended in the literature. We investigate the role of these challenges and guidelines in the generation of credible, legitimate, usable, and effective knowledge. We analyse this role in 13 co-production cases focused on sustainable transformative changes linked with the management and governance of natural resources across the globe. Despite challenges varying between groups and contexts, credibility, usability, and effectiveness are promoted simultaneously, especially when co-production empowers social actors via legitimate processes. Scientists and practitioners do so, through creative and flexible reshaping of existing knowledge and worldviews with a focus on common goals that link sustainability and livelihoods. They conceptualise a mutual understanding of knowledge and that is deemed trustworthy feasible to use in their socioecological context. Our findings complement existing scholarship on co-production, exploring the credibility of situated knowledge and its practical effectiveness together with its commonly addressed legitimacy and usability. A focus on the practices of different actors, including dynamics that are external to co-production, and changes in the scientific and social status quo, are needed to advance co-production effectiveness

    Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

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    Occupations and the Non-Standard Employment Career: How the Occupational Skill Level and Task Types Influence the Career Outcomes of Non-Standard Employment

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    This article examines to what extent the occupational skill level and task types determine whether non-standard employment (NSE) leads to a stepping-stone or a trap in the careers of workers. For this purpose, a typology of the individual careers of workers in the Netherlands who entered non-standard employment in 2007 is created using multichannel sequence analysis. This typology allows for classifying careers in terms of employment security and income security. An analysis of this typology shows that working in occupations with high-level tasks does not preclude trap careers with low levels of employment and income security. Routine tasks do not have an unequivocal effect on career outcomes, while manual tasks generally lead to trap careers. The combination of routine and manual tasks makes it most likely for NSE to function as a trap in workers’ careers

    Loopbanen van flexwerkers: nieuwe inzichten over werk- en inkomenszekerheid op basis van multichannel sequentieanalyse

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    In this paper we use multichannel sequence analysis to classify careers of Dutch workers in flexible employment in terms of employment and income security. We subsequently investigate to what extent this career typology leads to different conclusions about the extent to which flexible employment functions as a stepping stone or as a trap than when methods are used that only focus on transitions at specific moments in the career and do not take into account income development. Based on transition rates, we could conclude that 50% of the workers who start in a flexible job has a stepping stone career as they make their first transition to permanent employment, while 43% becomes unemployed and has a trap career. The results from the sequence analysis are more nuanced: 27% of the careers has both high employment and income security and can be classified as a stepping stone, while 44% has low employment and income security and has a trap career. 13% of the careers combines high employment security with low income security, and 4% low employment security and high income security. The results indicate that transition rates give insufficient insights in the careers of workers in flexible employment

    Job tasks and employment trajectories:The impact of the task content of the first occupation in non-standard employment on career development

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    In this paper, we investigate to what extent the task composition of the first occupation in non-standard employment influences further career development in the Netherlands. Using Goldthorpe’s (2007) replaceability framework and Autor et al.’s (2003) routine-biased technological change theory, we hypothesize that workers in routine occupations are most likely to be replaced by other workers, technology, and therefore are more likely to have a precarious career. Using the outcomes of sequence analysis in multinomial probit regressions, we find that it is manual tasks, rather than routine tasks, that lead to more precarious careers
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