State-space solutions to the dynamic magnetoencephalography inverse problem using high performance computing

Determining the magnitude and location of neural sources within the brain that are responsible for generating magnetoencephalography (MEG) signals measured on the surface of the head is a challenging problem in functional neuroimaging. The number of potential sources within the brain exceeds by an order of magnitude the number of recording sites. As a consequence, the estimates for the magnitude and location of the neural sources will be ill-conditioned because of the underdetermined nature of the problem. One well-known technique designed to address this imbalance is the minimum norm estimator (MNE). This approach imposes an $L^2$ regularization constraint that serves to stabilize and condition the source parameter estimates. However, these classes of regularizer are static in time and do not consider the temporal constraints inherent to the biophysics of the MEG experiment. In this paper we propose a dynamic state-space model that accounts for both spatial and temporal correlations within and across candidate intracortical sources. In our model, the observation model is derived from the steady-state solution to Maxwell's equations while the latent model representing neural dynamics is given by a random walk process.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS483 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

A fully pipelined memoryless 17.8 Gbps AES-128 encryptor

A fully pipelined implementation of the Advanced Encryption Stan-dard encryption algorithm with 128-bit input and key length (AES-128) was implemented on Xilinx ’ Virtex-E and Virtex-II devices. The design is called SIG-AES-E and it implements the S-boxes combinatorially and thus requires no internal memory. It is con-cluded, that SIG-AES-E is faster than other published FPGA-based implementations of the AES-128 encryption algorithm. Categories and Subject Descriptor

Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25

AbstractProtein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found that constitutive PKA activity was necessary to maintain a large number of vesicles in the release-ready, so-called primed, state, whereas calcineurin (protein phosphatase 2B) activity antagonized this effect. Overexpression of the SNARE protein SNAP-25a mutated in a PKA phosphorylation site (Thr-138) eliminated the effect of PKA inhibitors on the vesicle priming process. Another, unidentified, PKA target regulated the relative size of two different primed vesicle pools that are distinguished by their release kinetics. Overexpression of the SNAP-25b isoform increased the size of both primed vesicle pools by a factor of two, and mutations in the conserved Thr-138 site had similar effects as in the a isoform

Holographic Conformal Window - A Bottom Up Approach

We propose a five-dimensional framework for modeling the background geometry associated to ordinary Yang-Mills (YM) as well as to nonsupersymmetric gauge theories possessing an infrared fixed point with fermions in various representations of the underlying gauge group. The model is based on the improved holographic approach, on the string theory side, and on the conjectured all-orders beta function for the gauge theory one. We first analyze the YM gauge theory. We then investigate the effects of adding flavors and show that, in the holographic description of the conformal window, the geometry becomes AdS when approaching the ultraviolet and the infrared regimes. As the number of flavors increases within the conformal window we observe that the geometry becomes more and more of AdS type over the entire energy range.Comment: 20 Pages, 3 Figures. v2: references adde

Publisher Correction: Deep learning enables fast and dense single-molecule localization with high accuracy

In the version of this Article initially published, Jacob H. Macke and Jonas Ries were not listed as corresponding authors. Their contact information and designation as corresponding authors are now included. The error has been corrected in the online version of the Article

Electromagnetic wormholes via handlebody constructions

Cloaking devices are prescriptions of electrostatic, optical or electromagnetic parameter fields (conductivity $\sigma(x)$, index of refraction $n(x)$, or electric permittivity $\epsilon(x)$ and magnetic permeability $\mu(x)$) which are piecewise smooth on $\mathbb R^3$ and singular on a hypersurface $\Sigma$, and such that objects in the region enclosed by $\Sigma$ are not detectable to external observation by waves. Here, we give related constructions of invisible tunnels, which allow electromagnetic waves to pass between possibly distant points, but with only the ends of the tunnels visible to electromagnetic imaging. Effectively, these change the topology of space with respect to solutions of Maxwell's equations, corresponding to attaching a handlebody to $\mathbb R^3$. The resulting devices thus function as electromagnetic wormholes.Comment: 25 pages, 6 figures (some color

Fluctuations of a holographic quantum Hall fluid

We analyze the neutral spectrum of the holographic quantum Hall fluid described by the D2-D8' model. As expected for a quantum Hall state, we find the system to be stable and gapped and that, at least over much of the parameter space, the lowest excitation mode is a magneto-roton. In addition, we find magneto-rotons in higher modes as well. We show that these magneto-rotons are direct consequences of level crossings between vector and scalar modes.Comment: 20 pages, 8 figures; v.2 figures improved, 2 figures added, and text clarified particularly in Sec. 5, to appear in JHE

Full-wave invisibility of active devices at all frequencies

There has recently been considerable interest in the possibility, both theoretical and practical, of invisibility (or "cloaking") from observation by electromagnetic (EM) waves. Here, we prove invisibility, with respect to solutions of the Helmholtz and Maxwell's equations, for several constructions of cloaking devices. Previous results have either been on the level of ray tracing [Le,PSS] or at zero frequency [GLU2,GLU3], but recent numerical [CPSSP] and experimental [SMJCPSS] work has provided evidence for invisibility at frequency $k\ne 0$. We give two basic constructions for cloaking a region $D$ contained in a domain $\Omega$ from measurements of Cauchy data of waves at \p \Omega; we pay particular attention to cloaking not just a passive object, but an active device within $D$, interpreted as a collection of sources and sinks or an internal current.Comment: Final revision; to appear in Commun. in Math. Physic

G-structures and Domain Walls in Heterotic Theories

We consider heterotic string solutions based on a warped product of a four-dimensional domain wall and a six-dimensional internal manifold, preserving two supercharges. The constraints on the internal manifolds with SU(3) structure are derived. They are found to be generalized half-flat manifolds with a particular pattern of torsion classes and they include half-flat manifolds and Strominger's complex non-Kahler manifolds as special cases. We also verify that previous heterotic compactifications on half-flat mirror manifolds are based on this class of solutions.Comment: 29 pages, reference added, typos correcte