13,662 research outputs found
NASA-tricot - A lightweight radar reflective, knitted fabric
Fabric knitted on conventional knitting machines uses commercially available yarns, has high aerodynamic drag capability, and is relatively inexpensive. The two yarn components used are 15-denier nylon monofilament and aluminized Mylar tape
Lightweight inflatable material with low permeability
Material features combination of Mylar, for strength, and Saran, for impermeable qualities. Second lamination of Mylar prevents blocking, adds strength, and increases barrier rating. Different combinations of laminations produce variety of thicknesses and barrier ratings. Material can be metallized for increased barrier reliability and radar reflectivity, and can be treated with a heat-resistant coating
Lightweight, variable solidity knitted parachute fabric
A parachute fabric for aerodynamic decelerator applications is described. The fabric will permit deployment of the decelerator at high altitudes and low density conditions. The fabric consists of lightweight, highly open, circular knitted parachute fabric with ribbon-like yarns to assist in air deflection
Neutral Hydrogen Associated with NGC 7129
Observations of the environment of the star-forming region NGC 7129 obtained with an angular resolution of 1' in the 21 cm line of H I are described. Two features of the image are extensively discussed: (1) a ring of H I emission about 30' in extent and (2) a relatively dense concentration of H I with unusually wide line profiles positionally coincident with the B star BD +65°1638. The H I ring is consistent with photodissociation of H2 by the interstellar UV radiation field at the surface of an extended molecular cloud in which both BD +65°1638 and NGC 7129 are situated. We further show that BD +65°1638 appears to be an unusual example of a "dissociating star" surrounded by an extensive region of photodissociated H2 and accompanied by a small H II region. The derived spectral type (B2.5) and the absolute magnitude for BD +65°1638 further suggest that the latter is very close to the birthline. The very young stellar age implied by the parameters of the H I region, considerably less than 104 yr, is discussed, and the properties of the H I region are compared with those of the prototype for this rare class of objects. We discuss both aspects within the context of star formation in NGC 7129
A Constant Spectral Index for Sagittarius A* During Infrared/X-ray Intensity Variations
We report the first time-series of broadband infrared (IR) color measurements
of Sgr A*, the variable emission source associated with the supermassive black
hole at the Galactic Center. Using the laser and natural guide star AO systems
on the Keck II telescope, we imaged Sgr A* in multiple near-infrared broadband
filters with a typical cycle time of ~3 min during 4 observing runs
(2005-2006), two of which were simultaneous with Chandra X-ray measurements. In
spite of the large range of dereddened flux densities for Sgr A* (2-30 mJy),
all of our near-IR measurements are consistent with a constant spectral index
of alpha = -0.6+-0.2. Furthermore, this value is consistent with the spectral
indices observed at X-ray wavelengths during nearly all outbursts; which is
consistent with the synchrotron self-Compton model for the production of the
X-ray emission. During the coordinated observations, one IR outburst occurs <36
min after a possibly associated X-ray outburst, while several similar IR
outbursts show no elevated X-ray emission. A variable X-ray to IR ratio and
constant infrared spectral index challenge the notion that the IR and X-ray
emission are connected to the same electrons. We, therefore, posit that the
population of electrons responsible for both the IR and X-ray emission are
generated by an acceleration mechanism that leaves the bulk of the electron
energy distribution responsible for the IR emission unchanged, but has a
variable high-energy cutoff. Occasionally a tail of electrons >1 GeV is
generated, and it is this high-energy tail that gives rise to the X-ray
outbursts. One possible explanation for this type of variation is from the
turbulence induced by a magnetorotational instability, in which the outer scale
length of the turbulence varies and changes the high-energy cutoff.Comment: 11 pages, 7 figures (color), Accepted for publication in ApJ.
Resolution (Fig 1&2) downgraded for astro-ph. For full resolution, see
http://casa.colorado.edu/~hornstei/sgracolor.pd
Corticosteroids for the treatment of Duchenne muscular dystrophy.
BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy of childhood. Untreated, this incurable disease, which has an X-linked recessive inheritance, is characterised by muscle wasting and loss of walking ability, leading to complete wheelchair dependence by 13 years of age. Prolongation of walking is a major aim of treatment. Evidence from randomised controlled trials (RCTs) indicates that corticosteroids significantly improve muscle strength and function in boys with DMD in the short term (six months), and strength at two years (two-year data on function are very limited). Corticosteroids, now part of care recommendations for DMD, are largely in routine use, although questions remain over their ability to prolong walking, when to start treatment, longer-term balance of benefits versus harms, and choice of corticosteroid or regimen.We have extended the scope of this updated review to include comparisons of different corticosteroids and dosing regimens.
OBJECTIVES: To assess the effects of corticosteroids on prolongation of walking ability, muscle strength, functional ability, and quality of life in DMD; to address the question of whether benefit is maintained over the longer term (more than two years); to assess adverse events; and to compare efficacy and adverse effects of different corticosteroid preparations and regimens.
SEARCH METHODS: On 16 February 2016 we searched the Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE, EMBASE, CINAHL Plus, and LILACS. We wrote to authors of published studies and other experts. We checked references in identified trials, handsearched journal abstracts, and searched trials registries.
SELECTION CRITERIA: We considered RCTs or quasi-RCTs of corticosteroids (e.g. prednisone, prednisolone, and deflazacort) given for a minimum of three months to patients with a definite DMD diagnosis. We considered comparisons of different corticosteroids, regimens, and corticosteroids versus placebo.
DATA COLLECTION AND ANALYSIS: The review authors followed standard Cochrane methodology.
MAIN RESULTS: We identified 12 studies (667 participants) and two new ongoing studies for inclusion. Six RCTs were newly included at this update and important non-randomised cohort studies have also been published. Some important studies remain unpublished and not all published studies provide complete outcome data.
PRIMARY OUTCOME MEASURE: one two-year deflazacort RCT (n = 28) used prolongation of ambulation as an outcome measure but data were not adequate for drawing conclusions.
SECONDARY OUTCOME MEASURES: meta-analyses showed that corticosteroids (0.75 mg/kg/day prednisone or prednisolone) improved muscle strength and function versus placebo over six months (moderate quality evidence from up to four RCTs). Evidence from single trials showed 0.75 mg/kg/day superior to 0.3 mg/kg/day on most strength and function measures, with little evidence of further benefit at 1.5 mg/kg/day. Improvements were seen in time taken to rise from the floor (Gowers' time), timed walk, four-stair climbing time, ability to lift weights, leg function grade, and forced vital capacity. One new RCT (n = 66), reported better strength, function and quality of life with daily 0.75 mg/kg/day prednisone at 12 months. One RCT (n = 28) showed that deflazacort stabilised muscle strength versus placebo at two years, but timed function test results were too imprecise for conclusions to be drawn.One double-blind RCT (n = 64), largely at low risk of bias, compared daily prednisone (0.75 mg/kg/day) with weekend-only prednisone (5 mg/kg/weekend day), finding no overall difference in muscle strength and function over 12 months (moderate to low quality evidence). Two small RCTs (n = 52) compared daily prednisone 0.75 mg/kg/day with daily deflazacort 0.9 mg/kg/day, but study methods limited our ability to compare muscle strength or function.
ADVERSE EFFECTS: excessive weight gain, behavioural abnormalities, cushingoid appearance, and excessive hair growth were all previously shown to be more common with corticosteroids than placebo; we assessed the quality of evidence (for behavioural changes and weight gain) as moderate. Hair growth and cushingoid features were more frequent at 0.75 mg/kg/day than 0.3 mg/kg/day prednisone. Comparing daily versus weekend-only prednisone, both groups gained weight with no clear difference in body mass index (BMI) or in behavioural changes (low quality evidence for both outcomes, one study); the weekend-only group had a greater linear increase in height. Very low quality evidence suggested less weight gain with deflazacort than with prednisone at 12 months, and no difference in behavioural abnormalities. Data are insufficient to assess the risk of fractures or cataracts for any comparison.Non-randomised studies support RCT evidence in showing improved functional benefit from corticosteroids. These studies suggest sustained benefit for up to 66 months. Adverse effects were common, although generally manageable. According to a large comparative longitudinal study of daily or intermittent (10 days on, 10 days off) corticosteroid for a mean period of four years, a daily regimen prolongs ambulation and improves functional scores over the age of seven, but with a greater frequency of side effects than an intermittent regimen.
AUTHORS' CONCLUSIONS: Moderate quality evidence from RCTs indicates that corticosteroid therapy in DMD improves muscle strength and function in the short term (twelve months), and strength up to two years. On the basis of the evidence available for strength and function outcomes, our confidence in the effect estimate for the efficacy of a 0.75 mg/kg/day dose of prednisone or above is fairly secure. There is no evidence other than from non-randomised trials to establish the effect of corticosteroids on prolongation of walking. In the short term, adverse effects were significantly more common with corticosteroids than placebo, but not clinically severe. A weekend-only prednisone regimen is as effective as daily prednisone in the short term (12 months), according to low to moderate quality evidence from a single trial, with no clear difference in BMI (low quality evidence). Very low quality evidence indicates that deflazacort causes less weight gain than prednisone after a year's treatment. We cannot evaluate long-term benefits and hazards of corticosteroid treatment or intermittent regimens from published RCTs. Non-randomised studies support the conclusions of functional benefits, but also identify clinically significant adverse effects of long-term treatment, and a possible divergence of efficacy in daily and weekend-only regimens in the longer term. These benefits and adverse effects have implications for future research and clinical practice
High-Latitude HI in the Low Surface Brightness Galaxy UGC7321
From the analysis of sensitive HI 21-cm line observations, we find evidence
for vertically extended HI emission (|z|<~2.4 kpc) in the edge-on, low surface
brightness spiral galaxy UGC7321. Three-dimensional modelling suggests that the
HI disk of UGC7321 is both warped and flared, but that neither effect can fully
reproduce the spatial distribution and kinematics of the highest z-height gas.
We are able to model the high-latitude emission as an additional HI component
in the form of a ``thick disk'' or ``halo'' with a FWHM~3.3 kpc. We find
tentative evidence that the vertically extended gas declines in rotational
velocity as a function of z, although we are unable to completely rule out
models with constant V(z). In spite of the low star formation rate of UGC7321,
energy from supernovae may be sufficient to sustain this high-latitude gas.
However, alternative origins for this material, such as slow, sustained infall,
cannot yet be excluded.Comment: to appear in the August 20 Astrophysical Journal; 17 pages; version
with full resolution figures available at
http://cfa-www.harvard.edu/~lmatthew
Shape deformations and angular momentum transfer in trapped Bose-Einstein condensates
Angular momentum can be transferred to a trapped Bose-Einstein condensate by
distorting its shape with an external rotating field, provided the rotational
frequency is larger than a critical frequency fixed by the energy and angular
momentum of the excited states of the system. By using the Gross-Pitaevskii
equation and sum rules, we explore the dependence of such a critical frequency
on the multipolarity of the excitations and the asymmetry of the confining
potential. We also discuss its possible relevance for vortex nucleation in
rotating traps.Comment: 4 pages revtex, 2 figures include
3C 48: Stellar Populations and the Kinematics of Stars and Gas in the Host Galaxy
We present deep Keck LRIS spectroscopy of the host galaxy of 3C 48. Our
observations at various slit positions sample the different luminous components
near the quasar, including the apparent tidal tail to the NW and several strong
emission line regions.
By fitting Bruzual & Charlot (1996) population synthesis models to our
spectra, we obtain ages for the most recent major episodes of star formation in
various parts of the host galaxy covered by our slits. There is vigorous
current star formation in regions just NE and SE of the quasar and
post-starburst regions with ages up to ~10^8 years in other parts of the host
galaxy, but most of the NW tidal tail shows no sign of significant recent star
formation. We use these model fits, together with the kinematics of the stars
and gas, to outline a plausible evolutionary history for the host galaxy, its
recent starburst activity, the triggering of the quasar, and the interaction of
the radio jet with the ambient gas.
There is strong evidence that the 3C 48 host is an ongoing merger, and that
it is probably near the peak of its starburst activity. Nevertheless, the
quasar itself seems to suffer little extinction, perhaps because we are viewing
it along a particularly favorable line-of-sight.Comment: 27 pages plus 11 figures (7 postscript, 4 gif). Postscript version
including figures (1840 kb) available at
http://www.ifa.hawaii.edu/~canaguby/preprints.html . Accepted for publication
in Ap
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