Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams

Purpose: This work investigates the dose-response curves of GAFCHROMIC ® EBT, EBT2, and EBT3 radiochromic films using synchrotron-produced monochromatic x-ray beams. EBT2 film is being utilized for dose verification in photoactivated Auger electron therapy at the Louisiana State University Center for Advanced Microstructures and Devices (CAMD) synchrotron facility. Methods: Monochromatic beams of 25, 30, and 35 keV were generated on the tomography beamline at CAMD. Ion chamber depth-dose measurements were used to determine the dose delivered to films irradiated at depths from 0.7 to 8.5 cm in a 10 × 10 × 10-cm3 polymethylmethacrylate phantom. AAPM TG-61 protocol was applied to convert measured ionization into dose. Films were digitized using an Epson 1680 Professional flatbed scanner and analyzed using the net optical density (NOD) derived from the red channel. A dose-response curve was obtained at 35 keV for EBT film, and at 25, 30, and 35 keV for EBT2 and EBT3 films. Calibrations of films for 4 MV x-rays were obtained for comparison using a radiotherapy accelerator at Mary Bird Perkins Cancer Center. Results: The sensitivity (NOD per unit dose) of EBT film at 35 keV relative to that for 4-MV x-rays was 0.73 and 0.76 for doses 50 and 100 cGy, respectively. The sensitivity of EBT2 film at 25, 30, and 35 keV relative to that for 4-MV x-rays varied from 1.09-1.07, 1.23-1.17, and 1.27-1.19 for doses 50-200 cGy, respectively. For EBT3 film the relative sensitivity was within 3 of unity for all three monochromatic x-ray beams. Conclusions: EBT and EBT2 film sensitivity showed strong energy dependence over an energy range of 25 keV-4 MV, although this dependence becomes weaker for larger doses. EBT3 film shows weak energy dependence, indicating that it would be a better dosimeter for kV x-ray beams where beam hardening effects can result in large changes in the effective energy. © 2012 American Association of Physicists in Medicine

Hyperstrong Radio-Wave Scattering in the Galactic Center. II. A Likelihood Analysis of Free Electrons in the Galactic Center

The scattering diameters of Sgr A* and several nearby OH masers (~ 1" at 1 GHz) indicate that a region of enhanced scattering is along the line of sight to the Galactic center. We combine radio-wave scattering data and free-free emission and absorption measurements in a likelihood analysis that constrains the following parameters of the GC scattering region: The GC-scattering region separation, d; the angular extent of the region, \psi_l; the outer scale on which density fluctuations occur, l_0; and the gas temperature, T. The maximum likelihood estimates of these parameters are d = 133_{-80}^{+200} pc, 0.5 degrees <= \psi_l <~ 1 degrees, and (l_0/1 pc)^{2/3}T^{-1/2} = 10^{-7 +/- 0.8}. As host media for the scattering, we consider the photoionized surface layers of molecular clouds and the interfaces between molecular clouds and the 10^7 K ambient gas. We are unable to make an unambiguous determination, but we favor an interface model in which the scattering medium is hot (T ~ 10^6 K) and dense (n_e ~ 10 cm^{-3}). The GC scattering region produces a 1 GHz scattering diameter for an extragalactic source of 90", if the region is a single screen, or 180", if the region wraps around the GC, as appears probable. We modify the Taylor-Cordes model for the Galactic distribution of free electrons in order to include an explicit GC component. Pulsars seen through this region will have a dispersion measure of approximately 2000 pc cm^{-3}, of which 75% arises from the GC component. We stress the uniqueness of the GC scattering region, probably resulting from the high-pressure environment in the GC.Comment: 39 pages with 9 PostScript figures; LaTeX2e with AASTeX macro aaspp4, to be published in Ap

OH-Stretch Vibrational Spectroscopy of Hydroxymethyl Hydroperoxide

We report measurement and analysis of the photodissociation spectrum of hydroxymethyl hydroperoxide (HOCH_2OOH) and its partially deuterated analogue, HOCD_2OOH, in the OH-stretching region. Spectra are obtained by Fourier transform infrared spectroscopy in the 1ν_(OH) and 2ν_(OH) regions, and by laser induced fluorescence detection of the OH fragment produced from dissociation of HOCH_2OOH initiated by excitation of the 4ν_(OH) and 5ν_(OH) overtone regions (action spectroscopy). A one-dimensional local-mode model of each OH chromophore is used with ab initio calculated OH-stretching potential energy and dipole moment curves at the coupled-cluster level of theory. Major features in the observed absorption and photodissociation spectra are explained by our local-mode model. In the 4ν_(OH) region, explanation of the photodissocation spectrum requires a nonuniform quantum yield, which is estimated by assuming statistical energy distribution in the excited state. Based on the estimated dissociation threshold, overtone photodissociation is not expected to significantly influence the atmospheric lifetime of hydroxymethyl hydroperoxide

Key Science Goals for the Next Generation Very Large Array (ngVLA): Report from the ngVLA Science Advisory Council

This document describes some of the fundamental astrophysical problems that require observing capabilities at millimeter- and centimeter wavelengths well beyond those of existing, or already planned, telescopes. The results summarized in this report follow a solicitation from the National Radio Astronomy Observatory to develop key science cases for a future U. S.-led radio telescope, the "next generation Very Large Array" (ngVLA). The ngVLA will have roughly 10 times the collecting area of the Jansky VLA, operate at frequencies from 1 GHz to 116 GHz with up to 20 GHz of bandwidth, possess a compact core for high surface-brightness sensitivity, and extended baselines of at least hundreds of kilometers and ultimately across the continent to provide high-resolution imaging. The ngVLA builds on the scientific and technical legacy of the Jansky VLA and ALMA, and will be designed to provide the next leap forward in our understanding of planets, galaxies, and black holes.Comment: ngVLA memo 1

Implications of SU(2) symmetry on the dynamics of population difference in the two-component atomic vapor

We present an exact many body solution for the dynamics of the population difference $N_2-N_1$ induced by an rf-field in the two-component atomic cloud characterized by equal scattering lengths. This situation is very close to the actual JILA experiments with the two-component $^{87}$Rb vapor. We show that no intrinsic decoherence exists for $N_2-N_1$, provided the exact SU(2) symmetry holds. This contrasts with finite dissipation of the normal modes even in the presence of the SU(2) symmetry. The intrinsic decoherence for \$N_2-N_1$ may occur as long as deviations from the exact SU(2) symmetry are taken into account. Such decoherence, however, should be characterized by very long times governed by the smallness of the deviations from the symmetry. We suggest testing the evolution of $N_2-N_1$ by conducting echo-type experiments.Comment: 5 RevTex pages, no figures, typos correcte

Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects

Background: Articular cartilage pathology can result from a spectrum of origins, including trauma, osteochondritis dissecans, avascular necrosis, or degenerative joint disease. Purpose: To compare the differences in clinical and patient-reported outcomes after autologous chondrocyte implantation (ACI) versus osteochondral allograft transplantation (OCA) in patients with focal articular cartilage defects without underlying bone loss. Study design: Cohort study; Level of evidence, 3. Methods: A retrospective review identified patients who underwent ACI or OCA between 2008 and 2016 for isolated grades 3 and 4 articular cartilage defects without underlying bone loss. Outcome measures included the Knee injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR), International Knee Documentation Committee (IKDC) evaluation, and 12-Item Short Form Health Survey-Physical Component (SF-12-P) scores. Defect location, size, complications, and rate of subsequent surgery were determined. Results: Overall, 148 patients were included: 82 (55%) underwent ACI and 66 (45%) underwent OCA. The mean age at the time of surgery was 31.2 years within the ACI cohort and 37.7 years within the OCA cohort (P \u3c .001); the mean follow-up for both cohorts was 6.7 years (P = .902). Within the ACI group, 28 (34%) patients had multifocal defects, 21 (26%) had defects confined to the femoral condyles, and 33 (40%) had defects in the patellofemoral region. Within the OCA group, 23 (35%) patients had multifocal defects, 30 (46%) had confined femoral condyle lesions, and 13 (20%) had patellofemoral defects. When comparing by lesion location, there were no significant differences in KOOS JR, and IKDC scores between the ACI and OCA cohorts (P \u3c .05). There was, however, a significant difference for SF-12-P scores for FDD trochlear lesions. In both cohorts, traumatic patellofemoral pathology demonstrated lower patient-reported outcomes and higher failure rates than degenerative lesions. The overall rate of failure, defined as graft failure with revision surgery and/or conversion to arthroplasty, was significantly greater in the OCA group (21% vs 4%; P = .002). Conclusion: Study results indicated that ACI provides similar outcomes to OCA with or without concomitant procedures for the treatment of symptomatic articular cartilage defects in all lesion locations and may have a lower revision rate for multifocal and condylar lesions