Two-micron spectrophotometry of the galaxy NGC 253

A very strong Brackett-gamma hydrogen emission line, and the 2.3 micron CO stellar absorption feature were measured in NGC 253. The presence and strength of the CO feature indicates that late type giant stars produce most of the 2.2 micron continuum emission, while the rate of ionization implied by strength of the Brackett-gamma line indicates that much, perhaps all, of the luminosity detected at far infrared wavelengths originates from a large number of OB stars. As compared to the corresponding region of the Galaxy, the number of massive young stars in the central 200 pc of NGC 253 is thirty times greater, but the total mass of stars is roughly the same

Activating Audiences: How spatial music can help us to listen

This article discusses the importance of active listening when engaging new audiences with experimental and unfamiliar musical formats. Spatial music is examined as a physically immersive medium in which the audience is implicated as an active component in the execution of its performance. A brief account of the historic context of spatial music will be presented alongside speculation for the trajectory of its future; particularly its potential as a model for audience engagement. This article will first consider how spatially immersive performances have the capacity to activate listeners and how can this help to engage new audiences with new ways of listening. It will also question the notion of inhabiting spatial music, with an investigation of the multiple ways in which spatial music relates to physical space and the terms of its inhabitation. The concept of virtual listening will be discussed in response to trends towards passive hearing, as driven by recent technological developments in acoustic software and hardware, and the resultant abstraction of the spatial and social dynamics of sound in virtual space. The physiological and psychological differences between listening and hearing will also be examined as a means of establishing fundamental differences in the ways that we interact with music, and questioning what our listening habits tell us about audience engagement in the context of experimental music performance. This article will also question the individual roles of the musician, composer, architect/designer and audience in the ongoing responsibility to improve audience engagement in new, or unfamiliar musical works. Importantly, this article will also explicitly examine who we are referring to when we use the term ‘new audiences’. Major developments in acoustic technology during the last few decades have somewhat confused the diagram between music, space and listener. The understanding of which elements are active and which are passive is especially ambiguous at a time when ambisonic and binaural technologies have become developed enough to provide accurate simulations of the abstract, acoustic qualities of spaces, but on virtual terms. Architects, composers, musicians, engineers and audiences are at a crossroads in the development of new music and experimental, spatiosonic practice. ‘Spatiosonic’ is a hybrid term which is used throughout this article to describe work and phenomena which regard space (spatio) and sound (sonic) as equal, interactive partners. This article considers some of the opportunities and limitations at stake in current techniques of composition, performance and listening

Multiprotein DNA looping

DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.Comment: 11 pages, 4 figure

The Y-Band at 1.035 um: Photometric Calibration and the Dwarf Stellar/Sub-Stellar Color Sequence

We define and characterize a photometric bandpass (called "Y") that is centered at 1.035 um, in between the traditionally classified ``optical'' and ``infrared'' spectral regimes. We present Y magnitudes and Y-H and Y-K colors for a sample consisting mostly of photometric and spectral standards, spanning the spectral type range sdO to T5V. Deep molecular absorption features in the near-infrared spectra of extremely cool objects are such that the Y-H and Y-K colors grow rapidly with advancing spectral type especially from late M through mid L, substantially more rapidly than J-H or H-K which span a smaller total dynamic range. Consistent with other near-infrared colors, however, Y-H and Y-K colors turn blueward in the L6-L8 temperature range with later T-type objects having colors similar to those of warmer M and L stars. Use of the Y-band filter is nonetheless promising for easy identification of low-mass stars and brown dwarfs, especially at young ages. The slope of the interstellar reddening vector within this filter is A_Y = 0.38 x A_V. Reddening moves stars nearly along the YHK dwarf color sequence making it more difficult to distinguish unambiguously very low mass candidate brown dwarf objects from higher mass stars seen, e.g. through the galactic plane or towards star-forming regions. Other diagrams involving the Y-band may be somewhat more discriminating.Comment: accepted at PAS

Left Ventricular Mass in Physically Active Adults with a Family History of Hypertension

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A Constant Spectral Index for Sagittarius A* During Infrared/X-ray Intensity Variations

We report the first time-series of broadband infrared (IR) color measurements of Sgr A*, the variable emission source associated with the supermassive black hole at the Galactic Center. Using the laser and natural guide star AO systems on the Keck II telescope, we imaged Sgr A* in multiple near-infrared broadband filters with a typical cycle time of ~3 min during 4 observing runs (2005-2006), two of which were simultaneous with Chandra X-ray measurements. In spite of the large range of dereddened flux densities for Sgr A* (2-30 mJy), all of our near-IR measurements are consistent with a constant spectral index of alpha = -0.6+-0.2. Furthermore, this value is consistent with the spectral indices observed at X-ray wavelengths during nearly all outbursts; which is consistent with the synchrotron self-Compton model for the production of the X-ray emission. During the coordinated observations, one IR outburst occurs <36 min after a possibly associated X-ray outburst, while several similar IR outbursts show no elevated X-ray emission. A variable X-ray to IR ratio and constant infrared spectral index challenge the notion that the IR and X-ray emission are connected to the same electrons. We, therefore, posit that the population of electrons responsible for both the IR and X-ray emission are generated by an acceleration mechanism that leaves the bulk of the electron energy distribution responsible for the IR emission unchanged, but has a variable high-energy cutoff. Occasionally a tail of electrons >1 GeV is generated, and it is this high-energy tail that gives rise to the X-ray outbursts. One possible explanation for this type of variation is from the turbulence induced by a magnetorotational instability, in which the outer scale length of the turbulence varies and changes the high-energy cutoff.Comment: 11 pages, 7 figures (color), Accepted for publication in ApJ. Resolution (Fig 1&2) downgraded for astro-ph. For full resolution, see http://casa.colorado.edu/~hornstei/sgracolor.pd

Galactic Center Youth: Orbits and Origins of the Young Stars in the Central Parsec

We present new proper motions for the massive, young stars at the Galactic Center, based on 10 years of diffraction limited data from the Keck telescopes. Our proper motion measurements now have uncertainties of only 1-2 km/s and allow us to explore the origin of the young stars that reside within the sphere of inflience of the supermassive black hole whose strong tidal forces make this region inhospitable for star formation. Their presence, however, may be explained either by in situ star formation in an accretion disk or as the remnants of a massive stellar cluster which spiraled in via dynamical friction. Earlier stellar velocity vectors were used to postulate that all the young stars resided in two counter-rotating stellar disks, which is consistent with both of the above formation scenarios. Our precise proper motions allow us, for the frst time, to determine the orbital parameters of each individual star and thereby to test the hypothesis that the massive stars reside in two stellar disks. Of the 26 young stars in this study that were previously proposed to lie on the inner, clockwise disk, we find that nearly all exhibit orbital constraints consistent with such a disk. On the other hand, of the 7 stars in this study previously proposed to lie in the outer, less well-defhed counter-clockwise disk, 6 exhibit inclinations that are inconsistent with such a disk, bringing into question the existence of the outer disk. Furthermore, for stars in the inner disk that have eccentricity constraints, we find several that have lower limits to the eccentricity of more than 0.4, implying highly eccentric orbits. This stands in contrast to simple accretion disk formation scenarios which typically predict predominantly circular orbits

APM 08279+5255: Keck Near- and Mid-IR High-Resolution Imaging

We present Keck high-resolution near-IR (2.2 microns; FWHM~0.15") and mid-IR (12.5 microns; FWHM~0.4") images of APM08279+5255, a z=3.91 IR-luminous BALQSO with a prodigious apparent bolometric luminosity of 5x10^{15} Lsun, the largest known in the universe. The K-band image shows that this system consists of three components, all of which are likely to be the gravitationally lensed images of the same background object, and the 12.5 micron image shows a morphology consistent with such an image configuration. Our lens model suggests that the magnification factor is ~100 from the restframe UV to mid-IR, where most of the luminosity is released. The intrinsic bolometric luminosity and IR luminosity of APM08279+5255 are estimated to be 5x10^{13} Lsun and 1x10^{13} Lsun, respectively. This indicates that APM 08279+5255 is intriniscally luminous, but it is not the most luminous object known. As for its dust contents, little can be determined with the currently available data due to the uncertainties associated with the dust emissivity and the possible effects of differential magnification. We also suggest that the lensing galaxy is likely to be a massive galaxy at z~3.Comment: 32 pages, 4 tables, 11 figures; Accepted for publication in Ap

Probing the Reaction Mechanism of the D-ala-D-ala Dipeptidase, VanX, by Using Stopped-Flow Kinetic and Rapid-Freeze Quench EPR Studies on the Co(II)-Substituted Enzyme

In an effort to probe the reaction mechanism of VanX, the D-ala-D-ala dipeptidase required for high-level vancomycin resistance in bacteria, stopped-flow kinetic and rapid-freeze quench EPR studies were conducted on the Co(II)-substituted enzyme when reacted with d-ala-d-ala. The intensity of the Co(II) ligand field band at 550 nm decreased (ε550 = 140 to 18 M-1 cm-1) when VanX was reacted with substrate, suggesting that the coordination number of the metal increases from 5 to 6 upon substrate binding. The stopped-flow trace was fitted to a kinetic mechanism that suggests the presence of an intermediate whose breakdown is rate-limiting. Rapid-freeze quench EPR studies verified the presence of a reaction intermediate that exhibits an unusually low hyperfine constant (33 G), which suggests a bidentate coordination of the intermediate to the metal center. The EPR studies also identified a distinct enzyme product complex. The results were used to offer a detailed reaction mechanism for VanX that can be used to guide future inhibitor design efforts