The admissibility of extra-judicial confessions: a comparative study

Undoubtedly, one of the most contentious areas of law in England, Canada and the United States is, and has been for almost two hundred years, the rule of law relating to the admissibility of extra-Judicial confessions and statements. It IS generally accepted that confessions and incriminating statements must be voluntary in order to be admissible in evidence. However, debate arises as to the meaning, scope and effectiveness of voluntariness as the test of admissibility. The purpose of this thesis is to compare, by analysing separately and in depth the rules relating to the admissibility of incriminating statements and confessions in England, Canada and the United States as expressed by the United States Supreme Court. It IS intended to isolate the internal factors of the respective rules, and by so doing, to indicate their problem areas, similarities and differences, as well as to demonstrate the judicial attitude in each country as regards the rights of an accused person in police custody, in relation to police investigative practices. It is also intended to explore historical source regarding criminal confessions, and to follow the historical sequence of events leading to the modern voluntary rule, thus exposing the role played by the confession of an accused in the administration of criminal justice throughout history, as well as revealing the historical basis of the rule itself

An HI Imaging Survey of Asymptotic Giant Branch Stars

We present an imaging study of a sample of eight asymptotic giant branch (AGB) stars in the HI 21-cm line. Using observations from the Very Large Array, we have unambiguously detected HI emission associated with the extended circumstellar envelopes of six of the targets. The detected HI masses range from M_HI ~ 0.015-0.055 M_sun. The HI morphologies and kinematics are diverse, but in all cases appear to be significantly influenced by the interaction between the circumstellar envelope and the surrounding medium. Four stars (RX Lep, Y UMa, Y CVn, and V1942 Sgr) are surrounded by detached HI shells ranging from 0.36 to 0.76 pc across. We interpret these shells as resulting from material entrained in a stellar outflow being abruptly slowed at a termination shock where it meets the local medium. RX Lep and TX Psc, two stars with moderately high space velocities (V_space>56 km/s), exhibit extended gaseous wakes (~0.3 and 0.6 pc in the plane of the sky), trailing their motion through space. The other detected star, R Peg, displays a peculiar "horseshoe-shaped" HI morphology with emission extended on scales up to ~1.7 pc; in this case, the circumstellar debris may have been distorted by transverse flows in the local interstellar medium. We briefly discuss our new results in the context of the entire sample of evolved stars that has been imaged in HI to date.Comment: Accepted to AJ. A version with full resolution figures is available at http://www.haystack.mit.edu/hay/staff/lmatthew/matthews_HI_survey.pd

Multiprotein DNA looping

DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.Comment: 11 pages, 4 figure

Galactic Center Youth: Orbits and Origins of the Young Stars in the Central Parsec

We present new proper motions for the massive, young stars at the Galactic Center, based on 10 years of diffraction limited data from the Keck telescopes. Our proper motion measurements now have uncertainties of only 1-2 km/s and allow us to explore the origin of the young stars that reside within the sphere of inflience of the supermassive black hole whose strong tidal forces make this region inhospitable for star formation. Their presence, however, may be explained either by in situ star formation in an accretion disk or as the remnants of a massive stellar cluster which spiraled in via dynamical friction. Earlier stellar velocity vectors were used to postulate that all the young stars resided in two counter-rotating stellar disks, which is consistent with both of the above formation scenarios. Our precise proper motions allow us, for the frst time, to determine the orbital parameters of each individual star and thereby to test the hypothesis that the massive stars reside in two stellar disks. Of the 26 young stars in this study that were previously proposed to lie on the inner, clockwise disk, we find that nearly all exhibit orbital constraints consistent with such a disk. On the other hand, of the 7 stars in this study previously proposed to lie in the outer, less well-defhed counter-clockwise disk, 6 exhibit inclinations that are inconsistent with such a disk, bringing into question the existence of the outer disk. Furthermore, for stars in the inner disk that have eccentricity constraints, we find several that have lower limits to the eccentricity of more than 0.4, implying highly eccentric orbits. This stands in contrast to simple accretion disk formation scenarios which typically predict predominantly circular orbits

National Hospital Management Portal (NHMP): a framework for e-health implementation

Health information represents the main basis for health decisionmaking process and there have been some efforts to increase access to health information in developing countries. However, most of these efforts are based on the internet which has minimal penetration especially in the rural and sub-urban part of developing countries. In this work, a platform for medical record acquisition via the ubiquitous 2.5G/3G wireless communications technologies is presented. The National Hospital Management Portal (NHMP)platform has a central database at each specific country’s national hospita

Magnetic Field Structure around Low-Mass Class 0 Protostars: B335, L1527 and IC348-SMM2

We report new 350 micron polarization observations of the thermal dust emission from the cores surrounding the low-mass, Class 0 YSOs L1527, IC348-SMM2 and B335. We have inferred magnetic field directions from these observations, and have used them together with results in the literature to determine whether magnetically regulated core-collapse and star-formation models are consistent with the observations. These models predict a pseudo-disk with its symmetry axis aligned with the core magnetic field. The models also predict a magnetic field pinch structure on a scale less than or comparable to the infall radii for these sources. In addition, if the core magnetic field aligns (or nearly aligns) the core rotation axis with the magnetic field before core collapse, then the models predict the alignment (or near alignment) of the overall pinch field structure with the bipolar outflows in these sources. We show that if one includes the distorting effects of bipolar outflows on magnetic fields, then in general the observational results for L1527 and IC348-SMM2 are consistent with these magnetically regulated models. We can say the same for B335 only if we assume the distorting effects of the bipolar outflow on the magnetic fields within the B335 core are much greater than for L1527 and IC348-SMM2. We show that the energy densities of the outflows in all three sources are large enough to distort the magnetic fields predicted by magnetically regulated models.Comment: Accepted for publication in The Astrophysical Journa

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β. In addition, mouse caspase-11 (represented in humans by its orthologs, caspase-4 and caspase-5) detects cytosolic bacterial LPS directly. Activation of caspase-1 and caspase-11 initiates pyroptotic host cell death that releases potentially harmful bacteria from the nutrient-rich host cell cytosol into the extracellular environment. Here we use single cell analysis and time-lapse microscopy to identify a subpopulation of host cells, in which growth of cytosolic Salmonella Typhimurium is inhibited independently or prior to the onset of cell death. The enzymatic activities of caspase-1 and caspase-11 are required for growth inhibition in different cell types. Our results reveal that these proteases have important functions beyond the direct induction of pyroptosis and proinflammatory cytokine secretion in the control of growth and elimination of cytosolic bacteria

HI Observations of the Asymptotic Giant Branch Star X Herculis: Discovery of an Extended Circumstellar Wake Superposed on a Compact High-Velocity Cloud

We report HI 21-cm line observations of the AGB star X Her obtained with the Green Bank Telescope (GBT) and the Very Large Array (VLA). We have detected HI emission totaling M_HI=2.1e-03 M_sun associated with the circumstellar envelope of the star. The HI distribution exhibits a head-tail morphology, similar to those previously observed around Mira and RS Cnc. The tail extends ~6.0' (0.24 pc) in the plane of the sky, along the direction of the star's space motion. We also detect a velocity gradient of ~6.5 km/s across the envelope, consistent with the HI tracing a turbulent wake that arises from the motion of a mass-losing star through the ISM. GBT mapping of a 2x2deg region around X Her reveals that the star lies (in projection) near the periphery of a much larger HI cloud that also exhibits signatures of ISM interaction. The properties of the cloud are consistent with those of compact high-velocity clouds. Using CO observations, we have placed an upper limit on its molecular gas content of N_H2<1.3e20 cm^-2. Although the distance to the cloud is poorly constrained, the probability of a chance coincidence in position, velocity, and apparent position angle of space motion between X Her and the cloud is extremely small, suggesting a possible physical association. However, the large HI mass of the cloud (~>2.4~M_sun) and the blueshift of its mean velocity relative to X Her are inconsistent with an origin tied directly to stellar ejection. (abridged)Comment: Accepted to AJ; 47 pages, 15 figures; version with full resolution figures available at http://www.haystack.mit.edu/hay/staff/lmatthew/matthews_XHer.pd