The Separate or Concurrent Effects of Methylphenidate and Alcohol on Acquisition and Retention of the Morris Water Maze in Adolescent Rats

Alcohol’s (A) capacity to impair learning and memory has been well documented in the Morris Water Maze (MWM) but few studies have examined methylphenidate’s (MPH) impact on MWM performance (Haidun et al., 2010; Zeise et al., 2007). Even fewer studies have evaluated concurrent administration of these two drugs in adolescent rats (see Markwiese, et al., 1998). This project used a rat model of adolescent drug use to examine individual effects of MPH and A, as well as polypharmacy interactions between MPH and A, on MWM spatial acquisition and retention. Thirty-two adolescent (P30) male Long-Evans hooded rats were used. Subjects were assigned to one of 4 conditions based on drug administered prior to 6 consecutive acquisition sessions. Animals received 2 i.p. injections prior to each session. The methylphenidate group (MPH+S) received 2 mg/kg MPH and 1 ml/kg saline solution (S), the alcohol group (A+S) received 2 g/kg ethanol and S, the methylphenidate and alcohol group (MPH+A) received both MPH and A, and the saline control group (S+S) received S injections. MPH was administered 50 mins prior to each session and A administered 20 mins prior to each session. Each session consisted of 4 trials and rats swam from one of four start locations (N,E,S,W) to a submerged platform in the NE quadrant. Trial duration was 60 seconds and rats remained on the platform for 10 secs. Performances were video recorded, and latency and swim accuracy scored. Whishaw Corridors established a direct swim path from start location to platform and an error was recorded when swim paths exited the corridor. On day 7, the submerged platform was removed and a single, 60 sec retention test was conducted with no drug administered prior to test. Amount of time spent swimming in the NE quadrant was analyzed to assess retention. Acquisition: Both dependent measures, latency and swim accuracy, yielded similar outcomes. Factorial ANOVAs and post hoc tests showed improvement across training sessions for all groups. Importantly, the MPH+A group was impaired relative to all other conditions, and the S+S group performed better than the A group. No significant differences were observed between S+S and MPH+S groups. Retention: A one-way ANOVA of swim time in the NE quadrant revealed longer swim times for the S+S group compared to the A+S group, and longer swim times for the MPH+S group compared to the A+S group. No other significant differences were observed. While all groups improved performance during acquisition, methylphenidate + alcohol compromised spatial learning, and alcohol alone impaired learning relative to controls. Interestingly, measures of retention indicated only alcohol diminished spatial memory in adolescent rats

A Worst Practices Guide to Insider Threats: Lessons from Past Mistakes

Insider threats are perhaps the most serious challenges that nuclear security systems face. All of the cases of theft of nuclear materials where the circumstances of the theft are known were perpetrated either by insiders or with the help of insiders; given that the other cases involve bulk material stolen covertly without anyone being aware the material was missing, there is every reason to believe that they were perpetrated by insiders as well. Similarly, disgruntled workers from inside nuclear facilities have perpetrated many of the known incidents of nuclear sabotage. The most recent example of which we are aware is the apparent insider sabotage of a diesel generator at the San Onofre nuclear plant in the United States in 2012; the most spectacular was an incident three decades ago in which an insider placed explosives directly on the steel pressure vessel head of a nuclear reactor and then detonated them.While many such incidents, including the two just mentioned, appear to have been intended to send a message to management, not to spread radioactivity, they highlight the immense dangers that could arise from insiders with more malevolent intent. As it turns out, insiders perpetrate a large fraction of thefts from heavily guarded non-nuclear facilities as well. Yet organizations often find it difficult to understandand protect against insider threats. Why is this the case?Part of the answer is that there are deep organizational and cognitive biases that lead managers to downplay the threats insiders pose to their nuclear facilities and operations. But another part of the answer is that those managing nuclear security often have limited information about incidents that have happened in other countries or in other industries, and the lessons that might be learned from them.The IAEA and the World Institute for Nuclear Security (WINS) produce"best practices" guides as a way of disseminating ideas and procedures that have been identified as leading to improved security. Both have produced guides on protecting against insider threats.5 But sometimes mistakes are even moreinstructive than successes.Here, we are presenting a kind of "worst practices" guide of serious mistakes made in the past regarding insider threats. While each situation is unique, and serious insider problems are relatively rare, the incidents we describe reflect issues that exist in many contexts and that every nuclear security manager should consider. Common organizational practices -- such as prioritizing production over security, failure to share information across subunits, inadequate rules or inappropriate waiving of rules, exaggerated faith in group loyalty, and excessive focus on external threats -- can be seen in many past failures to protect against insider threats

Price Transparency in the Voluntary Price Reporting System for Live Cattle: Theory and Empirical Evidence from South Dakota

The ability of the former federal voluntary price reporting system to facilitate market efficiency in the cash markets for U.S. livestock was questioned by producer groups and academic researchers prior to implementation of federal mandatory price reporting regulations. In the cash market for slaughter cattle, concerns raised in the literature centered on the effect of thinning cash markets and strategic price reporting behavior on the robustness of voluntary cash price reports issued by the USDA-Agricultural Marketing Services. A theoretical framework is developed describing the interregional spatial linkages between cash markets and price reporting regimes (mandatory versus voluntary). Data from South Dakota and Nebraska cash markets for live cattle are used to test if the conditions necessary for interregional price transparency did exist prior to implementation of federal price reporting regulations. A set of testable hypotheses, based on the theoretical framework, is developed to test if the concerns raised in the literature about the voluntary price reporting system can be empiracally verified. The empirical results do not support the literature's proposition that the voluntary price reporting system for live cattle failed to provide timely and accurate market price information to the cash market prior to the implementation of the federal mandatory price reporting system in South Dakota and Nebraska. Furthermore, empirical evidence does not support the suppostion that a thinning cash market or strategic price reporting had a significant negative effect on the AMS voluntary price reporting system's accuracy or timely transmission of price information. Therefore, we conclude that the AMS voluntary price reporting system provided price transparency for South Dakota and Nebraska producers selling in the cash market and contributed to the price discovery process.grid pricing, price discovery, price reporting, slaughter cattle

Critical Phenomena Associated with Boson Stars

We present a brief synopsis of related work (gr-qc/0007039), describing a study of black hole threshold phenomena for a self-gravitating, massive complex scalar field in spherical symmetry. We construct Type I critical solutions dynamically by tuning a one-parameter family of initial data consisting of a boson star and a massless real scalar field, and numerically evolving this data. The resulting critical solutions appear to correspond to boson stars on the unstable branch, as we show via comparisons between our simulations and perturbation theory. For low-mass critical solutions, we find small ``halos'' of matter in the tails of the solutions, and these distort the profiles which otherwise agree with unstable boson stars. These halos seem to be artifacts of the collisions between the original boson stars and the massless fields, and do not appear to belong to the true critical solutions. From this study, it appears that unstable boson stars are unstable to dispersal (``explosion'') in addition to black hole formation. Given the similarities in macroscopic stability between boson stars and neutron stars, we suggest that similar phenomena could occur in models of neutron stars.Comment: 6 Pages, 5 Figures, LaTeX. To appear in Proceedings of the 20th Texas Symposium on Relativistic Astrophysics (Dec 9-15, 2000

Self-Assembly of Infinite Structures

We review some recent results related to the self-assembly of infinite structures in the Tile Assembly Model. These results include impossibility results, as well as novel tile assembly systems in which shapes and patterns that represent various notions of computation self-assemble. Several open questions are also presented and motivated