Is There a Numbers vs. Rights Trade-off in Immigration Policy? What the Data Say

This paper explores the empirical support behind the idea that there is a trade-off between the size of the migrant population and the rights and entitlements enjoyed by immigrants. We first look at the empirical correlation between measures of migrants’ rights and the size of the stock of immigrants in a number of existing databases. Using data on migrants’ rights from three recent studies—the Economist Intelligence Unit’s Migrant Accessibility Index, the Migration Policy Group and British Council’s Migrant Integration Policy Index (MIPEX) and the Human Development Report Office’s Migrant Entitlements and Services Index—we fail to find a systematic correlation of any sign. We then turn to regression analysis using OLS and instrumental variable techniques and again fail to find evidence in favor of the existence of a correlation. The numerical magnitudes of the correlations suggest a quantitatively small relationship which in several cases is positive rather than negative.migration rights and entitlements, measurement, migration data

Is There a Numbers versus Rights Trade-off in Immigration Policy? What the Data Say

This paper explores the empirical support behind the idea that there is a trade-off between the size of the migrant population and the rights and entitlements enjoyed by immigrants. We first look at the empirical correlation between measures of migrants’ rights and the size of the stock of immigrants in a number of existing databases. Using data on migrants’ rights from three recent studies—the Economist Intelligence Unit’s Migrant Accessibility Index, the Migration Policy Group and British Council’s Migrant Integration Policy Index (MIPEX) and the Human Development Report Office’s Migrant Entitlements and Services Index—we fail to find a systematic correlation of any sign. We then turn to regression analysis using OLS and instrumental variable techniques and again fail to find evidence in favor of the existence of a correlation. The numerical magnitudes of the correlations suggest a quantitatively small relationship which in several cases is positive rather than negative.migration rights and entitlements, measurement, migration data

Emission Line Properties of Seyfert Galaxies in the 12 Micron Sample

We present spectroscopy of emission lines for 81 Seyfert 1 and 104 Seyfert 2 galaxies in the IRAS 12$\mu$m galaxy sample. We analyzed the emission-line luminosity functions, reddening, and other gas diagnostics. The narrow-line regions (NLR) of Sy1 and 2 galaxies do not significantly differ from each other in most of these diagnostics. Combining the H$\alpha$/H$\beta$ ratio with a new reddening indicator-the [SII]6720/[OII]3727 ratio, we find the average $E(B-V)=0.49\pm0.35$ for Sy1s and $0.52\pm0.26$ for Sy2s. The NLR of Sy1 galaxies has only marginally higher ionization than the Sy2s. Our sample includes 22 Sy1.9s and 1.8s. In their narrow lines, these low-luminosity Seyferts are more similar to the Sy2s than the Sy1s. We construct a BPT diagram, and include the Sy1.8s and 1.9s. They overlap the region occupied by the Sy2s. The C IV equivalent width correlates more strongly with [O III]/H$\beta$ than with UV luminosity. The Sy1 and Sy2 luminosity functions of [OII]3727 and [OIII]5007 are indistinguishable. Unlike the LF's of Seyfert galaxies measured by SDSS, ours are nearly flat at low L. The larger number of faint Sloan "AGN" is attributable to their inclusion of weakly emitting LINERs and H II+AGN "composite" nuclei, which do not meet our classification criteria for Seyferts. An Appendix investigates which emission line luminosities provide the most reliable measures of the total non-stellar luminosity. The hard X-ray or near-ultraviolet continuum luminosity can be crudely predicted from either the [O III]5007 luminosity, or the combination of [O III]+H$\beta$, or [N II]+H$\alpha$ lines, with a scatter of $\pm\,4$ times for the Sy1s and $\pm\,10$ times for the Sy2s. The latter two hybrid (NLR+BLR) indicators have the advantage of predicting the same HX luminosity independent of Seyfert type.Comment: 70 pages, including 15 Figures and 10 Tables. Accepted for publication in The Astrophysical Journa

Antonio Gramsci: Life and Impact on Critical Pedagogy

Antonio Gramsci was born in the province of Cagliarli, Sardinia on 22 January 1891. One of seven children, his formative years was spent roaming the hills of Sardinia. Antonio\u27s political understanding was heavily influenced by the Socialism of his brother Gennaro and the imprisonment of his father, Francesco, from 1898-1904. Francesco\u27s imprisonment caused Antonio to curtail his formal education and take up employment. This continued for several years until Francesco was released, allowing young Antonio to return to formal studies

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces

The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can adopt different migratory modes in response to their microenvironment. Here we present a model that uses human stromal cell-derived matrices to demonstrate that plasticity in tumor cell movement is controlled by the tumor-associated collagen receptor Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) and the crosslinking of collagen fibers by stromal-derived lysyl oxidase (LOX). Human osteoblast-derived and fibroblast-derived ECM supported a rounded ‘amoeboid-like’ mode of cell migration and enhanced Endo180 expression in three prostate cancer cell lines (PC3, VCaP, DU145). Genetic silencing of Endo180 reverted PC3 cells from their rounded mode of migration towards a bipolar ‘mesenchymal-like’ mode of migration and blocked their translocation on human fibroblast-derived and osteoblast-derived matrices. The concomitant decrease in PC3 cell migration and increase in Endo180 expression induced by stromal LOX inhibition indicates that the Endo180-dependent rounded mode of prostate cancer cell migration requires ECM crosslinking. In conclusion, this study introduces a realistic in vitro model for the study of metastatic prostate cancer cell plasticity and pinpoints the cooperation between tumor-associated Endo180 and the stiff microenvironment imposed by stromal-derived LOX as a potential target for limiting metastatic progression in prostate cancer

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges.

Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could be achieved. The route of entry of Mycobacterium tuberculosis, the causative organism, is via inhalation making TB primarily a respiratory disease. There is therefore good reason to hypothesize that a mucosally delivered vaccine against TB could be more effective than one delivered via the systemic route.Areas covered: This review summarizes the progress that has been made in the area of TB mucosal vaccines in the last few years. It highlights some of the strengths and shortcomings of the published evidence and aims to discuss immunological and practical considerations in the development of mucosal vaccines.Expert opinion: There is a growing body of evidence that the mucosal approach to vaccination against TB is feasible and should be pursued. However, further key studies are necessary to both improve our understanding of the protective immune mechanisms operating in the mucosa and the technical aspects of aerosolized delivery, before such a vaccine could become a feasible, deployable strategy